IL114894A - Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments - Google Patents

Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments

Info

Publication number: IL114894A
Authority: IL; Israel
Prior art keywords: medicaments; preparation; pharmaceutical compositions; compositions containing; endothelin antagonists
Prior art date: 1994-08-19

Application number

IL11489495A

Other languages

English (en)

Other versions

IL114894A0 (en

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-19

Filing date

1995-08-10

Publication date

2003-04-10

1995-05-30 Priority claimed from US08/442,575 external-priority patent/US5767144A/en

1995-08-10 Application filed by Abbott Lab filed Critical Abbott Lab

1995-08-10 Priority to IL134905A priority Critical patent/IL134905A/en

1995-12-08 Publication of IL114894A0 publication Critical patent/IL114894A0/xx

2003-04-10 Publication of IL114894A publication Critical patent/IL114894A/xx

Links

102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000003235 pyrrolidines Chemical class 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Pyrrole Compounds (AREA)

IL11489495A 1994-08-19 1995-08-10 Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments IL114894A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL134905A IL134905A (en)	1994-08-19	1995-08-10	Intermediates for endothelin antagonistic pyrrolidine derivatives, their preparation and pharmaceutical compositions comprising them

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US29334994A	1994-08-19	1994-08-19
US33471794A	1994-11-04	1994-11-04
US08/442,575 US5767144A (en)	1994-08-19	1995-05-30	Endothelin antagonists
US49799895A	1995-08-02	1995-08-02

Publications (2)

Publication Number	Publication Date
IL114894A0 IL114894A0 (en)	1995-12-08
IL114894A true IL114894A (en)	2003-04-10

Family

ID=27501591

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL11489495A IL114894A (en)	1994-08-19	1995-08-10	Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments
IL134905A IL134905A (en)	1994-08-19	1995-08-10	Intermediates for endothelin antagonistic pyrrolidine derivatives, their preparation and pharmaceutical compositions comprising them

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL134905A IL134905A (en)	1994-08-19	1995-08-10	Intermediates for endothelin antagonistic pyrrolidine derivatives, their preparation and pharmaceutical compositions comprising them

Country Status (12)

Country	Link
EP (2)	EP0776324B1 (de)
JP (1)	JP3741441B2 (de)
KR (2)	KR100483222B1 (de)
AT (1)	ATE219077T1 (de)
AU (1)	AU711832B2 (de)
CA (2)	CA2195677C (de)
DE (1)	DE69527072T2 (de)
DK (1)	DK0776324T3 (de)
ES (1)	ES2179881T3 (de)
IL (2)	IL114894A (de)
PT (1)	PT776324E (de)
WO (1)	WO1996006095A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5852046A (en) *	1993-08-03	1998-12-22	Hoechst Aktiengesellschaft	Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
US7208517B1 (en)	1994-08-19	2007-04-24	Abbott Labortories	Endothelin antagonists
US6162927A (en) *	1994-08-19	2000-12-19	Abbott Laboratories	Endothelin antagonists
US5767144A (en) *	1994-08-19	1998-06-16	Abbott Laboratories	Endothelin antagonists
AU2763602A (en) *	1996-02-13	2002-05-16	Abbott Laboratories	Endothelin antagonists
ES2259803T3 (es) *	1996-02-13	2006-10-16	Abbott Laboratories	Nuevos derivados de pirrolidina sustituidos con benzo-1,3-dioxolilo y benzofuranilo como antagonistas de endostelina.
IL125453A0 (en) *	1996-02-13	1999-03-12	Abbott Lab	4-(Benzo-1,3-dioxylyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists
AU781355B2 (en) *	1996-02-13	2005-05-19	Abbott Laboratories	Novel benzo-1,3-dioxolyl-and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
US5801250A (en) *	1996-12-13	1998-09-01	Abbott Laboratories	Process for the stereoselective production of nitro-enamine compounds
US6030975A (en) *	1997-03-14	2000-02-29	Basf Aktiengesellschaft	Carboxylic acid derivatives, their preparation and use in treating cancer
AU7826398A (en) *	1997-06-17	1999-01-04	Abbott Laboratories	Pyrrolidine carboxylic acid derivatives as endothelin antagonists
NZ502395A (en) *	1997-08-04	2002-08-28	Abbott Lab	4-Benzodioxolyl substituted pyrrolidine-3-carboxylic acid derivatives useful as endothelin antagonists
IL125658A0 (en)	1997-08-18	1999-04-11	Hoffmann La Roche	Ccr-3 receptor antagonists
US6339087B1 (en)	1997-08-18	2002-01-15	Syntex (U.S.A.) Llc	Cyclic amine derivatives-CCR-3 receptor antagonists
DE19743681A1 (de) *	1997-10-02	1999-04-08	Knoll Ag	Methode zur Verhinderung der Transplantatabstoßung
US6410554B1 (en)	1998-03-23	2002-06-25	Merck & Co., Inc.	Combination therapy for the treatment of benign prostatic hyperplasia
US6245801B1 (en) *	1998-09-14	2001-06-12	Warner-Lambert Company	Branched alkyl pyrrolidine-3-carboxylic acids
CA2351631A1 (en)	1998-11-20	2000-06-02	F. Hoffmann-La Roche Ag	Piperidine quaternary salts-ccr-3 receptor antagonists
WO2002017912A1 (en) *	2000-08-31	2002-03-07	Abbott Laboratories	Endothelin antagonists
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
NZ549535A (en)	2004-03-17	2010-11-26	Novartis Ag	Use of aliskiren for treating renal and other disorders
EP2545920A1 (de)	2007-08-22	2013-01-16	Abbott GmbH & Co. KG	Therapie für Diabeteskomplikationen
WO2011114103A1 (en)	2010-03-18	2011-09-22	Biolipox Ab	Pyrimidinones for use as medicaments
JO2998B1 (ar)	2010-06-04	2016-09-05	Amgen Inc	مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
MX352672B (es)	2011-09-27	2017-12-04	Amgen Inc	Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
US11407721B2 (en)	2013-02-19	2022-08-09	Amgen Inc.	CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
CA2902856C (en)	2013-02-28	2021-02-16	Amgen Inc.	A benzoic acid derivative mdm2 inhibitor for the treatment of cancer
AU2014236812B2 (en)	2013-03-14	2018-03-01	Amgen Inc.	Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer
CN105358530A (zh)	2013-06-10	2016-02-24	美国安进公司	制备mdm2抑制剂的方法及其结晶形式
US8962675B1 (en) *	2013-09-12	2015-02-24	Abbvie Inc.	Atrasentan mandelate salts
KR102091932B1 (ko)	2018-08-16	2020-03-20	장남순	안전하고 간편한 접첩구조를 갖는 접이식 트램펄린
CN120919117A (zh) *	2025-09-24	2025-11-11	中山大学	一种四取代吡咯衍生物在制备治疗神经退行性疾病的产品中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
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US3342833A (en) *	1964-08-07	1967-09-19	Shell Oil Co	Pyrrolidine production from aziridines and olefins
UA44686C2 (uk) *	1991-11-05	2002-03-15	Смітклайн Бічем Корпорейшн	Похідні індану або індену як антагоністи ендотелінових рецепторів, фармацевтична композиція на їх основі, спосіб їх одержання та спосіб пригнічення ендотелінових рецепторів
WO1994002474A1 (en) *	1992-07-17	1994-02-03	Smithkline Beecham Corporation	Endothelin receptor antagonists

1995
- 1995-08-04 CA CA002195677A patent/CA2195677C/en not_active Expired - Lifetime
- 1995-08-04 EP EP95928323A patent/EP0776324B1/de not_active Expired - Lifetime
- 1995-08-04 WO PCT/US1995/009924 patent/WO1996006095A1/en not_active Ceased
- 1995-08-04 CA CA002517691A patent/CA2517691A1/en not_active Abandoned
- 1995-08-04 DE DE69527072T patent/DE69527072T2/de not_active Expired - Lifetime
- 1995-08-04 KR KR10-2004-7004682A patent/KR100483222B1/ko not_active Expired - Fee Related
- 1995-08-04 ES ES95928323T patent/ES2179881T3/es not_active Expired - Lifetime
- 1995-08-04 AU AU32137/95A patent/AU711832B2/en not_active Expired
- 1995-08-04 KR KR1019970701079A patent/KR100447000B1/ko not_active Expired - Lifetime
- 1995-08-04 EP EP01125462A patent/EP1186603A3/de not_active Withdrawn
- 1995-08-04 AT AT95928323T patent/ATE219077T1/de active
- 1995-08-04 DK DK95928323T patent/DK0776324T3/da active
- 1995-08-04 PT PT95928323T patent/PT776324E/pt unknown
- 1995-08-04 JP JP50810196A patent/JP3741441B2/ja not_active Expired - Lifetime
- 1995-08-10 IL IL11489495A patent/IL114894A/xx not_active IP Right Cessation
- 1995-08-10 IL IL134905A patent/IL134905A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2179881T3 (es)	2003-02-01
KR970705561A (ko)	1997-10-09
DK0776324T3 (da)	2002-10-07
IL134905A0 (en)	2001-05-20
EP1186603A3 (de)	2003-07-09
IL114894A0 (en)	1995-12-08
HK1008328A1 (en)	1999-05-07
AU3213795A (en)	1996-03-14
KR100447000B1 (ko)	2004-12-10
EP0776324B1 (de)	2002-06-12
KR100483222B1 (ko)	2005-04-15
EP1186603A2 (de)	2002-03-13
WO1996006095A1 (en)	1996-02-29
IL134905A (en)	2009-06-15
ATE219077T1 (de)	2002-06-15
DE69527072D1 (de)	2002-07-18
CA2195677C (en)	2005-11-08
EP0776324A1 (de)	1997-06-04
KR20040045036A (ko)	2004-05-31
DE69527072T2 (de)	2003-02-13
JPH10504565A (ja)	1998-05-06
CA2195677A1 (en)	1996-02-29
CA2517691A1 (en)	1996-02-29
JP3741441B2 (ja)	2006-02-01
PT776324E (pt)	2002-11-29
AU711832B2 (en)	1999-10-21

Legal Events

Date	Code	Title
2003-10-31	FF	Patent granted
2003-11-23	KB20	Patent renewed for 20 years
2016-03-31	EXP	Patent expired

Publication	Publication Date	Title
IL114894A (en)	2003-04-10	Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments
PT83647A (en)	1986-11-01	Process for the preparation of novel pharmaceutical benzimidazole derivatives and of pharmaceutical compositions containing the same
IE894048L (en)	1990-06-22	New therapeutically active compound and a process for its¹preparation
HU9601568D0 (en)	1996-08-28	Cyclic amide derivatives as neurokinin antagonists
AU2724292A (en)	1993-04-29	Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-d-neuraminic acid
MY127718A (en)	2006-12-29	Dolastatin 10 derivatives.
WO1999008501A3 (en)	1999-04-15	New heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
GB9322643D0 (en)	1993-12-22	Lactam derivatives
WO2001046200A8 (en)	2002-02-28	Novel piperidine and piperazine derivatives
CA2400268A1 (en)	2001-08-23	Pyrrolopyrimidinone derivatives, process of preparation and use
MY112102A (en)	2001-04-30	Therapeutic heterocycles.
GB0109122D0 (en)	2001-05-30	Novel compounds
GB9305295D0 (en)	1993-05-05	Therapeutic compounds
YU242789A (en)	1991-04-30	New compound, 4-fluoro-2-//(4-metoxy-2-pyridin-yl)methylsulphinyl/-1h-benzimidazole and process for obtaining
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