IL110103A - Bicyclic beta-lactam/paraben complexes their use and processes using them - Google Patents
Bicyclic beta-lactam/paraben complexes their use and processes using themInfo
- Publication number
- IL110103A IL110103A IL11010394A IL11010394A IL110103A IL 110103 A IL110103 A IL 110103A IL 11010394 A IL11010394 A IL 11010394A IL 11010394 A IL11010394 A IL 11010394A IL 110103 A IL110103 A IL 110103A
- Authority
- IL
- Israel
- Prior art keywords
- lactam
- processes
- complexes
- bicyclic beta
- paraben
- Prior art date
Links
- -1 Bicyclic beta-lactam Chemical class 0.000 title abstract 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical class OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/084,651 US5412094A (en) | 1993-06-28 | 1993-06-28 | Bicyclic beta-lactam/paraben complexes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110103A0 IL110103A0 (en) | 1994-10-07 |
| IL110103A true IL110103A (en) | 1999-04-11 |
Family
ID=22186328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11010394A IL110103A (en) | 1993-06-28 | 1994-06-23 | Bicyclic beta-lactam/paraben complexes their use and processes using them |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5412094A (cs) |
| EP (1) | EP0637587B1 (cs) |
| JP (1) | JPH0748383A (cs) |
| KR (1) | KR950000707A (cs) |
| CN (1) | CN1044246C (cs) |
| AT (1) | ATE159942T1 (cs) |
| AU (1) | AU674226B2 (cs) |
| BR (1) | BR9402561A (cs) |
| CA (1) | CA2126401A1 (cs) |
| CO (1) | CO4230098A1 (cs) |
| CZ (1) | CZ285452B6 (cs) |
| DE (1) | DE69406607T2 (cs) |
| DK (1) | DK0637587T3 (cs) |
| ES (1) | ES2110185T3 (cs) |
| FI (1) | FI106460B (cs) |
| GR (1) | GR3025563T3 (cs) |
| HU (1) | HU219484B (cs) |
| IL (1) | IL110103A (cs) |
| NO (1) | NO305480B1 (cs) |
| NZ (1) | NZ260791A (cs) |
| PE (1) | PE57294A1 (cs) |
| PL (1) | PL177317B1 (cs) |
| RU (1) | RU2134265C1 (cs) |
| YU (1) | YU40694A (cs) |
| ZA (1) | ZA944376B (cs) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550231A (en) * | 1993-06-15 | 1996-08-27 | Eli Lilly And Company | Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof |
| US6001996A (en) * | 1995-05-11 | 1999-12-14 | Eli Lilly And Company | Complexes of cephalosporins and carbacephalosporins with parabens |
| US20100311701A1 (en) * | 2002-02-15 | 2010-12-09 | Transform Pharmaceuticals, Inc | Pharmaceutical Co-Crystal Compositions |
| US7790905B2 (en) * | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US20090088443A1 (en) * | 2002-02-15 | 2009-04-02 | Julius Remenar | Novel crystalline forms of conazoles and methods of making and using the same |
| AU2003213719A1 (en) * | 2002-03-01 | 2003-09-16 | Regents Of The University Of Michigan | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| US20070059356A1 (en) * | 2002-05-31 | 2007-03-15 | Almarsson Oern | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| IL165383A0 (en) * | 2002-06-21 | 2006-01-15 | Transform Pharmaceuticals Inc | Pharmaceutical compositions with improved dissolution |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| CN102595879B (zh) * | 2009-11-06 | 2014-08-06 | 巴斯夫欧洲公司 | 4-羟基苯甲酸和选定农药的结晶配合物 |
| CN105997931A (zh) * | 2016-07-19 | 2016-10-12 | 南京正宽医药科技有限公司 | 一种头孢克肟胶囊及其制备方法 |
