IL105111A - SEMI-SYNTHETIC GLYCOSAMINOGLYCANS CONTAINING a-L- GALACTURONIC ACID SUBSTITUTED WITH NUCLEOPHILIC RADICALS IN POSITION 3 AND THEIR PREPARATION - Google Patents

SEMI-SYNTHETIC GLYCOSAMINOGLYCANS CONTAINING a-L- GALACTURONIC ACID SUBSTITUTED WITH NUCLEOPHILIC RADICALS IN POSITION 3 AND THEIR PREPARATION

Info

Publication number: IL105111A
Authority: IL; Israel
Prior art keywords: semi; preparation; galacturonic acid; acid substituted; synthetic glycosaminoglycans
Prior art date: 1992-04-17

Application number

IL105111A

Other languages

English (en)

Original Assignee

Alfa Wassermann Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-17

Filing date

1993-03-19

Publication date

1997-03-18

1993-03-19 Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa

1997-03-18 Publication of IL105111A publication Critical patent/IL105111A/xx

Links

229920002683 Glycosaminoglycan Polymers 0.000 title abstract 2
230000000269 nucleophilic effect Effects 0.000 title abstract 2
230000002785 anti-thrombosis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL105111A 1992-04-17 1993-03-19 SEMI-SYNTHETIC GLYCOSAMINOGLYCANS CONTAINING a-L- GALACTURONIC ACID SUBSTITUTED WITH NUCLEOPHILIC RADICALS IN POSITION 3 AND THEIR PREPARATION IL105111A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITBO920140A IT1260136B (it)	1992-04-17	1992-04-17	Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3

Publications (1)

Publication Number	Publication Date
IL105111A true IL105111A (en)	1997-03-18

Family

ID=11338174

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL105111A IL105111A (en)	1992-04-17	1993-03-19	SEMI-SYNTHETIC GLYCOSAMINOGLYCANS CONTAINING a-L- GALACTURONIC ACID SUBSTITUTED WITH NUCLEOPHILIC RADICALS IN POSITION 3 AND THEIR PREPARATION

Country Status (18)

Country	Link
US (1)	US5430132A (es)
EP (1)	EP0565862B1 (es)
JP (1)	JP2702377B2 (es)
KR (1)	KR0171623B1 (es)
AT (1)	ATE154615T1 (es)
AU (1)	AU658499B2 (es)
CA (1)	CA2093148C (es)
DE (1)	DE69311618T2 (es)
DK (1)	DK0565862T3 (es)
ES (1)	ES2103991T3 (es)
FI (1)	FI106555B (es)
GR (1)	GR3024582T3 (es)
IL (1)	IL105111A (es)
IT (1)	IT1260136B (es)
NO (1)	NO306305B1 (es)
NZ (1)	NZ247197A (es)
TW (1)	TW229213B (es)
ZA (1)	ZA931799B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1260137B (it) *	1992-04-17	1996-03-28	Alfa Wassermann Spa	Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US5696100A (en) *	1992-12-22	1997-12-09	Glycomed Incorporated	Method for controlling O-desulfation of heparin and compositions produced thereby
IT1264101B1 (it) *	1993-03-29	1996-09-10	Alfa Wassermann Spa	Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
IT1264102B1 (it) *	1993-03-29	1996-09-10	Alfa Wassermann Spa	Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
US5583121A (en) *	1994-01-12	1996-12-10	Michigan State University	Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US6127347A (en) *	1994-01-12	2000-10-03	Univ Michigan	Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
NO984143L (no)	1998-09-09	2000-03-10	Norsk Hydro As	Ny prosess for å fremstille overflatemodifiserende stoffer
CA2377734A1 (en) *	1999-06-30	2001-01-11	Hamilton Civic Hospitals Research Development, Inc.	Heparin compositions that inhibit clot associated coagulation factors
US7259152B2 (en)	2000-06-07	2007-08-21	Alfa Wasserman, Inc.	Methods and compositions using sulodexide for the treatment of diabetic nephropathy
IL154771A0 (en) *	2000-09-08	2003-10-31	Hamilton Civic Hospitals Res	Antithrombotic compositions
JP4828795B2 (ja)	2002-03-11	2011-11-30	モメンタファーマシューティカルズインコーポレイテッド	硫酸化多糖類の分析
US9139876B1 (en)	2007-05-03	2015-09-22	Momenta Pharmacueticals, Inc.	Method of analyzing a preparation of a low molecular weight heparin
ES2817779T3 (es) *	2010-01-19	2021-04-08	Momenta Pharmaceuticals Inc	Evaluación de preparaciones de heparina
WO2012036152A1 (ja) *	2010-09-14	2012-03-22	国立大学法人宮崎大学	高純度ヘパリンおよびその製造方法
US9068957B2 (en)	2011-02-21	2015-06-30	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
KR102468224B1 (ko)	2016-03-09	2022-11-17	가부시키가이샤 도우사 고가쿠 겐큐쇼	설페이트기 및/또는 포스페이트기를 갖는 당의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4987223A (en) *	1981-12-23	1991-01-22	Choay S.A.	Derivatives of the uronic acid
IT1234508B (it) *	1988-06-10	1992-05-19	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione
DE3821271A1 (de) *	1988-06-23	1989-12-28	Solco Basel Ag	Derivatisiertes heparin, verfahren zu dessen herstellung und arzneimittel, welches dieses enthaelt
IT1234826B (it) *	1989-01-30	1992-05-29	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione
US5200523A (en) *	1990-10-10	1993-04-06	Monsanto Company	Synthesis of nojirimycin derivatives

1992
- 1992-04-17 IT ITBO920140A patent/IT1260136B/it active IP Right Grant
1993
- 1993-03-10 DK DK93103847.5T patent/DK0565862T3/da active
- 1993-03-10 EP EP93103847A patent/EP0565862B1/en not_active Expired - Lifetime
- 1993-03-10 ES ES93103847T patent/ES2103991T3/es not_active Expired - Lifetime
- 1993-03-10 AT AT93103847T patent/ATE154615T1/de not_active IP Right Cessation
- 1993-03-10 DE DE69311618T patent/DE69311618T2/de not_active Expired - Fee Related
- 1993-03-12 ZA ZA931799A patent/ZA931799B/xx unknown
- 1993-03-18 NZ NZ247197A patent/NZ247197A/en unknown
- 1993-03-19 IL IL105111A patent/IL105111A/xx not_active IP Right Cessation
- 1993-03-19 TW TW082102015A patent/TW229213B/zh active
- 1993-03-30 NO NO931181A patent/NO306305B1/no not_active IP Right Cessation
- 1993-04-01 CA CA002093148A patent/CA2093148C/en not_active Expired - Fee Related
- 1993-04-13 AU AU36896/93A patent/AU658499B2/en not_active Ceased
- 1993-04-13 US US08/046,247 patent/US5430132A/en not_active Expired - Lifetime
- 1993-04-16 FI FI931740A patent/FI106555B/fi not_active IP Right Cessation
- 1993-04-16 JP JP5089977A patent/JP2702377B2/ja not_active Expired - Fee Related
- 1993-04-17 KR KR1019930006474A patent/KR0171623B1/ko not_active Expired - Fee Related
1997
- 1997-08-29 GR GR970402225T patent/GR3024582T3/el unknown

Also Published As

Publication number	Publication date
EP0565862A3 (en)	1993-11-10
DE69311618T2 (de)	1997-12-11
KR930021651A (ko)	1993-11-22
US5430132A (en)	1995-07-04
NO931181L (no)	1993-10-18
FI931740A0 (fi)	1993-04-16
DE69311618D1 (de)	1997-07-24
EP0565862A2 (en)	1993-10-20
NO306305B1 (no)	1999-10-18
AU658499B2 (en)	1995-04-13
NO931181D0 (no)	1993-03-30
TW229213B (es)	1994-09-01
CA2093148C (en)	1999-01-26
ZA931799B (en)	1993-12-27
JP2702377B2 (ja)	1998-01-21
FI106555B (fi)	2001-02-28
JPH0616704A (ja)	1994-01-25
ITBO920140A1 (it)	1993-10-17
GR3024582T3 (en)	1997-12-31
ATE154615T1 (de)	1997-07-15
FI931740L (fi)	1993-10-18
EP0565862B1 (en)	1997-06-18
NZ247197A (en)	1995-02-24
AU3689693A (en)	1993-10-21
DK0565862T3 (da)	1997-12-15
ES2103991T3 (es)	1997-10-01
KR0171623B1 (ko)	1999-02-01
ITBO920140A0 (it)	1992-04-17
IT1260136B (it)	1996-03-28
CA2093148A1 (en)	1993-10-18

Legal Events

Date	Code	Title
1997-09-30	FF	Patent granted
1998-01-04	KB	Patent renewed
1999-08-17	KB	Patent renewed
2001-06-14	RH	Patent void
2003-06-24	KB	Patent renewed
2008-01-06	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL105111A (en)	1997-03-18	SEMI-SYNTHETIC GLYCOSAMINOGLYCANS CONTAINING a-L- GALACTURONIC ACID SUBSTITUTED WITH NUCLEOPHILIC RADICALS IN POSITION 3 AND THEIR PREPARATION
AU3701384A (en)	1985-07-04	11-beta-arylestradienes
ZA848714B (en)	1985-07-31	Antimicrobial compositions
ES2004660A6 (es)	1989-02-01	Fotoiniciadores copolimerizables
AU1176083A (en)	1983-09-01	S-triazine derivatives and their use as sun screen agents
CA1244462A (en)	1988-11-08	GLYCEROPHOSPHOCHOLINE AND GLYCEROPHOSPHOETHANOLAMINE DERIVATIVES; PREPARATION AND USE
EP0222408A3 (en)	1989-02-22	Vulcanizable compositions of fluoroelastomers exhibiting improved processability and chemical stability
GR3017051T3 (en)	1995-11-30	Azeotropic or azeotropic-like composition of hydrochlorofluoropropane.
IL112098A (en)	1997-07-13	SULFAMIC ACID ESTERS OF PSEUDO-b-FRUCTOPYRANOSE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MY108259A (en)	1996-08-30	Liquid detergent composition
AU628665B2 (en)	1992-09-17	Substituted cycloalkano(b)dihydroindole - and - indolesulphonamides
EP0177153A3 (en)	1986-04-16	Interferon-cyclaradine combination
ATE38028T1 (de)	1988-11-15	Cycloaliphatische heilmittelzusammensetzungen.
AU582712B2 (en)	1989-04-06	Polymerizable carbamoyloxyalkyldicarboxylic acid esters carrying hydroxyl groups, a process for their preparation and their use
ES8306764A1 (es)	1983-06-01	Un procedimiento para la preparacion de derivados de sucrosa'4-halo-sustituidos.
EP0205005A3 (en)	1987-12-23	New biologically active fluorescent cyclic nucleotides
ES8201990A1 (es)	1982-01-16	Procedimiento para la obtencion de acetanilidas sustituidas de efecto herbicida
GR74737B (es)	1984-07-11
DK320685D0 (da)	1985-07-12	Fremstilling af glycosider ud fra glycosylfluorider
GR3007423T3 (es)	1993-07-30
MY108826A (en)	1996-11-30	(alpha)-aryl-(alpha) hydroxy-(beta)-imidazolindyl-propionamides
IT1214534B (it)	1990-01-18	4-cloro-arilossi-acetil-e 4-cloro-arilossi-propionil-malonati aventi proprieta' erbicide.
AU4649889A (en)	1990-05-14	Superconducting metal oxide compositions and processes for manufacture and use
AU580646B2 (en)	1989-01-19	13``-alkyl-17``-(3-aceloxy-propyl)-gonane
DE3175498D1 (en)	1986-11-27	D-homo corticoids, their preparation and utilization