IL104059A0 - Bicyclopolyazamacrocyclocarboxylic acid complexes,their conjugates,processes for their preparation,and use as contrast agents - Google Patents
Bicyclopolyazamacrocyclocarboxylic acid complexes,their conjugates,processes for their preparation,and use as contrast agentsInfo
- Publication number
- IL104059A0 IL104059A0 IL104059A IL10405992A IL104059A0 IL 104059 A0 IL104059 A0 IL 104059A0 IL 104059 A IL104059 A IL 104059A IL 10405992 A IL10405992 A IL 10405992A IL 104059 A0 IL104059 A0 IL 104059A0
- Authority
- IL
- Israel
- Prior art keywords
- conjugates
- processes
- contrast agents
- preparation
- acid complexes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80527091A | 1991-12-10 | 1991-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL104059A0 true IL104059A0 (en) | 1993-05-13 |
Family
ID=25191100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL104059A IL104059A0 (en) | 1991-12-10 | 1992-12-10 | Bicyclopolyazamacrocyclocarboxylic acid complexes,their conjugates,processes for their preparation,and use as contrast agents |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0579802B1 (de) |
| JP (1) | JPH07502277A (de) |
| AT (1) | ATE192047T1 (de) |
| AU (1) | AU3415493A (de) |
| CA (1) | CA2103554C (de) |
| DE (1) | DE69230970T2 (de) |
| ES (1) | ES2145041T3 (de) |
| HU (1) | HUT67602A (de) |
| IL (1) | IL104059A0 (de) |
| MX (1) | MX9207164A (de) |
| SG (1) | SG48889A1 (de) |
| WO (1) | WO1993011800A1 (de) |
| ZA (1) | ZA929575B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5334371A (en) * | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| US5385893A (en) * | 1993-05-06 | 1995-01-31 | The Dow Chemical Company | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| JP2000508625A (ja) * | 1996-03-13 | 2000-07-11 | モンサント カンパニー | スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガンまたは鉄錯体の生体分子結合体 |
| US6214817B1 (en) | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| US7445641B1 (en) | 1999-05-27 | 2008-11-04 | Pharmacia Corporation | Biomaterials modified with superoxide dismutase mimics |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| EP1322340A2 (de) * | 2000-09-25 | 2003-07-02 | The Procter & Gamble Company | Mangankomplexe für kernspinnresonanzbildgebung |
| FR2883562B1 (fr) | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
| FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| NO331773B1 (no) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| CA2909919C (fr) | 2013-04-26 | 2022-07-12 | Guerbet | Formulation de produit de contraste et son procede de preparation associe |
| EP3101012A1 (de) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| EP3544964B1 (de) | 2016-11-28 | 2020-06-17 | Bayer Pharma Aktiengesellschaft | Gadolinium-chelat-verbindung mit hoher relaxivität zur verwendung in der magnetresonanzbildgebung |
| IL321215B2 (en) | 2018-11-23 | 2026-05-01 | Bayer Ag | Contrast media formulation and process for its preparation |
| WO2025045168A1 (zh) | 2023-09-01 | 2025-03-06 | 江苏恒瑞医药股份有限公司 | 一种大环化合物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
| US4933441A (en) * | 1987-01-27 | 1990-06-12 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
| SE8702824L (sv) * | 1987-07-10 | 1989-01-11 | Wallac Oy | Metall-kelaterande 2,6-disubstituerade pyridinfoereningar och deras anvaendning |
| DE4001655A1 (de) * | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag, 13353 Berlin | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
-
1992
- 1992-12-10 DE DE69230970T patent/DE69230970T2/de not_active Expired - Fee Related
- 1992-12-10 AU AU34154/93A patent/AU3415493A/en not_active Abandoned
- 1992-12-10 IL IL104059A patent/IL104059A0/xx unknown
- 1992-12-10 WO PCT/US1992/011003 patent/WO1993011800A1/en not_active Ceased
- 1992-12-10 MX MX9207164A patent/MX9207164A/es not_active IP Right Cessation
- 1992-12-10 HU HU9302309A patent/HUT67602A/hu unknown
- 1992-12-10 SG SG1996003475A patent/SG48889A1/en unknown
- 1992-12-10 EP EP93902658A patent/EP0579802B1/de not_active Expired - Lifetime
- 1992-12-10 CA CA002103554A patent/CA2103554C/en not_active Expired - Fee Related
- 1992-12-10 ES ES93902658T patent/ES2145041T3/es not_active Expired - Lifetime
- 1992-12-10 JP JP51119493A patent/JPH07502277A/ja active Pending
- 1992-12-10 AT AT93902658T patent/ATE192047T1/de not_active IP Right Cessation
- 1992-12-10 ZA ZA929575A patent/ZA929575B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9302309D0 (en) | 1993-12-28 |
| ATE192047T1 (de) | 2000-05-15 |
| ZA929575B (en) | 1994-06-10 |
| HUT67602A (en) | 1995-04-28 |
| DE69230970T2 (de) | 2001-01-04 |
| EP0579802A4 (en) | 1994-07-06 |
| JPH07502277A (ja) | 1995-03-09 |
| DE69230970D1 (de) | 2000-05-31 |
| AU3415493A (en) | 1993-07-19 |
| CA2103554C (en) | 2002-07-30 |
| WO1993011800A1 (en) | 1993-06-24 |
| EP0579802A1 (de) | 1994-01-26 |
| ES2145041T3 (es) | 2000-07-01 |
| SG48889A1 (en) | 1998-05-18 |
| MX9207164A (es) | 1993-07-01 |
| EP0579802B1 (de) | 2000-04-26 |
| CA2103554A1 (en) | 1993-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA929575B (en) | Bicyclopolyazamacrocyclocarboxyclic acid complexes,their conjugates,processes for their preparation,and use as contrast agents | |
| CA2090700A1 (en) | Modified antibodies with controlled clearance time | |
| BG100194A (bg) | Трициклополиазамакроциклофосфонови киселини,техни производни и комплекси и използването им като контрастни средства | |
| FI955319A0 (fi) | 2-pyridyylimetyleenipolyatsamakrosyklofosfonihappoja, niiden komplekseja ja johdannaisia käytettäväksi vasta-aineina | |
| AU7366687A (en) | Coupling agents for radiolabeling proteins | |
| HUT51594A (en) | Process for production of celates and their complexes containing ortolizating functional groups, compositions containing such active substances and process for production of conjugates consisting of one complex and linked to it antibody or fragment of antibody | |
| IL104060A0 (en) | Bicyclopolyazamacrocyclophosphonic acids,their complexes and conjugates,for use as contrast agents,and processes for their preparation | |
| RU93053767A (ru) | Бициклополиазамакроциклофосфоновые кислоты, их комплексы и конъюгаты для применения в качестве контрастных агентов и способы их получения | |
| FI933506L (fi) | Bisyklopolyatsamakrosyklokarboksyylihappokomplekseja, niiden konjugaatteja, menetelmä niiden valmistamiseksi ja käyttö varjoaineina | |
| NO954442L (no) | Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler, og fremgangsmåter for deres fremstilling | |
| AU8962191A (en) | A process for the preparation of a pasteurized and iron-free human transferrin and the use thereof | |
| MY109649A (en) | Bicyclopol yazamacrocyclocarboxylic acid complexes, and conjugates, processes for their prepration, and use as contrast agents | |
| MY141501A (en) | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents and processes for their preparation | |
| RU93053897A (ru) | Комплексы бициклополиазамакроциклокарбоновых кислот, их конъюгаты, фармацевтическая композиция, способ диагностики, набор и способ получения | |
| IT1242026B (it) | Composizione farmaceutica contenente un complesso ferro-schizokinene per il trattamento dell'anemia ferropenica. |