IL110821A - Carbocyclic and heterocyclic fused-ring quinolinecarboxylic acids and pharmaceutical compositions comprising them - Google Patents

Carbocyclic and heterocyclic fused-ring quinolinecarboxylic acids and pharmaceutical compositions comprising them

Info

Publication number: IL110821A
Authority: IL; Israel
Prior art keywords: carbons; alkyl; formula; compounds; phenyl
Prior art date: 1993-08-31

Application number

IL110821A

Other languages

English (en)

Other versions

IL110821A0 (en

Original Assignee

Du Pont Merck Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-31

Filing date

1994-08-30

Publication date

1997-04-15

1994-08-30 Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma

1994-11-11 Publication of IL110821A0 publication Critical patent/IL110821A0/xx

1997-04-15 Publication of IL110821A publication Critical patent/IL110821A/xx

Links

125000002837 carbocyclic group Chemical group 0.000 title 1
125000000623 heterocyclic group Chemical group 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 11
150000001875 compounds Chemical class 0.000 abstract 8
-1 phenoxy, phenylthio, phenylsulfinyl Chemical group 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000002541 furyl group Chemical group 0.000 abstract 2
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
125000002971 oxazolyl group Chemical group 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
125000000335 thiazolyl group Chemical group 0.000 abstract 2
125000001544 thienyl group Chemical group 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)

IL110821A 1993-08-31 1994-08-30 Carbocyclic and heterocyclic fused-ring quinolinecarboxylic acids and pharmaceutical compositions comprising them IL110821A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/114,712 US5428040A (en)	1993-08-31	1993-08-31	Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents

Publications (2)

Publication Number	Publication Date
IL110821A0 IL110821A0 (en)	1994-11-11
IL110821A true IL110821A (en)	1997-04-15

Family

ID=22356972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL110821A IL110821A (en)	1993-08-31	1994-08-30	Carbocyclic and heterocyclic fused-ring quinolinecarboxylic acids and pharmaceutical compositions comprising them

Country Status (19)

Country	Link
US (4)	US5428040A (cs)
EP (1)	EP0716652A1 (cs)
JP (1)	JPH09501442A (cs)
KR (1)	KR960704851A (cs)
AU (1)	AU690140B2 (cs)
CA (1)	CA2170349A1 (cs)
CZ (1)	CZ51696A3 (cs)
FI (1)	FI960933A0 (cs)
HR (1)	HRP940484A2 (cs)
HU (1)	HUT74585A (cs)
IL (1)	IL110821A (cs)
NO (1)	NO960811L (cs)
NZ (1)	NZ273156A (cs)
PL (1)	PL313981A1 (cs)
RU (1)	RU2133740C1 (cs)
SK (1)	SK27096A3 (cs)
TW (1)	TW342390B (cs)
WO (1)	WO1995006640A1 (cs)
ZA (1)	ZA946658B (cs)

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ATE405568T1 (de) *	2001-11-14	2008-09-15	Univ Rutgers	Cytotoxische mittel
DE60225943T2 (de) *	2001-11-14	2009-01-29	Rutgers, The State University	Topoisomerase-giftmittel
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US20050158371A1 (en) *	2002-02-12	2005-07-21	Sumitomo Pharmaceuticals Co., Ltd.	Novel external agent
WO2004012746A2 (en) *	2002-08-02	2004-02-12	The Regents Of The University Of California	New uses for inhibitors of inosine monophosphate dehydrogenase
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US6992088B2 (en) *	2002-08-09	2006-01-31	Rutgers, The State University Of New Jersey	Nitro and amino substituted heterocycles as topoisomerase I targeting agents
US6989387B2 (en) *	2002-08-09	2006-01-24	Rutgers, The State University Of New Jersey	Nitro and amino substituted topoisomerase agents
AU2003290818A1 (en) *	2002-11-12	2004-06-03	Edmond J. Lavoie	Topoisomerase-targeting agents
FR2856687B1 (fr) *	2003-06-25	2005-09-16	Servier Lab	Nouveaux derives de benzo[a]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TW200517114A (en) *	2003-10-15	2005-06-01	Combinatorx Inc	Methods and reagents for the treatment of immunoinflammatory disorders
RU2257915C2 (ru) *	2003-10-17	2005-08-10	Государственное учреждение Московский областной научно-исследовательский институт им. М.Ф. Владимирского (МОНИКИ им. М.Ф. Владимирского)	Способ лечения обострений рассеянного склероза
JP2008512458A (ja)	2004-09-07	2008-04-24	ワイス	６Ｈ−［１］ベンゾピラノ［４，３−ｂ］キノリン及びエストロゲン様物質としてのそれらの使用
EP1799684B1 (en)	2004-10-04	2014-12-03	Millennium Pharmaceuticals, Inc.	Lactam compounds useful as protein kinase inhibitors
WO2007002867A1 (en)	2005-06-28	2007-01-04	Cv Therapeutics, Inc.	Abca1 elevating compounds
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PE20080145A1 (es)	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
MX2008014828A (es) *	2006-05-22	2009-02-06	Combinatorx Inc	Metodos y composiciones para el tratamiento de enfermedades o condiciones asociadas con niveles incrementados de proteina c-reactiva, interleucina-6 o interferon-gamma.
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JP5562865B2 (ja)	2007-12-17	2014-07-30	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｔｒｐｖ１のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター
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1993
- 1993-08-31 US US08/114,712 patent/US5428040A/en not_active Expired - Fee Related
1994
- 1994-08-26 WO PCT/US1994/009463 patent/WO1995006640A1/en not_active Ceased
- 1994-08-26 RU RU96107400A patent/RU2133740C1/ru active
- 1994-08-26 EP EP94926555A patent/EP0716652A1/en not_active Withdrawn
- 1994-08-26 CA CA002170349A patent/CA2170349A1/en not_active Abandoned
- 1994-08-26 AU AU76358/94A patent/AU690140B2/en not_active Ceased
- 1994-08-26 KR KR1019960701035A patent/KR960704851A/ko not_active Withdrawn
- 1994-08-26 JP JP7508162A patent/JPH09501442A/ja active Pending
- 1994-08-26 NZ NZ273156A patent/NZ273156A/en unknown
- 1994-08-26 PL PL94313981A patent/PL313981A1/xx unknown
- 1994-08-26 SK SK270-96A patent/SK27096A3/sk unknown
- 1994-08-26 CZ CZ96516A patent/CZ51696A3/cs unknown
- 1994-08-26 HU HU9600501A patent/HUT74585A/hu unknown
- 1994-08-30 IL IL110821A patent/IL110821A/xx not_active IP Right Cessation
- 1994-08-30 HR HR08/114,712A patent/HRP940484A2/hr not_active Application Discontinuation
- 1994-08-30 TW TW083107968A patent/TW342390B/zh active
- 1994-08-31 ZA ZA946658A patent/ZA946658B/xx unknown
1995
- 1995-03-27 US US08/411,251 patent/US5639759A/en not_active Expired - Lifetime
1996
- 1996-02-28 FI FI960933A patent/FI960933A0/fi unknown
- 1996-02-28 NO NO960811A patent/NO960811L/no unknown
1997
- 1997-03-18 US US08/820,222 patent/US5874441A/en not_active Expired - Fee Related
1998
- 1998-11-18 US US09/195,366 patent/US6110910A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NO960811D0 (no)	1996-02-28
PL313981A1 (en)	1996-08-05
NZ273156A (en)	1997-06-24
HUT74585A (en)	1997-01-28
HU9600501D0 (en)	1996-04-29
CZ51696A3 (en)	1996-06-12
CA2170349A1 (en)	1995-03-09
US6110910A (en)	2000-08-29
AU690140B2 (en)	1998-04-23
WO1995006640A1 (en)	1995-03-09
US5874441A (en)	1999-02-23
NO960811L (no)	1996-04-29
TW342390B (en)	1998-10-11
IL110821A0 (en)	1994-11-11
FI960933A7 (fi)	1996-02-28
EP0716652A1 (en)	1996-06-19
RU2133740C1 (ru)	1999-07-27
ZA946658B (en)	1996-02-29
AU7635894A (en)	1995-03-22
HRP940484A2 (en)	1997-02-28
US5639759A (en)	1997-06-17
FI960933A0 (fi)	1996-02-28
US5428040A (en)	1995-06-27
KR960704851A (ko)	1996-10-09
SK27096A3 (en)	1996-12-04
JPH09501442A (ja)	1997-02-10

Legal Events

Date	Code	Title
1997-11-20	FF	Patent granted
1998-02-22	KB	Patent renewed
1999-07-14	HS	Change of address for service
2001-06-14	RH	Patent void

Publication	Publication Date	Title
TW342390B (en)	1998-10-11	Carbocyclic and heterocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
HUT56370A (en)	1991-08-28	Process for producing tricyclic carbapenem derivatives and pharmaceutical compositions comprising such compounds as active ingredient
NO178697C (no)	1996-05-15	Analogifremgangsmåte for fremstilling av terapeutisk aktive pyrazolopyridin-forbindelser
HU9500006D0 (en)	1995-03-28	Heterocyclic compounds as pharmaceutical
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