IL122459A - Antagonistic medicinal preparations for calcium channels in vascular tissues containing 2-aryl-3-aroylbenzo [b] thiopane - Google Patents

Antagonistic medicinal preparations for calcium channels in vascular tissues containing 2-aryl-3-aroylbenzo [b] thiopane

Info

Publication number: IL122459A
Authority: IL; Israel
Prior art keywords: compound; piperidino; pharmaceutical composition; alkyl; salt
Prior art date: 1995-06-07

Application number

IL12245996A

Other languages

English (en)

Hebrew (he)

Other versions

IL122459A0 (en

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-04

Publication date

2001-05-20

1996-06-04 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1998-06-15 Publication of IL122459A0 publication Critical patent/IL122459A0/xx

2001-05-20 Publication of IL122459A publication Critical patent/IL122459A/en

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 21
230000002792 vascular Effects 0.000 title claims abstract description 20
108090000312 Calcium Channels Proteins 0.000 title claims abstract description 19
102000003922 Calcium Channels Human genes 0.000 title claims abstract description 19
230000003042 antagnostic effect Effects 0.000 title claims abstract description 13
229930192474 thiophene Natural products 0.000 title description 6
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims abstract description 68
150000003839 salts Chemical class 0.000 claims abstract description 29
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims abstract description 21
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 18
239000001257 hydrogen Substances 0.000 claims abstract description 18
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 15
230000000903 blocking effect Effects 0.000 claims abstract description 11
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 10
RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims abstract 12
-1 -CO-(Ci-C6 alkyl) Chemical group 0.000 claims description 41
239000003814 drug Substances 0.000 claims description 16
125000000217 alkyl group Chemical group 0.000 claims description 10
150000002431 hydrogen Chemical class 0.000 claims description 10
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
208000020446 Cardiac disease Diseases 0.000 claims description 7
230000002490 cerebral effect Effects 0.000 claims description 7
208000019622 heart disease Diseases 0.000 claims description 7
208000019553 vascular disease Diseases 0.000 claims description 7
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 4
206010002383 Angina Pectoris Diseases 0.000 claims description 4
206010002388 Angina unstable Diseases 0.000 claims description 4
206010003173 Arterial rupture Diseases 0.000 claims description 4
208000018522 Gastrointestinal disease Diseases 0.000 claims description 4
206010020772 Hypertension Diseases 0.000 claims description 4
208000019695 Migraine disease Diseases 0.000 claims description 4
201000001068 Prinzmetal angina Diseases 0.000 claims description 4
208000006011 Stroke Diseases 0.000 claims description 4
208000007814 Unstable Angina Diseases 0.000 claims description 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
201000004332 intermediate coronary syndrome Diseases 0.000 claims description 4
208000001286 intracranial vasospasm Diseases 0.000 claims description 4
208000017169 kidney disease Diseases 0.000 claims description 4
210000004165 myocardium Anatomy 0.000 claims description 4
206010003119 arrhythmia Diseases 0.000 claims description 3
230000006793 arrhythmia Effects 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
206010059245 Angiopathy Diseases 0.000 claims 3
208000027418 Wounds and injury Diseases 0.000 claims 3
230000006378 damage Effects 0.000 claims 3
208000014674 injury Diseases 0.000 claims 3
206010027599 migraine Diseases 0.000 claims 3
125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
210000001519 tissue Anatomy 0.000 description 25
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 24
230000009989 contractile response Effects 0.000 description 21
210000003038 endothelium Anatomy 0.000 description 19
238000000034 method Methods 0.000 description 16
230000000694 effects Effects 0.000 description 15
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 13
229960002748 norepinephrine Drugs 0.000 description 13
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 13
239000004480 active ingredient Substances 0.000 description 12
229940011871 estrogen Drugs 0.000 description 12
239000000262 estrogen Substances 0.000 description 12
239000000203 mixture Substances 0.000 description 12
229940076279 serotonin Drugs 0.000 description 12
241000700159 Rattus Species 0.000 description 11
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 9
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229960005309 estradiol Drugs 0.000 description 9
239000003826 tablet Substances 0.000 description 9
LQANGKSBLPMBTJ-BRSNVKEHSA-N (z)-7-[(1s,2s,3r,4r)-3-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid Chemical compound C1[C@@H]2CO[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@H]2C\C=C/CCCC(O)=O LQANGKSBLPMBTJ-BRSNVKEHSA-N 0.000 description 8
229940127291 Calcium channel antagonist Drugs 0.000 description 8
241001465754 Metazoa Species 0.000 description 8
238000009472 formulation Methods 0.000 description 8
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230000005764 inhibitory process Effects 0.000 description 8
239000000243 solution Substances 0.000 description 8
239000002253 acid Substances 0.000 description 7
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
229920002472 Starch Polymers 0.000 description 6
239000002585 base Chemical group 0.000 description 6
GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 description 6
235000019698 starch Nutrition 0.000 description 6
230000009286 beneficial effect Effects 0.000 description 5
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 5
239000000480 calcium channel blocker Substances 0.000 description 5
102000015694 estrogen receptors Human genes 0.000 description 5
108010038795 estrogen receptors Proteins 0.000 description 5
229960004622 raloxifene Drugs 0.000 description 5
239000008107 starch Substances 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 4
OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 4
229960004373 acetylcholine Drugs 0.000 description 4
239000000556 agonist Substances 0.000 description 4
125000005605 benzo group Chemical group 0.000 description 4
239000000801 calcium channel stimulating agent Substances 0.000 description 4
230000004087 circulation Effects 0.000 description 4
231100000673 dose–response relationship Toxicity 0.000 description 4
239000007903 gelatin capsule Substances 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
239000001267 polyvinylpyrrolidone Substances 0.000 description 4
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
230000003389 potentiating effect Effects 0.000 description 4
239000000843 powder Substances 0.000 description 4
238000009256 replacement therapy Methods 0.000 description 4
239000006188 syrup Substances 0.000 description 4
235000020357 syrup Nutrition 0.000 description 4
150000003577 thiophenes Chemical class 0.000 description 4
125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 3
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
229910052791 calcium Inorganic materials 0.000 description 3
239000011575 calcium Substances 0.000 description 3
239000002775 capsule Substances 0.000 description 3
239000001768 carboxy methyl cellulose Substances 0.000 description 3
239000001913 cellulose Substances 0.000 description 3
229920002678 cellulose Polymers 0.000 description 3
235000010980 cellulose Nutrition 0.000 description 3
230000001419 dependent effect Effects 0.000 description 3
239000003085 diluting agent Substances 0.000 description 3
239000000796 flavoring agent Substances 0.000 description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
239000000546 pharmaceutical excipient Substances 0.000 description 3
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
239000000725 suspension Substances 0.000 description 3
239000000454 talc Substances 0.000 description 3
229910052623 talc Inorganic materials 0.000 description 3
235000012222 talc Nutrition 0.000 description 3
238000011282 treatment Methods 0.000 description 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 2
HQALDKFFRYFTKP-UHFFFAOYSA-N 2-[4-[4-(2-benzyl-1-benzothiophen-3-yl)phenyl]-2-bromo-6-(3-methoxyphenyl)phenoxy]acetic acid Chemical compound COC1=CC=CC(C=2C(=C(Br)C=C(C=2)C=2C=CC(=CC=2)C=2C3=CC=CC=C3SC=2CC=2C=CC=CC=2)OCC(O)=O)=C1 HQALDKFFRYFTKP-UHFFFAOYSA-N 0.000 description 2
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
239000005711 Benzoic acid Substances 0.000 description 2
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206010012735 Diarrhoea Diseases 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
JLERVPBPJHKRBJ-UHFFFAOYSA-N LY 117018 Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCC3)=CC=2)C2=CC=C(O)C=C2S1 JLERVPBPJHKRBJ-UHFFFAOYSA-N 0.000 description 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
206010028980 Neoplasm Diseases 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
241000282898 Sus scrofa Species 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000000908 ammonium hydroxide Substances 0.000 description 2
235000010233 benzoic acid Nutrition 0.000 description 2
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
210000004351 coronary vessel Anatomy 0.000 description 2
PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 2
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239000000839 emulsion Substances 0.000 description 2
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229930182833 estradiol Natural products 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
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125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
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RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
230000007306 turnover Effects 0.000 description 1
230000001836 utereotrophic effect Effects 0.000 description 1
230000004865 vascular response Effects 0.000 description 1
230000000304 vasodilatating effect Effects 0.000 description 1
230000035899 viability Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229940071104 xylenesulfonate Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

IL12245996A 1995-06-07 1996-06-04 Antagonistic medicinal preparations for calcium channels in vascular tissues containing 2-aryl-3-aroylbenzo [b] thiopane IL122459A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/485,406 US5840747A (en)	1995-06-07	1995-06-07	Calcium channel antagonists
PCT/US1996/009162 WO1996040134A1 (en)	1995-06-07	1996-06-04	Calcium channel antagonists

Publications (2)

Publication Number	Publication Date
IL122459A0 IL122459A0 (en)	1998-06-15
IL122459A true IL122459A (en)	2001-05-20

Family

ID=23928032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12245996A IL122459A (en)	1995-06-07	1996-06-04	Antagonistic medicinal preparations for calcium channels in vascular tissues containing 2-aryl-3-aroylbenzo [b] thiopane

Country Status (21)

Country	Link
US (1)	US5840747A (de)
EP (1)	EP0831822B1 (de)
JP (1)	JPH11506788A (de)
KR (1)	KR19990022499A (de)
CN (1)	CN1193274A (de)
AT (1)	ATE252902T1 (de)
AU (1)	AU714403B2 (de)
CA (1)	CA2223711A1 (de)
CZ (1)	CZ288546B6 (de)
DE (1)	DE69630523T2 (de)
EA (1)	EA001928B1 (de)
ES (1)	ES2210373T3 (de)
HU (1)	HUP9900916A3 (de)
IL (1)	IL122459A (de)
MX (1)	MX9709468A (de)
NO (1)	NO975561L (de)
NZ (1)	NZ310178A (de)
PL (1)	PL183998B1 (de)
RO (1)	RO116344B1 (de)
UA (1)	UA43895C2 (de)
WO (1)	WO1996040134A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6008232A (en) *	1997-08-20	1999-12-28	Eli Lilly And Company	Methods for preventing headaches
AU7896100A (en) *	1999-10-14	2001-04-23	Endorecherche Inc.	Selective estrogen receptor modulators in the treatment or reduction of the riskof acquiring hypertension, cardiovascular diseases, and insulin resistance
EP1113007A1 (de)	1999-12-24	2001-07-04	Pfizer Inc.	Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
US5441965A (en) *	1993-12-21	1995-08-15	Eli Lilly And Company	Methods of inhibiting thrombin
US5447941A (en) *	1993-12-21	1995-09-05	Eli Lilly And Company	Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes
US6562862B1 (en) *	1994-10-20	2003-05-13	Eli Lilly And Company	Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
US5532254A (en) *	1995-06-07	1996-07-02	Eli Lilly And Company	Modulation of calcium channels using benzothiophenes

1995
- 1995-06-07 US US08/485,406 patent/US5840747A/en not_active Expired - Fee Related
1996
- 1996-04-06 UA UA97125831A patent/UA43895C2/uk unknown
- 1996-06-04 NZ NZ310178A patent/NZ310178A/en unknown
- 1996-06-04 AU AU60919/96A patent/AU714403B2/en not_active Ceased
- 1996-06-04 WO PCT/US1996/009162 patent/WO1996040134A1/en not_active Ceased
- 1996-06-04 EA EA199800033A patent/EA001928B1/ru not_active IP Right Cessation
- 1996-06-04 ES ES96918210T patent/ES2210373T3/es not_active Expired - Lifetime
- 1996-06-04 EP EP96918210A patent/EP0831822B1/de not_active Expired - Lifetime
- 1996-06-04 MX MX9709468A patent/MX9709468A/es not_active IP Right Cessation
- 1996-06-04 RO RO97-02247A patent/RO116344B1/ro unknown
- 1996-06-04 HU HU9900916A patent/HUP9900916A3/hu unknown
- 1996-06-04 AT AT96918210T patent/ATE252902T1/de not_active IP Right Cessation
- 1996-06-04 PL PL96324086A patent/PL183998B1/pl unknown
- 1996-06-04 CN CN96195976A patent/CN1193274A/zh active Pending
- 1996-06-04 KR KR1019970708980A patent/KR19990022499A/ko not_active Ceased
- 1996-06-04 CA CA002223711A patent/CA2223711A1/en not_active Abandoned
- 1996-06-04 DE DE69630523T patent/DE69630523T2/de not_active Expired - Fee Related
- 1996-06-04 JP JP9501551A patent/JPH11506788A/ja active Pending
- 1996-06-04 CZ CZ19973828A patent/CZ288546B6/cs not_active IP Right Cessation
- 1996-06-04 IL IL12245996A patent/IL122459A/en not_active IP Right Cessation
1997
- 1997-12-02 NO NO975561A patent/NO975561L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
PL324086A1 (en)	1998-05-11
CZ382897A3 (cs)	1999-01-13
EA001928B1 (ru)	2001-10-22
ES2210373T3 (es)	2004-07-01
EP0831822B1 (de)	2003-10-29
DE69630523T2 (de)	2004-08-12
AU6091996A (en)	1996-12-30
IL122459A0 (en)	1998-06-15
KR19990022499A (ko)	1999-03-25
NZ310178A (en)	2000-06-23
MX9709468A (es)	1998-04-30
EP0831822A4 (de)	2001-12-19
NO975561D0 (no)	1997-12-02
EP0831822A1 (de)	1998-04-01
UA43895C2 (uk)	2002-01-15
JPH11506788A (ja)	1999-06-15
CZ288546B6 (cs)	2001-07-11
CA2223711A1 (en)	1996-12-19
US5840747A (en)	1998-11-24
ATE252902T1 (de)	2003-11-15
WO1996040134A1 (en)	1996-12-19
CN1193274A (zh)	1998-09-16
EA199800033A1 (ru)	1998-06-25
HUP9900916A2 (hu)	1999-09-28
NO975561L (no)	1997-12-02
DE69630523D1 (de)	2003-12-04
HUP9900916A3 (en)	1999-11-29
AU714403B2 (en)	2000-01-06
RO116344B1 (ro)	2001-01-30
PL183998B1 (pl)	2002-08-30

Legal Events

Date	Code	Title
2001-10-31	FF	Patent granted
2001-11-25	KB	Patent renewed
2002-07-25	KB	Patent renewed
2007-03-08	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5604248A (en)	1997-02-18	Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs
US5663184A (en)	1997-09-02	Methods of inhibiting CNS problems in post-menopausal women
US5698572A (en)	1997-12-16	Methods of inhibiting turner's syndrome
EP0873051B1 (de)	2004-08-04	Modulierung von calciumkanälen
US5451590A (en)	1995-09-19	Methods of inhibiting sexual precocity
CZ260798A3 (cs)	1999-05-12	Benzothiofeny, přípravky s jejich obsahem a způsoby
EP0831822B1 (de)	2003-10-29	Verwendung von Calciumkanalanantagonisten zur Behandlung von Herz-, Nieren-, Magen-und Darmkrankheiten sowie Bluthochdruck
US5571808A (en)	1996-11-05	Method for treating smoking-related bone loss
NZ319948A (en)	2000-06-23	use of 2-phenyl-3benzoyl-benzo[b]thiophene derivatives for inhibiting plasminogen activator inhibitor-1
MXPA97009467A (en)	1999-05-31	Pharmaceutical compositions to minimize loss or
JPH08253417A (ja)	1996-10-01	脳又はｃｎｓのエストロゲン陽性腫瘍抑制用製剤
MXPA97009542A (en)	1998-10-15	Modulation of cal calc