IL120701A - 2-phenyl-1-[4-(2-aminoethoxy or propoxy))-benzyl] - indole compounds and pharmaceutical compositions containing them - Google Patents

2-phenyl-1-[4-(2-aminoethoxy or propoxy))-benzyl] - indole compounds and pharmaceutical compositions containing them

Info

Publication number: IL120701A
Authority: IL; Israel
Prior art keywords: aminoethoxy; propoxy; benzyl; phenyl; pharmaceutical compositions
Prior art date: 1996-04-19

Application number

IL12070197A

Other languages

English (en)

Other versions

IL120701A0 (en

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-19

Filing date

1997-04-18

Publication date

2005-09-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27092026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL120701(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-04-04 Priority claimed from US08/833,271 external-priority patent/US5998402A/en

1997-04-18 Application filed by Wyeth Corp filed Critical Wyeth Corp

1997-09-30 Publication of IL120701A0 publication Critical patent/IL120701A0/xx

2005-09-25 Publication of IL120701A publication Critical patent/IL120701A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL12070197A 1996-04-19 1997-04-18 2-phenyl-1-[4-(2-aminoethoxy or propoxy))-benzyl] - indole compounds and pharmaceutical compositions containing them IL120701A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63397496A	1996-04-19	1996-04-19
US08/833,271 US5998402A (en)	1996-04-19	1997-04-04	2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents

Publications (2)

Publication Number	Publication Date
IL120701A0 IL120701A0 (en)	1997-09-30
IL120701A true IL120701A (en)	2005-09-25

Family

ID=27092026

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12070197A IL120701A (en)	1996-04-19	1997-04-18	2-phenyl-1-[4-(2-aminoethoxy or propoxy))-benzyl] - indole compounds and pharmaceutical compositions containing them

Country Status (26)

Country	Link
EP (1)	EP0802183B1 (th)
JP (1)	JP4093611B2 (th)
KR (1)	KR100480193B1 (th)
CN (1)	CN1106383C (th)
AR (1)	AR011503A1 (th)
AT (1)	ATE206701T1 (th)
AU (1)	AU710149B2 (th)
BR (1)	BRPI9715334B8 (th)
CO (1)	CO4900051A1 (th)
CY (2)	CY2325B1 (th)
CZ (1)	CZ291701B6 (th)
DE (2)	DE122009000061I1 (th)
DK (1)	DK0802183T3 (th)
EA (1)	EA001448B1 (th)
ES (1)	ES2162198T3 (th)
FR (1)	FR09C0048I2 (th)
HU (1)	HU227077B1 (th)
IL (1)	IL120701A (th)
LU (1)	LU91608I2 (th)
MX (1)	MX9702865A (th)
NL (1)	NL300416I2 (th)
NO (2)	NO309564B1 (th)
NZ (1)	NZ314601A (th)
PT (1)	PT802183E (th)
SK (1)	SK281737B6 (th)
UA (1)	UA48148C2 (th)

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CN1342144A (zh) *	1999-03-04	2002-03-27	美国家用产品公司	用作雌激素药物的n－取代的苯甲酰基吲哚类化合物
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AR029538A1 (es)	2000-07-06	2003-07-02	Wyeth Corp	Composiciones farmaceuticas de agentes estrogenicos
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RU2006132180A (ru)	2004-04-07	2008-05-20	Вайет (Us)	Кристаллический полиморф базедоксифен ацетата
BRPI0509385A (pt)	2004-04-08	2007-09-18	Wyeth Corp	composto, composição, métodos de preparar o sal, ea dispensão sólida, de tratar um mamìfero tendo uma doença ou sìndrome associadas com a deficiência de estrogênio ou excesso de estrogênio, uma doença ou distúrbio associados com a proliferação ou desenvolvimento anormal dos tecidos endometriais, de tratar cáncer de mama em um mamìfero, e uma mulher pós-menopáusica quanto a um ou mais distúrbios vasomotores, de reduzir colesterol, e de inibir perda óssea em um mamìfero, dispersão sólida, e, uso de um composto
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CN102690225B (zh) *	2012-04-11	2014-12-24	南京友杰医药科技有限公司	巴多昔芬的合成方法
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1997
- 1997-04-15 SK SK472-97A patent/SK281737B6/sk not_active IP Right Cessation
- 1997-04-15 DE DE122009000061C patent/DE122009000061I1/de active Pending
- 1997-04-15 PT PT97302576T patent/PT802183E/pt unknown
- 1997-04-15 DE DE69707189T patent/DE69707189T2/de not_active Expired - Lifetime
- 1997-04-15 ES ES97302576T patent/ES2162198T3/es not_active Expired - Lifetime
- 1997-04-15 DK DK97302576T patent/DK0802183T3/da active
- 1997-04-15 AT AT97302576T patent/ATE206701T1/de active
- 1997-04-15 NZ NZ314601A patent/NZ314601A/en not_active IP Right Cessation
- 1997-04-15 EP EP97302576A patent/EP0802183B1/en not_active Expired - Lifetime
- 1997-04-17 AU AU18920/97A patent/AU710149B2/en not_active Expired
- 1997-04-17 CZ CZ19971175A patent/CZ291701B6/cs not_active IP Right Cessation
- 1997-04-17 UA UA97041833A patent/UA48148C2/uk unknown
- 1997-04-18 CO CO97020584A patent/CO4900051A1/es unknown
- 1997-04-18 MX MX9702865A patent/MX9702865A/es unknown
- 1997-04-18 CN CN97113496A patent/CN1106383C/zh not_active Expired - Lifetime
- 1997-04-18 JP JP10156397A patent/JP4093611B2/ja not_active Expired - Lifetime
- 1997-04-18 HU HU9700777A patent/HU227077B1/hu active Protection Beyond IP Right Term
- 1997-04-18 NO NO971815A patent/NO309564B1/no not_active IP Right Cessation
- 1997-04-18 EA EA199700044A patent/EA001448B1/ru not_active IP Right Cessation
- 1997-04-18 IL IL12070197A patent/IL120701A/xx active Protection Beyond IP Right Term
- 1997-04-18 KR KR1019970014894A patent/KR100480193B1/ko not_active Expired - Lifetime
- 1997-04-18 AR ARP970101580A patent/AR011503A1/es active IP Right Grant
- 1997-04-22 BR BRPI9715334A patent/BRPI9715334B8/pt not_active IP Right Cessation
2003
- 2003-04-08 CY CY0300038A patent/CY2325B1/xx unknown
2009
- 2009-09-23 LU LU91608C patent/LU91608I2/fr unknown
- 2009-09-28 NL NL300416C patent/NL300416I2/nl unknown
- 2009-09-30 CY CY2009016C patent/CY2009016I1/el unknown
- 2009-09-30 FR FR09C0048C patent/FR09C0048I2/fr active Active
- 2009-11-09 NO NO2009025C patent/NO2009025I2/no unknown

Also Published As

Publication number	Publication date
CZ117597A3 (en)	1997-11-12
DE69707189T2 (de)	2002-06-20
CY2009016I2 (el)	2010-07-28
AU1892097A (en)	1997-10-23
NL300416I2 (nl)	2010-02-01
BR9715334B1 (pt)	2012-09-04
ATE206701T1 (de)	2001-10-15
UA48148C2 (uk)	2002-08-15
ES2162198T3 (es)	2001-12-16
FR09C0048I1 (th)	2009-06-11
HK1002863A1 (en)	1998-09-25
NL300416I1 (nl)	2009-12-01
HUP9700777A2 (hu)	1999-06-28
FR09C0048I2 (th)	2010-06-11
NO971815L (no)	1997-10-20
MX9702865A (es)	1998-05-31
NO2009025I1 (no)	2009-11-30
NZ314601A (en)	1999-09-29
CY2325B1 (en)	2003-11-14
CZ291701B6 (cs)	2003-05-14
JP4093611B2 (ja)	2008-06-04
EA199700044A1 (ru)	1997-12-30
KR100480193B1 (ko)	2005-08-30
SK281737B6 (sk)	2001-07-10
SK47297A3 (en)	1997-11-05
EA001448B1 (ru)	2001-04-23
AU710149B2 (en)	1999-09-16
JPH1036346A (ja)	1998-02-10
CN1106383C (zh)	2003-04-23
HU9700777D0 (en)	1997-06-30
IL120701A0 (en)	1997-09-30
NO309564B1 (no)	2001-02-19
PT802183E (pt)	2002-03-28
EP0802183A1 (en)	1997-10-22
BRPI9715334B8 (pt)	2021-05-25
HUP9700777A3 (en)	2000-04-28
AR011503A1 (es)	2000-08-30
CN1170719A (zh)	1998-01-21
EP0802183B1 (en)	2001-10-10
DK0802183T3 (da)	2002-02-04
DE122009000061I1 (de)	2009-12-31
LU91608I2 (fr)	2009-11-23
NO971815D0 (no)	1997-04-18
CO4900051A1 (es)	2000-03-27
DE69707189D1 (de)	2001-11-15
NO2009025I2 (no)	2010-11-22
KR970069037A (ko)	1997-11-07
CY2009016I1 (el)	2010-07-28
HU227077B1 (en)	2010-06-28

Legal Events

Date	Code	Title	Description
2006-03-12	KB	Patent renewed
2007-07-24	KB	Patent renewed
2011-04-28	KB	Patent renewed
2012-10-31	EXTF	Application for patent extension filed
2013-10-31	PEL	Intention of commissioner to extend period of protection
2014-02-27	EXTG	Extension of patent term granted
2015-04-30	KB	Patent renewed
2015-06-30	PEL	Intention of commissioner to extend period of protection	Free format text: PRODUCT NAME: BAZEDOXIFENE Extension date: 20220414
2015-11-30	EXTG	Extension of patent term granted	Free format text: PRODUCT NAME: BAZEDOXIFENE Extension date: 20220414
2019-06-30	EXTN	Extension order renewed
2020-03-31	EXTN	Extension order renewed

Publication	Publication Date	Title
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IL120699A0 (en)	1997-08-14	Indole derivatives and pharmaceutical compositions containing them
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HUP9901452A3 (en)	2001-02-28	Bicyclic-aromatic compounds and pharmaceutical compositions containing them
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AU5856898A (en)	1998-07-31	Heteroarylsulfonamide derivatives and pharmaceutical compositions containing them
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HUP0100085A3 (en)	2002-12-28	Biphenylamidine derivatives and pharmaceutical compositions containing them
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ZA9710919B (en)	1999-06-04	Pharmaceutical compositions containing N-sulphony-lindole derivatives
HUP0001010A3 (en)	2001-06-28	Benzimidazole derivatives and pharmaceutical compositions containing them
HUP0000460A3 (en)	2001-04-28	Imidazopyridazines and pharmaceutical compositions thereof