IL116539A - Preparations given through the skin of unstable anti-acid drugs - Google Patents

Preparations given through the skin of unstable anti-acid drugs

Info

Publication number: IL116539A
Authority: IL; Israel
Prior art keywords: weight; composition; percent; total composition; drug
Prior art date: 1995-01-06

Application number

IL11653995A

Other languages

English (en)

Hebrew (he)

Other versions

IL116539A0 (en

Original Assignee

Noven Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-06

Filing date

1995-12-25

Publication date

2002-02-10

1995-12-25 Application filed by Noven Pharma filed Critical Noven Pharma

1996-03-31 Publication of IL116539A0 publication Critical patent/IL116539A0/xx

2002-02-10 Publication of IL116539A publication Critical patent/IL116539A/en

Links

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235000003441 saturated fatty acids Nutrition 0.000 description 1
239000013464 silicone adhesive Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
230000007928 solubilization Effects 0.000 description 1
238000005063 solubilization Methods 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
229960002256 spironolactone Drugs 0.000 description 1
LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
229960000912 stanozolol Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
229950005638 stenbolone Drugs 0.000 description 1
210000000434 stratum corneum Anatomy 0.000 description 1
229920003048 styrene butadiene rubber Polymers 0.000 description 1
239000000758 substrate Substances 0.000 description 1
ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
229960003484 testosterone enanthate Drugs 0.000 description 1
VOCBWIIFXDYGNZ-IXKNJLPQSA-N testosterone enanthate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCC)[C@@]1(C)CC2 VOCBWIIFXDYGNZ-IXKNJLPQSA-N 0.000 description 1
229960001712 testosterone propionate Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
YUOZKOLALXNELS-SQVYRKCQSA-N tiomesterone Chemical compound C1C[C@]2(C)[C@](O)(C)CC[C@H]2[C@@H]2[C@H](SC(=O)C)CC3=CC(=O)C[C@H](SC(C)=O)[C@]3(C)[C@H]21 YUOZKOLALXNELS-SQVYRKCQSA-N 0.000 description 1
229950008366 tiomesterone Drugs 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
239000006211 transdermal dosage form Substances 0.000 description 1
230000008733 trauma Effects 0.000 description 1
229960000312 trenbolone Drugs 0.000 description 1
MEHHPFQKXOUFFV-OWSLCNJRSA-N trenbolone Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@H](CC3)O)C=C3)C3=C21 MEHHPFQKXOUFFV-OWSLCNJRSA-N 0.000 description 1
229950003256 trengestone Drugs 0.000 description 1
USXVMPAWZOOYDE-HGUQNLGYSA-N trengestone Chemical compound C1=C(Cl)C2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 USXVMPAWZOOYDE-HGUQNLGYSA-N 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
150000004072 triols Chemical class 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
150000003673 urethanes Chemical class 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000008096 xylene Substances 0.000 description 1
150000003738 xylenes Chemical class 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Dermatology (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL11653995A 1995-01-06 1995-12-25 Preparations given through the skin of unstable anti-acid drugs IL116539A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US36975695A	1995-01-06	1995-01-06

Publications (2)

Publication Number	Publication Date
IL116539A0 IL116539A0 (en)	1996-03-31
IL116539A true IL116539A (en)	2002-02-10

Family

ID=23456790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11653995A IL116539A (en)	1995-01-06	1995-12-25	Preparations given through the skin of unstable anti-acid drugs

Country Status (16)

Country	Link
EP (1)	EP0801561B1 (de)
JP (1)	JP4081139B2 (de)
KR (1)	KR100543351B1 (de)
AR (1)	AR002701A1 (de)
AT (1)	ATE292457T1 (de)
AU (1)	AU718530B2 (de)
CA (1)	CA2209669C (de)
DE (1)	DE69634559T2 (de)
DK (1)	DK0801561T3 (de)
ES (1)	ES2239767T3 (de)
IL (1)	IL116539A (de)
NZ (1)	NZ301153A (de)
PT (1)	PT801561E (de)
TW (1)	TW438598B (de)
WO (1)	WO1996020699A1 (de)
ZA (1)	ZA9670B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5780050A (en) *	1995-07-20	1998-07-14	Theratech, Inc.	Drug delivery compositions for improved stability of steroids
EP1021204B1 (de) *	1997-09-26	2005-12-28	Noven Pharmaceuticals, Inc.	Biologische kleber und verfahren zur topischen verabreichung von wirkstoffen
DE19906152B4 (de) *	1999-02-10	2005-02-10	Jenapharm Gmbh & Co. Kg	Wirkstoffhaltige Laminate für Transdermalsysteme
US6503894B1 (en)	2000-08-30	2003-01-07	Unimed Pharmaceuticals, Inc.	Pharmaceutical composition and method for treating hypogonadism
BRPI0210074B1 (pt) *	2001-05-31	2017-05-30	Hisamitsu Pharmaceutical Co	emplastro de anti-inflamatórios não esteroidais percutaneamente absorvível, contendo sais de amônio, promotores de permeação e/ou agentes de solubilização em uma camada de substrato adesivo
DE10220230A1 (de) *	2002-05-06	2003-11-27	Sanol Arznei Schwarz Gmbh	Verwendung von Rotigotine zur Behandlung des Restless Leg Syndroms
FR2905601A1 (fr) *	2006-09-11	2008-03-14	Innoderm Sarl	Utilisation de derives oleiques comme methode et composition favorisant la penetration cutanee des actifs contenus dans les compositions cosmetiques, pharmaceutiques ou dermatologiques.
HU227970B1 (en)	2007-07-10	2012-07-30	Egis Gyogyszergyar Nyrt	Pharmaceutical compositions containing silicones of high volatility
KR100963162B1 (ko) *	2008-12-15	2010-06-15	김유근	5-아미노레불린산의 안정화 방법
US10213421B2 (en)	2012-04-04	2019-02-26	Alkahest, Inc.	Pharmaceutical formulations comprising CCR3 antagonists
US10045935B2 (en)	2012-07-31	2018-08-14	Egis Pharmaceuticals Plc	Transdermal formulation containing COX inhibitors
US11154535B2 (en)	2012-07-31	2021-10-26	Egis Pharmaceuticals Plc	Transdermal formulation containing COX inhibitors
CN109503692A (zh) *	2018-12-05	2019-03-22	华中药业股份有限公司	一种雄甾-17α-甲基-17β-羟基-3-酮的合成方法
US20220160697A1 (en)	2019-03-19	2022-05-26	Nobelpharma Co., Ltd.	Pharmaceutical composition having excellent drug absorption into the living body and excellent chemical stability

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3685895T2 (de) *	1985-02-25	1992-12-24	Univ Rutgers	Dosierungssystem fuer transdermale absorption von arzneimittelwirkstoffen.
AU601528B2 (en) *	1986-12-22	1990-09-13	Ortho-Mcneil Pharmaceutical, Inc.	Resilient transdermal drug-delivery device and compositions and devices employing fatty acid esters/ethers of alkanediols and percutaneous absorption enhancers
CN1021196C (zh) *	1986-12-29	1993-06-16	新泽西州州立大学(鲁杰斯)	透皮雌激素/孕激素药剂单元、系统及方法
US4994267A (en) *	1988-03-04	1991-02-19	Noven Pharmaceuticals, Inc.	Transdermal acrylic multipolymer drug delivery system
US5656286A (en) *	1988-03-04	1997-08-12	Noven Pharmaceuticals, Inc.	Solubility parameter based drug delivery system and method for altering drug saturation concentration
EP0394429B1 (de) *	1988-10-27	1996-01-10	Schering Aktiengesellschaft	Mittel zur transdermalen applikation enthaltend gestoden
US5202125A (en) *	1990-12-10	1993-04-13	Theratech, Inc.	Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
DE4210711A1 (de) *	1991-10-31	1993-05-06	Schering Ag Berlin Und Bergkamen, 1000 Berlin, De	Transdermale therapeutische systeme mit kristallisationsinhibitoren

1995
- 1995-12-25 IL IL11653995A patent/IL116539A/en not_active IP Right Cessation
1996
- 1996-01-05 TW TW085100091A patent/TW438598B/zh not_active IP Right Cessation
- 1996-01-05 AR ARP960100904A patent/AR002701A1/es active IP Right Grant
- 1996-01-05 ZA ZA9670A patent/ZA9670B/xx unknown
- 1996-01-11 WO PCT/US1996/000015 patent/WO1996020699A1/en not_active Ceased
- 1996-01-11 ES ES96902047T patent/ES2239767T3/es not_active Expired - Lifetime
- 1996-01-11 DE DE69634559T patent/DE69634559T2/de not_active Expired - Lifetime
- 1996-01-11 PT PT96902047T patent/PT801561E/pt unknown
- 1996-01-11 AU AU46505/96A patent/AU718530B2/en not_active Expired
- 1996-01-11 NZ NZ301153A patent/NZ301153A/xx not_active IP Right Cessation
- 1996-01-11 CA CA002209669A patent/CA2209669C/en not_active Expired - Lifetime
- 1996-01-11 JP JP52121296A patent/JP4081139B2/ja not_active Expired - Lifetime
- 1996-01-11 DK DK96902047T patent/DK0801561T3/da active
- 1996-01-11 AT AT96902047T patent/ATE292457T1/de active
- 1996-01-11 EP EP96902047A patent/EP0801561B1/de not_active Expired - Lifetime
- 1996-01-11 KR KR1019970704622A patent/KR100543351B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2209669C (en)	2007-03-27
DE69634559D1 (de)	2005-05-12
JPH10512245A (ja)	1998-11-24
KR100543351B1 (ko)	2006-04-06
EP0801561B1 (de)	2005-04-06
AR002701A1 (es)	1998-04-29
EP0801561A2 (de)	1997-10-22
IL116539A0 (en)	1996-03-31
JP4081139B2 (ja)	2008-04-23
WO1996020699A1 (en)	1996-07-11
DE69634559T2 (de)	2006-02-16
AU4650596A (en)	1996-07-24
ATE292457T1 (de)	2005-04-15
NZ301153A (en)	1999-11-29
DK0801561T3 (da)	2005-08-08
MX9705070A (es)	1998-07-31
AU718530B2 (en)	2000-04-13
ZA9670B (en)	1996-07-18
CA2209669A1 (en)	1996-07-11
KR19980701233A (ko)	1998-05-15
TW438598B (en)	2001-06-07
ES2239767T3 (es)	2005-10-01
PT801561E (pt)	2005-07-29

Legal Events

Date	Code	Title
2002-06-30	FF	Patent granted
2002-08-14	KB	Patent renewed
2006-02-21	KB	Patent renewed
2013-12-31	KB	Patent renewed
2016-07-31	EXP	Patent expired

Publication	Publication Date	Title
US6024974A (en)	2000-02-15	Composition and methods for transdermal delivery of acid labile drugs
US7846916B2 (en)	2010-12-07	Enhanced drug delivery in transdermal systems
AU2002320038A1 (en)	2003-05-15	Enhanced drug delivery in transdermal systems
EP0801561B1 (de)	2005-04-06	Mittel und verfahren zur transdermalen verabreichung säurelabiler arzneistoffe
US20030152616A1 (en)	2003-08-14	Crystallization inhibition of drugs in transdermal drug delivery systems and methods of use
US8586080B1 (en)	2013-11-19	Inhibiting crystallization of steroidal hormones in transdermal delivery systems
MXPA97005070A (en)	1998-11-09	Composition and methods for a transdermal release of pharmacy acid la
EP1016417A1 (de)	2000-07-05	Drucksensitive adhesive für perkutane pflaster
HK1064920B (en)	2011-12-09	Enhanced drug delivery in transdermal systems