IL105472A - Medicament composition for suppression of t-cell proliferation and immune response against introduction of non-self tissue containing major histocompatibility complex class ii antigens or synthetic peptides corresponding to class ii antigens - Google Patents

Medicament composition for suppression of t-cell proliferation and immune response against introduction of non-self tissue containing major histocompatibility complex class ii antigens or synthetic peptides corresponding to class ii antigens

Info

Publication number: IL105472A
Authority: IL; Israel
Prior art keywords: mammal; class; peptide; antigen; histocompatibility complex
Prior art date: 1992-04-20

Application number

IL10547293A

Other languages

English (en)

Other versions

IL105472A0 (en

Original Assignee

Autoimmune Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-20

Filing date

1993-04-20

Publication date

1999-06-20

1993-04-20 Application filed by Autoimmune Inc filed Critical Autoimmune Inc

1993-08-18 Publication of IL105472A0 publication Critical patent/IL105472A0/xx

1999-06-20 Publication of IL105472A publication Critical patent/IL105472A/en

Links

108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 64
239000000427 antigen Substances 0.000 title claims abstract description 21
108091007433 antigens Proteins 0.000 title claims abstract description 20
102000036639 antigens Human genes 0.000 title claims abstract description 20
230000028993 immune response Effects 0.000 title claims abstract description 10
102000018713 Histocompatibility Antigens Class II Human genes 0.000 title claims abstract 5
108010027412 Histocompatibility Antigens Class II Proteins 0.000 title claims abstract 5
102000043131 MHC class II family Human genes 0.000 title claims abstract 4
108091054438 MHC class II family Proteins 0.000 title claims abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title claims description 39
239000003814 drug Substances 0.000 title claims description 10
239000000203 mixture Substances 0.000 title abstract description 43
230000006052 T cell proliferation Effects 0.000 title description 2
230000001629 suppression Effects 0.000 title description 2
230000004044 response Effects 0.000 claims abstract description 34
241000124008 Mammalia Species 0.000 claims abstract description 30
210000001744 T-lymphocyte Anatomy 0.000 claims abstract description 14
230000035755 proliferation Effects 0.000 claims abstract description 14
239000012634 fragment Substances 0.000 claims abstract description 13
230000000638 stimulation Effects 0.000 claims abstract 3
108700018351 Major Histocompatibility Complex Proteins 0.000 claims description 50
230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims description 49
230000000735 allogeneic effect Effects 0.000 claims description 21
241000700159 Rattus Species 0.000 claims description 16
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238000001990 intravenous administration Methods 0.000 description 8
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 8
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108010002350 Interleukin-2 Proteins 0.000 description 2
108010038807 Oligopeptides Proteins 0.000 description 2
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230000017274 T cell anergy Effects 0.000 description 2
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UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
230000002992 thymic effect Effects 0.000 description 2
230000020192 tolerance induction in gut-associated lymphoid tissue Effects 0.000 description 2
230000003614 tolerogenic effect Effects 0.000 description 2
238000002054 transplantation Methods 0.000 description 2
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 1
238000010600 3H thymidine incorporation assay Methods 0.000 description 1
208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
101100245381 Caenorhabditis elegans pbs-6 gene Proteins 0.000 description 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
229930105110 Cyclosporin A Natural products 0.000 description 1
108010036949 Cyclosporine Proteins 0.000 description 1
206010011968 Decreased immune responsiveness Diseases 0.000 description 1
102000009123 Fibrin Human genes 0.000 description 1
108010073385 Fibrin Proteins 0.000 description 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
239000007995 HEPES buffer Substances 0.000 description 1
102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 description 1
108010039343 HLA-DRB1 Chains Proteins 0.000 description 1
102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 1
108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
241000282412 Homo Species 0.000 description 1
101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
206010062016 Immunosuppression Diseases 0.000 description 1
108090001005 Interleukin-6 Proteins 0.000 description 1
108090001007 Interleukin-8 Proteins 0.000 description 1
102000003979 Mineralocorticoid Receptors Human genes 0.000 description 1
108090000375 Mineralocorticoid Receptors Proteins 0.000 description 1
101100460844 Mus musculus Nr2f6 gene Proteins 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
102000047918 Myelin Basic Human genes 0.000 description 1
101710107068 Myelin basic protein Proteins 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
102000007079 Peptide Fragments Human genes 0.000 description 1
108010033276 Peptide Fragments Proteins 0.000 description 1
102000007659 Protein Deglycase DJ-1 Human genes 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
102000009661 Repressor Proteins Human genes 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
238000000692 Student's t-test Methods 0.000 description 1
230000005867 T cell response Effects 0.000 description 1
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000009471 action Effects 0.000 description 1
230000004913 activation Effects 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000000781 anti-lymphocytic effect Effects 0.000 description 1
210000003719 b-lymphocyte Anatomy 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000008859 change Effects 0.000 description 1
229960001265 ciclosporin Drugs 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
229930182912 cyclosporin Natural products 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000008021 deposition Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
230000003828 downregulation Effects 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
229950003499 fibrin Drugs 0.000 description 1
238000009472 formulation Methods 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
238000003304 gavage Methods 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000006058 immune tolerance Effects 0.000 description 1
230000002998 immunogenetic effect Effects 0.000 description 1
230000001506 immunosuppresive effect Effects 0.000 description 1
239000003018 immunosuppressive agent Substances 0.000 description 1
229940125721 immunosuppressive agent Drugs 0.000 description 1
238000001764 infiltration Methods 0.000 description 1
230000008595 infiltration Effects 0.000 description 1
108040006849 interleukin-2 receptor activity proteins Proteins 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
210000000822 natural killer cell Anatomy 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
108010083127 phage repressor proteins Proteins 0.000 description 1
239000012071 phase Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000008884 pinocytosis Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000008569 process Effects 0.000 description 1
238000003375 selectivity assay Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
210000004989 spleen cell Anatomy 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
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238000012546 transfer Methods 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
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238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Cell Biology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Developmental Biology & Embryology (AREA)
Bioinformatics & Cheminformatics (AREA)
Transplantation (AREA)
Microbiology (AREA)
Mycology (AREA)
Virology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Plant Substances (AREA)

IL10547293A 1992-04-20 1993-04-20 Medicament composition for suppression of t-cell proliferation and immune response against introduction of non-self tissue containing major histocompatibility complex class ii antigens or synthetic peptides corresponding to class ii antigens IL105472A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US87128992A	1992-04-20	1992-04-20
US96177992A	1992-10-15	1992-10-15
US97773792A	1992-11-13	1992-11-13
US08/027,127 US5593698A (en)	1990-10-31	1993-03-05	Suppression of proliferative response and induction of tolerance with polymorphic class II MHC allopeptides

Publications (2)

Publication Number	Publication Date
IL105472A0 IL105472A0 (en)	1993-08-18
IL105472A true IL105472A (en)	1999-06-20

Family

ID=27487557

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10547293A IL105472A (en)	1992-04-20	1993-04-20	Medicament composition for suppression of t-cell proliferation and immune response against introduction of non-self tissue containing major histocompatibility complex class ii antigens or synthetic peptides corresponding to class ii antigens

Country Status (13)

Country	Link
US (1)	US5593698A (de)
EP (1)	EP0637249B1 (de)
JP (1)	JPH07505892A (de)
KR (1)	KR100275656B1 (de)
AT (1)	ATE205400T1 (de)
AU (1)	AU686101B2 (de)
BR (1)	BR9306345A (de)
CA (1)	CA2118502A1 (de)
DE (1)	DE69330752D1 (de)
HU (1)	HUT71310A (de)
IL (1)	IL105472A (de)
NO (1)	NO943967L (de)
WO (1)	WO1993020842A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99699A (en)	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
US6156306A (en) *	1994-08-17	2000-12-05	Albert Einstein College Of Medicine Of Yeshiva University	Pancreatic β-cells for allogeneic transplantation without immunosuppression
GB9505784D0 (en) *	1995-03-22	1995-05-10	Lynxvale Ltd	Anti-tumour treatment
US7361331B2 (en) *	1996-10-18	2008-04-22	Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food	Plant bioreactors
US6617171B2 (en) *	1998-02-27	2003-09-09	The General Hospital Corporation	Methods for diagnosing and treating autoimmune disease
US6599710B1 (en)	1999-03-10	2003-07-29	The General Hospital Corporation	Treatment of autoimmune disease
US7348005B2 (en) *	2000-03-15	2008-03-25	Advanced Research And Technology Institute	Oral tolerance induction by collagen to prevent allograft rejection
AU2001245848A1 (en) *	2000-03-15	2001-10-23	Advanced Research And Technology Institute	Oral tolerance induction by collagen to prevent allograft rejection
WO2001089557A2 (en)	2000-05-24	2001-11-29	The United States Of America, As Represented By Secretary Of The Department Of Health & Human Services	Methods for preventing strokes by inducing tolerance to e-selectin
KR20030062321A (ko)	2000-08-21	2003-07-23	아피토프 테크놀러지 (브리스톨) 리미티드	펩티드 선별 방법
US7628988B2 (en) *	2002-06-27	2009-12-08	The General Hospital Corporation	Methods and compositions for treating type 1 diabetes
US7582313B2 (en)	2002-06-27	2009-09-01	The General Hospital Corporation	Methods of organ regeneration using Hox 11-expressing pluripotent cells
US20040229785A1 (en) *	2002-11-15	2004-11-18	Denise Faustman	Screening methods to identify treatments for autoimmune disease
US20080102054A1 (en) *	2005-01-18	2008-05-01	Faustman Denise L	Compositions Containing Agm Cells And Methods Of Use Thereof
GB0710529D0 (en)	2007-06-01	2007-07-11	Circassia Ltd	Vaccine
BRPI0815395A2 (pt)	2007-08-15	2015-02-10	Circassia Ltd	Composição, vetor, produto, formulação farmacêutica, me´todo in vitro para determinar se as células t reconhecem um polipeptídeo, e, método in vitro para determinar se um indivíduo se encontra ou está em risco de uma condição.
JP6367836B2 (ja)	2013-02-07	2018-08-01	ザジェネラルホスピタルコーポレイション	Ｔ制御性細胞の増殖または枯渇方法
WO2015057968A2 (en)	2013-10-17	2015-04-23	The General Hospital Corporation	Methods of identifying subjects responsive to treatment for an autoimmune disease and compositions for treating the same
US10137181B2 (en) *	2014-04-01	2018-11-27	INSERM (Institut National de la Santé et de la Recherche Médicale)	Isolated donor MHC-derived peptide and uses thereof
DK3447075T3 (da)	2015-05-15	2023-11-13	Massachusetts Gen Hospital	Antagonistiske antistoffer af antitumornekrosefaktorreceptor-superfamilien
WO2017040312A1 (en)	2015-08-28	2017-03-09	The General Hospital Corporation	Agonistic anti-tumor necrosis factor receptor 2 antibodies
WO2017059132A1 (en)	2015-09-29	2017-04-06	The General Hospital Corporation	Methods of treating and diagnosing disease using biomarkers for bcg therapy
KR20250007678A (ko)	2016-05-13	2025-01-14	더 제너럴 하스피탈 코포레이션	길항성 항-종양 괴사 인자 수용체 슈퍼패밀리 항체
WO2020041361A1 (en)	2018-08-20	2020-02-27	The General Hospital Corporation	Antagonistic anti-tumor necrosis factor receptor superfamily polypeptides
EP3880711A4 (de)	2018-11-15	2022-12-28	The General Hospital Corporation	Agonistische polypeptide der tumornekrosefaktorrezeptorsuperfamilie

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5364762A (en) *	1990-03-21	1994-11-15	Board Of Trustees Of The Leland Stanford Junior University	Major histocompatibility complex (MHC) molecules

1993
- 1993-03-05 US US08/027,127 patent/US5593698A/en not_active Expired - Fee Related
- 1993-04-20 CA CA002118502A patent/CA2118502A1/en not_active Abandoned
- 1993-04-20 HU HU9403006A patent/HUT71310A/hu unknown
- 1993-04-20 DE DE69330752T patent/DE69330752D1/de not_active Expired - Lifetime
- 1993-04-20 JP JP5518673A patent/JPH07505892A/ja not_active Ceased
- 1993-04-20 AU AU41083/93A patent/AU686101B2/en not_active Ceased
- 1993-04-20 AT AT93910671T patent/ATE205400T1/de not_active IP Right Cessation
- 1993-04-20 BR BR9306345A patent/BR9306345A/pt not_active Application Discontinuation
- 1993-04-20 EP EP93910671A patent/EP0637249B1/de not_active Expired - Lifetime
- 1993-04-20 IL IL10547293A patent/IL105472A/en not_active IP Right Cessation
- 1993-04-20 WO PCT/US1993/003708 patent/WO1993020842A1/en not_active Ceased
- 1993-04-20 KR KR1019940703715A patent/KR100275656B1/ko not_active Expired - Fee Related
1994
- 1994-10-19 NO NO943967A patent/NO943967L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0637249A4 (de)	1997-01-08
DE69330752D1 (de)	2001-10-18
ATE205400T1 (de)	2001-09-15
CA2118502A1 (en)	1993-10-28
KR950701228A (ko)	1995-03-23
BR9306345A (pt)	1998-06-30
NO943967D0 (no)	1994-10-19
WO1993020842A1 (en)	1993-10-28
EP0637249A1 (de)	1995-02-08
JPH07505892A (ja)	1995-06-29
NO943967L (no)	1994-10-19
HU9403006D0 (en)	1994-12-28
IL105472A0 (en)	1993-08-18
KR100275656B1 (ko)	2000-12-15
AU4108393A (en)	1993-11-18
US5593698A (en)	1997-01-14
EP0637249B1 (de)	2001-09-12
AU686101B2 (en)	1998-02-05
HUT71310A (en)	1995-11-28

Legal Events

Date	Code	Title
1999-10-28	FF	Patent granted
2000-06-29	KB	Patent renewed
2003-07-06	KB	Patent renewed
2008-01-06	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5593698A (en)	1997-01-14	Suppression of proliferative response and induction of tolerance with polymorphic class II MHC allopeptides
Sayegh et al.	1996	Role of indirect allorecognition in allograft rejection
Afzali et al.	2008	Pathways of major histocompatibility complex allorecognition
Allez et al.	2004	Regulatory T cells: peace keepers in the gut
EP1301202B1 (de)	2011-01-05	Genetisch hergestellte mhc moleküle
US5681556A (en)	1997-10-28	Method and compositions for suppressing allograft rejection in mammals
Dong et al.	1999	Transplantation tolerance: the concept and its applicability
Bharat et al.	2007	Allopeptides and the alloimmune response
CA2110055C (en)	2002-08-20	T cell receptor peptides as therapeutics for immune-related disease
Miller et al.	1993	Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein VI. Suppression of adoptively transferred disease and differential effects of oral vs. intravenous tolerization
Miller et al.	1991	Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases
US5961977A (en)	1999-10-05	Method of treating or preventing autoimmune uveoretinitis in mammals
Ohm et al.	2025	Chimerism and immunological tolerance in solid organ transplantation
Zavazava et al.	2000	Oral feeding of an immunodominant MHC donor-derived synthetic class I peptide prolongs graft survival of heterotopic cardiac allografts in a high-responder rat strain combination
Benichou et al.	1998	The presentation of self and allogeneic MHC peptides to T lymphocytes
Oluwole et al.	2003	CD4+ CD25+ regulatory T cells mediate acquired transplant tolerance
Kroemer et al.	1991	The fail-safe paradigm of immunological self-tolerance
Saborio et al.	1999	Regulatory T cells maintain peripheral tolerance to islet allografts induced by intrathymic injection of MHC class I allopeptides
EP0883406A1 (de)	1998-12-16	Verwendung von il-7 zur behandlung von autoimmunkrankheiten, insbesondere insulinabhängigem diabetes mellitus
Ten Berge et al.	1982	A longitudinal study on the effects of azathioprine and high doses of prednisone on the immune system of kidney-transplant recipients
Murphy et al.	1996	Immunomodulatory function of major histocompatibility complexderived peptides
Kozovska et al.	1996	TT cellular interaction between CD4-CD8-regulatory T cells and T cell clones presenting TCR peptide. Its implication for TCR vaccination against experimental autoimmune encephalomyelitis
Benichou et al.	1996	The influence of two distinct alloresponse pathways on the design of peptide-based strategies for allograft tolerance
Waaga et al.	1999	Major histocompatibility complex–derived peptides as novel forms of immunosuppression
Otto et al.	2002	Prolongation of small bowel allograft survival with a sequential therapy consisting of a synthetic MHC class II peptide and temporarily low-dose cyclosporine A