IL110689A - Vasodilative pharmaceutical compositions containing aryloxyalkyldiamine derivatives certain such new compounds and their preparation - Google Patents
Vasodilative pharmaceutical compositions containing aryloxyalkyldiamine derivatives certain such new compounds and their preparationInfo
- Publication number
- IL110689A IL110689A IL11068994A IL11068994A IL110689A IL 110689 A IL110689 A IL 110689A IL 11068994 A IL11068994 A IL 11068994A IL 11068994 A IL11068994 A IL 11068994A IL 110689 A IL110689 A IL 110689A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- formula
- 6alkyl
- compound
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93202445 | 1993-08-19 | ||
| EP93202444 | 1993-08-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110689A0 IL110689A0 (en) | 1994-11-11 |
| IL110689A true IL110689A (en) | 1998-12-27 |
Family
ID=26133971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11068994A IL110689A (en) | 1993-08-19 | 1994-08-17 | Vasodilative pharmaceutical compositions containing aryloxyalkyldiamine derivatives certain such new compounds and their preparation |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5677310A (fr) |
| EP (1) | EP0714388B1 (fr) |
| JP (1) | JP3659969B2 (fr) |
| KR (1) | KR100345046B1 (fr) |
| CN (1) | CN1066718C (fr) |
| AT (1) | ATE165091T1 (fr) |
| AU (1) | AU682396B2 (fr) |
| BR (1) | BR9407313A (fr) |
| CA (1) | CA2168023C (fr) |
| CZ (1) | CZ39396A3 (fr) |
| DE (1) | DE69409652T2 (fr) |
| FI (1) | FI120145B (fr) |
| HU (1) | HU222275B1 (fr) |
| IL (1) | IL110689A (fr) |
| NO (1) | NO305283B1 (fr) |
| NZ (1) | NZ271994A (fr) |
| PL (1) | PL179008B1 (fr) |
| RU (1) | RU2158126C2 (fr) |
| SK (1) | SK21596A3 (fr) |
| WO (1) | WO1995005366A1 (fr) |
| ZA (1) | ZA946270B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9507288D0 (en) * | 1995-04-07 | 1995-05-31 | Sod Conseils Rech Applic | Phenoxyethylamine derivatives with high affinity for 5-HT1A receptors |
| FR2753967B1 (fr) * | 1996-09-27 | 1998-11-27 | Sod Conseils Rech Applic | Nouveaux derives de la phenoxyethylamine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| CA2581623A1 (fr) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Composes a base de pyridine, leur procede de preparation et compositions les contenant |
| TWI417095B (zh) * | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| CA2696948C (fr) | 2007-09-14 | 2013-04-30 | Jose Maria Cid-Nunez | 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1, 4'] bipyridinyl-2'-ones 1', 3'-disusbstituees |
| KR20100080597A (ko) * | 2007-09-14 | 2010-07-09 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | １,３-이치환된-４-페닐-1ｈ-피리딘-2-온 |
| KR20100065191A (ko) | 2007-09-14 | 2010-06-15 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | １,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온 |
| EP2220083B1 (fr) * | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Dérivés d'imidazo[1,2-a]pyridines et leur utilisation en tant que modulateurs allostériques positifs de récepteurs mglur2 |
| CA2735764C (fr) | 2008-09-02 | 2016-06-14 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Derives de 3-azabicyclo[3.1.0]hexyle comme modulateurs des recepteurs metabotropiques du glutamate |
| AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| BRPI0921333A2 (pt) | 2008-11-28 | 2015-12-29 | Addex Pharmaceuticals Sa | derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos |
| EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| NZ596078A (en) | 2009-05-12 | 2013-06-28 | Janssen Pharmaceuticals Inc | 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS |
| CA2815002C (fr) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | Derives 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allosteriques positifs des recepteurs mglur2 |
| CN103298810B (zh) | 2010-11-08 | 2016-03-16 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| EP2643320B1 (fr) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | Dérivés de la 1,2,4-triazolo [4,3-a] pyridine et leur utilisation en tant que modulateurs allostériques positifs des récepteurs mglur2 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| WO2015074081A1 (fr) | 2013-11-18 | 2015-05-21 | Bair Kenneth W | Compositions de benzopipérazine en tant qu'inhibiteurs de bromodomaines bet |
| PT3071203T (pt) | 2013-11-18 | 2021-03-11 | Forma Therapeutics Inc | Composições de tetra-hidroquinolina como inibidores de bromodomínio bet |
| KR102414246B1 (ko) | 2014-01-21 | 2022-06-27 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| LT3431106T (lt) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3023369A1 (de) * | 1980-06-23 | 1982-01-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4593039A (en) * | 1984-04-02 | 1986-06-03 | Merck & Co., Inc. | 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols |
| US5231166A (en) * | 1988-10-25 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Endothelin |
| US5399581A (en) * | 1990-12-26 | 1995-03-21 | Laragh; John H. | Method and compositions for treatment of sexual impotence |
| FR2675799B1 (fr) * | 1991-04-24 | 1993-12-24 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| FR2697253B1 (fr) * | 1992-10-22 | 1994-12-02 | Synthelabo | Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique. |
-
1994
- 1994-08-12 DE DE69409652T patent/DE69409652T2/de not_active Expired - Lifetime
- 1994-08-12 WO PCT/EP1994/002702 patent/WO1995005366A1/fr not_active Ceased
- 1994-08-12 EP EP94926190A patent/EP0714388B1/fr not_active Expired - Lifetime
- 1994-08-12 RU RU96105988/14A patent/RU2158126C2/ru active
- 1994-08-12 SK SK215-96A patent/SK21596A3/sk unknown
- 1994-08-12 CA CA002168023A patent/CA2168023C/fr not_active Expired - Lifetime
- 1994-08-12 US US08/612,849 patent/US5677310A/en not_active Expired - Lifetime
- 1994-08-12 HU HU9600349A patent/HU222275B1/hu active IP Right Grant
- 1994-08-12 CZ CZ96393A patent/CZ39396A3/cs unknown
- 1994-08-12 JP JP50675195A patent/JP3659969B2/ja not_active Expired - Lifetime
- 1994-08-12 BR BR9407313A patent/BR9407313A/pt not_active Application Discontinuation
- 1994-08-12 AT AT94926190T patent/ATE165091T1/de not_active IP Right Cessation
- 1994-08-12 AU AU76130/94A patent/AU682396B2/en not_active Expired
- 1994-08-12 NZ NZ271994A patent/NZ271994A/en not_active IP Right Cessation
- 1994-08-12 CN CN94193180A patent/CN1066718C/zh not_active Expired - Lifetime
- 1994-08-12 PL PL94313081A patent/PL179008B1/pl unknown
- 1994-08-12 KR KR1019960700634A patent/KR100345046B1/ko not_active Expired - Lifetime
- 1994-08-17 IL IL11068994A patent/IL110689A/en not_active IP Right Cessation
- 1994-08-18 ZA ZA946270A patent/ZA946270B/xx unknown
-
1996
- 1996-02-16 FI FI960722A patent/FI120145B/fi not_active IP Right Cessation
- 1996-02-19 NO NO960648A patent/NO305283B1/no not_active IP Right Cessation
-
1997
- 1997-06-02 US US08/867,870 patent/US5801179A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995005366A1 (fr) | 1995-02-23 |
| AU682396B2 (en) | 1997-10-02 |
| HU222275B1 (hu) | 2003-05-28 |
| CA2168023C (fr) | 2006-10-24 |
| CA2168023A1 (fr) | 1995-02-23 |
| ATE165091T1 (de) | 1998-05-15 |
| PL179008B1 (pl) | 2000-07-31 |
| KR100345046B1 (ko) | 2002-12-05 |
| NO960648D0 (no) | 1996-02-19 |
| PL313081A1 (en) | 1996-05-27 |
| CN1066718C (zh) | 2001-06-06 |
| DE69409652T2 (de) | 1998-10-15 |
| FI960722A7 (fi) | 1996-02-16 |
| EP0714388A1 (fr) | 1996-06-05 |
| HUT73977A (en) | 1996-10-28 |
| NZ271994A (en) | 1997-06-24 |
| RU2158126C2 (ru) | 2000-10-27 |
| SK21596A3 (en) | 1997-03-05 |
| HU9600349D0 (en) | 1996-04-29 |
| FI960722A0 (fi) | 1996-02-16 |
| NO305283B1 (no) | 1999-05-03 |
| CZ39396A3 (en) | 1996-05-15 |
| DE69409652D1 (de) | 1998-05-20 |
| BR9407313A (pt) | 1996-10-08 |
| FI120145B (fi) | 2009-07-15 |
| JPH09502962A (ja) | 1997-03-25 |
| IL110689A0 (en) | 1994-11-11 |
| CN1129935A (zh) | 1996-08-28 |
| NO960648L (no) | 1996-02-19 |
| JP3659969B2 (ja) | 2005-06-15 |
| AU7613094A (en) | 1995-03-14 |
| ZA946270B (en) | 1996-02-19 |
| EP0714388B1 (fr) | 1998-04-15 |
| US5801179A (en) | 1998-09-01 |
| US5677310A (en) | 1997-10-14 |
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| KR100190300B1 (ko) | 선택적 혈관수축제로서[(벤조디옥산,벤조푸란 또는 벤조피란)-알킬아미노]알킬 치환된 구아니딘 | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |