IL124364A - 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol -2(3h)- one derivatives, their preparation and pharmaceutical compositions comprising them - Google Patents

5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol -2(3h)- one derivatives, their preparation and pharmaceutical compositions comprising them

Info

Publication number: IL124364A
Authority: IL; Israel
Prior art keywords: oxadiazol; piperidin; phenyl; derivatives; preparation
Prior art date: 1995-11-09

Application number

IL12436496A

Other languages

English (en)

Other versions

IL124364A0 (en

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-09

Filing date

1996-11-05

Publication date

2001-08-08

1995-11-09 Priority claimed from FR9513253A external-priority patent/FR2741070B1/fr

1995-11-09 Priority claimed from FR9513252A external-priority patent/FR2741069B1/fr

1996-03-04 Priority claimed from FR9602663A external-priority patent/FR2745574B1/fr

1996-11-05 Application filed by Synthelabo filed Critical Synthelabo

1998-12-06 Publication of IL124364A0 publication Critical patent/IL124364A0/xx

2001-08-08 Publication of IL124364A publication Critical patent/IL124364A/xx

Links

RJIHZTHWMPTLQL-UHFFFAOYSA-N 5-phenyl-3-piperidin-4-yl-1,3,4-oxadiazol-2-one Chemical class O=C1OC(C=2C=CC=CC=2)=NN1C1CCNCC1 RJIHZTHWMPTLQL-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL12436496A 1995-11-09 1996-11-05 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol -2(3h)- one derivatives, their preparation and pharmaceutical compositions comprising them IL124364A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR9513253A FR2741070B1 (fr)	1995-11-09	1995-11-09	Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
FR9513252A FR2741069B1 (fr)	1995-11-09	1995-11-09	Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
FR9602663A FR2745574B1 (fr)	1996-03-04	1996-03-04	Derives de 5-phenyl-3-(piperidin-4-yl)-1, 3, 4-oxadiazol-2 (3h)-one, leur preparation et leur application en therapeutique
PCT/FR1996/001730 WO1997017345A1 (fr)	1995-11-09	1996-11-05	Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one, utiles comme ligands des recepteurs 5-ht4 ou h¿3?

Publications (2)

Publication Number	Publication Date
IL124364A0 IL124364A0 (en)	1998-12-06
IL124364A true IL124364A (en)	2001-08-08

Family

ID=27253120

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12436496A IL124364A (en)	1995-11-09	1996-11-05	5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol -2(3h)- one derivatives, their preparation and pharmaceutical compositions comprising them

Country Status (29)

Country	Link
US (1)	US5929089A (de)
EP (1)	EP0863897B1 (de)
JP (1)	JP4263240B2 (de)
CN (1)	CN1077891C (de)
AR (1)	AR004708A1 (de)
AT (1)	ATE181328T1 (de)
AU (1)	AU707325B2 (de)
BG (1)	BG63463B1 (de)
BR (1)	BR9611311A (de)
CA (1)	CA2236357C (de)
CO (1)	CO4770968A1 (de)
CZ (1)	CZ287268B6 (de)
DE (1)	DE69602970T2 (de)
EE (1)	EE03487B1 (de)
ES (1)	ES2135934T3 (de)
GR (1)	GR3030823T3 (de)
HU (1)	HUP0001168A3 (de)
IL (1)	IL124364A (de)
MX (1)	MX9803696A (de)
NO (1)	NO309606B1 (de)
NZ (1)	NZ321626A (de)
PL (1)	PL186204B1 (de)
RU (1)	RU2167160C2 (de)
SI (1)	SI0863897T1 (de)
SK (1)	SK282335B6 (de)
TR (1)	TR199800827T2 (de)
TW (1)	TW371303B (de)
UA (1)	UA50748C2 (de)
WO (1)	WO1997017345A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW467902B (en)	1996-07-31	2001-12-11	Bristol Myers Squibb Co	Diphenyl heterocycles as potassium channel modulators
FR2762316B1 (fr) *	1997-04-18	1999-12-17	Sanofi Synthelabo	Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
WO1998050383A1 (fr) *	1997-05-06	1998-11-12	Sanofi-Synthelabo	Derives de 5-phenyl-1,3,4-oxadiazol-2(3h)-one et leur utilisation comme ligands 5-ht4
FR2763068B1 (fr) *	1997-05-06	1999-06-04	Synthelabo	Derives de 3-(pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
GB9715816D0 (en) *	1997-07-25	1997-10-01	Black James Foundation	Histamine H receptor ligands
US6960579B1 (en)	1998-05-19	2005-11-01	Alcon Manufacturing, Ltd.	Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
AU755119B2 (en)	1998-09-18	2002-12-05	Alcon Laboratories, Inc.	Serotonergic 5HT2 agonists for treating glaucoma
WO2000064441A2 (en) *	1999-04-28	2000-11-02	Respiratorius Ab	Compound for use as a medicament for treatment of disorders involving bronchocontraction
CN1355698A (zh) *	1999-06-15	2002-06-26	呼吸器有限公司	可用作治疗有关支气管收缩的机能障碍的药物的化合物
US6638967B2 (en)	2000-08-08	2003-10-28	Ortho-Mcneil Phamraceutical, Inc.	Thiophene of furan pyrrolidine compounds
CA2418369A1 (en)	2000-08-08	2002-02-14	Richard Apodaca	Non-imidazole aryloxyalkylamines as h3 receptor ligands
CZ2003686A3 (cs) *	2000-08-08	2003-08-13	Ortho Mcneil Pharmaceutical, Inc.	Neimidazolové aryloxypiperidiny
US7208497B2 (en)	2001-07-02	2007-04-24	Novo Nordisk A/S	Substituted piperazines and diazepanes
WO2003004480A2 (en)	2001-07-02	2003-01-16	Novo Nordisk A/S	Substituted piperazine and diazepanes as histamine h3 receptor agonists
EP1434765B1 (de) *	2001-09-14	2009-12-02	High Point Pharmaceuticals, LLC	Substituierte piperidinen mit selektiver bindungsfähigkeit zu histamin h3-rezeptoren
US20030186963A1 (en)	2001-09-14	2003-10-02	Dorwald Florencio Zaragoza	Substituted piperidines
US6673829B2 (en)	2001-09-14	2004-01-06	Novo Nordisk A/S	Aminoazetidine,-pyrrolidine and -piperidine derivatives
JP4619655B2 (ja)	2001-09-14	2011-01-26	ハイ・ポイント・ファーマスーティカルズ、エルエルシー	新規アミノアゼチジン、−ピロリジンおよび−ピペリジン誘導体
US7064135B2 (en)	2001-10-12	2006-06-20	Novo Nordisk Inc.	Substituted piperidines
WO2003031432A1 (en)	2001-10-12	2003-04-17	Novo Nordisk A/S	Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor
JP2005511764A (ja)	2001-12-14	2005-04-28	アルコン，インコーポレイテッド	緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物
US20030236259A1 (en) *	2002-02-05	2003-12-25	Rolf Hohlweg	Novel aryl- and heteroarylpiperazines
GB0211230D0 (en) *	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
US7332508B2 (en) *	2002-12-18	2008-02-19	Novo Nordisk A/S	Substituted homopiperidine, piperidine or pyrrolidine derivatives
GB0325956D0 (en) *	2003-11-06	2003-12-10	Addex Pharmaceuticals Sa	Novel compounds
EA200801607A1 (ru)	2004-06-15	2008-10-30	Пфайзер Инк.	Производные бензимидазолонкарбоновой кислоты
US7737163B2 (en)	2004-06-15	2010-06-15	Pfizer Inc.	Benzimidazolone carboxylic acid derivatives
CN103110635A (zh) *	2005-07-04	2013-05-22	海波因特制药有限责任公司	组胺h3受体拮抗剂
DE602006011363D1 (de) *	2005-12-01	2010-02-04	Hoffmann La Roche	Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer
ATE538116T1 (de) *	2006-05-29	2012-01-15	High Point Pharmaceuticals Llc	3-(1,3-benyodioxol-5-yl)-6- (4- cyclopropylpiperazin-1-yl)-pyridazin, dessen salze und solvate und dessen verwendung als histamin-h3-rezeptorantagonist
EP2014656A3 (de)	2007-06-11	2011-08-24	High Point Pharmaceuticals, LLC	Neue heterocyclische H3-Antagonisten
DK2758394T3 (en) *	2011-09-19	2015-04-20	Suven Life Sciences Ltd	HETEROARYL COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5055476A (en) *	1990-08-13	1991-10-08	Hoechst-Roussel Pharmaceuticals Incorporated	3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives
NZ243993A (en) *	1991-08-20	1994-10-26	Smithkline Beecham Plc	Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
ES2135414T3 (es) *	1991-09-12	1999-11-01	Smithkline Beecham Plc	Antagonistas del receptor 5-ht4.
CA2129112A1 (en) *	1992-02-06	1993-08-19	Francis David King	Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
GB9219163D0 (en) *	1992-09-10	1992-10-28	Smithkline Beecham Plc	Pharmaceuticals
JPH06157518A (ja) *	1992-11-27	1994-06-03	Yamanouchi Pharmaceut Co Ltd	新規なオキサジアゾール誘導体又はその塩

1996
- 1996-11-05 JP JP51791797A patent/JP4263240B2/ja not_active Expired - Fee Related
- 1996-11-05 BR BR9611311A patent/BR9611311A/pt not_active IP Right Cessation
- 1996-11-05 TR TR1998/00827T patent/TR199800827T2/xx unknown
- 1996-11-05 SI SI9630092T patent/SI0863897T1/xx not_active IP Right Cessation
- 1996-11-05 AT AT96937390T patent/ATE181328T1/de active
- 1996-11-05 CA CA002236357A patent/CA2236357C/en not_active Expired - Fee Related
- 1996-11-05 EP EP96937390A patent/EP0863897B1/de not_active Expired - Lifetime
- 1996-11-05 EE EE9800155A patent/EE03487B1/xx not_active IP Right Cessation
- 1996-11-05 DE DE69602970T patent/DE69602970T2/de not_active Expired - Lifetime
- 1996-11-05 ES ES96937390T patent/ES2135934T3/es not_active Expired - Lifetime
- 1996-11-05 UA UA98031589A patent/UA50748C2/uk unknown
- 1996-11-05 IL IL12436496A patent/IL124364A/xx not_active IP Right Cessation
- 1996-11-05 AU AU75001/96A patent/AU707325B2/en not_active Ceased
- 1996-11-05 PL PL96326671A patent/PL186204B1/pl not_active IP Right Cessation
- 1996-11-05 HU HU0001168A patent/HUP0001168A3/hu unknown
- 1996-11-05 SK SK599-98A patent/SK282335B6/sk not_active IP Right Cessation
- 1996-11-05 NZ NZ321626A patent/NZ321626A/xx not_active IP Right Cessation
- 1996-11-05 CN CN96198208A patent/CN1077891C/zh not_active Expired - Fee Related
- 1996-11-05 RU RU98110976/04A patent/RU2167160C2/ru not_active IP Right Cessation
- 1996-11-05 US US09/068,390 patent/US5929089A/en not_active Expired - Lifetime
- 1996-11-05 WO PCT/FR1996/001730 patent/WO1997017345A1/fr not_active Ceased
- 1996-11-05 CZ CZ19981421A patent/CZ287268B6/cs not_active IP Right Cessation
- 1996-11-07 TW TW085113594A patent/TW371303B/zh not_active IP Right Cessation
- 1996-11-08 CO CO96059097A patent/CO4770968A1/es unknown
- 1996-11-08 AR ARP960105098A patent/AR004708A1/es active IP Right Grant
1998
- 1998-04-28 BG BG102412A patent/BG63463B1/bg unknown
- 1998-05-07 NO NO982092A patent/NO309606B1/no not_active IP Right Cessation
- 1998-05-08 MX MX9803696A patent/MX9803696A/es unknown
1999
- 1999-07-20 GR GR990401913T patent/GR3030823T3/el unknown

Also Published As

Publication number	Publication date
BG63463B1 (bg)	2002-02-28
AR004708A1 (es)	1999-03-10
TW371303B (en)	1999-10-01
CN1202169A (zh)	1998-12-16
AU7500196A (en)	1997-05-29
PL326671A1 (en)	1998-10-12
US5929089A (en)	1999-07-27
WO1997017345A1 (fr)	1997-05-15
CZ287268B6 (en)	2000-10-11
EE9800155A (et)	1998-12-15
HUP0001168A2 (hu)	2001-04-28
BG102412A (en)	1999-08-31
EP0863897A1 (de)	1998-09-16
JP2000500125A (ja)	2000-01-11
DE69602970D1 (de)	1999-07-22
HK1016165A1 (en)	1999-10-29
ES2135934T3 (es)	1999-11-01
MX9803696A (es)	1998-09-30
SK59998A3 (en)	1998-11-04
CN1077891C (zh)	2002-01-16
IL124364A0 (en)	1998-12-06
JP4263240B2 (ja)	2009-05-13
RU2167160C2 (ru)	2001-05-20
NO309606B1 (no)	2001-02-26
DE69602970T2 (de)	2000-01-20
UA50748C2 (uk)	2002-11-15
CZ142198A3 (cs)	1998-08-12
SI0863897T1 (en)	1999-10-31
NO982092L (no)	1998-06-29
NZ321626A (en)	1998-10-28
HUP0001168A3 (en)	2001-07-30
NO982092D0 (no)	1998-05-07
EE03487B1 (et)	2001-08-15
EP0863897B1 (de)	1999-06-16
BR9611311A (pt)	1999-06-29
PL186204B1 (pl)	2003-11-28
ATE181328T1 (de)	1999-07-15
SK282335B6 (sk)	2002-01-07
GR3030823T3 (en)	1999-11-30
AU707325B2 (en)	1999-07-08
TR199800827T2 (xx)	1999-02-22
CO4770968A1 (es)	1999-04-30
CA2236357C (en)	2006-10-17
CA2236357A1 (en)	1997-05-15