| CN113845529B (zh) * | 2021-10-15 | 2024-02-27 | 东南大学 | 一种头孢氨苄共晶化合物及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3531481A (en) * | 1969-04-21 | 1970-09-29 | Lilly Co Eli | Method for manufacture of crystalline cephalosporin |
| GB1510794A (en) * | 1974-08-06 | 1978-05-17 | Univ Kingston | 1-oxacephems and intermediates therefor |
| AT363594B (de) * | 1978-02-01 | 1981-08-10 | Biochemie Gmbh | Verfahren zur herstellung eines neuen formamidkomplexes von 7-beta-(d-2-amino-2-phenylacetamido)-3-methylceph-3-emcarbonsaeure |
| US4534898A (en) * | 1982-07-23 | 1985-08-13 | Merck & Co., Inc. | 1-Oxa-1-dethia-cephalosporin derivatives |
| US4782144A (en) * | 1987-09-14 | 1988-11-01 | Eli Lilly And Company | 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof |
| ZA887409B (en) * | 1987-10-06 | 1990-06-27 | Lilly Co Eli | Crystalline beta-lactam hydrate |
| KR0135979B1 (ko) * | 1988-05-13 | 1998-04-25 | 메리 앤 터커 | 모액으로부터의 항생물질 회수방법 및 그의 약학적으로 허용할 수 있는 신규한 염 |
| CA2002596A1 (en) * | 1988-11-14 | 1990-05-14 | Thomas M. Eckrich | Hydrates of b-lactam antibiotic |
| US4977257A (en) * | 1988-11-14 | 1990-12-11 | Eli Lilly And Company | DMF solvates of a β-lactam antibiotic |
| US5142042A (en) * | 1989-01-23 | 1992-08-25 | Purzer Pharmaceutical Co., Ltd. | Process for preparing well crystallized alkali metal salts of 3, 7-substituted 7-aminocephalosporanic acid derivatives |
-
1993
- 1993-06-28 US US08/084,651 patent/US5412094A/en not_active Expired - Fee Related
-
1994
- 1994-06-20 ES ES94304442T patent/ES2110185T3/es not_active Expired - Lifetime
- 1994-06-20 ZA ZA944376A patent/ZA944376B/xx unknown
- 1994-06-20 DK DK94304442.0T patent/DK0637587T3/da active
- 1994-06-20 AT AT94304442T patent/ATE159942T1/de not_active IP Right Cessation
- 1994-06-20 CZ CZ941519A patent/CZ285452B6/cs not_active IP Right Cessation
- 1994-06-20 DE DE69406607T patent/DE69406607T2/de not_active Expired - Fee Related
- 1994-06-20 NZ NZ260791A patent/NZ260791A/en unknown
- 1994-06-20 EP EP94304442A patent/EP0637587B1/en not_active Expired - Lifetime
- 1994-06-20 PE PE1994244825A patent/PE57294A1/es not_active Application Discontinuation
- 1994-06-21 CA CA002126401A patent/CA2126401A1/en not_active Abandoned
- 1994-06-21 NO NO942364A patent/NO305480B1/no not_active IP Right Cessation
- 1994-06-23 IL IL11010394A patent/IL110103A/xx not_active IP Right Cessation
- 1994-06-24 CO CO94027493A patent/CO4230098A1/es unknown
- 1994-06-24 PL PL94303977A patent/PL177317B1/pl unknown
- 1994-06-24 AU AU65950/94A patent/AU674226B2/en not_active Ceased
- 1994-06-25 KR KR1019940014713A patent/KR950000707A/ko not_active Abandoned
- 1994-06-27 JP JP6144637A patent/JPH0748383A/ja active Pending
- 1994-06-27 YU YU40694A patent/YU40694A/sh unknown
- 1994-06-27 FI FI943081A patent/FI106460B/fi active
- 1994-06-27 CN CN94106572A patent/CN1044246C/zh not_active Expired - Fee Related
- 1994-06-27 BR BR9402561A patent/BR9402561A/pt not_active Application Discontinuation
- 1994-06-27 RU RU94022484A patent/RU2134265C1/ru active
- 1994-06-28 HU HU9401935A patent/HU219484B/hu not_active IP Right Cessation
-
1997
- 1997-12-02 GR GR970403213T patent/GR3025563T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |