IL103852A - Method and kit for detecting antibodies in the blood with a negative serum of people - Google Patents

Method and kit for detecting antibodies in the blood with a negative serum of people

Info

Publication number: IL103852A
Authority: IL; Israel
Prior art keywords: kit; virus; mitogen; container; antigen
Prior art date: 1991-11-25

Application number

IL10385292A

Other languages

English (en)

Hebrew (he)

Other versions

IL103852A0 (en

Original Assignee

Shiloov Medical Technologies L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-25

Filing date

1992-11-24

Publication date

1999-06-20

1992-11-24 Application filed by Shiloov Medical Technologies L filed Critical Shiloov Medical Technologies L

1993-04-04 Publication of IL103852A0 publication Critical patent/IL103852A0/xx

1999-06-20 Publication of IL103852A publication Critical patent/IL103852A/en

Links

238000000034 method Methods 0.000 title claims abstract description 53
238000001514 detection method Methods 0.000 title claims abstract description 20
239000008280 blood Substances 0.000 claims abstract description 84
210000004369 blood Anatomy 0.000 claims abstract description 80
241000725303 Human immunodeficiency virus Species 0.000 claims abstract description 33
238000003556 assay Methods 0.000 claims abstract description 26
239000003226 mitogen Substances 0.000 claims abstract description 26
210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 38
241000700605 Viruses Species 0.000 claims description 27
238000012360 testing method Methods 0.000 claims description 20
238000002965 ELISA Methods 0.000 claims description 17
108010033737 Pokeweed Mitogens Proteins 0.000 claims description 17
239000000427 antigen Substances 0.000 claims description 14
102000036639 antigens Human genes 0.000 claims description 14
108091007433 antigens Proteins 0.000 claims description 14
239000006228 supernatant Substances 0.000 claims description 13
238000001262 western blot Methods 0.000 claims description 13
230000004913 activation Effects 0.000 claims description 6
239000011521 glass Substances 0.000 claims description 4
238000010166 immunofluorescence Methods 0.000 claims description 4
108090001090 Lectins Proteins 0.000 claims description 3
102000004856 Lectins Human genes 0.000 claims description 3
239000002158 endotoxin Substances 0.000 claims description 3
239000002523 lectin Substances 0.000 claims description 3
GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims description 3
239000004033 plastic Substances 0.000 claims description 3
241001430294 unidentified retrovirus Species 0.000 claims description 3
102000008072 Lymphokines Human genes 0.000 claims description 2
108010074338 Lymphokines Proteins 0.000 claims description 2
239000007769 metal material Substances 0.000 claims 2
230000010460 detection of virus Effects 0.000 claims 1
208000015181 infectious disease Diseases 0.000 abstract description 11
208000031886 HIV Infections Diseases 0.000 abstract description 10
238000012216 screening Methods 0.000 abstract description 5
208000037357 HIV infectious disease Diseases 0.000 abstract description 3
210000003719 b-lymphocyte Anatomy 0.000 abstract description 3
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract description 3
108060003951 Immunoglobulin Proteins 0.000 abstract description 2
102000018358 immunoglobulin Human genes 0.000 abstract description 2
239000012503 blood component Substances 0.000 abstract 1
230000002458 infectious effect Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
210000002966 serum Anatomy 0.000 description 16
239000012530 fluid Substances 0.000 description 13
239000002609 medium Substances 0.000 description 13
241000282693 Cercopithecidae Species 0.000 description 12
210000004027 cell Anatomy 0.000 description 12
239000001963 growth medium Substances 0.000 description 10
208000030507 AIDS Diseases 0.000 description 9
241000713772 Human immunodeficiency virus 1 Species 0.000 description 8
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 8
241000713311 Simian immunodeficiency virus Species 0.000 description 7
210000000601 blood cell Anatomy 0.000 description 7
238000010790 dilution Methods 0.000 description 7
239000012895 dilution Substances 0.000 description 7
206010028980 Neoplasm Diseases 0.000 description 6
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 5
239000012980 RPMI-1640 medium Substances 0.000 description 5
239000012298 atmosphere Substances 0.000 description 5
201000011510 cancer Diseases 0.000 description 5
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
230000016784 immunoglobulin production Effects 0.000 description 5
230000000405 serological effect Effects 0.000 description 5
108091003079 Bovine Serum Albumin Proteins 0.000 description 4
208000008771 Lymphadenopathy Diseases 0.000 description 4
229930182555 Penicillin Natural products 0.000 description 4
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 4
210000001744 T-lymphocyte Anatomy 0.000 description 4
201000010099 disease Diseases 0.000 description 4
239000012894 fetal calf serum Substances 0.000 description 4
238000011534 incubation Methods 0.000 description 4
210000000056 organ Anatomy 0.000 description 4
229940049954 penicillin Drugs 0.000 description 4
238000000926 separation method Methods 0.000 description 4
229960005322 streptomycin Drugs 0.000 description 4