Legal Events

Date	Code	Title
2002-02-10	FF	Patent granted
2003-01-12	KB	Patent renewed
2007-02-12	KB	Patent renewed
2015-06-30	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
HUP0001168A3 (en)	2001-07-30	5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one derivatives for use as 5-ht4 or h3 receptor ligands, process for their preparation and pharmaceuticals containing the same
IL117621A0 (en)	1996-07-23	Pyrido [3,2-e] pyrazinones their preparation and pharmaceutical compositions containing them
NZ304901A (en)	1998-12-23	Taxoid derivatives, preparation thereof and pharmaceutical compositions containing same
IL116917A0 (en)	1996-05-14	Piperidine derivatives and pharmaceutical compositions containing the same
IL119995A0 (en)	1997-04-15	Pyrido-fused thienyl - and furanyl-oxazolidinones their preparation and pharmaceutical compositions containing them
NZ305166A (en)	1998-12-23	5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments
HUP9900346A3 (en)	2000-04-28	Endoparasiticidal pharmaceutical compositions containing avermectines and depsipeptides
HUP0001652A3 (en)	2002-12-28	Oxadiazole derivatives, processes for their preparation, their use and pharmaceutical compositions containing them
HUP9701194A3 (en)	1999-06-28	4-hydroxy-piperidine derivatives, preparation and use thereof, pharmaceutical compositions containing these compounds
IL119559A0 (en)	1997-02-18	Purin -6- one derivatives their preparation and pharmaceutical compositions containing them
IL118410A0 (en)	1996-09-12	Substituted camptothecin derivatives their preparation and pharmaceutical compositions containing them
HUP9801386A3 (en)	2000-03-28	Indazolecarboxamide derivatives, preparation thereof and pharmaceutical compositions containing them
IL117817A0 (en)	1996-08-04	N-subsituted azaheterocyclic compounds their preparation and pharmaceutical compositions containing them
IL117808A0 (en)	1996-08-04	1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-one derivatives their preparation and pharmaceutical compositions containing them
HUP0002650A3 (en)	2002-09-30	4-oxo-3,5-dihydro-4h-pyridazino[4,5-b]-indole-1-acetamide derivatives, process for their preparation and pharmaceutical compositions containing them
HUP9901349A3 (en)	2000-02-28	Oxazolidinone derivatives, their preparation and pharmaceutical compositions containing these compounds
IL117315A (en)	2000-07-26	Prokinetic piperidine substituted oxadiazole derivatives their preparation and pharmaceutical compositions containing them
FR2762316B1 (fr)	1999-12-17	Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
IL122072A0 (en)	1998-03-10	Piperidine derivatives their preparation and pharmaceutical compositions containing them
IL122352A0 (en)	1998-04-05	4-hydroxy-piperidine derivatives their preparation and pharmaceutical compositions containing them
IL123000A (en)	2000-10-31	Aza-anthracylinone derivatives their preparation and pharmaceutical compositions containing them
IL117045A0 (en)	1996-06-18	Substituted 2,3-dihydro-1,4-dioxinopyridines their preparation and pharmaceutical compositions containing them
IL120469A0 (en)	1997-07-13	1, 25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives their preparation and pharmaceutical compositions containing them
IL122542A0 (en)	1998-06-15	Spiro Ú2h-1-benzopyran-2,4'-piperidine¾-4(3h)-one derivatives and pharmaceutical compositions containing them
ZA969418B (en)	1997-06-02	5-Phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol 2(3H)-one derivatives their preparation and their application in therapeutics