IL117519A - Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them - Google Patents

Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them

Info

Publication number: IL117519A
Authority: IL; Israel
Prior art keywords: hydrogen; pharmaceutical compositions; alkylcarbonyl; hydroxy; integer
Prior art date: 1995-03-17

Application number

IL11751996A

Other languages

English (en)

Other versions

IL117519A0 (en

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-17

Filing date

1996-03-17

Publication date

2000-08-31

1996-03-17 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1996-07-23 Publication of IL117519A0 publication Critical patent/IL117519A0/xx

2000-08-31 Publication of IL117519A publication Critical patent/IL117519A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
FYKGUURZJVYPQE-UHFFFAOYSA-N 1-(1-benzothiophen-2-yl)piperazine Chemical class C1CNCCN1C1=CC2=CC=CC=C2S1 FYKGUURZJVYPQE-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
-1 benzothienylcarbonyl Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL11751996A 1995-03-17 1996-03-17 Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them IL117519A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41381895A	1995-03-17	1995-03-17

Publications (2)

Publication Number	Publication Date
IL117519A0 IL117519A0 (en)	1996-07-23
IL117519A true IL117519A (en)	2000-08-31

Family

ID=23638775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11751996A IL117519A (en)	1995-03-17	1996-03-17	Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them

Country Status (23)

Country	Link
US (1)	US5801176A (fr)
EP (1)	EP0732332B1 (fr)
JP (1)	JPH093060A (fr)
KR (1)	KR100402510B1 (fr)
CN (1)	CN1082959C (fr)
AT (1)	ATE211137T1 (fr)
AU (1)	AU700077B2 (fr)
CA (1)	CA2171695A1 (fr)
CZ (1)	CZ80496A3 (fr)
DE (1)	DE69618050T2 (fr)
DK (1)	DK0732332T3 (fr)
ES (1)	ES2170177T3 (fr)
HU (1)	HUP9600665A3 (fr)
IL (1)	IL117519A (fr)
NO (1)	NO315652B1 (fr)
NZ (1)	NZ286186A (fr)
PL (1)	PL182310B1 (fr)
PT (1)	PT732332E (fr)
RO (1)	RO117453B1 (fr)
RU (1)	RU2157371C2 (fr)
SG (1)	SG54269A1 (fr)
TW (1)	TW328957B (fr)
ZA (1)	ZA962075B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5703083A (en) *	1996-04-15	1997-12-30	Neurogen Corporation	N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands
US6642228B1 (en)	1999-06-24	2003-11-04	Toray Industries, Inc.	α1b-adrenergic receptor antagonists
WO2002066468A2 (fr) *	2001-02-16	2002-08-29	Aventis Pharmaceuticals Inc.	Nouveaux derives d'uree heterocycliques et leur utilisation en tant que ligands des recepteurs de la dopamine d3
GB0117531D0 (en) *	2001-02-16	2001-09-12	Aventis Pharm Prod Inc	Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands
IL157412A0 (en) *	2001-02-16	2004-03-28	Aventis Pharmaceuticals Inc Av	Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
EP1374855A1 (fr) *	2001-03-30	2004-01-02	Takeda Chemical Industries, Ltd.	Solutions medicinales
TWI320783B (en)	2005-04-14	2010-02-21	Otsuka Pharma Co Ltd	Heterocyclic compound
AR055203A1 (es) *	2005-08-31	2007-08-08	Otsuka Pharma Co Ltd	Derivados de benzotiofeno con propiedades antipsicoticas
CN105985314A (zh) *	2015-02-05	2016-10-05	苏州旺山旺水生物医药有限公司	布瑞哌唑类似物的制备方法
PT4082616T (pt) *	2019-12-24	2025-12-02	Sumitomo Pharma Co Ltd	Derivado de amida ácida alifática
JP7655885B2 (ja) *	2021-06-30	2025-04-02	住友ファーマ株式会社	脂肪族酸アミド誘導体を含有する医薬組成物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU577802B2 (en) *	1983-10-17	1988-10-06	Duphar International Research B.V.	Blood-pressure lowering piperazine derivatives
ES2052675T3 (es) *	1987-11-20	1994-07-16	Hoechst Roussel Pharma	3-(4-piperazinil-sustituido en 1)butil)-4-tiazolidinonas, un procedimiento para su preparacion y su uso como medicamentos.
US5001130A (en) *	1988-02-18	1991-03-19	Bristol-Myers Company	Psychotropic heterobicycloalkylpiperazine derivatives
US4780466A (en) *	1988-03-17	1988-10-25	Hoechst-Roussel Pharmaceuticals, Inc.	Arylpiperazinylalkoxy derivatives of cyclic imides
US5776963A (en) *	1989-05-19	1998-07-07	Hoechst Marion Roussel, Inc.	3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4968792A (en) *	1989-09-25	1990-11-06	American Home Products Corporation	Psychotropic benzisothiazole derivatives
US5143923B1 (en) *	1991-04-29	1993-11-02	Hoechst-Roussel Pharmaceuticals Incorporated	Benzoisothiazole-and benzisoxazole-3-carboxamides
RU2024520C1 (ru) *	1991-10-08	1994-12-15	Институт органической химии Уральского отделения РАН	10-метокси-5- метил-6- (1',1'- диоксидо-2'- метахлорфенилазо -3'- гидрокси -4'-метоксибензо(в)тиофен- 7-ил) -5h-3,4,6,7- тетрагидрофуро [4.3.2-q] [3]бензазоцин, обладающий антидепрессивным действием
GB9202915D0 (en) *	1992-02-12	1992-03-25	Wellcome Found	Chemical compounds
US5240927A (en) *	1992-05-19	1993-08-31	Hoechst-Roussel Pharmaceuticals Incorporated	Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
GB9302622D0 (en) *	1993-02-10	1993-03-24	Wellcome Found	Heteroaromatic compounds
US5395835A (en) *	1994-03-24	1995-03-07	Warner-Lambert Company	Naphthalamides as central nervous system agents
GB9410031D0 (en) *	1994-05-19	1994-07-06	Merck Sharp & Dohme	Therapeutic agents

1996
- 1996-03-11 AT AT96103772T patent/ATE211137T1/de not_active IP Right Cessation
- 1996-03-11 EP EP96103772A patent/EP0732332B1/fr not_active Expired - Lifetime
- 1996-03-11 DK DK96103772T patent/DK0732332T3/da active
- 1996-03-11 ES ES96103772T patent/ES2170177T3/es not_active Expired - Lifetime
- 1996-03-11 PT PT96103772T patent/PT732332E/pt unknown
- 1996-03-11 DE DE69618050T patent/DE69618050T2/de not_active Expired - Fee Related
- 1996-03-12 SG SG1996006846A patent/SG54269A1/en unknown
- 1996-03-13 CA CA002171695A patent/CA2171695A1/fr not_active Abandoned
- 1996-03-14 ZA ZA9602075A patent/ZA962075B/xx unknown
- 1996-03-14 PL PL96313251A patent/PL182310B1/pl unknown
- 1996-03-14 AU AU48113/96A patent/AU700077B2/en not_active Ceased
- 1996-03-14 HU HU9600665A patent/HUP9600665A3/hu unknown
- 1996-03-15 JP JP8058707A patent/JPH093060A/ja not_active Abandoned
- 1996-03-15 RO RO96-00568A patent/RO117453B1/ro unknown
- 1996-03-15 RU RU96104547/04A patent/RU2157371C2/ru not_active IP Right Cessation
- 1996-03-15 CZ CZ96804A patent/CZ80496A3/cs unknown
- 1996-03-15 NZ NZ286186A patent/NZ286186A/en unknown
- 1996-03-15 CN CN96103608A patent/CN1082959C/zh not_active Expired - Fee Related
- 1996-03-15 NO NO19961077A patent/NO315652B1/no not_active IP Right Cessation
- 1996-03-16 KR KR1019960007100A patent/KR100402510B1/ko not_active Expired - Fee Related
- 1996-03-17 IL IL11751996A patent/IL117519A/xx not_active IP Right Cessation
- 1996-05-15 TW TW085105712A patent/TW328957B/zh active
1997
- 1997-06-06 US US08/870,988 patent/US5801176A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HU9600665D0 (en)	1996-05-28
JPH093060A (ja)	1997-01-07
RO117453B1 (ro)	2002-03-29
IL117519A0 (en)	1996-07-23
HUP9600665A2 (en)	1997-10-28
NO315652B1 (no)	2003-10-06
ZA962075B (en)	1997-12-31
PT732332E (pt)	2002-06-28
NZ286186A (en)	1997-07-27
US5801176A (en)	1998-09-01
EP0732332A1 (fr)	1996-09-18
PL182310B1 (pl)	2001-12-31
NO961077D0 (no)	1996-03-15
NO961077L (no)	1996-09-18
CZ80496A3 (en)	1996-10-16
ATE211137T1 (de)	2002-01-15
CA2171695A1 (fr)	1996-09-18
KR960034201A (ko)	1996-10-22
ES2170177T3 (es)	2002-08-01
CN1082959C (zh)	2002-04-17
AU700077B2 (en)	1998-12-17
CN1139108A (zh)	1997-01-01
AU4811396A (en)	1996-09-26
EP0732332B1 (fr)	2001-12-19
HUP9600665A3 (en)	1998-08-28
DK0732332T3 (da)	2002-04-15
PL313251A1 (en)	1996-09-30
DE69618050D1 (de)	2002-01-31
DE69618050T2 (de)	2002-07-11
RU2157371C2 (ru)	2000-10-10
TW328957B (en)	1998-04-01
SG54269A1 (en)	1998-11-16
KR100402510B1 (ko)	2004-03-18

Legal Events

Date	Code	Title
2001-01-11	FF	Patent granted
2001-06-14	KB	Patent renewed
2002-05-23	KB	Patent renewed
2006-12-07	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL110151A0 (en)	1994-10-07	Amide and urea derivatives and pharmaceutical compositions containing the same
PH23607A (en)	1989-09-11	Amide derivatives and pharmaceutical composition containing said compounds
NZ235223A (en)	1992-11-25	10-(1-hydroxyethyl)-11-oxo-1-azatricyclo(7.2.0.0 3,8 )undec-2-ene-2-carboxylic acid derivatives and pharmaceutical compositions
HU9702040D0 (en)	1998-01-28	Atherosclerosis treatment
JO2321B1 (en)	2005-09-12	4-phenyl-pyridine derivatives
IL117519A (en)	2000-08-31	Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them
ZA89389B (en)	1989-10-25	Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
EP1156031A4 (fr)	2004-09-15	Nouveau compose, polymere prepare a partir de ce compose, et composition renfermant ce polymere
GR3034023T3 (en)	2000-11-30	Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
IL103595A0 (en)	1993-03-15	2-heterocyclicethylamine derivatives,their preparation and pharmaceutical compositions containing them
HUT50354A (en)	1990-01-29	Process for producing new s-adenosylmethionine decarboxilase inhibitors
EP1142883A4 (fr)	2002-08-21	Nouveaux composes heterocycliques et compositions de medicaments les renfermant
AU625238B2 (en)	1992-07-02	Anti-psychotic piperidylbenzimidazole compounds
HU895648D0 (en)	1990-01-28	Process for the preparation of n,n-disubstituted diaryl-alkancarboxylic acid amide derivatives and pharmaceutical compositions containing such compounds
IL78780A (en)	1990-02-09	1,3-oxathiane-4-phenyl-5-alkenyl derivatives,their preparation and pharmaceutical compositions containing them
GR3017280T3 (en)	1995-11-30	Aminoalkylchromones, process for their preparation and compositions containing them.
EP0381508A3 (en)	1990-09-19	Use of cinnamamide for relaxing muscle tone
DE69226443D1 (de)	1998-09-03	N-(mercaptoacyl)aminosäure, ihre herstellung, ihre therapeutische verwendung und sie enthaltende pharmazeutische zusammensetzungen
GR3000488T3 (en)	1991-06-28	Novel 1,4-dihydropyridines containing fluorine, process for their preparation and their use as medicaments
IE890161L (en)	1989-07-20	2-Amino Acetamide Derivatives
IT1261958B (it)	1996-06-11	2-(sostituite immino)-tiazolidine e procedimento per la loro preparazione e loro impiego quali antianginose e/o analgesiche