IL123294A0 - Monoclonal antibody BR110 and uses thereof - Google Patents

Monoclonal antibody BR110 and uses thereof

Info

Publication number
IL123294A0
IL123294A0 IL12329496A IL12329496A IL123294A0 IL 123294 A0 IL123294 A0 IL 123294A0 IL 12329496 A IL12329496 A IL 12329496A IL 12329496 A IL12329496 A IL 12329496A IL 123294 A0 IL123294 A0 IL 123294A0
Authority
IL
Israel
Prior art keywords
antigen
monoclonal antibody
complex
ligands
ligand
Prior art date
Application number
IL12329496A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL123294A0 publication Critical patent/IL123294A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL12329496A 1995-10-19 1996-10-07 Monoclonal antibody BR110 and uses thereof IL123294A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US564195P 1995-10-19 1995-10-19
PCT/US1996/016070 WO1997014796A1 (en) 1995-10-19 1996-10-07 Monoclonal antibody br110 and uses thereof

Publications (1)

Publication Number Publication Date
IL123294A0 true IL123294A0 (en) 1998-09-24

Family

ID=21716930

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12329496A IL123294A0 (en) 1995-10-19 1996-10-07 Monoclonal antibody BR110 and uses thereof

Country Status (11)

Country Link
US (1) US5840854A (de)
EP (1) EP0856054B1 (de)
JP (1) JP2001501801A (de)
AT (1) ATE265532T1 (de)
AU (1) AU7394296A (de)
CA (1) CA2235269C (de)
DE (1) DE69632333T2 (de)
ES (1) ES2219699T3 (de)
IL (1) IL123294A0 (de)
NO (1) NO321548B1 (de)
WO (1) WO1997014796A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354587B1 (en) * 1994-07-06 2008-04-08 Immunomedics, Inc. Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6366762B1 (en) * 1999-03-31 2002-04-02 Qualcomm, Inc. System and method for measuring round trip delay on the paging and access channels
US6617432B1 (en) * 1999-10-15 2003-09-09 University Of Pittsburgh Nuclear matrix proteins polynucleotide sequences encoding them and their use
US20030009781A1 (en) * 2001-03-29 2003-01-09 Allen Keith D. Transgenic mice containing Kir3.3 potassium channel gene disruptions
US20020155109A1 (en) * 2001-04-20 2002-10-24 Lynch David H. Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2
US8435529B2 (en) 2002-06-14 2013-05-07 Immunomedics, Inc. Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy
US9745380B2 (en) * 2002-03-01 2017-08-29 Immunomedics, Inc. RS7 antibodies
US9770517B2 (en) * 2002-03-01 2017-09-26 Immunomedics, Inc. Anti-Trop-2 antibody-drug conjugates and uses thereof
WO2003074566A2 (en) 2002-03-01 2003-09-12 Immunomedics, Inc. Rs7 antibodies
US9701754B1 (en) 2002-10-23 2017-07-11 City Of Hope Covalent disulfide-linked diabodies and uses thereof
US20080305104A1 (en) * 2006-02-24 2008-12-11 Young David S F Cytotoxicity mediation of cells evidencing surface expression of TROP-2
US7420040B2 (en) * 2006-02-24 2008-09-02 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of TROP-2
US20080131428A1 (en) * 2006-02-24 2008-06-05 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of TROP-2
US20080213267A1 (en) * 2006-02-24 2008-09-04 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of TROP-2
WO2007109321A2 (en) 2006-03-20 2007-09-27 The Regents Of The University Of California Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
JP4689521B2 (ja) * 2006-04-07 2011-05-25 財団法人電力中央研究所 抗鉛モノクローナル抗体
US8940298B2 (en) 2007-09-04 2015-01-27 The Regents Of The University Of California High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection
EP2398504B1 (de) 2009-02-17 2018-11-28 Cornell Research Foundation, Inc. Verfahren und Kits zur Diagnose von Krebs und Vorhersage des therapeutischen Nutzens
CA2782333C (en) 2009-12-02 2019-06-04 Imaginab, Inc. J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use
MX369106B (es) * 2010-05-17 2019-10-29 Chiome Bioscience Inc Anticuerpo anti trop-2 humano que tiene actividad anti-tumoral in vivo.
JPWO2011155579A1 (ja) * 2010-06-10 2013-08-15 北海道公立大学法人 札幌医科大学 抗Ｔｒｏｐ−２抗体
AU2012335205A1 (en) 2011-11-11 2014-05-29 Rinat Neuroscience Corp. Antibodies specific for Trop-2 and their uses
US9427464B2 (en) 2011-11-22 2016-08-30 Chiome Bioscience Inc. Anti-human TROP-2 antibody having an antitumor activity in vivo
WO2015126548A1 (en) 2014-02-21 2015-08-27 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to trop-2 expressing cells
WO2016172427A1 (en) 2015-04-22 2016-10-27 Immunomedics, Inc. Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
WO2017027325A1 (en) 2015-08-07 2017-02-16 Imaginab, Inc. Antigen binding constructs to target molecules
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
CN113260384A (zh) 2018-11-05 2021-08-13 西纳福克斯股份有限公司 用于靶向表达trop-2的肿瘤的抗体缀合物
KR20230015888A (ko) 2020-03-20 2023-01-31 이뮤노메딕스, 인코오포레이티드 사시투주맙 고비테칸 요법에 대한 바이오마커
TWI889920B (zh) 2020-10-14 2025-07-11 大陸商上海翰森生物醫藥科技有限公司 抗ｔｒｏｐ-２抗體、其抗原結合片段或其突變體、及其醫藥用途
EP4349371A4 (de) 2021-06-02 2025-06-25 Bio-Thera Solutions, Ltd. Arzneimittelkonjugat und verwendung davon
CN118139891A (zh) 2021-09-23 2024-06-04 上海翰森生物医药科技有限公司 抗体药物偶联物及其制备方法和医药用途
KR20250024743A (ko) 2022-03-23 2025-02-19 시나픽스 비.브이. Trop-2를 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트
CN119421724A (zh) 2022-06-27 2025-02-11 百奥泰生物制药股份有限公司 治疗实体瘤的方法
KR20260013515A (ko) 2023-04-24 2026-01-28 머크 샤프 앤드 돔 엘엘씨 Trop2 결합제 및 그의 접합체
AU2024292473A1 (en) 2023-07-19 2026-01-29 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with trop-2 targeting adc

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185254A (en) * 1988-12-29 1993-02-09 The Wistar Institute Gene family of tumor-associated antigens
ES2091824T3 (es) * 1989-04-21 1996-11-16 Us Health Proteina recombinante de fusion toxina anticuerpo.
CA2120507A1 (en) * 1991-10-18 1993-04-29 Alban J. Linnenbach Soluble variants of type 1 membrane proteins, and methods of using them

Also Published As

Publication number Publication date
DE69632333D1 (de) 2004-06-03
JP2001501801A (ja) 2001-02-13
MX9802129A (es) 1998-05-31
NO321548B1 (no) 2006-05-29
WO1997014796A1 (en) 1997-04-24
US5840854A (en) 1998-11-24
ATE265532T1 (de) 2004-05-15
NO981745L (no) 1998-04-17
EP0856054B1 (de) 2004-04-28
AU7394296A (en) 1997-05-07
ES2219699T3 (es) 2004-12-01
CA2235269C (en) 2006-09-19
EP0856054A1 (de) 1998-08-05
CA2235269A1 (en) 1997-04-24
NO981745D0 (no) 1998-04-17
DE69632333T2 (de) 2004-12-30

Similar Documents

Publication Publication Date Title
IL123294A0 (en) Monoclonal antibody BR110 and uses thereof
EP1378525A3 (de) Humanisierte Antikörper die and das gleiche Antigen wie Antikörper NR-LU-13 binden und deren Verwendung in "Pretargeting" Verfahren
AU2001257012A1 (en) Methods for selective targeting
GEP20105118B (en) Anti-vegf antibodies
PT724456E (pt) Anticorpos contra cd4
DE69221147D1 (de) Nicht glycosylierter Anti-CD3-IgG-Antikörper
AU8432498A (en) Human-cd28 specific monoclonal antibodies for antigen non-specific activation oft-lymphocytes
PT973550E (pt) Anticorpos antagonistas anti-integrina avb3
GB2383331A (en) Monoclonal antibody DS6 Tumor-associated antigen CA6 and methods of use thereof
AU688953B2 (en) Determination of a specific immunoglobulin using multiple antigens
CA2442182A1 (en) Modulation of pd-1 interactions with its ligands
WO1999006834A3 (en) Methods for identifying ligand specific binding molecules
IL126314A (en) Monoclonal antibodies having an antigen binding region specific for the extracellular domain of prostate specific membrane antigen (psma)
WO2004025248A3 (en) Antibody pair screening methods
IL162117A0 (en) Humanized collagen antibodies and methods utilizing the same
ATE248859T1 (de) Metallion-ligand koordinationskomplexe, antikorper dagegen und tests die solche antikorper verwenden
CA2348026A1 (en) Antibodies against semp1, methods for their production and uses thereof
WO2005046597A3 (en) Antibodies to cd44 glycoforms and uses thereof
IL108607A0 (en) Preparation of photoprotein conjugates and methods of use thereof
GB2307041B (en) Sheets,kits and methods for detecting antigens or antibodies
EP0781846A3 (de) Treponema palladium Fusions-Antigen, Nachweis für Anti-treponema palladium Antikörpern mit diesen Fusions-Antigenen
DE59608073D1 (de) Antikörper gegen ein, einen histidin-anteil aufweisendes fusionspolypeptid
NO20001051D0 (no) Monoklonale antistoffer som binder testosteron
SE9902155D0 (sv) Serum antibodies
AU2169797A (en) Improved production of antibodies through the use of antigen antibody complexes