206010001513 AIDS related complex Diseases 0.000 description 3
229930182816 L-glutamine Natural products 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
239000000020 Nitrocellulose Substances 0.000 description 3
208000005074 Retroviridae Infections Diseases 0.000 description 3
238000003149 assay kit Methods 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
230000001684 chronic effect Effects 0.000 description 3
208000018555 lymphatic system disease Diseases 0.000 description 3
229920001220 nitrocellulos Polymers 0.000 description 3
238000003752 polymerase chain reaction Methods 0.000 description 3
230000008569 process Effects 0.000 description 3
239000000126 substance Substances 0.000 description 3
208000011580 syndromic disease Diseases 0.000 description 3
208000023275 Autoimmune disease Diseases 0.000 description 2
206010053567 Coagulopathies Diseases 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
238000012286 ELISA Assay Methods 0.000 description 2
240000007643 Phytolacca americana Species 0.000 description 2
235000009074 Phytolacca americana Nutrition 0.000 description 2
230000001413 cellular effect Effects 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
230000035602 clotting Effects 0.000 description 2
238000005345 coagulation Methods 0.000 description 2
230000015271 coagulation Effects 0.000 description 2
238000012790 confirmation Methods 0.000 description 2
210000003743 erythrocyte Anatomy 0.000 description 2
230000036541 health Effects 0.000 description 2
210000002443 helper t lymphocyte Anatomy 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
210000000987 immune system Anatomy 0.000 description 2
208000026278 immune system disease Diseases 0.000 description 2
210000000265 leukocyte Anatomy 0.000 description 2
244000005700 microbiome Species 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
230000000638 stimulation Effects 0.000 description 2
-1 such as Proteins 0.000 description 2
238000002054 transplantation Methods 0.000 description 2
206010000159 Abnormal loss of weight Diseases 0.000 description 1
230000003844 B-cell-activation Effects 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
108010062580 Concanavalin A Proteins 0.000 description 1
241000701022 Cytomegalovirus Species 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
238000008157 ELISA kit Methods 0.000 description 1
238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
206010062016 Immunosuppression Diseases 0.000 description 1
102000004388 Interleukin-4 Human genes 0.000 description 1
108090000978 Interleukin-4 Proteins 0.000 description 1
102000000743 Interleukin-5 Human genes 0.000 description 1
108010002616 Interleukin-5 Proteins 0.000 description 1
208000007766 Kaposi sarcoma Diseases 0.000 description 1
239000007757 Media 199 Substances 0.000 description 1
208000001388 Opportunistic Infections Diseases 0.000 description 1
208000007027 Oral Candidiasis Diseases 0.000 description 1
208000005384 Pneumocystis Pneumonia Diseases 0.000 description 1
241000288906 Primates Species 0.000 description 1
206010037660 Pyrexia Diseases 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
206010052779 Transplant rejections Diseases 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
239000012190 activator Substances 0.000 description 1
230000004075 alteration Effects 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000011324 bead Substances 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000003124 biologic agent Substances 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
230000037029 cross reaction Effects 0.000 description 1
238000012258 culturing Methods 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
239000003599 detergent Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
206010016256 fatigue Diseases 0.000 description 1
238000001914 filtration Methods 0.000 description 1
230000006870 function Effects 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
230000036737 immune function Effects 0.000 description 1
230000008105 immune reaction Effects 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
230000001506 immunosuppresive effect Effects 0.000 description 1
238000007901 in situ hybridization Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
229940028885 interleukin-4 Drugs 0.000 description 1
229940100602 interleukin-5 Drugs 0.000 description 1
238000002955 isolation Methods 0.000 description 1
201000002364 leukopenia Diseases 0.000 description 1
231100001022 leukopenia Toxicity 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
239000013642 negative control Substances 0.000 description 1
206010029410 night sweats Diseases 0.000 description 1
230000036565 night sweats Effects 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
244000052769 pathogen Species 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
230000035939 shock Effects 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
230000001629 suppression Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000035899 viability Effects 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Virology (AREA)
Food Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Tropical Medicine & Parasitology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
AIDS & HIV (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Prostheses (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

IL10385292A 1991-11-25 1992-11-24 Method and kit for detecting antibodies in the blood with a negative serum of people IL103852A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US79773091A	1991-11-25	1991-11-25

Publications (2)

Publication Number	Publication Date
IL103852A0 IL103852A0 (en)	1993-04-04
IL103852A true IL103852A (en)	1999-06-20

Family

ID=25171653

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL10385292A IL103852A (en)	1991-11-25	1992-11-24	Method and kit for detecting antibodies in the blood with a negative serum of people
IL12533098A IL125330A0 (en)	1991-11-25	1998-07-13	Method of matching tissue for transplantation

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL12533098A IL125330A0 (en)	1991-11-25	1998-07-13	Method of matching tissue for transplantation

Country Status (13)

Country	Link
US (2)	US5637453A (de)
EP (1)	EP0643838B1 (de)
JP (2)	JPH07509557A (de)
AT (1)	ATE191791T1 (de)
CA (2)	CA2200363A1 (de)
DE (1)	DE69230918T2 (de)
DK (1)	DK0643838T3 (de)
ES (1)	ES2147195T3 (de)
GR (1)	GR3033919T3 (de)
IL (2)	IL103852A (de)
PT (1)	PT643838E (de)
WO (1)	WO1993011435A1 (de)
ZA (1)	ZA929160B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6280962B1 (en)	1991-11-25	2001-08-28	Yoreh Biotechnologies Ltd.	Whole blood/mitogen assay for the early detection of a subject with cancer and kit
US6352826B1 (en)	1991-11-25	2002-03-05	Yoreh Biotechnologies, Ltd.	Method and kit for the detection of retroviral specific antibodies in seronegative individuals
US6322989B1 (en)	1991-11-25	2001-11-27	Yoreh Biotechnologies, Ltd.	Whole blood/mitogen assay for the early detection of a subject with ovarian or breast cancer and kit
JP2001504233A (ja) *	1996-11-22	2001-03-27	シルーヴメディカルテクノロジーズリミテッド	癌を有する被験者の早期検出のための全血／マイトジェンアッセイおよびキット
EP0973944A1 (de) *	1997-03-31	2000-01-26	Abbott Laboratories	Reagentien und verfahren zur erkennung von krankheiten des gastrointestinaltraktes
WO1998044160A1 (en) *	1997-03-31	1998-10-08	Abbott Laboratories	Reagents and methods useful for detecting diseases of the gastrointestinal tract
GB9913819D0 (en)	1999-06-14	1999-08-11	Plasmacute As	Assay
DE10125730A1 (de) *	2001-05-17	2002-11-21	A I D Autoimmun Diagnostika Gm	Verfahren zum Nachweis von Erregern und durch diese induzierten zellulär produzierten Stoffen im lebenden Organismus
WO2004064608A2 (en) *	2003-01-17	2004-08-05	Aethlon Medical, Inc.	Method for removal of viruses from blood by lectin affinity hemodialysis
GB0325483D0 (en) *	2003-10-31	2003-12-03	Plasmacute As	Assay
EP2309269B1 (de) *	2004-09-08	2016-10-26	THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES	Zusammensetzungen und verfahren zur detektion von hiv-1/hiv-2 infektion
US7770050B2 (en) *	2006-05-03	2010-08-03	Sony Computer Entertainment Inc.	Method and apparatus for resolving clock management issues in emulation involving both interpreted and translated code
CA2810770A1 (en) *	2010-09-07	2012-03-15	Smart Biotech Ltd.	Methods and kits for the detection of an infection in subjects with low specific antibody levels
BR112013024317A2 (pt) *	2011-03-23	2019-09-24	Smart Biotech Ltd	método e kit para a determinação do tempo de seroconversão de um paciente infectado com um vírus
US9651557B2 (en) *	2012-03-08	2017-05-16	Dror Atzmon	Method and kit for the detection of hepatitis-specific antibodies
WO2013132496A1 (en) *	2012-03-08	2013-09-12	Smart Biotech Ltd.	Methods and kits for the detection of viral infections
WO2016014861A1 (en) *	2014-07-25	2016-01-28	Incelldx, Inc.	Methods of evaluating a cellular sample for latent cellular replication competent hiv-1, and compositions and kits for use in practicing the same
DE102019214137A1 (de) *	2019-09-17	2021-03-18	Hot Screen Gmbh	Verwendung in vitro eines Kits und eines Verfahrens zur Diagnostik von Transplantationen und/oder Autoimmunerkrankungen und/oder Tumorerkrankungen und/oder Vakzinierungen sowie ein botenstoffhaltiger Überstand, zellhaltiges Sediment und eine Kombination zur Anwendung bei der Diagnostik von Transplantationen und/oder Autoimmunerkrankungen und/oder Tumorerkrankungen und/oder Vakzinierungen
CN113917162B (zh) *	2021-12-14	2022-04-01	江苏为真生物医药技术股份有限公司	去唾液酸糖蛋白受体片段sH2a作为标志物的应用

1992
- 1992-11-24 CA CA002200363A patent/CA2200363A1/en not_active Abandoned
- 1992-11-24 PT PT93900599T patent/PT643838E/pt unknown
- 1992-11-24 AT AT93900599T patent/ATE191791T1/de active
- 1992-11-24 DE DE69230918T patent/DE69230918T2/de not_active Expired - Fee Related
- 1992-11-24 DK DK93900599T patent/DK0643838T3/da active
- 1992-11-24 ES ES93900599T patent/ES2147195T3/es not_active Expired - Lifetime
- 1992-11-24 IL IL10385292A patent/IL103852A/en not_active IP Right Cessation
- 1992-11-24 EP EP93900599A patent/EP0643838B1/de not_active Expired - Lifetime
- 1992-11-24 CA CA002124319A patent/CA2124319A1/en not_active Abandoned
- 1992-11-24 WO PCT/US1992/010075 patent/WO1993011435A1/en not_active Ceased
- 1992-11-24 JP JP5510189A patent/JPH07509557A/ja active Pending
- 1992-11-25 ZA ZA929160A patent/ZA929160B/xx unknown
1994
- 1994-07-15 US US08/275,933 patent/US5637453A/en not_active Expired - Lifetime
1996
- 1996-11-22 US US08/755,287 patent/US20020006608A1/en not_active Abandoned
1998
- 1998-07-13 IL IL12533098A patent/IL125330A0/xx unknown
- 1998-10-20 JP JP10298800A patent/JPH11237381A/ja active Pending
2000
- 2000-07-10 GR GR20000401604T patent/GR3033919T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE191791T1 (de)	2000-04-15
JPH07509557A (ja)	1995-10-19
EP0643838A4 (de)	1996-02-28
WO1993011435A1 (en)	1993-06-10
EP0643838B1 (de)	2000-04-12
DE69230918D1 (de)	2000-05-18
US5637453A (en)	1997-06-10
CA2200363A1 (en)	1993-05-26
JPH11237381A (ja)	1999-08-31
EP0643838A1 (de)	1995-03-22
US20020006608A1 (en)	2002-01-17
IL125330A0 (en)	1999-08-17
CA2124319A1 (en)	1993-06-10
IL103852A0 (en)	1993-04-04
ES2147195T3 (es)	2000-09-01
GR3033919T3 (en)	2000-11-30
DK0643838T3 (da)	2000-09-11
DE69230918T2 (de)	2000-11-09
ZA929160B (en)	1993-08-16
PT643838E (pt)	2000-10-31

Legal Events

Date	Code	Title
1999-10-28	FF	Patent granted
2000-06-01	KB	Patent renewed
2003-07-31	RH1	Patent not in force

Publication	Publication Date	Title
US5637453A (en)	1997-06-10	Whole blood method and kit for the detection of antibodies against human immunodeficiency virus (HIV) in HIV-seronegative individuals
JP2729212B2 (ja)	1998-03-18	Ｈｉｖの精製単離されたレトロウィルス
WITTEK et al.	1987	Detection of human immunodeficiency virus core protein in plasma by enzyme immunoassay: association of antigenemia with symptomatic disease and T-helper cell depletion
US4904581A (en)	1990-02-27	Method of detecting AIDS virus infection
US5773232A (en)	1998-06-30	Methods for measurement of lymphocyte function
US4968601A (en)	1990-11-06	Method for diagnosing latent viral infection
US6352826B1 (en)	2002-03-05	Method and kit for the detection of retroviral specific antibodies in seronegative individuals
US4917998A (en)	1990-04-17	Method of detecting AIDS virus infection
US20010008760A1 (en)	2001-07-19	Reagent system and kit for detecting hiv infected cells
Prince et al.	1991	Immunologic correlates of spontaneous lymphocyte proliferation in human T-lymphotropic virus infection
EP0196873B1 (de)	1989-12-13	Diagnose für Mikroorganismen
US6306581B1 (en)	2001-10-23	Diagnostic assay method and kit for the detection of HHV-8 infection
AU743937B2 (en)	2002-02-07	Reagent system and kit for detecting HIV infected cells
US7169571B2 (en)	2007-01-30	Methods for measurement of lymphocyte function
De Stasio et al.	1990	Screening for anti-human T-lymphotropic virus antibody in blood donors and polytransfused patients in Apulia (Italy)
EP0220970B1 (de)	1996-01-10	Methoden zur Verwendung von an humanen Klasse-II-Histokompatibilitätsantigenen mangelnden Zellinien
Prince et al.	1992	Lymphocyte subsets in HTLV-II-infected former blood donors: relationship to spontaneous lymphocyte proliferation
Roberts	1991	Laboratory diagnosis of retroviral infections
EP0514494B1 (de)	1995-06-28	Verfahren zum nachweis des humanen immunodeficiency virus (hiv) und dafür geeignete zellinien
US5580772A (en)	1996-12-03	Association between a novel human intracisternal A-type retroviral particle-type II (HIAP-II) and idiopathic CD4+ T-lymphocytopenia (ICL)
JPH05188057A (ja)	1993-07-27	Ｈｉｖ−１抗体の免疫酵素的検出法
WO1993010222A1 (en)	1993-05-27	New human intracisternal retrovirus associated with cd4+ t cell deficiency/dysfunction
Ovčak et al.	1987	Evaluation of EIA kits for the detection of HIV antibodies.
Howanitz et al.	1991	Assessment of biological reagents for presence of human immunodeficiency virus-1 (HIV-1) antigens