IL107330A - SUBSTITUTED (PYRIDINYLAMINO)- BENZISOXAZOLES AND-BENZO £b| THIOPHENES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
SUBSTITUTED (PYRIDINYLAMINO)- BENZISOXAZOLES AND-BENZO £b| THIOPHENES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- IL107330A IL107330A IL107330A IL10733093A IL107330A IL 107330 A IL107330 A IL 107330A IL 107330 A IL107330 A IL 107330A IL 10733093 A IL10733093 A IL 10733093A IL 107330 A IL107330 A IL 107330A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- formula
- hydrogen
- loweralkyl
- arylloweralkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/964,546 US5328920A (en) | 1991-04-17 | 1992-10-21 | Substituted (pyridinylamino)-indoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL107330A0 IL107330A0 (en) | 1994-01-25 |
| IL107330A true IL107330A (en) | 1998-04-05 |
Family
ID=25508677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL107330A IL107330A (en) | 1992-10-21 | 1993-10-20 | SUBSTITUTED (PYRIDINYLAMINO)- BENZISOXAZOLES AND-BENZO £b| THIOPHENES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5328920A (de) |
| EP (1) | EP0594000B1 (de) |
| KR (1) | KR100297651B1 (de) |
| AT (1) | ATE168689T1 (de) |
| AU (1) | AU665637B2 (de) |
| CA (1) | CA2108800A1 (de) |
| DE (1) | DE69319830T2 (de) |
| DK (1) | DK0594000T3 (de) |
| ES (1) | ES2120463T3 (de) |
| FI (1) | FI934611L (de) |
| GR (1) | GR3027574T3 (de) |
| HU (1) | HUT68875A (de) |
| IL (1) | IL107330A (de) |
| NO (1) | NO300806B1 (de) |
| NZ (1) | NZ248991A (de) |
| PL (1) | PL173540B1 (de) |
| RU (1) | RU2083575C1 (de) |
| ZA (1) | ZA937823B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5668154A (en) * | 1995-06-06 | 1997-09-16 | Hoechst Marion Roussel Inc. | Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles |
| HUP9802492A3 (en) * | 1995-06-06 | 1999-10-28 | Hoechst Marion Roussel Inc Cin | Benzisoxazole and indazole derivatives as antipsychotic agents, process for their preparation and pharmaceutical compositions containing the same |
| GB2308362A (en) * | 1995-12-19 | 1997-06-25 | Lilly Industries Ltd | Pharmaceutical indole derivatives |
| JP4256937B2 (ja) * | 1996-12-27 | 2009-04-22 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | Ｎ−（ピリジニルアミノ）イソインドリン類および関連化合物 |
| US5886191A (en) * | 1997-08-18 | 1999-03-23 | Dupont Pharmaceuticals Company | Amidinoindoles, amidinoazoles, and analogs thereof |
| US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| WO2002053104A2 (en) * | 2001-01-02 | 2002-07-11 | Sention, Inc. | Use of catecholamine reuptake inhibitors to enhance memory |
| DE60328675D1 (de) * | 2002-04-23 | 2009-09-17 | Aventis Pharma Inc | 3-(substitutierte amino)-1h-indole-2-carbonsäureester und 3-(substitutierte amino)-benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| CA2575018A1 (en) * | 2004-08-02 | 2006-02-09 | F. Hoffman-La Roche Ag | Benzyloxy derivatives as maob inhibitors |
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| ES2528797T3 (es) * | 2006-08-21 | 2015-02-12 | Genentech, Inc. | Compuestos de aza-benzotiofenilo y métodos de uso |
| AU2007286808B2 (en) * | 2006-08-21 | 2012-12-06 | Genentech, Inc. | Aza-benzofuranyl compounds and methods of use |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3166987D1 (en) * | 1980-09-18 | 1984-12-06 | Asahi Chemical Ind | 3-aminoindazole derivatives and process for preparation thereof |
| US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| US4717658A (en) * | 1985-12-03 | 1988-01-05 | Miles Inc. | Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL) |
| EP0287982B1 (de) * | 1987-04-24 | 1994-12-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel |
| US4954502A (en) * | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| DE69021645T2 (de) * | 1989-05-19 | 1996-02-22 | Hoechst-Roussel Pharmaceuticals Inc., Somerville, N.J. | N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. |
| US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
| CA2030051C (en) * | 1989-11-17 | 2001-08-07 | Haruhiko Kikuchi | Indole derivatives |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
-
1992
- 1992-10-21 US US07/964,546 patent/US5328920A/en not_active Expired - Lifetime
-
1993
- 1993-10-08 ES ES93116316T patent/ES2120463T3/es not_active Expired - Lifetime
- 1993-10-08 AT AT93116316T patent/ATE168689T1/de not_active IP Right Cessation
- 1993-10-08 EP EP93116316A patent/EP0594000B1/de not_active Expired - Lifetime
- 1993-10-08 DK DK93116316T patent/DK0594000T3/da active
- 1993-10-08 DE DE69319830T patent/DE69319830T2/de not_active Expired - Fee Related
- 1993-10-19 NZ NZ248991A patent/NZ248991A/en unknown
- 1993-10-19 FI FI934611A patent/FI934611L/fi not_active Application Discontinuation
- 1993-10-20 RU RU9393047920A patent/RU2083575C1/ru active
- 1993-10-20 CA CA002108800A patent/CA2108800A1/en not_active Abandoned
- 1993-10-20 NO NO933772A patent/NO300806B1/no not_active IP Right Cessation
- 1993-10-20 IL IL107330A patent/IL107330A/en not_active IP Right Cessation
- 1993-10-20 AU AU49125/93A patent/AU665637B2/en not_active Ceased
- 1993-10-21 KR KR1019930021922A patent/KR100297651B1/ko not_active Expired - Fee Related
- 1993-10-21 PL PL93300804A patent/PL173540B1/pl unknown
- 1993-10-21 ZA ZA937823A patent/ZA937823B/xx unknown
- 1993-10-21 HU HU9302979A patent/HUT68875A/hu unknown
-
1998
- 1998-08-04 GR GR980401759T patent/GR3027574T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69319830T2 (de) | 1999-01-14 |
| DK0594000T3 (da) | 1999-04-26 |
| HUT68875A (en) | 1995-08-28 |
| NZ248991A (en) | 1996-02-27 |
| ES2120463T3 (es) | 1998-11-01 |
| FI934611A7 (fi) | 1994-04-22 |
| NO300806B1 (no) | 1997-07-28 |
| NO933772D0 (no) | 1993-10-20 |
| NO933772L (no) | 1994-04-22 |
| FI934611L (fi) | 1994-04-22 |
| KR100297651B1 (ko) | 2001-10-24 |
| US5328920A (en) | 1994-07-12 |
| AU665637B2 (en) | 1996-01-11 |
| ZA937823B (en) | 1994-05-19 |
| IL107330A0 (en) | 1994-01-25 |
| CA2108800A1 (en) | 1994-04-22 |
| AU4912593A (en) | 1994-05-05 |
| PL173540B1 (pl) | 1998-03-31 |
| PL300804A1 (en) | 1994-05-16 |
| FI934611A0 (fi) | 1993-10-19 |
| EP0594000A1 (de) | 1994-04-27 |
| ATE168689T1 (de) | 1998-08-15 |
| GR3027574T3 (en) | 1998-11-30 |
| EP0594000B1 (de) | 1998-07-22 |
| KR940009182A (ko) | 1994-05-20 |
| RU2083575C1 (ru) | 1997-07-10 |
| HU9302979D0 (en) | 1994-01-28 |
| DE69319830D1 (de) | 1998-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |