IL112125A - Quinazolinone-containing pharmaceutical compositions - Google Patents

Quinazolinone-containing pharmaceutical compositions

Info

Publication number: IL112125A
Authority: IL; Israel
Prior art keywords: cells; halofuginone; mesangial; vol; cell proliferation
Prior art date: 1994-12-22

Application number

IL112125A

Other languages

English (en)

Other versions

IL112125A0 (en

Inventor

Arnon Nagler

Shimon Slavin

Israel Vlodavsky

Mark Pines

Original Assignee

Hadasit Med Res Service

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-22

Filing date

1994-12-22

Publication date

1998-02-08

1994-12-22 Application filed by Hadasit Med Res Service filed Critical Hadasit Med Res Service

1994-12-22 Priority to IL112125A priority Critical patent/IL112125A/en

1995-03-15 Publication of IL112125A0 publication Critical patent/IL112125A0/xx

1995-12-21 Priority to PCT/US1995/016932 priority patent/WO1996019224A1/en

1995-12-21 Priority to CA002207097A priority patent/CA2207097C/en

1995-12-21 Priority to JP52003596A priority patent/JP3808505B2/ja

1995-12-21 Priority to DE69530510T priority patent/DE69530510T2/de

1995-12-21 Priority to US08/860,946 priority patent/US5998422A/en

1995-12-21 Priority to AU46465/96A priority patent/AU693652B2/en

1995-12-21 Priority to EP95944408A priority patent/EP0794780B1/de

1995-12-21 Priority to AT95944408T priority patent/ATE238055T1/de

1995-12-21 Priority to CNB951969048A priority patent/CN1149995C/zh

1998-02-08 Publication of IL112125A publication Critical patent/IL112125A/en

Links

AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical compound C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title description 6
239000008194 pharmaceutical composition Substances 0.000 title 1
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229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 4
125000000217 alkyl group Chemical group 0.000 claims abstract description 4
125000005605 benzo group Chemical group 0.000 claims abstract description 4
229910052736 halogen Inorganic materials 0.000 claims abstract description 4
150000002367 halogens Chemical class 0.000 claims abstract description 4
150000002431 hydrogen Chemical class 0.000 claims abstract description 4
-1 hydroxy, acetoxy Chemical group 0.000 claims abstract description 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 4
LVASCWIMLIKXLA-LSDHHAIUSA-N halofuginone Chemical compound O[C@@H]1CCCN[C@H]1CC(=O)CN1C(=O)C2=CC(Cl)=C(Br)C=C2N=C1 LVASCWIMLIKXLA-LSDHHAIUSA-N 0.000 claims description 29
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208000011580 syndromic disease Diseases 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
230000009261 transgenic effect Effects 0.000 description 1
238000011830 transgenic mouse model Methods 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
230000002792 vascular Effects 0.000 description 1
210000003556 vascular endothelial cell Anatomy 0.000 description 1
108010047303 von Willebrand Factor Proteins 0.000 description 1
102100036537 von Willebrand factor Human genes 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000011684 zucker rat (obese) Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Plant Substances (AREA)

IL112125A 1994-12-12 1994-12-22 Quinazolinone-containing pharmaceutical compositions IL112125A (en)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
IL112125A IL112125A (en)	1994-12-22	1994-12-22	Quinazolinone-containing pharmaceutical compositions
CNB951969048A CN1149995C (zh)	1994-12-22	1995-12-21	喹唑啉酮类化合物在制药中的用途
DE69530510T DE69530510T2 (de)	1994-12-22	1995-12-21	Chinazolinon enthaltende arzneimittel und verfahren zu deren verwendung
CA002207097A CA2207097C (en)	1994-12-22	1995-12-21	Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
JP52003596A JP3808505B2 (ja)	1994-12-22	1995-12-21	キナゾリノンを含有する医薬組成物およびそれの利用方法
PCT/US1995/016932 WO1996019224A1 (en)	1994-12-22	1995-12-21	Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
US08/860,946 US5998422A (en)	1994-12-12	1995-12-21	Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
AU46465/96A AU693652B2 (en)	1994-12-22	1995-12-21	Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
EP95944408A EP0794780B1 (de)	1994-12-22	1995-12-21	Chinazolinon enthaltende arzneimittel und verfahren zu deren verwendung
AT95944408T ATE238055T1 (de)	1994-12-22	1995-12-21	Chinazolinon enthaltende arzneimittel und verfahren zu deren verwendung

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL112125A IL112125A (en)	1994-12-22	1994-12-22	Quinazolinone-containing pharmaceutical compositions

Publications (2)

Publication Number	Publication Date
IL112125A0 IL112125A0 (en)	1995-03-15
IL112125A true IL112125A (en)	1998-02-08

Family

ID=11066921

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL112125A IL112125A (en)	1994-12-12	1994-12-22	Quinazolinone-containing pharmaceutical compositions

Country Status (9)

Country	Link
EP (1)	EP0794780B1 (de)
JP (1)	JP3808505B2 (de)
CN (1)	CN1149995C (de)
AT (1)	ATE238055T1 (de)
AU (1)	AU693652B2 (de)
CA (1)	CA2207097C (de)
DE (1)	DE69530510T2 (de)
IL (1)	IL112125A (de)
WO (1)	WO1996019224A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL114951A (en) *	1995-08-15	1999-08-17	Hadasit Med Res Service	Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization
US6440445B1 (en)	1996-09-30	2002-08-27	Brigham & Women's Hospital	Methods and compounds for treatment of abnormal uterine bleeding
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
JP2005529076A (ja)	2002-02-15	2005-09-29	サイトキネティクス・インコーポレーテッド	キナゾリノンの合成
EP1553931A4 (de)	2002-05-09	2006-08-30	Cytokinetics Inc	Verbindungen, zusammensetzungen und verfahren
RU2004135554A (ru)	2002-05-09	2006-01-20	Цитокинетикс, Инк. (Us)	Пиримидиноны, композиции на их основе и способы их использования
EP1513820A4 (de)	2002-05-23	2006-09-13	Cytokinetics Inc	Verbindungen, zusammensetzungen und verfahren
CA2489367A1 (en)	2002-06-14	2003-12-24	Cytokinetics, Inc.	Compounds, compositions, and methods
EP1537089A4 (de)	2002-07-23	2008-04-16	Cytokinetics Inc	Verbindungen, zusammenstellungen und verfahren
WO2004034972A2 (en)	2002-09-30	2004-04-29	Cytokinetics, Inc.	Compounds, compositions, and methods
EP1692112A4 (de)	2003-12-08	2008-09-24	Cytokinetics Inc	Verbindungen, zusammensetzungen und verfahren
KR20100024494A (ko)	2007-06-22	2010-03-05	아르퀼 인코포레이티드	퀴나졸리논 화합물 및 이의 사용 방법
CN114469956B (zh) *	2022-01-29	2023-07-18	中国科学技术大学	常山酮在治疗和预防动脉粥样硬化性疾病的药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3320124A (en) *	1964-07-20	1967-05-16	American Cyanamid Co	Method for treating coccidiosis with quinazolinones
DE2934069A1 (de) *	1979-08-23	1981-03-12	Hoechst Ag, 6000 Frankfurt	Mittel gegen theileriosen und seine verwendung.
CA2113229C (en) *	1994-01-11	1999-04-20	Mark Pines	Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof

1994
- 1994-12-22 IL IL112125A patent/IL112125A/en not_active IP Right Cessation
1995
- 1995-12-21 JP JP52003596A patent/JP3808505B2/ja not_active Expired - Fee Related
- 1995-12-21 AT AT95944408T patent/ATE238055T1/de not_active IP Right Cessation
- 1995-12-21 CA CA002207097A patent/CA2207097C/en not_active Expired - Fee Related
- 1995-12-21 CN CNB951969048A patent/CN1149995C/zh not_active Expired - Fee Related
- 1995-12-21 WO PCT/US1995/016932 patent/WO1996019224A1/en not_active Ceased
- 1995-12-21 AU AU46465/96A patent/AU693652B2/en not_active Ceased
- 1995-12-21 EP EP95944408A patent/EP0794780B1/de not_active Expired - Lifetime
- 1995-12-21 DE DE69530510T patent/DE69530510T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1176601A (zh)	1998-03-18
EP0794780A4 (de)	1997-11-12
AU693652B2 (en)	1998-07-02
CA2207097C (en)	2002-05-28
EP0794780A1 (de)	1997-09-17
EP0794780B1 (de)	2003-04-23
CN1149995C (zh)	2004-05-19
WO1996019224A1 (en)	1996-06-27
ATE238055T1 (de)	2003-05-15
JPH10511939A (ja)	1998-11-17
DE69530510D1 (de)	2003-05-28
CA2207097A1 (en)	1996-06-27
DE69530510T2 (de)	2004-02-19
IL112125A0 (en)	1995-03-15
AU4646596A (en)	1996-07-10
JP3808505B2 (ja)	2006-08-16

Legal Events

Date	Code	Title
1998-07-15	FF	Patent granted
1998-12-06	KB	Patent renewed
2005-02-20	KB	Patent renewed
2010-04-08	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
EP0794780B1 (de)	2003-04-23	Chinazolinon enthaltende arzneimittel und verfahren zu deren verwendung
CA2280850C (en)	2004-01-13	Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies
US5449678A (en)	1995-09-12	Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof
EP0787000B1 (de)	2000-11-08	Chinazolinon-arzneimittel sowie deren verwendung
US5891879A (en)	1999-04-06	Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
WO1996006616A9 (en)	1996-07-11	Quinazolinone pharmaceuticals and use thereof
US5998422A (en)	1999-12-07	Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
DE69633673T2 (de)	2006-02-09	Verwendung von Halofuginon zur Herstellung eines Medikaments zur Vorbeugung von Neovaskularisation und zur Behandlung bösartiger Tumoren
US6211188B1 (en)	2001-04-03	Treatment of skin disorders
US6090814A (en)	2000-07-18	Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization
CA2198875C (en)	2005-11-15	Quinazolinone pharmaceuticals and use thereof
KR20010012838A (ko)	2001-02-26	간경변의 치료방법