IL113411A - Pharmaceutical composition for the treatment or prophylaxis of hyperglycaemias comprising moxonidine as active ingredient and process for the production of such composition - Google Patents

Pharmaceutical composition for the treatment or prophylaxis of hyperglycaemias comprising moxonidine as active ingredient and process for the production of such composition

Info

Publication number: IL113411A
Authority: IL; Israel
Prior art keywords: composition; treatment; hyperglycaemias; moxonidine; prophylaxis
Prior art date: 1994-07-01

Application number

IL11341195A

Other languages

English (en)

Other versions

IL113411A0 (en

Original Assignee

Solvay Pharm Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-01

Filing date

1995-04-18

Publication date

1999-07-14

1995-04-18 Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh

1995-07-31 Publication of IL113411A0 publication Critical patent/IL113411A0/xx

1999-07-14 Publication of IL113411A publication Critical patent/IL113411A/xx

Links

201000001421 hyperglycemia Diseases 0.000 title abstract 2
238000011282 treatment Methods 0.000 title abstract 2
WPNJAUFVNXKLIM-UHFFFAOYSA-N Moxonidine Chemical compound COC1=NC(C)=NC(Cl)=C1NC1=NCCN1 WPNJAUFVNXKLIM-UHFFFAOYSA-N 0.000 title 1
239000004480 active ingredient Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229960003938 moxonidine Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
238000011321 prophylaxis Methods 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
FEJPHYPTHAAKRE-UHFFFAOYSA-N 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxypyrimidin-5-amine Chemical compound COC1=NC=NC(Cl)=C1NC1=NCCN1 FEJPHYPTHAAKRE-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000002552 dosage form Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Dental Preparations (AREA)
Fats And Perfumes (AREA)

IL11341195A 1994-07-01 1995-04-18 Pharmaceutical composition for the treatment or prophylaxis of hyperglycaemias comprising moxonidine as active ingredient and process for the production of such composition IL113411A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4423177A DE4423177A1 (de)	1994-07-01	1994-07-01	Antihyperglykämisch wirksame Arzneimittel

Publications (2)

Publication Number	Publication Date
IL113411A0 IL113411A0 (en)	1995-07-31
IL113411A true IL113411A (en)	1999-07-14

Family

ID=6522064

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11341195A IL113411A (en)	1994-07-01	1995-04-18	Pharmaceutical composition for the treatment or prophylaxis of hyperglycaemias comprising moxonidine as active ingredient and process for the production of such composition

Country Status (23)

Country	Link
US (1)	US5712283A (cs)
EP (1)	EP0689837B1 (cs)
JP (1)	JP3841846B2 (cs)
KR (1)	KR100366130B1 (cs)
CN (1)	CN1092961C (cs)
AT (1)	ATE210444T1 (cs)
AU (1)	AU691580B2 (cs)
CA (1)	CA2152998C (cs)
CZ (1)	CZ287563B6 (cs)
DE (2)	DE4423177A1 (cs)
DK (1)	DK0689837T3 (cs)
DZ (1)	DZ1894A1 (cs)
ES (1)	ES2167385T3 (cs)
FI (1)	FI117374B (cs)
HU (1)	HU226946B1 (cs)
IL (1)	IL113411A (cs)
NO (1)	NO307029B1 (cs)
NZ (1)	NZ270990A (cs)
PT (1)	PT689837E (cs)
RU (1)	RU2145857C1 (cs)
SK (1)	SK282227B6 (cs)
UA (1)	UA27954C2 (cs)
ZA (1)	ZA954691B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5977121A (en) *	1995-02-28	1999-11-02	Eli Lilly And Company	Use of moxonidine for the treatment of atherosclerosis
TR199802496T2 (xx) *	1996-06-06	1999-02-22	Eli Lilly And Company	Konjestif kalp yetmezli�ini tedavi i�in form�lasyon.
NO980546L (no) *	1997-02-11	1998-08-12	Lilly Co Eli	Farmas°ytiske midler
DE19722322A1 (de) *	1997-05-28	1998-12-03	Solvay Pharm Gmbh	Nephroprotektives Arzneimittel
WO1999020279A1 (en) *	1997-10-17	1999-04-29	Eli Lilly And Company	Potentiation of pharmaceuticals
US6897019B1 (en) *	1998-04-17	2005-05-24	Tufts College	Methods for treating and preventing insulin resistance and related disorders
AU2727400A (en) *	1999-01-29	2000-08-18	Eli Lilly And Company	Moxonidine salts
DE50009220D1 (de) *	1999-02-01	2005-02-17	Solvay Pharm Gmbh	Verwendung von moxonidin zur behandlung nach herzinfarkt
DE19911371A1 (de)	1999-03-15	2000-09-21	Solvay Pharm Gmbh	Arzneimittel zur Behandlung von funktionellen Störungen und Erkrankungen der unteren Darmwege, insbesondere von damit einhergehenden abdominalen visceralen Schmerzen
RU2219930C2 (ru) *	2001-09-24	2003-12-27	Государственное образовательное учреждение высшего профессионального образования Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова	Способ лечения заболеваний печени
AU2003257418A1 (en) *	2002-06-19	2004-01-06	Solvay Pharmaceuticals Gmbh	Medicament for the treatment of diseases requiring inhibition or a reduction in the activity of ph value-regulating bicarbonate transporter proteins
MXPA06004029A (es) *	2003-10-10	2006-06-28	Solvay Pharm Gmbh	Composicion farmaceutica que comprende un agonista del receptor de imidazolina selectivo i1 y un bloqueante del receptor de angiotensina ii.
RU2426543C1 (ru) *	2010-05-24	2011-08-20	Учреждение Российской академии медицинских наук Научно-исследовательский институт фармакологии Сибирского отделения РАМН НИИ фармакологии СО РАМН	Способ дифференцированного назначения моксонидина у пациентов с артериальной гипертензией на фоне метаболического синдрома
RU2542462C2 (ru) *	2013-06-28	2015-02-20	Андрей Владиславович Струтынский	Способ коррекции кризового течения гипертонической болезни и абдоминального ожирения

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2849537C2 (de) *	1978-11-15	1983-03-17	Beiersdorf Ag, 2000 Hamburg	Substituierte 5-(2-Imidazolin-2-yl)-aminopyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US4323570A (en) *	1978-11-15	1982-04-06	Beiersdorf Aktiengesellschaft	Substituted aminopyrimidines
FR2669927B1 (fr) *	1990-11-29	1994-04-08	Adir Cie	Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

1994
- 1994-07-01 DE DE4423177A patent/DE4423177A1/de not_active Withdrawn
1995
- 1995-04-18 IL IL11341195A patent/IL113411A/xx not_active IP Right Cessation
- 1995-04-26 NZ NZ270990A patent/NZ270990A/en unknown
- 1995-04-27 AU AU17757/95A patent/AU691580B2/en not_active Ceased
- 1995-05-20 KR KR1019950012695A patent/KR100366130B1/ko not_active Expired - Fee Related
- 1995-05-30 DZ DZ950067A patent/DZ1894A1/fr active
- 1995-05-30 CZ CZ19951393A patent/CZ287563B6/cs not_active IP Right Cessation
- 1995-06-01 RU RU95109157A patent/RU2145857C1/ru not_active IP Right Cessation
- 1995-06-06 SK SK749-95A patent/SK282227B6/sk not_active IP Right Cessation
- 1995-06-07 ZA ZA954691A patent/ZA954691B/xx unknown
- 1995-06-20 US US08/492,656 patent/US5712283A/en not_active Expired - Lifetime
- 1995-06-23 ES ES95109812T patent/ES2167385T3/es not_active Expired - Lifetime
- 1995-06-23 PT PT95109812T patent/PT689837E/pt unknown
- 1995-06-23 DK DK95109812T patent/DK0689837T3/da active
- 1995-06-23 DE DE59509928T patent/DE59509928D1/de not_active Expired - Lifetime
- 1995-06-23 EP EP95109812A patent/EP0689837B1/de not_active Expired - Lifetime
- 1995-06-23 AT AT95109812T patent/ATE210444T1/de active
- 1995-06-26 UA UA95062992A patent/UA27954C2/uk unknown
- 1995-06-28 HU HU9501900A patent/HU226946B1/hu not_active IP Right Cessation
- 1995-06-29 CA CA002152998A patent/CA2152998C/en not_active Expired - Fee Related
- 1995-06-30 FI FI953256A patent/FI117374B/fi not_active IP Right Cessation
- 1995-06-30 NO NO19952624A patent/NO307029B1/no not_active IP Right Cessation
- 1995-06-30 CN CN95107767A patent/CN1092961C/zh not_active Expired - Fee Related
- 1995-07-03 JP JP16770595A patent/JP3841846B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU691580B2 (en)	1998-05-21
RU2145857C1 (ru)	2000-02-27
EP0689837A3 (de)	1996-06-05
DK0689837T3 (da)	2002-03-11
SK74995A3 (en)	1996-05-08
ATE210444T1 (de)	2001-12-15
US5712283A (en)	1998-01-27
EP0689837B1 (de)	2001-12-12
SK282227B6 (sk)	2001-12-03
CN1092961C (zh)	2002-10-23
CN1122224A (zh)	1996-05-15
NO307029B1 (no)	2000-01-31
FI117374B (fi)	2006-09-29
HU226946B1 (en)	2010-03-29
AU1775795A (en)	1996-01-18
NO952624L (no)	1996-01-02
DE59509928D1 (de)	2002-01-24
PT689837E (pt)	2002-04-29
FI953256A0 (fi)	1995-06-30
KR960003729A (ko)	1996-02-23
CA2152998C (en)	2002-09-03
HU9501900D0 (en)	1995-08-28
ES2167385T3 (es)	2002-05-16
JPH0840906A (ja)	1996-02-13
CZ139395A3 (en)	1996-01-17
NO952624D0 (no)	1995-06-30
DZ1894A1 (fr)	2002-02-17
JP3841846B2 (ja)	2006-11-08
NZ270990A (en)	1997-06-24
UA27954C2 (uk)	2000-10-16
CA2152998A1 (en)	1996-01-02
HUT72599A (en)	1996-05-28
ZA954691B (en)	1996-01-29
KR100366130B1 (ko)	2003-03-26
CZ287563B6 (en)	2000-12-13
IL113411A0 (en)	1995-07-31
FI953256L (fi)	1996-01-02
EP0689837A2 (de)	1996-01-03
DE4423177A1 (de)	1996-01-04

Legal Events

Date	Code	Title
1999-11-30	FF	Patent granted
2000-06-01	KB	Patent renewed
2001-07-24	KB	Patent renewed
2005-07-25	KB	Patent renewed
2010-05-17	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
GR3031492T3 (en)	2000-01-31	1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders
HU9501900D0 (en)	1995-08-28	Pharmaceutical compositions against hyperglychemia
HUT59109A (en)	1992-04-28	Process for producing hydroxymethyl-(methylenecyclopentyl)-purines and -pyrimidines, their pharmaceutically acceptable salts and pharmaceutical compositions comprising same
GEP20043315B (en)	2004-02-10	Non-Peptide GnRH Agents, Methods For Their Preparation and Use Thereof
GR3004482T3 (cs)	1993-03-31
DE59410151D1 (de)	2002-08-14	Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe
GB9510037D0 (en)	1995-07-12	Improvements in or relating to organic compounds
CA2148194A1 (en)	1995-10-31	Cyclopeptides of the formula i
DE58906387D1 (de)	1994-01-27	Verwendung von Benzimidazolen zur Herstellung eines Arzneimittels mit antiischämischen Wirkungen am Herzen und dessen Kombinationen mit Beta-Blockern oder Bradycardica.
HUT61763A (en)	1993-03-01	Process for producing xanthine derivatives and pharmaceutical compositions comprising same as active ingredient, against disorders of cerebration
HU9400868D0 (en)	1994-06-28	Sparfloxacine salts and solutions containing same and process for producing them
CA2038025A1 (en)	1991-09-15	Optically active alkylenedioxybenzene derivatives and their use in therapy
NZ238022A (en)	1993-09-27	Indole derivatives and pharmaceutical compositions
AU4890593A (en)	1994-04-28	New thiazolidinedione compounds, a process for their preparation and pharmaceutical compositions containing them
IL100889A0 (en)	1992-11-15	Substituted benzofuranylpiperidine as a nootropic agent
KR900016130A (ko)	1990-11-12	2-피리딜메틸티오 유도체 및 궤양 치료제
ATE116296T1 (de)	1995-01-15	Säureadditionssalze einer optisch aktiven alaninanilidverbindung und diese enthaltende, pharmazeutische zusammensetzungen.
JPS6434920A (en)	1989-02-06	Therapy for mycobacterium abium intracellular complex infection
PH30180A (en)	1997-01-21	Leustroducsin h its preparation and its therapeutic use