IL118527A - Process for the preparation of D4T polymorphic form I of stavudine - Google Patents

Process for the preparation of D4T polymorphic form I of stavudine

Info

Publication number: IL118527A
Authority: IL; Israel
Prior art keywords: polymorphic form; stavudine; preparation; polymorphic; approved
Prior art date: 1995-06-05

Application number

IL11852796A

Other languages

English (en)

Other versions

IL118527A0 (en

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-05

Filing date

1996-06-02

Publication date

2000-07-16

1996-06-02 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1996-10-16 Publication of IL118527A0 publication Critical patent/IL118527A0/xx

2000-07-16 Publication of IL118527A publication Critical patent/IL118527A/xx

Links

238000000034 method Methods 0.000 title abstract 2
XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 title 2
229960001203 stavudine Drugs 0.000 title 1
208000030507 AIDS Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000001816 cooling Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

IL11852796A 1995-06-05 1996-06-02 Process for the preparation of D4T polymorphic form I of stavudine IL118527A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/465,208 US5608048A (en)	1995-06-05	1995-06-05	d4 T polymorphic Form 1 process

Publications (2)

Publication Number	Publication Date
IL118527A0 IL118527A0 (en)	1996-10-16
IL118527A true IL118527A (en)	2000-07-16

Family

ID=23846880

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11852796A IL118527A (en)	1995-06-05	1996-06-02	Process for the preparation of D4T polymorphic form I of stavudine

Country Status (18)

Country	Link
US (1)	US5608048A (fr)
EP (1)	EP0749969B1 (fr)
JP (1)	JP4208976B2 (fr)
KR (1)	KR100375957B1 (fr)
CN (1)	CN1058723C (fr)
AT (1)	ATE205203T1 (fr)
AU (1)	AU694653B2 (fr)
CA (1)	CA2176181C (fr)
DE (1)	DE69614936T2 (fr)
DK (1)	DK0749969T3 (fr)
ES (1)	ES2160768T3 (fr)
GR (1)	GR3036768T3 (fr)
HU (1)	HU222285B1 (fr)
IL (1)	IL118527A (fr)
MX (1)	MX9601957A (fr)
PT (1)	PT749969E (fr)
SG (1)	SG43372A1 (fr)
TW (1)	TW336937B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001285197A1 (en) *	2000-09-06	2002-03-22	Bristol-Myers Squibb Company	Stavudine polymorphic form 1 process
US7737133B2 (en) *	2003-09-03	2010-06-15	Agi Therapeutics Ltd.	Formulations and methods of treating inflammatory bowel disease
US7825106B2 (en) *	2003-09-03	2010-11-02	Agi Therapeutics Ltd.	Modified release formulations and methods of treating inflammatory bowel disease
US7160537B2 (en) *	2003-12-15	2007-01-09	Siemens Medical Solutions Usa, Inc.	Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) *	2003-12-15	2005-06-16	Cti Pet Systems, Inc.	Method for preparing radiolabeled thymidine
WO2007099389A1 (fr) *	2005-07-11	2007-09-07	Aurobindo Pharma Limited	Nouveau procédé amélioré de fabrication de stavudine de forme i
ITMI20060360A1 (it) *	2006-02-28	2007-09-01	Clariant Lsm Italia Spa	Novel method for the preparation of stavudine polymorphic form 1 and form ii
US20140020618A1 (en) *	2011-02-08	2014-01-23	Japan Agency For Marine-Earth Science And Technology	Method for producing calcite single crystal

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4476248A (en) *	1983-02-28	1984-10-09	The Upjohn Company	Crystallization of ibuprofen
US4978655A (en) *	1986-12-17	1990-12-18	Yale University	Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
US4904770A (en) *	1988-03-24	1990-02-27	Bristol-Myers Company	Production of 2',3'-dideoxy-2',3'-didehydronucleosides
US5672698A (en) *	1993-11-15	1997-09-30	Bristol-Myers Squibb Co.	Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5539099A (en) *	1993-11-15	1996-07-23	Bristol-Myers Squibb Company	Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides
US5608049A (en) *	1995-03-10	1997-03-04	Bristol-Myers Squibb Company	Preparation of d4T from 5-methyluridine

