IL113532A - Process for the preparation of 4-amino-delta4-3-ketosteroids via 4-nitro-delta4-3-ketosteroids - Google Patents

Process for the preparation of 4-amino-delta4-3-ketosteroids via 4-nitro-delta4-3-ketosteroids

Info

Publication number
IL113532A
IL113532A IL11353295A IL11353295A IL113532A IL 113532 A IL113532 A IL 113532A IL 11353295 A IL11353295 A IL 11353295A IL 11353295 A IL11353295 A IL 11353295A IL 113532 A IL113532 A IL 113532A
Authority
IL
Israel
Prior art keywords
ketosteroids
delta4
hydrogen
alkyl
nitro
Prior art date
Application number
IL11353295A
Other languages
English (en)
Other versions
IL113532A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL113532A0 publication Critical patent/IL113532A0/xx
Publication of IL113532A publication Critical patent/IL113532A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL11353295A 1994-05-02 1995-04-28 Process for the preparation of 4-amino-delta4-3-ketosteroids via 4-nitro-delta4-3-ketosteroids IL113532A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23143394A 1994-05-02 1994-05-02

Publications (2)

Publication Number Publication Date
IL113532A0 IL113532A0 (en) 1995-07-31
IL113532A true IL113532A (en) 2000-02-17

Family

ID=22869232

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11353295A IL113532A (en) 1994-05-02 1995-04-28 Process for the preparation of 4-amino-delta4-3-ketosteroids via 4-nitro-delta4-3-ketosteroids

Country Status (18)

Country Link
US (4) US5750744A (de)
EP (1) EP0758340B1 (de)
JP (1) JPH09512547A (de)
CN (1) CN1042540C (de)
AT (1) ATE175419T1 (de)
AU (1) AU686793B2 (de)
CA (1) CA2188760A1 (de)
DE (1) DE69507139T2 (de)
DK (1) DK0758340T3 (de)
ES (1) ES2128052T3 (de)
FI (1) FI964410A0 (de)
GR (1) GR3029433T3 (de)
HU (1) HUT75523A (de)
IL (1) IL113532A (de)
NO (1) NO964627L (de)
NZ (1) NZ283974A (de)
WO (1) WO1995029932A1 (de)
ZA (1) ZA953357B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4093799A (en) 1998-05-22 1999-12-13 Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1562975A2 (de) * 2002-10-25 2005-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroide welche gruppen zur nachahmung von superoxidase dismutase sowie stickoxid donorgruppen beinhalten und ihre verwendung in der darstellung von medikamenten
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP1945240B1 (de) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Zusammensetzungen mit rezeptor-assoziierten protein (rap) varianten, die für cr-haltige proteine spezifisch sind und ihre verwendungen
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB892620A (en) * 1957-07-20 1962-03-28 Syntex Sa Cyclopentanophenanthrene derivatives
US3014632A (en) * 1961-03-06 1961-12-26 American Can Co Divider
US3159622A (en) * 1963-03-22 1964-12-01 Searle & Co 17 alpha-(2-carboxyethyl)-17 belta-hydroxy-6-nitroandrost-4-en-3-one gamma-lactones
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives
US5218110A (en) * 1990-08-01 1993-06-08 Merrell Dow Pharmaceuticals 4-amino-Δ4 -steroids and their use as 5α-reductase inhibitors
US5143909A (en) * 1991-03-19 1992-09-01 Merrell Dow Pharmaceuticals Inc. Aminosteroids in a method for inhibiting c17-20 lyase
US5120840A (en) * 1990-08-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors
AU642757B2 (en) * 1990-08-01 1993-10-28 Merrell Dow Pharmaceuticals Inc. 4-amino-delta4, 6-steroids and their use as 5alpha-reductase inhibitors

Also Published As

Publication number Publication date
CA2188760A1 (en) 1995-11-09
US5965550A (en) 1999-10-12
DE69507139T2 (de) 1999-09-30
US5990328A (en) 1999-11-23
AU686793B2 (en) 1998-02-12
CN1042540C (zh) 1999-03-17
ATE175419T1 (de) 1999-01-15
FI964410L (fi) 1996-11-01
FI964410A7 (fi) 1996-11-01
HUT75523A (en) 1997-05-28
FI964410A0 (fi) 1996-11-01
NZ283974A (en) 1998-02-26
DE69507139D1 (de) 1999-02-18
AU2244995A (en) 1995-11-29
US5869475A (en) 1999-02-09
EP0758340A1 (de) 1997-02-19
ES2128052T3 (es) 1999-05-01
HU9603035D0 (en) 1997-01-28
US5750744A (en) 1998-05-12
WO1995029932A1 (en) 1995-11-09
GR3029433T3 (en) 1999-05-28
CN1147258A (zh) 1997-04-09
IL113532A0 (en) 1995-07-31
DK0758340T3 (da) 1999-08-30
ZA953357B (en) 1996-01-17
NO964627L (no) 1997-01-02
NO964627D0 (no) 1996-11-01
EP0758340B1 (de) 1999-01-07
JPH09512547A (ja) 1997-12-16

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees