IL117527A - Lactam-containing hydroxamic acids useful in combating matrix metalloprotease activity and compositions containing them - Google Patents

Lactam-containing hydroxamic acids useful in combating matrix metalloprotease activity and compositions containing them

Info

Publication number: IL117527A
Authority: IL; Israel
Prior art keywords: combating; lactam; matrix metalloprotease; acids useful; hydroxamic acids
Prior art date: 1995-03-21

Application number

IL11752796A

Other languages

English (en)

Other versions

IL117527A0 (en

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-21

Filing date

1996-03-18

Publication date

1999-12-22

1996-03-18 Application filed by Procter & Gamble filed Critical Procter & Gamble

1996-07-23 Publication of IL117527A0 publication Critical patent/IL117527A0/xx

1999-12-22 Publication of IL117527A publication Critical patent/IL117527A/xx

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
102000005741 Metalloproteases Human genes 0.000 title 1
108010006035 Metalloproteases Proteins 0.000 title 1
150000003951 lactams Chemical class 0.000 title 1
239000011159 matrix material Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Virology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL11752796A 1995-03-21 1996-03-18 Lactam-containing hydroxamic acids useful in combating matrix metalloprotease activity and compositions containing them IL117527A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/407,839 US5672598A (en)	1995-03-21	1995-03-21	Lactam-containing hydroxamic acids

Publications (2)

Publication Number	Publication Date
IL117527A0 IL117527A0 (en)	1996-07-23
IL117527A true IL117527A (en)	1999-12-22

Family

ID=23613737

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11752796A IL117527A (en)	1995-03-21	1996-03-18	Lactam-containing hydroxamic acids useful in combating matrix metalloprotease activity and compositions containing them

Country Status (17)

Country	Link
US (1)	US5672598A (cs)
EP (1)	EP0815084B1 (cs)
JP (1)	JPH11502523A (cs)
KR (1)	KR19980703151A (cs)
AR (1)	AR002718A1 (cs)
AT (1)	ATE248150T1 (cs)
AU (1)	AU711889B2 (cs)
BR (1)	BR9607772A (cs)
CA (1)	CA2216129C (cs)
CZ (1)	CZ295197A3 (cs)
DE (1)	DE69629670T2 (cs)
HU (1)	HUP9800813A3 (cs)
IL (1)	IL117527A (cs)
NO (1)	NO974335L (cs)
NZ (1)	NZ304689A (cs)
WO (1)	WO1996029313A1 (cs)
ZA (1)	ZA962253B (cs)

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HUP0000505A3 (en) *	1996-08-28	2001-12-28	Procter & Gamble	Saturated 7-9 membered heterocyclic n-hydroxycarboxamide derivatives and pharmaceutical compositions containing them
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US20030206874A1 (en) *	1996-11-21	2003-11-06	The Proctor & Gamble Company	Promoting whole body health
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US6774125B2 (en) *	1998-06-22	2004-08-10	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en)	1998-06-22	2003-03-04	Elan Pharmaceuticals, Inc.	Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) *	1998-06-22	2003-05-27	Elan Pharmaceutials, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en)	1998-06-22	2003-04-22	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
HRP990246A2 (en) *	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
AU2003203805B8 (en) *	1998-08-07	2007-02-15	Bristol-Myers Squibb Pharma Company	Succinoylamino lactams as inhibitors of ABeta protein production
NZ525513A (en)	1998-08-07	2004-09-24	Pont Pharmaceuticals Du	Succinoylamino lactams as inhibitors of Abeta protein production
US6737038B1 (en) *	1998-11-12	2004-05-18	Bristol-Myers Squibb Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
EP1129355B1 (en) *	1998-11-12	2005-07-20	Bristol-Myers Squibb Pharma Company	Use of radioligands to screen inhibitors of amyloid-beta peptide production
CN1636011A (zh) *	1998-12-24	2005-07-06	杜邦药品公司	作为Aβ蛋白产生抑制剂的琥珀酰氨基苯并二氮杂䓬
CA2358939A1 (en) *	1998-12-31	2000-07-13	Joseph P. Burkhart	3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase
US6262080B1 (en) *	1998-12-31	2001-07-17	Avantis Pharmaceuticals Inc.	3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase
AU1836900A (en) *	1998-12-31	2000-07-24	Aventis Pharmaceuticals Inc.	N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
WO2000047563A1 (en) *	1999-02-09	2000-08-17	Bristol-Myers Squibb Co.	LACTAM INHIBITORS OF FXa AND METHOD
WO2000047207A1 (en)	1999-02-09	2000-08-17	Bristol-Myers Squibb Company	LACTAM INHIBITORS OF FXa AND METHOD
US6344450B1 (en)	1999-02-09	2002-02-05	Bristol-Myers Squibb Company	Lactam compounds and their use as inhibitors of serine proteases and method
GB9929527D0 (en) *	1999-12-14	2000-02-09	Smithkline Beecham Plc	Novel compounds
US6509330B2 (en) *	2000-02-17	2003-01-21	Bristol-Myers Squibb Company	Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
EP1261610A2 (en)	2000-02-17	2002-12-04	Bristol-Myers Squibb Pharma Company	Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production
MXPA02009755A (es) *	2000-04-03	2003-03-27	Bristol Myers Squibb Pharma Co	Lactamas ciclicas como inhibidores de la produccion de proteina a-beta.
WO2001077086A1 (en)	2000-04-11	2001-10-18	Dupont Pharmaceuticals Company	SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION
AU2000258650A1 (en) *	2000-05-11	2001-11-20	Eli Lilly And Co	2-piperidone compounds for the treatment of cancer
WO2001087354A2 (en)	2000-05-17	2001-11-22	Bristol-Myers Squibb Pharma Company	Use of small molecule radioligands for diagnostic imaging
IL147629A0 (en)	2000-06-01	2002-08-14	Bristol Myers Squibb Pharma Co	LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
AU2001271545A1 (en) *	2000-06-30	2002-01-14	The Procter And Gamble Company	Promoting whole body health
US8283135B2 (en)	2000-06-30	2012-10-09	The Procter & Gamble Company	Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
AU2001271544A1 (en) *	2000-06-30	2002-01-14	The Procter And Gamble Company	Oral compositions comprising host-response modulating agent
US6511973B2 (en)	2000-08-02	2003-01-28	Bristol-Myers Squibb Co.	Lactam inhibitors of FXa and method
WO2003033018A1 (en) *	2001-10-18	2003-04-24	Warner-Lambert Company Llc	Method for preparing purified matrix metalloproteinase
WO2004060346A2 (en)	2002-12-30	2004-07-22	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
US20050192265A1 (en) *	2003-03-20	2005-09-01	Thompson Richard C.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
BRPI0413533A (pt) *	2003-09-09	2006-10-10	Hoffmann La Roche	derivados de malonamida que bloqueiam a atividade de gama-secretase
KR101155335B1 (ko) *	2005-01-07	2012-06-11	엘지전자 주식회사	이동통신 단말기의 멀티미디어 메시지 동작방법

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CN1105799A (zh) *	1993-03-18	1995-07-26	大制药株式会社	作为基质金属蛋白酶抑制剂的喹诺酮衍生物

1995
- 1995-03-21 US US08/407,839 patent/US5672598A/en not_active Expired - Fee Related
1996
- 1996-03-18 IL IL11752796A patent/IL117527A/xx not_active IP Right Cessation
- 1996-03-19 CA CA002216129A patent/CA2216129C/en not_active Expired - Fee Related
- 1996-03-19 KR KR1019970706554A patent/KR19980703151A/ko not_active Abandoned
- 1996-03-19 AU AU52558/96A patent/AU711889B2/en not_active Ceased
- 1996-03-19 NZ NZ304689A patent/NZ304689A/xx unknown
- 1996-03-19 BR BR9607772A patent/BR9607772A/pt not_active Application Discontinuation
- 1996-03-19 CZ CZ972951A patent/CZ295197A3/cs unknown
- 1996-03-19 AT AT96908856T patent/ATE248150T1/de not_active IP Right Cessation
- 1996-03-19 WO PCT/US1996/003726 patent/WO1996029313A1/en not_active Ceased
- 1996-03-19 HU HU9800813A patent/HUP9800813A3/hu unknown
- 1996-03-19 EP EP96908856A patent/EP0815084B1/en not_active Expired - Lifetime
- 1996-03-19 DE DE69629670T patent/DE69629670T2/de not_active Expired - Fee Related
- 1996-03-19 JP JP8528560A patent/JPH11502523A/ja not_active Withdrawn
- 1996-03-20 ZA ZA962253A patent/ZA962253B/xx unknown
- 1996-03-21 AR ARP960101859A patent/AR002718A1/es unknown
1997
- 1997-09-19 NO NO974335A patent/NO974335L/no unknown

Also Published As

Publication number	Publication date
IL117527A0 (en)	1996-07-23
CA2216129C (en)	2002-08-20
AU711889B2 (en)	1999-10-21
NO974335L (no)	1997-11-21
AR002718A1 (es)	1998-04-29
ZA962253B (en)	1996-09-30
CA2216129A1 (en)	1996-09-26
DE69629670D1 (de)	2003-10-02
WO1996029313A1 (en)	1996-09-26
DE69629670T2 (de)	2004-06-17
ATE248150T1 (de)	2003-09-15
US5672598A (en)	1997-09-30
BR9607772A (pt)	1998-07-07
NO974335D0 (no)	1997-09-19
CZ295197A3 (cs)	1998-05-13
HUP9800813A3 (en)	1998-09-28
HUP9800813A2 (hu)	1998-07-28
MX9707214A (es)	1997-11-29
EP0815084B1 (en)	2003-08-27
JPH11502523A (ja)	1999-03-02
NZ304689A (en)	1999-05-28
EP0815084A1 (en)	1998-01-07
AU5255896A (en)	1996-10-08
KR19980703151A (ko)	1998-10-15

Legal Events

Date	Code	Title
2000-06-01	FF	Patent granted
2000-08-31	KB	Patent renewed
2006-12-07	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
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HUP9903014A2 (en)	2000-07-28	Phosphinate derivatives having matrix metalloprotease inhibitor effect and medicaments containing the same
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HUP9801880A3 (en)	1999-08-30	Novel cryptophycins, their use and pharmaceutical compositions containing them
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