1995
- 1995-06-05 US US08/465,208 patent/US5608048A/en not_active Expired - Lifetime
1996
- 1996-05-03 TW TW085105338A patent/TW336937B/zh not_active IP Right Cessation
- 1996-05-09 CA CA002176181A patent/CA2176181C/fr not_active Expired - Fee Related
- 1996-05-23 MX MX9601957A patent/MX9601957A/es unknown
- 1996-06-02 IL IL11852796A patent/IL118527A/xx not_active IP Right Cessation
- 1996-06-04 ES ES96304030T patent/ES2160768T3/es not_active Expired - Lifetime
- 1996-06-04 HU HU9601517A patent/HU222285B1/hu not_active IP Right Cessation
- 1996-06-04 PT PT96304030T patent/PT749969E/pt unknown
- 1996-06-04 AU AU54692/96A patent/AU694653B2/en not_active Ceased
- 1996-06-04 DK DK96304030T patent/DK0749969T3/da active
- 1996-06-04 DE DE69614936T patent/DE69614936T2/de not_active Expired - Lifetime
- 1996-06-04 EP EP96304030A patent/EP0749969B1/fr not_active Expired - Lifetime
- 1996-06-04 AT AT96304030T patent/ATE205203T1/de not_active IP Right Cessation
- 1996-06-05 SG SG1996009966A patent/SG43372A1/en unknown
- 1996-06-05 JP JP14245796A patent/JP4208976B2/ja not_active Expired - Fee Related
- 1996-06-05 CN CN96110463A patent/CN1058723C/zh not_active Expired - Fee Related
- 1996-06-05 KR KR1019960020025A patent/KR100375957B1/ko not_active Expired - Fee Related
2001
- 2001-10-01 GR GR20010401625T patent/GR3036768T3/el unknown

Also Published As

Publication number	Publication date
ATE205203T1 (de)	2001-09-15
EP0749969B1 (fr)	2001-09-05
EP0749969A3 (fr)	1997-03-19
HK1003435A1 (en)	1998-10-30
AU5469296A (en)	1996-12-19
ES2160768T3 (es)	2001-11-16
IL118527A0 (en)	1996-10-16
EP0749969A2 (fr)	1996-12-27
HUP9601517A2 (en)	1997-05-28
DE69614936D1 (de)	2001-10-11
MX9601957A (es)	1997-08-30
SG43372A1 (en)	1997-10-17
HU222285B1 (hu)	2003-05-28
JPH08333364A (ja)	1996-12-17
KR970001369A (ko)	1997-01-24
CA2176181A1 (fr)	1996-12-06
PT749969E (pt)	2001-12-28
TW336937B (en)	1998-07-21
GR3036768T3 (en)	2002-01-31
DE69614936T2 (de)	2002-04-25
DK0749969T3 (da)	2001-11-26
HUP9601517A3 (en)	2000-03-28
JP4208976B2 (ja)	2009-01-14
CA2176181C (fr)	2007-03-13
AU694653B2 (en)	1998-07-23
CN1058723C (zh)	2000-11-22
CN1145903A (zh)	1997-03-26
KR100375957B1 (ko)	2003-12-31
US5608048A (en)	1997-03-04
HU9601517D0 (en)	1996-07-29

Legal Events

Date	Code	Title
2000-11-21	FF	Patent granted
2002-07-25	KB	Patent renewed
2006-08-01	KB	Patent renewed
2010-10-31	KB	Patent renewed
2014-12-31	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
AU695352B2 (en)	1998-08-13	Process for producing derivatives of 4a,5,9,10,11,12,-hexahydro-6h-benzofuro{3a,3,2-ef}{2} benzazepine
TW218869B (fr)	1994-01-11
AU694653B2 (en)	1998-07-23	D4T polymorphic form I process
HUP9602713A3 (en)	1998-01-28	Bordeaux mixture, process for producing it and fungicide compositions containing copper and using them
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EP1134213A3 (fr)	2002-04-17	Procédé de préparation de glycinamides N-(indole-2-carbonyl) substituées
AU694320B2 (en)	1998-07-16	Preparation of D4T from 5-methyluridine
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BG98125A (en)	1994-06-30	Medical substances, containing 1,5,6,7-tetrahydro-4h-indazol-4-ones, and method for preparing them
ZA968383B (en)	1997-08-01	Composition for treatment of osteoporosis.
IL119112A0 (en)	1996-11-14	Process for the preparation of 4,6-dichloropyrimidines
HU9501132D0 (en)	1995-06-28	Process for producing of 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphtalene