IL114876A - Purified interleukin 6 inhibitor and a method for its preparation - Google Patents

Purified interleukin 6 inhibitor and a method for its preparation

Info

Publication number: IL114876A
Authority: IL; Israel
Prior art keywords: inhibitor; supernatant; activity; protein; cell line
Prior art date: 1994-08-10

Application number

IL11487695A

Other languages

English (en)

Other versions

IL114876A0 (en

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-10

Filing date

1995-08-09

Publication date

2000-06-01

1995-08-09 Application filed by Bayer Ag filed Critical Bayer Ag

1995-12-08 Publication of IL114876A0 publication Critical patent/IL114876A0/xx

2000-06-01 Publication of IL114876A publication Critical patent/IL114876A/xx

Links

239000003112 inhibitor Substances 0.000 title abstract 4
102000004889 Interleukin-6 Human genes 0.000 title abstract 2
108090001005 Interleukin-6 Proteins 0.000 title abstract 2
229940100601 interleukin-6 Drugs 0.000 title abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
239000006228 supernatant Substances 0.000 abstract 3
YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
101000573199 Homo sapiens Protein PML Proteins 0.000 abstract 1
102000004142 Trypsin Human genes 0.000 abstract 1
108090000631 Trypsin Proteins 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
102000054896 human PML Human genes 0.000 abstract 1
238000011534 incubation Methods 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
238000005374 membrane filtration Methods 0.000 abstract 1
238000004366 reverse phase liquid chromatography Methods 0.000 abstract 1
239000012588 trypsin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL11487695A 1994-08-10 1995-08-09 Purified interleukin 6 inhibitor and a method for its preparation IL114876A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/288,516 US5527546A (en)	1994-08-10	1994-08-10	Human interleukin 6 inhibitor

Publications (2)

Publication Number	Publication Date
IL114876A0 IL114876A0 (en)	1995-12-08
IL114876A true IL114876A (en)	2000-06-01

Family

ID=23107451

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11487695A IL114876A (en)	1994-08-10	1995-08-09	Purified interleukin 6 inhibitor and a method for its preparation

Country Status (13)

Country	Link
US (1)	US5527546A (de)
EP (1)	EP0696594B1 (de)
JP (1)	JPH08169840A (de)
KR (1)	KR100424553B1 (de)
CN (1)	CN1157407C (de)
AT (1)	ATE224914T1 (de)
AU (1)	AU684968B2 (de)
CA (1)	CA2155629A1 (de)
DE (1)	DE69528325T2 (de)
ES (1)	ES2183846T3 (de)
IL (1)	IL114876A (de)
TW (1)	TW438808B (de)
ZA (1)	ZA956636B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7321891A (en) *	1990-02-15	1991-09-03	Cetus Corporation	Inhibitor of cytokine activity and applications thereof
US5527546A (en) *	1994-08-10	1996-06-18	Bayer Corporation	Human interleukin 6 inhibitor
AU6038196A (en) *	1995-06-07	1996-12-30	Private Biologicals Corporation	Compositions and methods of treating il-6 associated disease s
AU2003216591A1 (en) *	2002-04-10	2003-10-20	Orichid Chemicals And Pharmaceuticals Limited	Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological
US7521465B2 (en) *	2003-01-17	2009-04-21	Bexel Pharmaceuticals, Inc.	Diphenyl ether derivatives
US6794401B2 (en) *	2003-01-17	2004-09-21	Bexel Pharmaceuticals, Inc.	Amino acid phenoxy ethers
US7781464B2 (en) *	2003-01-17	2010-08-24	Bexel Pharmaceuticals, Inc.	Heterocyclic diphenyl ethers
US7087576B2 (en) *	2003-10-07	2006-08-08	Bexel Pharmaceuticals, Inc.	Dipeptide phenyl ethers
AT412785B (de) *	2003-12-04	2005-07-25	Kungl Andreas J Dr	Gag-bindungsproteine
JP2008533122A (ja) *	2005-03-18	2008-08-21	オーキッドケミカルズアンドファーマシューティカルズリミテッド	新規なチロシン誘導体
WO2006126074A2 (en) *	2005-05-26	2006-11-30	Orchid Research Laboratories Limited	Heterocyclic derivatives
US20090163521A1 (en) *	2005-06-28	2009-06-25	Orchid Research Laboratories Limited	Novel Pyrazolopyrimidinone Derivatives
PL1973884T3 (pl) *	2006-01-19	2017-05-31	Orchid Pharma Limited	Nowe związki heterocykliczne
US7863446B2 (en) *	2006-01-19	2011-01-04	Orchid Research Laboratories Limited	Heterocycles
US20080221103A1 (en) *	2007-03-09	2008-09-11	Orchid Research Laboratories Ltd.	New heterocyclic compounds
AU2009208712B2 (en)	2008-02-01	2013-03-14	Orchid Chemicals & Pharmaceuticals Limited	Novel heterocycles
US20190060286A1 (en)	2016-02-29	2019-02-28	University Of Florida Research Foundation, Incorpo	Chemotherapeutic Methods
JP6889458B2 (ja) *	2016-08-05	2021-06-18	学校法人中部大学	細胞増殖抑制剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE910955A1 (en) *	1990-03-23	1991-09-25	Yamanouchi Europ Bv	Il-6 inhibiting compositions
US5527546A (en) *	1994-08-10	1996-06-18	Bayer Corporation	Human interleukin 6 inhibitor

1994
- 1994-08-10 US US08/288,516 patent/US5527546A/en not_active Expired - Fee Related
1995
- 1995-07-28 DE DE69528325T patent/DE69528325T2/de not_active Expired - Fee Related
- 1995-07-28 AT AT95111894T patent/ATE224914T1/de not_active IP Right Cessation
- 1995-07-28 EP EP95111894A patent/EP0696594B1/de not_active Expired - Lifetime
- 1995-07-28 ES ES95111894T patent/ES2183846T3/es not_active Expired - Lifetime
- 1995-08-03 AU AU28389/95A patent/AU684968B2/en not_active Ceased
- 1995-08-07 JP JP7221018A patent/JPH08169840A/ja active Pending
- 1995-08-08 ZA ZA956636A patent/ZA956636B/xx unknown
- 1995-08-08 CA CA002155629A patent/CA2155629A1/en not_active Abandoned
- 1995-08-09 KR KR1019950024486A patent/KR100424553B1/ko not_active Expired - Fee Related
- 1995-08-09 CN CNB95116323XA patent/CN1157407C/zh not_active Expired - Fee Related
- 1995-08-09 IL IL11487695A patent/IL114876A/xx not_active IP Right Cessation
1996
- 1996-03-01 TW TW085102457A patent/TW438808B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0696594A1 (de)	1996-02-14
EP0696594B1 (de)	2002-09-25
AU2838995A (en)	1996-02-22
ZA956636B (en)	1996-03-19
CN1136043A (zh)	1996-11-20
DE69528325T2 (de)	2003-01-23
ATE224914T1 (de)	2002-10-15
DE69528325D1 (de)	2002-10-31
US5527546A (en)	1996-06-18
TW438808B (en)	2001-06-07
KR100424553B1 (ko)	2004-07-01
IL114876A0 (en)	1995-12-08
AU684968B2 (en)	1998-01-08
CA2155629A1 (en)	1996-02-11
ES2183846T3 (es)	2003-04-01
CN1157407C (zh)	2004-07-14
KR960006937A (ko)	1996-03-22
JPH08169840A (ja)	1996-07-02

Legal Events

Date	Code	Title
2000-11-21	FF	Patent granted
2001-10-31	KB	Patent renewed
2005-11-20	KB	Patent renewed
2010-10-31	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL114876A0 (en)	1995-12-08	Interleukin 6 inhibitor
IL79957A (en)	1991-08-16	Purification and activation of proteins from insoluble inclusion bodies
WO1999012968A3 (en)	1999-07-29	Chemokine peptides, variants, derivatives and analogs, their use in methods to inhibit or augment an inflammatory response
CA2190373A1 (en)	1995-12-14	Yeast strains
EP0218531A3 (de)	1989-07-12	Immunogenische Peptide von menschlichem Interleukin-1 und die entsprechenden Antipeptid-Antikörper
AU3228789A (en)	1989-10-05	Biologically active proteins
NZ244731A (en)	1994-07-26	Colostrum fraction, its preparation and its use as a cell culture media
AU4218389A (en)	1990-04-02	Peptide compounds
AU576942B2 (en)	1988-09-08	Pulsation reduction in compressor
AU577446B2 (en)	1988-09-22	Compressor valve plate
DE3569112D1 (en)	1989-05-03	4,5-dihydro-4-oxo-2- û(2-trans-phenylcyclopropyl)amino¨-3-furancarboxylic acids and derivatives thereof
CA2088068A1 (en)	1992-02-15	Protein structure of the plant toxin gelonin
AU576059B2 (en)	1988-08-11	Pulsation reduction in compressor
AU3320989A (en)	1989-10-26	Expression of human interleukin-2 in methylotrophic yeasts
CA2163805A1 (en)	1996-05-29	Novel activating factor of leukocytes
AU2560888A (en)	1989-05-18	Peptides for use in the purification of factor viii
MY103539A (en)	1993-07-31	Purification of gm-csf
AU671301C (en)	1997-11-27	Adsorbent for cellular fibronectin, separation and purification of fibronectin, and purification of blood
EP0118311A3 (de)	1987-04-29	Monoklonaler Faktor mit 5'-nukleotidasehemmender Wirkung
AU6300894A (en)	1994-08-18	Human IFN-beta 2/IL-6, its purification and use
AU2696395A (en)	1996-01-04	A purified 80 kda protein implicated in abdominal aortic aneurysms, antibodies directed thereto, and uses thereof
AU7095796A (en)	1997-04-17	Neutrophil chemotactic lymphokine, and drug and kit for the diagnosis of drug hypersensitive granulocytopenia containing the same
AU4833493A (en)	1994-04-26	Adsorbent for cellular fibronectin, separation and purification of fibronectin, and purification of blood
PL270142A1 (en)	1989-07-24	Membrane valve
BG45809A1 (en)	1989-08-15	Rubber- textile membrane for membrane pumps