IL110689A - Vasodilative pharmaceutical compositions containing aryloxyalkyldiamine derivatives certain such new compounds and their preparation - Google Patents
Vasodilative pharmaceutical compositions containing aryloxyalkyldiamine derivatives certain such new compounds and their preparationInfo
- Publication number
- IL110689A IL110689A IL11068994A IL11068994A IL110689A IL 110689 A IL110689 A IL 110689A IL 11068994 A IL11068994 A IL 11068994A IL 11068994 A IL11068994 A IL 11068994A IL 110689 A IL110689 A IL 110689A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- formula
- 6alkyl
- compound
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93202445 | 1993-08-19 | ||
| EP93202444 | 1993-08-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110689A0 IL110689A0 (en) | 1994-11-11 |
| IL110689A true IL110689A (en) | 1998-12-27 |
Family
ID=26133971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11068994A IL110689A (en) | 1993-08-19 | 1994-08-17 | Vasodilative pharmaceutical compositions containing aryloxyalkyldiamine derivatives certain such new compounds and their preparation |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5677310A (fr) |
| EP (1) | EP0714388B1 (fr) |
| JP (1) | JP3659969B2 (fr) |
| KR (1) | KR100345046B1 (fr) |
| CN (1) | CN1066718C (fr) |
| AT (1) | ATE165091T1 (fr) |
| AU (1) | AU682396B2 (fr) |
| BR (1) | BR9407313A (fr) |
| CA (1) | CA2168023C (fr) |
| CZ (1) | CZ39396A3 (fr) |
| DE (1) | DE69409652T2 (fr) |
| FI (1) | FI120145B (fr) |
| HU (1) | HU222275B1 (fr) |
| IL (1) | IL110689A (fr) |
| NO (1) | NO305283B1 (fr) |
| NZ (1) | NZ271994A (fr) |
| PL (1) | PL179008B1 (fr) |
| RU (1) | RU2158126C2 (fr) |
| SK (1) | SK21596A3 (fr) |
| WO (1) | WO1995005366A1 (fr) |
| ZA (1) | ZA946270B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9507288D0 (en) * | 1995-04-07 | 1995-05-31 | Sod Conseils Rech Applic | Phenoxyethylamine derivatives with high affinity for 5-HT1A receptors |
| FR2753967B1 (fr) * | 1996-09-27 | 1998-11-27 | Sod Conseils Rech Applic | Nouveaux derives de la phenoxyethylamine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| CA2581454A1 (fr) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Nouveaux composes de pyrimidine, leur procede de preparation, et compositions les contenant |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| CN101801930B (zh) * | 2007-09-14 | 2013-01-30 | 奥梅-杨森制药有限公司 | 1,3-二取代的-4-苯基-1h-吡啶-2-酮 |
| PL2200985T3 (pl) | 2007-09-14 | 2011-12-30 | Ortho Mcneil Janssen Pharmaceuticals Inc | 1,3-Dipodstawione-4-(arylo-X-fenylo)-1H-pirydyn-2-ony |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| CN101861316B (zh) * | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| EP2344470B1 (fr) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | Dérivés de 3-azabicyclo[3.1.0]hexyle comme modulateurs des récepteurs métabotropiques du glutamate |
| WO2010043396A1 (fr) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Dérivés d’indole et de benzomorpholine en tant que modulateurs des récepteurs métabotropiques du glutamate |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| RU2720237C2 (ru) | 2013-11-18 | 2020-04-28 | Форма Терапеутикс, Инк. | Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет |
| CN110627770A (zh) | 2013-11-18 | 2019-12-31 | 福马疗法公司 | 作为bet溴域抑制剂的四氢喹啉组成物 |
| MX386697B (es) | 2014-01-21 | 2025-03-19 | Janssen Pharmaceutica Nv | Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso |
| ME03518B (fr) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Combinaisons comprenant des modulateurs allostériques positifs de sous-type 2 de récepteurs glutamatergiques métabotropes et leur utilisation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3023369A1 (de) * | 1980-06-23 | 1982-01-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4593039A (en) * | 1984-04-02 | 1986-06-03 | Merck & Co., Inc. | 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols |
| US5231166A (en) * | 1988-10-25 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Endothelin |
| US5399581A (en) * | 1990-12-26 | 1995-03-21 | Laragh; John H. | Method and compositions for treatment of sexual impotence |
| FR2675799B1 (fr) * | 1991-04-24 | 1993-12-24 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| FR2697253B1 (fr) * | 1992-10-22 | 1994-12-02 | Synthelabo | Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique. |
-
1994
- 1994-08-12 WO PCT/EP1994/002702 patent/WO1995005366A1/fr not_active Ceased
- 1994-08-12 US US08/612,849 patent/US5677310A/en not_active Expired - Lifetime
- 1994-08-12 JP JP50675195A patent/JP3659969B2/ja not_active Expired - Lifetime
- 1994-08-12 BR BR9407313A patent/BR9407313A/pt not_active Application Discontinuation
- 1994-08-12 HU HU9600349A patent/HU222275B1/hu active IP Right Grant
- 1994-08-12 RU RU96105988/14A patent/RU2158126C2/ru active
- 1994-08-12 PL PL94313081A patent/PL179008B1/pl unknown
- 1994-08-12 AU AU76130/94A patent/AU682396B2/en not_active Expired
- 1994-08-12 NZ NZ271994A patent/NZ271994A/en not_active IP Right Cessation
- 1994-08-12 CN CN94193180A patent/CN1066718C/zh not_active Expired - Lifetime
- 1994-08-12 KR KR1019960700634A patent/KR100345046B1/ko not_active Expired - Lifetime
- 1994-08-12 CA CA002168023A patent/CA2168023C/fr not_active Expired - Lifetime
- 1994-08-12 SK SK215-96A patent/SK21596A3/sk unknown
- 1994-08-12 CZ CZ96393A patent/CZ39396A3/cs unknown
- 1994-08-12 DE DE69409652T patent/DE69409652T2/de not_active Expired - Lifetime
- 1994-08-12 AT AT94926190T patent/ATE165091T1/de not_active IP Right Cessation
- 1994-08-12 EP EP94926190A patent/EP0714388B1/fr not_active Expired - Lifetime
- 1994-08-17 IL IL11068994A patent/IL110689A/en not_active IP Right Cessation
- 1994-08-18 ZA ZA946270A patent/ZA946270B/xx unknown
-
1996
- 1996-02-16 FI FI960722A patent/FI120145B/fi not_active IP Right Cessation
- 1996-02-19 NO NO960648A patent/NO305283B1/no not_active IP Right Cessation
-
1997
- 1997-06-02 US US08/867,870 patent/US5801179A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HUT73977A (en) | 1996-10-28 |
| CZ39396A3 (en) | 1996-05-15 |
| RU2158126C2 (ru) | 2000-10-27 |
| US5801179A (en) | 1998-09-01 |
| CA2168023A1 (fr) | 1995-02-23 |
| CN1066718C (zh) | 2001-06-06 |
| WO1995005366A1 (fr) | 1995-02-23 |
| IL110689A0 (en) | 1994-11-11 |
| NO960648D0 (no) | 1996-02-19 |
| PL313081A1 (en) | 1996-05-27 |
| FI960722A7 (fi) | 1996-02-16 |
| HU9600349D0 (en) | 1996-04-29 |
| DE69409652D1 (de) | 1998-05-20 |
| DE69409652T2 (de) | 1998-10-15 |
| NO305283B1 (no) | 1999-05-03 |
| CA2168023C (fr) | 2006-10-24 |
| SK21596A3 (en) | 1997-03-05 |
| ZA946270B (en) | 1996-02-19 |
| HU222275B1 (hu) | 2003-05-28 |
| NO960648L (no) | 1996-02-19 |
| BR9407313A (pt) | 1996-10-08 |
| PL179008B1 (pl) | 2000-07-31 |
| US5677310A (en) | 1997-10-14 |
| JPH09502962A (ja) | 1997-03-25 |
| FI120145B (fi) | 2009-07-15 |
| JP3659969B2 (ja) | 2005-06-15 |
| EP0714388B1 (fr) | 1998-04-15 |
| KR100345046B1 (ko) | 2002-12-05 |
| ATE165091T1 (de) | 1998-05-15 |
| NZ271994A (en) | 1997-06-24 |
| EP0714388A1 (fr) | 1996-06-05 |
| CN1129935A (zh) | 1996-08-28 |
| AU682396B2 (en) | 1997-10-02 |
| FI960722A0 (fi) | 1996-02-16 |
| AU7613094A (en) | 1995-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL110689A (en) | Vasodilative pharmaceutical compositions containing aryloxyalkyldiamine derivatives certain such new compounds and their preparation | |
| US6100268A (en) | Vasoconstrictive dihydrobenzopyran derivatives | |
| KR100190300B1 (ko) | 선택적 혈관수축제로서[(벤조디옥산,벤조푸란 또는 벤조피란)-알킬아미노]알킬 치환된 구아니딘 | |
| CA2168022C (fr) | Derives de substitution de dihydropyranopyridines, vasoconstricteurs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |