IL109177A - Inhibitor of stem cell proliferation antibody thereto pharmaceutical compositions containing the inhibitor its use in the manufacture of medicaments and in an in vitro method for treating bone marrow and gene comprising a recombinant DNA encoding such protein inhibitor - Google Patents

Inhibitor of stem cell proliferation antibody thereto pharmaceutical compositions containing the inhibitor its use in the manufacture of medicaments and in an in vitro method for treating bone marrow and gene comprising a recombinant DNA encoding such protein inhibitor

Info

Publication number
IL109177A
IL109177A IL10917794A IL10917794A IL109177A IL 109177 A IL109177 A IL 109177A IL 10917794 A IL10917794 A IL 10917794A IL 10917794 A IL10917794 A IL 10917794A IL 109177 A IL109177 A IL 109177A
Authority
IL
Israel
Prior art keywords
inhibitor
stem cell
medicaments
cell proliferation
gene
Prior art date
Application number
IL10917794A
Other languages
English (en)
Other versions
IL109177A0 (en
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Publication of IL109177A0 publication Critical patent/IL109177A0/xx
Priority to IL11547395A priority Critical patent/IL115473A/xx
Publication of IL109177A publication Critical patent/IL109177A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL10917794A 1993-03-31 1994-03-30 Inhibitor of stem cell proliferation antibody thereto pharmaceutical compositions containing the inhibitor its use in the manufacture of medicaments and in an in vitro method for treating bone marrow and gene comprising a recombinant DNA encoding such protein inhibitor IL109177A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL11547395A IL115473A (en) 1994-03-30 1995-09-29 Pharmaceutical compositions and compounds for inhibition of stem cell proliferation, use of such compounds in the manufacture of medicaments for this purpose, and in vitro methods for treating bone marrow and for preparing hematopoietic cells for therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4094293A 1993-03-31 1993-03-31

Publications (2)

Publication Number Publication Date
IL109177A0 IL109177A0 (en) 1994-06-24
IL109177A true IL109177A (en) 2000-12-06

Family

ID=21913839

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10917794A IL109177A (en) 1993-03-31 1994-03-30 Inhibitor of stem cell proliferation antibody thereto pharmaceutical compositions containing the inhibitor its use in the manufacture of medicaments and in an in vitro method for treating bone marrow and gene comprising a recombinant DNA encoding such protein inhibitor

Country Status (17)

Country Link
US (3) US6022848A (de)
EP (1) EP0691988B1 (de)
JP (1) JPH08510997A (de)
CN (1) CN1089344C (de)
AT (1) ATE225370T1 (de)
AU (1) AU694111B2 (de)
CA (1) CA2159506A1 (de)
DE (1) DE69431473T2 (de)
DK (1) DK0691988T3 (de)
ES (1) ES2185649T3 (de)
IL (1) IL109177A (de)
NZ (1) NZ263736A (de)
PT (1) PT691988E (de)
RU (1) RU2155066C2 (de)
TW (1) TW403761B (de)
UA (1) UA40613C2 (de)
WO (1) WO1994022915A1 (de)

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RU2155066C2 (ru) * 1993-03-31 2000-08-27 Про-Ньюрон, Инк. Ингибитор пролиферации стволовых клеток и его использование
US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
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US6946445B1 (en) 1998-03-13 2005-09-20 The University Of British Columbia Therapeutic chemokine receptor antagonists
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CA2335109A1 (en) * 2000-04-12 2001-10-12 Chemokine Therapeutics Corporation Cxcr4 agonist treatment of hematopoietic cells
US20050059584A1 (en) * 2002-08-16 2005-03-17 Ahmed Merzouk Novel chemokine mimetics synthesis and their use
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP2206772A3 (de) * 2000-12-06 2010-08-04 Robert J. Hariri Verfahren zum Sammeln von Plazentastammzellen
US20080152629A1 (en) * 2000-12-06 2008-06-26 James Edinger Placental stem cell populations
EP2336299A1 (de) * 2001-02-14 2011-06-22 Anthrogenesis Corporation Post-partum Säugetier-Plazenta, deren Verwendung und daraus gewonnene Stammzellen
US6515001B2 (en) 2001-03-05 2003-02-04 Chemokine Therapeutic Corporation IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases
US7700090B2 (en) 2002-02-13 2010-04-20 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
RU2205026C1 (ru) * 2002-03-15 2003-05-27 Эпштейн Олег Ильич Лекарственное средство и способ лечения патологического синдрома, обусловленного нарушением кроветворения
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
WO2003102151A2 (en) * 2002-05-30 2003-12-11 Celgene Corporation Modulating cell differentiation and treating myeloprolifertive disorders with jnk/mkk inhibitors
WO2004012765A1 (fr) * 2002-08-02 2004-02-12 Oleg Iliich Epshtein Preparation medicinale et procede de traitement d'un syndrome pathologique determine par une perturbation de l'hematopoiese
KR101042448B1 (ko) 2002-11-26 2011-06-16 안트로제네시스 코포레이션 세포요법제, 세포요법제 단위 및 이를 이용한 치료방법
CN1770976A (zh) * 2003-02-13 2006-05-10 人类起源公司 利用脐带血治疗患有疾病、紊乱或状况的个体的用途
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NZ548049A (en) * 2003-12-02 2009-01-31 Celgene Corp Methods and compositions for the treatment and management of hemoglobinopathy and anemia
US7741287B2 (en) * 2004-08-18 2010-06-22 Ipf Pharmaceuticals Gmbh Peptides for the treatment of herpes virus infections
RU2283654C1 (ru) * 2005-03-30 2006-09-20 Борис Владимирович Афанасьев Способ получения ростовых факторов белковой природы, ростовой фактор белковой природы и ингибитор пролиферации фибробластов
CA2624925C (en) 2005-10-13 2014-09-30 Anthrogenesis Corporation Immunomodulation using placental stem cells
ES2708933T3 (es) 2005-12-29 2019-04-12 Celularity Inc Poblaciones de células madre placentarias
RU2318519C2 (ru) * 2006-03-06 2008-03-10 ФГУ Ростовский научно-исследовательский онкологический институт Росздрава Способ химиотерапии острого лейкоза
EP2412805B1 (de) * 2006-06-09 2014-04-30 Kabushiki Kaisha Yakult Honsha An der Verewigung menschlicher Krebszellen beteiligtes Gen und Verwendung dafür
KR101569168B1 (ko) 2007-02-12 2015-11-13 안트로제네시스 코포레이션 태반 줄기세포를 이용한 염증 질환의 치료
US20100172830A1 (en) * 2007-03-29 2010-07-08 Cellx Inc. Extraembryonic Tissue cells and method of use thereof
TWM322542U (en) * 2007-05-23 2007-11-21 Universal Scient Ind Co Ltd Testing machine
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
CA2700613C (en) * 2007-09-26 2022-09-20 Celgene Cellular Therapeutics Angiogenic cells from human placental perfusate
CA2700617C (en) * 2007-09-28 2018-11-06 Celgene Cellular Therapeutics Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
DK2217329T3 (en) * 2007-11-07 2018-04-23 Anthrogenesis Corp APPLICATION OF NAVLINE BLOOD IN THE TREATMENT OF COMPLIANCES IN CONNECTION WITH PREGNANCY BIRTH
KR101651661B1 (ko) * 2008-06-30 2016-08-26 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 분화
DK2330889T3 (en) * 2008-08-20 2017-01-30 Anthrogenesis Corp Improved cell composition and process for making the same
JP5950577B2 (ja) * 2008-08-20 2016-07-13 アンスロジェネシス コーポレーション 単離胎盤細胞を使用した脳卒中の治療
HRP20130812T1 (en) * 2008-08-22 2013-09-30 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
CN102282252B (zh) * 2008-11-19 2017-07-04 人类起源公司 羊膜来源的贴壁细胞
MX2011005230A (es) * 2008-11-21 2011-06-16 Anthrogenesis Corp Tratamiento de enfermedades, desordenes o condiciones del pulmon usando celulas de placenta.
US8586360B2 (en) 2009-07-02 2013-11-19 Anthrogenesis Corporation Method of producing erythrocytes without feeder cells
ES2646750T3 (es) * 2010-01-26 2017-12-15 Anthrogenesis Corporation Tratamiento de cánceres relacionados con hueso utilizando células madre placentarias
IL250234B2 (en) 2010-04-07 2023-10-01 Anthrogenesis Llc Angiogenesis using placental stem cells
MX2012011543A (es) 2010-04-08 2013-05-06 Anthrogenesis Corp Tratamiento de sarcoidosis empleando celulas madre placentarias.
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Also Published As

Publication number Publication date
CA2159506A1 (en) 1994-10-13
DK0691988T3 (da) 2003-04-14
ES2185649T3 (es) 2003-05-01
IL109177A0 (en) 1994-06-24
NZ263736A (en) 2000-12-22
JPH08510997A (ja) 1996-11-19
DE69431473T2 (de) 2003-08-07
WO1994022915A1 (en) 1994-10-13
EP0691988A4 (de) 1997-07-30
CN1124491A (zh) 1996-06-12
CN1089344C (zh) 2002-08-21
PT691988E (pt) 2003-02-28
AU694111B2 (en) 1998-07-16
EP0691988A1 (de) 1996-01-17
US6432917B1 (en) 2002-08-13
EP0691988B1 (de) 2002-10-02
US20020098583A1 (en) 2002-07-25
UA40613C2 (uk) 2001-08-15
US6022848A (en) 2000-02-08
ATE225370T1 (de) 2002-10-15
RU2155066C2 (ru) 2000-08-27
AU6493794A (en) 1994-10-24
TW403761B (en) 2000-09-01
DE69431473D1 (de) 2002-11-07

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