IL113464A - Process for the preparation of medrogestone and 3beta, 5alpha, 6beta trihydroxy - 6alpha, 17alpha - dimethylpregnan - 20 - one monomethanolate used as intermediate in this process - Google Patents

Process for the preparation of medrogestone and 3beta, 5alpha, 6beta trihydroxy - 6alpha, 17alpha - dimethylpregnan - 20 - one monomethanolate used as intermediate in this process

Info

Publication number: IL113464A
Authority: IL; Israel
Prior art keywords: dimethylpregnan; monomethanolate; 6beta; 6alpha; medrogestone
Prior art date: 1994-05-05

Application number

IL11346495A

Other languages

English (en)

Other versions

IL113464A0 (en

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-05

Filing date

1995-04-24

Publication date

1999-06-20

1995-04-24 Application filed by American Home Prod filed Critical American Home Prod

1995-07-31 Publication of IL113464A0 publication Critical patent/IL113464A0/xx

1999-06-20 Publication of IL113464A publication Critical patent/IL113464A/xx

Links

HCFSGRMEEXUOSS-JXEXPEPMSA-N medrogestone Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(C)[C@@]1(C)CC2 HCFSGRMEEXUOSS-JXEXPEPMSA-N 0.000 title 1
229960000606 medrogestone Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)

IL11346495A 1994-05-05 1995-04-24 Process for the preparation of medrogestone and 3beta, 5alpha, 6beta trihydroxy - 6alpha, 17alpha - dimethylpregnan - 20 - one monomethanolate used as intermediate in this process IL113464A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/239,187 US5428151A (en)	1994-05-05	1994-05-05	Medrogestrone production
SG1996002940A SG64315A1 (en)	1994-05-05	1994-11-09	Medrogestrone

Publications (2)

Publication Number	Publication Date
IL113464A0 IL113464A0 (en)	1995-07-31
IL113464A true IL113464A (en)	1999-06-20

Family

ID=26665090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11346495A IL113464A (en)	1994-05-05	1995-04-24	Process for the preparation of medrogestone and 3beta, 5alpha, 6beta trihydroxy - 6alpha, 17alpha - dimethylpregnan - 20 - one monomethanolate used as intermediate in this process

Country Status (10)

Country	Link
US (3)	US5428151A (de)
EP (1)	EP0680970B1 (de)
JP (1)	JP4015206B2 (de)
AU (1)	AU691256B2 (de)
CA (1)	CA2148525A1 (de)
GR (1)	GR3034943T3 (de)
HU (1)	HU226299B1 (de)
IL (1)	IL113464A (de)
SG (1)	SG64315A1 (de)
ZA (1)	ZA953602B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5428151A (en) *	1994-05-05	1995-06-27	American Home Products Corporation	Medrogestrone production
US20050215535A1 (en) *	2004-03-24	2005-09-29	Kristof Chwalisz	Sequential SPRM/progestin treatment
US20060178520A1 (en) *	2005-01-18	2006-08-10	Solvay Pharmaceuticals Gmbh	Process for preparing medrogestone
EP1841778B1 (de) *	2005-01-18	2012-03-14	Abbott Products GmbH	Verfahren zur herstellung von medrogeston

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2387830A (en) *	1942-12-12	1945-10-30	Claude R Wickard	Nonbenzenoid fused polycyclic compounds
US3170936A (en) *	1963-08-07	1965-02-23	American Home Prod	Process for the preparation of 6, 17alpha-dimethyl-4, 6-pregnadiene-3, 20-dione
KR100257445B1 (ko) *	1992-04-15	2000-08-01	에드워드 이. 데이비스	스테롤 혼합물로부터 5,7-디엔작용기를 함유한 스테로이드를 분리하는 방법
US5428151A (en) *	1994-05-05	1995-06-27	American Home Products Corporation	Medrogestrone production

1994
- 1994-05-05 US US08/239,187 patent/US5428151A/en not_active Expired - Lifetime
- 1994-11-09 SG SG1996002940A patent/SG64315A1/en unknown
1995
- 1995-03-14 US US08/403,312 patent/US5519153A/en not_active Expired - Lifetime
- 1995-03-14 US US08/403,314 patent/US5523427A/en not_active Expired - Lifetime
- 1995-04-24 IL IL11346495A patent/IL113464A/xx not_active IP Right Cessation
- 1995-04-28 EP EP95302934A patent/EP0680970B1/de not_active Expired - Lifetime
- 1995-04-28 JP JP10529895A patent/JP4015206B2/ja not_active Expired - Fee Related
- 1995-05-03 CA CA002148525A patent/CA2148525A1/en not_active Abandoned
- 1995-05-03 AU AU17867/95A patent/AU691256B2/en not_active Ceased
- 1995-05-04 HU HU9501282A patent/HU226299B1/hu not_active IP Right Cessation
- 1995-05-04 ZA ZA953602A patent/ZA953602B/xx unknown
2000
- 2000-11-30 GR GR20000402533T patent/GR3034943T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU691256B2 (en)	1998-05-14
US5519153A (en)	1996-05-21
HUT71794A (en)	1996-02-28
AU1786795A (en)	1995-11-16
EP0680970B1 (de)	2000-11-29
US5523427A (en)	1996-06-04
IL113464A0 (en)	1995-07-31
JPH07304793A (ja)	1995-11-21
HU226299B1 (en)	2008-08-28
GR3034943T3 (en)	2001-02-28
US5428151A (en)	1995-06-27
CA2148525A1 (en)	1995-11-06
EP0680970A2 (de)	1995-11-08
SG64315A1 (en)	1999-04-27
EP0680970A3 (de)	1997-05-02
ZA953602B (en)	1996-11-04
JP4015206B2 (ja)	2007-11-28

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Legal Events

Date	Code	Title
1999-10-28	FF	Patent granted
2000-06-01	KB	Patent renewed
2001-07-24	KB	Patent renewed
2002-11-10	HCA	Change of name of proprietor(s) after amalgamation
2005-06-19	KB	Patent renewed
2009-11-18	KB	Patent renewed
2013-12-31	MM9K	Patent not in force due to non-payment of renewal fees