IL113581A - Propiophenone derivatives their preparation and pharmaceutical compositions containing them - Google Patents
Propiophenone derivatives their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL113581A IL113581A IL11358195A IL11358195A IL113581A IL 113581 A IL113581 A IL 113581A IL 11358195 A IL11358195 A IL 11358195A IL 11358195 A IL11358195 A IL 11358195A IL 113581 A IL113581 A IL 113581A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- glucopyranosyl
- compositions containing
- beta
- Prior art date
Links
- KRIOVPPHQSLHCZ-UHFFFAOYSA-N propiophenone Chemical class CCC(=O)C1=CC=CC=C1 KRIOVPPHQSLHCZ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 beta -D-glucopyranosyl Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9680594 | 1994-05-11 | ||
| JP28234494 | 1994-11-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL113581A0 IL113581A0 (en) | 1995-08-31 |
| IL113581A true IL113581A (en) | 1999-07-14 |
Family
ID=26437976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11358195A IL113581A (en) | 1994-05-11 | 1995-05-02 | Propiophenone derivatives their preparation and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5830873A (de) |
| EP (1) | EP0684254B1 (de) |
| KR (1) | KR100318793B1 (de) |
| CN (1) | CN1042637C (de) |
| AT (1) | ATE178069T1 (de) |
| AU (1) | AU680118B2 (de) |
| BR (1) | BR9502016A (de) |
| CA (1) | CA2149160C (de) |
| DE (1) | DE69508463T2 (de) |
| DK (1) | DK0684254T3 (de) |
| ES (1) | ES2133614T3 (de) |
| FI (1) | FI116975B (de) |
| GR (1) | GR3029795T3 (de) |
| IL (1) | IL113581A (de) |
| MY (1) | MY119134A (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1020944C (zh) | 1990-01-30 | 1993-05-26 | 阿图尔-费希尔股份公司费希尔厂 | 紧固件 |
| JP3059088B2 (ja) * | 1995-11-07 | 2000-07-04 | 田辺製薬株式会社 | プロピオフェノン誘導体およびその製法 |
| TW406086B (en) * | 1996-12-26 | 2000-09-21 | Tanabe Seiyaku Co | Propiophenone derivatives and process for preparing the same |
| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| US6683056B2 (en) | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| US6555519B2 (en) | 2000-03-30 | 2003-04-29 | Bristol-Myers Squibb Company | O-glucosylated benzamide SGLT2 inhibitors and method |
| US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| JP4590159B2 (ja) * | 2001-04-04 | 2010-12-01 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | グルコース再吸収阻害剤およびｐｐａｒモジュレーターを含んで成る併用療法 |
| CA2443325C (en) * | 2001-04-04 | 2011-06-14 | Ortho-Mcneil Pharmaceutical, Inc. | Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators |
| DE10258007B4 (de) * | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| TW200504021A (en) | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
| AU2004261660A1 (en) * | 2003-08-01 | 2005-02-10 | Janssen Pharmaceutica N.V. | Substituted fused heterocyclic C-glycosides |
| EP1680131A4 (de) * | 2003-08-01 | 2009-05-27 | Janssen Pharmaceutica Nv | Substituierte indol-o-glucoside |
| MXPA06001274A (es) * | 2003-08-01 | 2006-04-11 | Tanabe Seiyaku Co | Compuestos novedosos que poseen actividad inhibitoria contra transporador dependiente de sodio. |
| TW200524951A (en) * | 2003-08-01 | 2005-08-01 | Janssen Pharmaceutica Nv | Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides |
| RS20060320A (sr) * | 2003-08-01 | 2008-08-07 | Janssen Pharmaceutica N.V., | Supstituisani indazol-o-glukozidi |
| US8785403B2 (en) | 2003-08-01 | 2014-07-22 | Mitsubishi Tanabe Pharma Corporation | Glucopyranoside compound |
| TW200606129A (en) | 2004-07-26 | 2006-02-16 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same |
| TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| MY147375A (en) * | 2005-01-31 | 2012-11-30 | Mitsubishi Tanabe Pharma Corp | Indole derivatives |
| AR053329A1 (es) * | 2005-01-31 | 2007-05-02 | Tanabe Seiyaku Co | Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt) |
| TWI418556B (zh) * | 2006-07-27 | 2013-12-11 | Mitsubishi Tanabe Pharma Corp | 吲哚衍生物 |
| JP5298025B2 (ja) * | 2006-12-04 | 2013-09-25 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗糖尿病薬としてのチエニル含有グリコピラノシル誘導体 |
| UY30730A1 (es) * | 2006-12-04 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp | Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno |
| CN101801371B (zh) | 2007-09-10 | 2012-11-28 | 詹森药业有限公司 | 可用作sglt抑制剂的化合物的制备方法 |
| CL2008003653A1 (es) | 2008-01-17 | 2010-03-05 | Mitsubishi Tanabe Pharma Corp | Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica. |
| BRPI0913129A2 (pt) | 2008-05-22 | 2016-01-05 | Bristol Myers Squibb Co | método para tratamento de hiperuricemia empregando um inibidor de sglt2 e composição contendo o mesmo |
| US9056850B2 (en) * | 2008-10-17 | 2015-06-16 | Janssen Pharmaceutica N.V. | Process for the preparation of compounds useful as inhibitors of SGLT |
| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| KR101532412B1 (ko) | 2009-07-10 | 2015-06-29 | 얀센 파마슈티카 엔.브이. | 1-(β-Ｄ-글루코피라노실)-4-메틸-3-(5-(4-플루오로페닐)-2-티에닐메틸) 벤젠의 결정화 방법 |
| SG10201500258WA (en) * | 2009-10-14 | 2015-03-30 | Janssen Pharmaceutica Nv | Process for the preparation of compounds useful as inhibitors of sglt2 |
| LT2568988T (lt) | 2010-05-11 | 2016-09-12 | Janssen Pharmaceutica, N.V. | Farmacinės kompozicijos, apimančios 1-(beta-d-gliukopiranozil)-2-tienilmetilbenzeno darinius kaip sglt inhibitorius |
| AU2012241897C1 (en) | 2011-04-13 | 2017-05-11 | Janssen Pharmaceutica Nv | Process for the preparation of compounds useful as inhibitors of SGLT2 |
| TWI542596B (zh) | 2011-05-09 | 2016-07-21 | 健生藥品公司 | （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體 |
| US20170071970A1 (en) | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
| WO2020016335A1 (en) | 2018-07-19 | 2020-01-23 | Astrazeneca Ab | Methods of treating hfpef employing dapagliflozin and compositions comprising the same |
| PT4188389T (pt) | 2020-07-27 | 2025-10-07 | Astrazeneca Ab | Dapagliflozina para utilização em métodos de tratamento de doença renal crónica |
| AU2021202643B2 (en) | 2020-07-27 | 2023-02-02 | Astrazeneca Ab | Methods of treating chronic kidney disease with dapagliflozin |
| WO2022208172A1 (en) | 2021-04-01 | 2022-10-06 | Astrazeneca Uk Limited | Systems and methods for managing prediabetes with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition |
| CN118510504A (zh) | 2022-01-26 | 2024-08-16 | 阿斯利康(瑞典)有限公司 | 用于在治疗糖尿病前期或降低发展2型糖尿病的风险中使用的达格列净 |
