IL111185A0 - Quinolizinone type compounds - Google Patents
Quinolizinone type compoundsInfo
- Publication number
- IL111185A0 IL111185A0 IL11118594A IL11118594A IL111185A0 IL 111185 A0 IL111185 A0 IL 111185A0 IL 11118594 A IL11118594 A IL 11118594A IL 11118594 A IL11118594 A IL 11118594A IL 111185 A0 IL111185 A0 IL 111185A0
- Authority
- IL
- Israel
- Prior art keywords
- loweralkyl
- amino
- cycloalkyl
- aryl
- nitrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13723693A | 1993-10-14 | 1993-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL111185A0 true IL111185A0 (en) | 1994-12-29 |
Family
ID=22476419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11118594A IL111185A0 (en) | 1993-10-14 | 1994-10-06 | Quinolizinone type compounds |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0723545B1 (de) |
| JP (1) | JPH09503783A (de) |
| KR (1) | KR960704887A (de) |
| CN (1) | CN1053188C (de) |
| AT (1) | ATE217309T1 (de) |
| AU (1) | AU689809B2 (de) |
| BR (1) | BR9407806A (de) |
| CA (1) | CA2173459A1 (de) |
| DE (1) | DE69430581D1 (de) |
| IL (1) | IL111185A0 (de) |
| WO (1) | WO1995010519A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5599816A (en) * | 1990-05-02 | 1997-02-04 | Abbott Laboratories | Quinolizinone type compounds |
| EP0726269B1 (de) * | 1993-10-28 | 2001-09-05 | Kaken Pharmaceutical Co., Ltd. | Chinolincarbonsäurederivate und ihre salze |
| RU2140919C1 (ru) * | 1994-07-18 | 1999-11-10 | Убе Индастриз Лтд. | Производные 8-трифторметилхинолинкарбоновой кислоты, фармацевтическая композиция и способ ингибирования вируса иммунодефицита |
| AU6181296A (en) * | 1995-04-27 | 1996-11-18 | Kaken Pharmaceutical Co., Ltd. | Optically active quinolinecarboxylic acid derivatives and sa lts thereof |
| US5618813A (en) * | 1995-05-26 | 1997-04-08 | Abbott Laboratories | Benzo[5.6]pyrano[2.3.4-ij]quinolizine and benzo[5.6]thiopyrano[2.3.4-ij]quinolizine derivatives as antibacterial and antineoplastic agents |
| KR19990022524A (ko) * | 1995-06-06 | 1999-03-25 | 웨인스톡 스티븐 에프. | 퀴놀리지논형화합물 |
| US5789591A (en) * | 1996-10-23 | 1998-08-04 | Abbott Laboratories | Process for preparing 1-substituted 8-chloro-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester compounds |
| US5703244A (en) * | 1996-11-21 | 1997-12-30 | Abbott Laboratories | Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds |
| US5693813A (en) * | 1997-02-26 | 1997-12-02 | Abbott Laboratories | Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid |
| CN1263527A (zh) * | 1997-05-21 | 2000-08-16 | 第一制药株式会社 | 顺式取代－取代氨基环烷基吡咯烷衍生物 |
| KR100241673B1 (ko) * | 1997-08-09 | 2000-03-02 | 김충섭 | 퀴놀리진 카르복실산 유도체 |
| CN1264837C (zh) | 1997-09-15 | 2006-07-19 | 普罗克特和甘保尔公司 | 喹诺酮抗微生物剂、其组合物和应用 |
| HK1040076A1 (zh) * | 1998-09-21 | 2002-05-24 | 希雷生物化学有限公司 | 作为整联蛋白抑制剂的喹嗪酮 |
| US6197974B1 (en) | 1998-10-26 | 2001-03-06 | Abbott Laboratories | Enantioselective synthesis of 3-aminopyrrolidines |
| EP1227096B1 (de) * | 1999-10-19 | 2004-09-22 | Sato Pharmaceutical Co. Ltd. | Antimikrobielle 4-oxochinolizine mit 2-pyridongerüsten als teilstruktur |
| ATE304539T1 (de) | 2000-12-14 | 2005-09-15 | Procter & Gamble | Antimikrobielle chinolone |
| AU2002230893B2 (en) | 2000-12-14 | 2005-06-09 | The Procter & Gamble Company | Antimicrobial 2-pyridones, their compositions and uses |
| BR0210099A (pt) | 2001-05-30 | 2004-04-13 | Warner Lambert Co | Agentes antibacterianos |
| DOP2002000386A (es) * | 2001-05-30 | 2002-12-15 | Warner Lambert Co | Agentes antibacterianos |
| AU2002310409C1 (en) | 2001-06-11 | 2008-04-17 | Xenoport, Inc. | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| WO2003029253A1 (en) * | 2001-09-28 | 2003-04-10 | Sato Pharmaceutical Co.,Ltd. | 4-oxoquinolizine antimicrobials having 2-pyridone skeleton as partial structure |
| US6900224B2 (en) * | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
| RS20050532A (sr) * | 2003-01-14 | 2007-12-31 | Arena Pharmaceuticals Inc., | Derivati 1,2,3-trisupstituisanog arila i heteroarila kao modulatori metabolizma za profilaksu i tretman poremećaja povezanih sa njim, kao što su dijebetes i hiperglikemija |
| WO2005033108A1 (en) * | 2003-09-22 | 2005-04-14 | Janssen Pharmaceutica, N.V. | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| US7977346B2 (en) | 2006-01-17 | 2011-07-12 | Guoqing Paul Chen | Spiro compounds and methods of use |
| CA2647454A1 (en) | 2006-03-28 | 2007-10-04 | The Procter & Gamble Company | A coupling process for preparing quinolone intermediates |
| ES2366150T3 (es) | 2006-03-28 | 2011-10-17 | Warner Chilcott Company, Llc | Malatos de polimorfos de ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinocarboxílico. |
| US8278313B2 (en) | 2008-03-11 | 2012-10-02 | Abbott Laboratories | Macrocyclic spiro pyrimidine derivatives |
| US8436005B2 (en) | 2008-04-03 | 2013-05-07 | Abbott Laboratories | Macrocyclic pyrimidine derivatives |
| CL2009001152A1 (es) * | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| WO2011149993A2 (en) * | 2010-05-25 | 2011-12-01 | Abbott Laboratories | SUBSTITUTED OCTAHYDROCYCLOPENTA[c]PYRROLES AS CALCIUM CHANNEL MODULATORS |
| WO2011149995A1 (en) | 2010-05-25 | 2011-12-01 | Abbott Laboratories | Novel substituted octahydrocyclopenta [c]pyrrol-4-amines as calcium channel blockers |
| EP3034078A1 (de) | 2010-09-27 | 2016-06-22 | Emergent Product Development Gaithersburg Inc. | Antimikrobielle 2-pyridon-zusammensetzungen |
| EP3312176A1 (de) * | 2011-02-01 | 2018-04-25 | Emergent Product Development Gaithersburg Inc. | Antimikrobielle 4-oxochinolizine |
| CN105001216B (zh) * | 2015-07-08 | 2017-03-01 | 中国科学院兰州化学物理研究所 | 一种喹嗪酮的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3508816A1 (de) * | 1985-01-10 | 1986-07-10 | Bayer Ag, 5090 Leverkusen | 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren |
| US4921857A (en) * | 1987-09-18 | 1990-05-01 | Merck & Co., Inc. | 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof |
| WO1991016894A1 (en) * | 1990-05-02 | 1991-11-14 | Abbott Laboratories | Quinolizinone type compounds |
-
1994
- 1994-09-30 AT AT94929998T patent/ATE217309T1/de not_active IP Right Cessation
- 1994-09-30 CA CA002173459A patent/CA2173459A1/en not_active Abandoned
- 1994-09-30 JP JP7511876A patent/JPH09503783A/ja active Pending
- 1994-09-30 WO PCT/US1994/011166 patent/WO1995010519A1/en not_active Ceased
- 1994-09-30 CN CN94194479A patent/CN1053188C/zh not_active Expired - Fee Related
- 1994-09-30 BR BR9407806A patent/BR9407806A/pt not_active Application Discontinuation
- 1994-09-30 DE DE69430581T patent/DE69430581D1/de not_active Expired - Lifetime
- 1994-09-30 KR KR1019960701906A patent/KR960704887A/ko not_active Ceased
- 1994-09-30 AU AU79258/94A patent/AU689809B2/en not_active Ceased
- 1994-09-30 EP EP94929998A patent/EP0723545B1/de not_active Expired - Lifetime
- 1994-10-06 IL IL11118594A patent/IL111185A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2173459A1 (en) | 1995-04-20 |
| ATE217309T1 (de) | 2002-05-15 |
| AU7925894A (en) | 1995-05-04 |
| KR960704887A (ko) | 1996-10-09 |
| CN1137273A (zh) | 1996-12-04 |
| JPH09503783A (ja) | 1997-04-15 |
| CN1053188C (zh) | 2000-06-07 |
| EP0723545A1 (de) | 1996-07-31 |
| WO1995010519A1 (en) | 1995-04-20 |
| DE69430581D1 (de) | 2002-06-13 |
| AU689809B2 (en) | 1998-04-09 |
| BR9407806A (pt) | 1997-08-19 |
| EP0723545B1 (de) | 2002-05-08 |
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