IL110204A0 - Novel indolene derivatives, processes for their preparation and their use for the treatment of cns disorders - Google Patents

Novel indolene derivatives, processes for their preparation and their use for the treatment of cns disorders

Info

Publication number
IL110204A0
IL110204A0 IL11020494A IL11020494A IL110204A0 IL 110204 A0 IL110204 A0 IL 110204A0 IL 11020494 A IL11020494 A IL 11020494A IL 11020494 A IL11020494 A IL 11020494A IL 110204 A0 IL110204 A0 IL 110204A0
Authority
IL
Israel
Prior art keywords
novel
processes
preparation
treatment
cns disorders
Prior art date
Application number
IL11020494A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of IL110204A0 publication Critical patent/IL110204A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Eyeglasses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL11020494A 1993-07-06 1994-07-04 Novel indolene derivatives, processes for their preparation and their use for the treatment of cns disorders IL110204A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939313913A GB9313913D0 (en) 1993-07-06 1993-07-06 Novel compounds

Publications (1)

Publication Number Publication Date
IL110204A0 true IL110204A0 (en) 1995-01-24

Family

ID=10738344

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11020494A IL110204A0 (en) 1993-07-06 1994-07-04 Novel indolene derivatives, processes for their preparation and their use for the treatment of cns disorders

Country Status (15)

Country Link
US (1) US5834494A (pt)
EP (1) EP0707581B1 (pt)
JP (1) JPH08512299A (pt)
CN (1) CN1129937A (pt)
AP (1) AP463A (pt)
AT (1) ATE149163T1 (pt)
AU (1) AU7228394A (pt)
CA (1) CA2166624A1 (pt)
DE (1) DE69401823T2 (pt)
GB (1) GB9313913D0 (pt)
IL (1) IL110204A0 (pt)
MA (1) MA23254A1 (pt)
TW (1) TW297023B (pt)
WO (1) WO1995001976A1 (pt)
ZA (1) ZA944807B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618824A (en) * 1994-03-09 1997-04-08 Merrell Pharmaceuticals Inc. Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
GB9414139D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Novel compounds
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
WO1996023769A2 (en) * 1995-02-02 1996-08-08 Smithkline Beecham Plc Heterocyclic compounds possessing 5ht2c receptor antagonist activity
FI973205L (fi) * 1995-02-02 1997-10-01 Smithkline Beecham Plc Indolijohdannaisia 5-HT-reseptoriantagonisteina
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
CA2253941A1 (en) * 1996-05-16 1997-11-20 Sumanas Rakhit Thiophene- and furan-tryptamine derivatives
GB9612883D0 (en) 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
GB9612885D0 (en) 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000023437A1 (en) * 1998-10-16 2000-04-27 Takeda Chemical Industries, Ltd. Nitrogenous fused heterocycle compounds, process for the preparation thereof and agents containing the same
US6453357B1 (en) 1999-01-07 2002-09-17 Cisco Technology, Inc. Method and system for processing fragments and their out-of-order delivery during address translation
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
CN1242995C (zh) * 1999-05-21 2006-02-22 比奥维特罗姆股份公司 化合物,它们的用途和制备方法
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
FR2810979B1 (fr) * 2000-06-29 2002-08-23 Adir Nouveaux derives de diphenyluree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
EP1304589A1 (en) * 2001-07-09 2003-04-23 Alcatel Connector for optical fibers
US6861440B2 (en) 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
FR2837823B1 (fr) * 2002-03-27 2005-04-08 Servier Lab Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2003243089B2 (en) 2002-06-19 2010-01-07 Biovitrum Ab (Publ) Novel compounds, their use and preparation
BRPI0411509A (pt) 2003-06-20 2006-07-25 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para tratamento e/ou profilaxia de enfermidades que estão associadas com dpp-iv e sua utilização
BRPI0411713B8 (pt) 2003-06-20 2021-05-25 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para tratamento e/ou profilaxia de enfermidades que estão associadas com dpp-iv e sua utilização
BRPI0616000B1 (pt) * 2005-09-13 2016-04-19 Bayer Cropscience Ag composto derivado de fenil-amidina, processo de preparação de composto, composto derivado de nitrofeniléter, composto derivado de aminofeniléter, método de controle de fungos fitopatogênicos de safras e método de controle de insetos daninhos.
US8293100B2 (en) 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
CN106278987A (zh) * 2016-08-16 2017-01-04 都创(上海)医药科技有限公司 吲哚啉类化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428881A (en) * 1977-12-23 1984-01-31 Gulf Oil Corporation Control of unwanted vegetation with N-carbamylindolines
WO1992005170A1 (en) * 1990-09-13 1992-04-02 Beecham Group Plc Indole ureas as 5 ht receptor antagonist
NZ254785A (en) * 1992-08-20 1995-09-26 Smithkline Beecham Plc Heterocyclically-condensed indoles and medicaments

Also Published As

Publication number Publication date
EP0707581A1 (en) 1996-04-24
US5834494A (en) 1998-11-10
AP9400653A0 (en) 1994-07-31
CA2166624A1 (en) 1995-01-19
CN1129937A (zh) 1996-08-28
MA23254A1 (fr) 1995-04-01
ATE149163T1 (de) 1997-03-15
DE69401823T2 (de) 1997-08-28
AU7228394A (en) 1995-02-06
ZA944807B (en) 1996-01-04
WO1995001976A1 (en) 1995-01-19
GB9313913D0 (en) 1993-08-18
DE69401823D1 (de) 1997-04-03
TW297023B (pt) 1997-02-01
JPH08512299A (ja) 1996-12-24
AP463A (en) 1996-02-19
EP0707581B1 (en) 1997-02-26

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