| WO2025125513A1 (en) | 2023-12-15 | 2025-06-19 | AstraZeneca Ireland Limited | Sglt2 inhibitors and baxdrostat for treating chronic kidney disease and hypertension |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4031260A (en) * | 1971-05-14 | 1977-06-21 | Nutrilite Products, Inc. | Salts of dihydrochalcone derivatives and their use as sweeteners |
| US3984394A (en) * | 1971-05-14 | 1976-10-05 | Nutrilite Products, Inc. | Salts of dihydrochalcone derivatives and their use as sweeteners |
| US4049715A (en) * | 1973-10-01 | 1977-09-20 | Sterling Drug Inc. | 3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols |
| US4684627A (en) * | 1981-09-08 | 1987-08-04 | Leveen Harry H | Treatment of cancer with phlorizin and its derivatives |
| CA1289077C (en) * | 1984-08-13 | 1991-09-17 | Harry H. Leveen | Treatment of cancer with phlorizin and its derivatives |
| US5110801A (en) * | 1984-08-13 | 1992-05-05 | Leveen Harry H | Treatment of acne |
| US4760135A (en) * | 1984-09-06 | 1988-07-26 | University Of Kentucky Research Foundation | Phloretin and phlorizin derivative containing compounds |
| US4665058A (en) * | 1985-03-16 | 1987-05-12 | The University Of Kentucky Research Foundation | Compositions and method of treatment for sickle cell anemia |
| CA2102591C (en) * | 1992-11-12 | 2000-12-26 | Kenji Tsujihara | Hypoglycemic agent |
-
1995
- 1995-04-27 US US08/429,567 patent/US5830873A/en not_active Expired - Lifetime
- 1995-05-02 IL IL11358195A patent/IL113581A/xx not_active IP Right Cessation
- 1995-05-02 AU AU17790/95A patent/AU680118B2/en not_active Expired
- 1995-05-03 MY MYPI95001176A patent/MY119134A/en unknown
- 1995-05-10 KR KR1019950011506A patent/KR100318793B1/ko not_active Expired - Lifetime
- 1995-05-10 FI FI952260A patent/FI116975B/fi not_active IP Right Cessation
- 1995-05-11 AT AT95107150T patent/ATE178069T1/de active
- 1995-05-11 ES ES95107150T patent/ES2133614T3/es not_active Expired - Lifetime
- 1995-05-11 BR BR9502016A patent/BR9502016A/pt not_active IP Right Cessation
- 1995-05-11 DK DK95107150T patent/DK0684254T3/da active
- 1995-05-11 CN CN95104932A patent/CN1042637C/zh not_active Expired - Lifetime
- 1995-05-11 DE DE69508463T patent/DE69508463T2/de not_active Expired - Lifetime
- 1995-05-11 EP EP95107150A patent/EP0684254B1/de not_active Expired - Lifetime
- 1995-05-11 CA CA002149160A patent/CA2149160C/en not_active Expired - Lifetime
-
1999
- 1999-03-26 GR GR990400674T patent/GR3029795T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1042637C (zh) | 1999-03-24 |
| DE69508463D1 (de) | 1999-04-29 |
| CA2149160A1 (en) | 1995-11-12 |
| ES2133614T3 (es) | 1999-09-16 |
| FI952260A0 (fi) | 1995-05-10 |
| EP0684254A1 (de) | 1995-11-29 |
| FI116975B (fi) | 2006-04-28 |
| GR3029795T3 (en) | 1999-06-30 |
| KR100318793B1 (ko) | 2002-07-04 |
| AU1779095A (en) | 1995-11-16 |
| FI952260L (fi) | 1995-11-12 |
| EP0684254B1 (de) | 1999-03-24 |
| CA2149160C (en) | 2002-01-29 |
| US5830873A (en) | 1998-11-03 |
| ATE178069T1 (de) | 1999-04-15 |
| BR9502016A (pt) | 1995-12-12 |
| DK0684254T3 (da) | 1999-10-11 |
| CN1121925A (zh) | 1996-05-08 |
| IL113581A0 (en) | 1995-08-31 |
| MY119134A (en) | 2005-04-30 |
| KR950032262A (ko) | 1995-12-20 |
| DE69508463T2 (de) | 1999-08-19 |
| AU680118B2 (en) | 1997-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |