IL112455A - Benzothiophene derivatives for use in combination therapy of osteoporosis together with a progestin uses thereof and pharmaceutical compositions containing them - Google Patents
Benzothiophene derivatives for use in combination therapy of osteoporosis together with a progestin uses thereof and pharmaceutical compositions containing themInfo
- Publication number
- IL112455A IL112455A IL11245595A IL11245595A IL112455A IL 112455 A IL112455 A IL 112455A IL 11245595 A IL11245595 A IL 11245595A IL 11245595 A IL11245595 A IL 11245595A IL 112455 A IL112455 A IL 112455A
- Authority
- IL
- Israel
- Prior art keywords
- progestin
- pharmaceutical compositions
- compositions containing
- combination therapy
- benzothiophene derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/189,399 US5591753A (en) | 1994-01-28 | 1994-01-28 | Combination treatment for osteoporosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL112455A0 IL112455A0 (en) | 1995-03-30 |
| IL112455A true IL112455A (en) | 1999-12-31 |
Family
ID=22697178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11245595A IL112455A (en) | 1994-01-28 | 1995-01-26 | Benzothiophene derivatives for use in combination therapy of osteoporosis together with a progestin uses thereof and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5591753A (ru) |
| EP (1) | EP0665015A3 (ru) |
| JP (1) | JPH07267858A (ru) |
| KR (1) | KR950031068A (ru) |
| CN (1) | CN1084617C (ru) |
| AU (1) | AU692811B2 (ru) |
| CA (1) | CA2140952A1 (ru) |
| CZ (1) | CZ290045B6 (ru) |
| HU (1) | HUT72633A (ru) |
| IL (1) | IL112455A (ru) |
| NO (1) | NO950275L (ru) |
| NZ (1) | NZ270386A (ru) |
| PH (1) | PH31553A (ru) |
| RU (1) | RU2181048C2 (ru) |
| TW (1) | TW401296B (ru) |
| UA (1) | UA29451C2 (ru) |
| ZA (1) | ZA95556B (ru) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| USRE38968E1 (en) | 1992-07-28 | 2006-02-07 | Eli Lilly And Company | Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride |
| USRE39049E1 (en) | 1992-07-28 | 2006-03-28 | Eli Lilly And Company | Methods for inhibiting bone loss |
| TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6319914B1 (en) | 1993-11-05 | 2001-11-20 | Apollo Biopharmaceuticals, Inc. | Cytoprotective effect of polycyclic phenolic compounds |
| US5478847A (en) | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
| TW398975B (en) * | 1994-07-22 | 2000-07-21 | Lilly Co Eli | Pharmaceutical composition for inhibiting bone loss |
| IL120265A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | Combination therapy to treat osteoporosis - polyphosphonates or progestins and estrogen agonists |
| IL120270A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | Combination therapy to treat osteoporosis |
| IL120263A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | Combination therapy to prevent bone loss-progesterone and estrogen agonists |
| WO1998046588A2 (en) | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| CA2287244A1 (en) * | 1997-04-25 | 1998-11-05 | Henry Uhlman Bryant | Indene compounds having activity as serms |
| US6653297B1 (en) | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
| US6326392B1 (en) | 1997-11-06 | 2001-12-04 | American Home Products Corporation | Anti-estrogen plus progestin containing oral contraceptives |
| US6096781A (en) | 1997-11-14 | 2000-08-01 | Eli Lilly And Company | 2-arylbenzo[B]thiophenes useful for the treatment of estrogen deprivation syndrome |
| US6054446A (en) | 1997-12-24 | 2000-04-25 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| AU3171099A (en) * | 1998-04-17 | 1999-11-08 | Senga Pharmaceutical Laboratory Inc. | 1-heteroindene derivatives and medicinal composition containing the same |
| US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
| US6479535B1 (en) * | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| US6265393B1 (en) | 1998-08-07 | 2001-07-24 | Heinrichs William Leroy | Prevention of endometriosis signs or symptons |
| US6258826B1 (en) | 1998-10-13 | 2001-07-10 | Eli Lilly And Company | Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome |
| CZ20013912A3 (cs) | 1999-05-04 | 2002-05-15 | Strakan Limited | Androgen glykosid, sloučenina, testosteron-ß-D-glukosid, 5 alfa-Dihydrotestosteron- 17ß-D-glukosid, farmaceutický prostředek a pouľití sloučeniny |
| US6159959A (en) * | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
| US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
| CA2448235A1 (en) * | 2001-07-31 | 2003-02-13 | Pfizer Products Inc. | Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins |
| US20060106010A1 (en) * | 2003-05-27 | 2006-05-18 | Black Larry J | Methods for inhibiting bone loss |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US4425339A (en) * | 1981-04-09 | 1984-01-10 | Syntex (U.S.A.) Inc. | Treatment of menopausal symptoms |
| ZA87332B (en) * | 1986-02-27 | 1987-08-26 | Warner Lambert Co | Compositions containing fixed combinations |
| US5075321A (en) * | 1987-03-24 | 1991-12-24 | University Of Pennsylvania | Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes |
| HUT52382A (en) * | 1988-03-14 | 1990-07-28 | Sandoz Ag | Process for producing pharmaceutical compositions comprising as active ingredient unsubstituted progestin in 19-position and estrogen in the given case |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| AU3126593A (en) * | 1991-11-25 | 1993-06-28 | Healthguard, Incorporated | Multistage coaxial encapsulated filter assembly |
| TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
-
1994
- 1994-01-28 US US08/189,399 patent/US5591753A/en not_active Expired - Fee Related
-
1995
- 1995-01-24 CZ CZ1995176A patent/CZ290045B6/cs not_active IP Right Cessation
- 1995-01-24 UA UA95018071A patent/UA29451C2/ru unknown
- 1995-01-24 TW TW084100589A patent/TW401296B/zh not_active IP Right Cessation
- 1995-01-24 ZA ZA95556A patent/ZA95556B/xx unknown
- 1995-01-24 CA CA002140952A patent/CA2140952A1/en not_active Abandoned
- 1995-01-24 AU AU11390/95A patent/AU692811B2/en not_active Ceased
- 1995-01-24 NZ NZ270386A patent/NZ270386A/en unknown
- 1995-01-25 EP EP95300439A patent/EP0665015A3/en not_active Withdrawn
- 1995-01-25 NO NO950275A patent/NO950275L/no unknown
- 1995-01-25 KR KR1019950001289A patent/KR950031068A/ko not_active Abandoned
- 1995-01-25 PH PH49830A patent/PH31553A/en unknown
- 1995-01-25 HU HU9500229A patent/HUT72633A/hu unknown
- 1995-01-26 IL IL11245595A patent/IL112455A/xx not_active IP Right Cessation
- 1995-01-26 RU RU95101044/14A patent/RU2181048C2/ru active
- 1995-01-26 CN CN95101458A patent/CN1084617C/zh not_active Expired - Fee Related
- 1995-01-26 JP JP7010490A patent/JPH07267858A/ja not_active Withdrawn
-
1996
- 1996-08-20 US US08/700,184 patent/US5646137A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1084617C (zh) | 2002-05-15 |
| CZ17695A3 (en) | 1995-10-18 |
| JPH07267858A (ja) | 1995-10-17 |
| US5591753A (en) | 1997-01-07 |
| IL112455A0 (en) | 1995-03-30 |
| US5646137A (en) | 1997-07-08 |
| HU9500229D0 (en) | 1995-03-28 |
| CN1111511A (zh) | 1995-11-15 |
| RU2181048C2 (ru) | 2002-04-10 |
| ZA95556B (en) | 1996-07-24 |
| NO950275L (no) | 1995-07-31 |
| CA2140952A1 (en) | 1995-07-29 |
| EP0665015A2 (en) | 1995-08-02 |
| EP0665015A3 (en) | 1998-04-08 |
| TW401296B (en) | 2000-08-11 |
| NO950275D0 (no) | 1995-01-25 |
| HUT72633A (en) | 1996-05-28 |
| AU1139095A (en) | 1995-08-10 |
| KR950031068A (ko) | 1995-12-18 |
| UA29451C2 (ru) | 2000-11-15 |
| PH31553A (en) | 1998-11-03 |
| NZ270386A (en) | 1996-09-25 |
| AU692811B2 (en) | 1998-06-18 |
| CZ290045B6 (cs) | 2002-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |