IL124792A - Compositions and kits containing bismuth and one or more antimicrobials, for the treatment of gastrointestinal disorders caused or mediated by algae or cyanobacteria - Google Patents

Compositions and kits containing bismuth and one or more antimicrobials, for the treatment of gastrointestinal disorders caused or mediated by algae or cyanobacteria

Info

Publication number: IL124792A
Authority: IL; Israel
Prior art keywords: bismuth; milligrams; antimicrobials; administration; days
Prior art date: 1995-12-07

Application number

IL12479296A

Other languages

English (en)

Other versions

IL124792A0 (en

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-07

Filing date

1996-11-22

Publication date

2004-01-04

1996-11-22 Application filed by Procter & Gamble filed Critical Procter & Gamble

1999-01-26 Publication of IL124792A0 publication Critical patent/IL124792A0/xx

2004-01-04 Publication of IL124792A publication Critical patent/IL124792A/en

Links

229910052797 bismuth Inorganic materials 0.000 title claims abstract description 65
JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 title claims abstract description 65
239000004599 antimicrobial Substances 0.000 title claims abstract description 47
239000000203 mixture Substances 0.000 title claims abstract description 37
241000195493 Cryptophyta Species 0.000 title claims abstract description 29
208000018522 Gastrointestinal disease Diseases 0.000 title claims abstract description 27
241000192700 Cyanobacteria Species 0.000 title claims abstract description 26
238000011282 treatment Methods 0.000 title claims abstract description 23
230000001404 mediated effect Effects 0.000 title claims abstract description 16
208000010643 digestive system disease Diseases 0.000 claims abstract description 15
208000018685 gastrointestinal system disease Diseases 0.000 claims abstract description 15
230000000845 anti-microbial effect Effects 0.000 claims description 20
ZREIPSZUJIFJNP-UHFFFAOYSA-K bismuth subsalicylate Chemical compound C1=CC=C2O[Bi](O)OC(=O)C2=C1 ZREIPSZUJIFJNP-UHFFFAOYSA-K 0.000 claims description 8
229960000782 bismuth subsalicylate Drugs 0.000 claims description 8
239000004098 Tetracycline Substances 0.000 claims description 7
229960000282 metronidazole Drugs 0.000 claims description 7
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 7
235000019364 tetracycline Nutrition 0.000 claims description 7
150000003522 tetracyclines Chemical class 0.000 claims description 7
KKMOSYLWYLMHAL-UHFFFAOYSA-N 2-bromo-6-nitroaniline Chemical compound NC1=C(Br)C=CC=C1[N+]([O-])=O KKMOSYLWYLMHAL-UHFFFAOYSA-N 0.000 claims description 6
229930182555 Penicillin Natural products 0.000 claims description 6
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 6
229960003159 atovaquone Drugs 0.000 claims description 6
KUCQYCKVKVOKAY-CTYIDZIISA-N atovaquone Chemical compound C1([C@H]2CC[C@@H](CC2)C2=C(C(C3=CC=CC=C3C2=O)=O)O)=CC=C(Cl)C=C1 KUCQYCKVKVOKAY-CTYIDZIISA-N 0.000 claims description 6
SULICOHAQXOMED-YDXPQRMKSA-H dibismuth;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Bi+3].[Bi+3].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O.[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O.[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O SULICOHAQXOMED-YDXPQRMKSA-H 0.000 claims description 6
239000002552 dosage form Substances 0.000 claims description 6
229960000564 nitrofurantoin Drugs 0.000 claims description 6
NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 claims description 6
150000001622 bismuth compounds Chemical class 0.000 claims description 5
229960002180 tetracycline Drugs 0.000 claims description 5
229930101283 tetracycline Natural products 0.000 claims description 5
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 4
241000192710 Microcystis aeruginosa Species 0.000 claims description 4
229940104825 bismuth aluminate Drugs 0.000 claims description 4
229960003722 doxycycline Drugs 0.000 claims description 4
PDSAKIXGSONUIX-UHFFFAOYSA-N hexaaluminum;dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Bi+3].[Bi+3] PDSAKIXGSONUIX-UHFFFAOYSA-N 0.000 claims description 4
229940049954 penicillin Drugs 0.000 claims description 4
229910000014 Bismuth subcarbonate Inorganic materials 0.000 claims description 3
241000195649 Chlorella <Chlorellales> Species 0.000 claims description 3
HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims description 3
229960003022 amoxicillin Drugs 0.000 claims description 3
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 3
229960000723 ampicillin Drugs 0.000 claims description 3
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 3
MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 claims description 3
229940036358 bismuth subcarbonate Drugs 0.000 claims description 3
229960004645 bismuth subcitrate Drugs 0.000 claims description 3
ZQUAVILLCXTKTF-UHFFFAOYSA-H bismuth;tripotassium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [K+].[K+].[K+].[Bi+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O ZQUAVILLCXTKTF-UHFFFAOYSA-H 0.000 claims description 3
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 3
229960005053 tinidazole Drugs 0.000 claims description 3
-1 ampiciUin Chemical compound 0.000 claims 2
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244000085413 Aphanizomenon flos aquae Species 0.000 claims 1
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241000192117 Trichodesmium erythraeum Species 0.000 claims 1
229940054349 aphanizomenon flos-aquae Drugs 0.000 claims 1
238000000034 method Methods 0.000 abstract description 25
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150000001621 bismuth Chemical class 0.000 description 7
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ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 6
239000003795 chemical substances by application Substances 0.000 description 6
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FUBFWTUFPGFHOJ-UHFFFAOYSA-N 2-nitrofuran Chemical class [O-][N+](=O)C1=CC=CO1 FUBFWTUFPGFHOJ-UHFFFAOYSA-N 0.000 description 2
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MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
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UXZFQZANDVDGMM-UHFFFAOYSA-N iodoquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(I)C2=C1 UXZFQZANDVDGMM-UHFFFAOYSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
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WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
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AEUAEICGCMSYCQ-UHFFFAOYSA-N 4-n-(7-chloroquinolin-1-ium-4-yl)-1-n,1-n-diethylpentane-1,4-diamine;dihydrogen phosphate Chemical compound OP(O)(O)=O.ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 AEUAEICGCMSYCQ-UHFFFAOYSA-N 0.000 description 1
GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 description 1
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CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
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229960001699 ofloxacin Drugs 0.000 description 1
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IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
235000019366 oxytetracycline Nutrition 0.000 description 1
229940056360 penicillin g Drugs 0.000 description 1
229940056367 penicillin v Drugs 0.000 description 1
230000035699 permeability Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000029553 photosynthesis Effects 0.000 description 1
238000010672 photosynthesis Methods 0.000 description 1
230000004260 plant-type cell wall biogenesis Effects 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
238000001243 protein synthesis Methods 0.000 description 1
208000028172 protozoa infectious disease Diseases 0.000 description 1
238000000746 purification Methods 0.000 description 1
GPKJTRJOBQGKQK-UHFFFAOYSA-N quinacrine Chemical compound C1=C(OC)C=C2C(NC(C)CCCN(CC)CC)=C(C=CC(Cl)=C3)C3=NC2=C1 GPKJTRJOBQGKQK-UHFFFAOYSA-N 0.000 description 1
229960001225 rifampicin Drugs 0.000 description 1
JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
235000012045 salad Nutrition 0.000 description 1
235000014102 seafood Nutrition 0.000 description 1
235000015170 shellfish Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
241000894007 species Species 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
239000000126 substance Substances 0.000 description 1
229960005404 sulfamethoxazole Drugs 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
230000014616 translation Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
229960001082 trimethoprim Drugs 0.000 description 1
VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
235000003563 vegetarian diet Nutrition 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
230000004580 weight loss Effects 0.000 description 1
208000016261 weight loss Diseases 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL12479296A 1995-12-07 1996-11-22 Compositions and kits containing bismuth and one or more antimicrobials, for the treatment of gastrointestinal disorders caused or mediated by algae or cyanobacteria IL124792A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/569,029 US5744168A (en)	1995-12-07	1995-12-07	Methods and compositions for the prevention and treatment of gastrointestinal disorders
PCT/US1996/018652 WO1997020565A1 (en)	1995-12-07	1996-11-22	Compositions, containing bismuth and one or more antimicrobials, for the prevention and treatment of gastrointestinal disorders

Publications (2)

Publication Number	Publication Date
IL124792A0 IL124792A0 (en)	1999-01-26
IL124792A true IL124792A (en)	2004-01-04

Family

ID=24273803

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12479296A IL124792A (en)	1995-12-07	1996-11-22	Compositions and kits containing bismuth and one or more antimicrobials, for the treatment of gastrointestinal disorders caused or mediated by algae or cyanobacteria

Country Status (17)

Country	Link
US (1)	US5744168A (de)
EP (1)	EP0865284B1 (de)
AT (1)	ATE231726T1 (de)
BR (1)	BR9612123A (de)
CA (1)	CA2239423C (de)
CO (1)	CO4940459A1 (de)
DE (1)	DE69626036T2 (de)
DK (1)	DK0865284T3 (de)
ES (1)	ES2191776T3 (de)
IL (1)	IL124792A (de)
MX (1)	MX9804577A (de)
MY (1)	MY113635A (de)
NO (1)	NO319386B1 (de)
PT (1)	PT865284E (de)
TR (1)	TR199801024T2 (de)
TW (1)	TW445143B (de)
WO (1)	WO1997020565A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9224739D0 (en) *	1992-11-26	1993-01-13	Wellcome Found	Medicaments
ES2346955T3 (es) *	2001-08-08	2010-10-22	Btg International Limited	Espuma inyectable y aplicaciones farmaceuticas novedosas de la misma.
FR2962684B1 (fr)	2010-07-13	2012-08-24	Oberthur Technologies	Procede de realisation d'un motif sur un support avec une encre de securite

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR962163A (de) *		1950-06-02
US4049817A (en) *	1972-08-14	1977-09-20	Sandoz Ltd.	Synergistic compositions
US4514421A (en) *	1979-08-30	1985-04-30	Herschler R J	Dietary and pharmaceutical uses of methylsulfonylmethane and compositions comprising it
EP0222834A4 (de) *	1985-04-18	1989-10-04	Borody Thomas J	Behandlung von nichtulcerativer dyspepsia mit wismutsalzen.
DE3686836T2 (de) *	1985-06-13	1993-03-04	Marshall Barry James	Zusammensetzungen zur behandlung von magen-darmstoerungen.
US5256684A (en) *	1985-06-13	1993-10-26	The Procter & Gamble Company	Methods and compositions for the treatment of gastrointestinal disorders
JPS63174926A (ja) *	1987-01-09	1988-07-19	Nitto Kasei Kk	家禽用抗コクシジウム剤
IL85472A (en) *	1987-03-09	1991-06-30	Procter & Gamble	Pharmaceutical compositions for treating gastrointestinal disorders
DE3887353T2 (de) *	1987-10-12	1994-05-05	Capability Services Pty Ltd	Behandlungsverfahren für magen-darm-krankheiten.
EP0375068A1 (de) *	1988-12-23	1990-06-27	Gist-Brocades N.V.	Mischungen von Bismuth-Verbindungen und Tetracyclinen
US5221664A (en) *	1990-04-23	1993-06-22	Magainin Pharmaaceuticals Inc.	Composition and treatment with biologically active peptides and toxic cations
DE69117955T2 (de) *	1990-07-20	1996-09-19	Tillotts Pharma Ag, Ziefen	Produkte und verfahren zur behandlung des verdauungskanals
EP0624373B1 (de) *	1993-05-11	1999-09-08	Spirig Ag Pharmazeutische Präparate	Festes bismut- und amoxycillinhaltiges Arzneipräparat und seine Verwendung
AUPM596894A0 (en) *	1994-05-30	1994-06-23	Hybrid Scientific Pty Ltd	Composition for treating gastrointestinal disorders - a combination of bismuth salts plus lactobacillus or bifidobacteria species bacteria for treating gastrointestinal disorders

1995
- 1995-12-07 US US08/569,029 patent/US5744168A/en not_active Expired - Fee Related
1996
- 1996-11-22 ES ES96940568T patent/ES2191776T3/es not_active Expired - Lifetime
- 1996-11-22 DE DE69626036T patent/DE69626036T2/de not_active Expired - Fee Related
- 1996-11-22 WO PCT/US1996/018652 patent/WO1997020565A1/en not_active Ceased
- 1996-11-22 PT PT96940568T patent/PT865284E/pt unknown
- 1996-11-22 IL IL12479296A patent/IL124792A/en not_active IP Right Cessation
- 1996-11-22 TR TR1998/01024T patent/TR199801024T2/xx unknown
- 1996-11-22 AT AT96940568T patent/ATE231726T1/de not_active IP Right Cessation
- 1996-11-22 EP EP96940568A patent/EP0865284B1/de not_active Expired - Lifetime
- 1996-11-22 BR BR9612123A patent/BR9612123A/pt not_active Application Discontinuation
- 1996-11-22 DK DK96940568T patent/DK0865284T3/da active
- 1996-11-22 CA CA002239423A patent/CA2239423C/en not_active Expired - Fee Related
- 1996-12-04 CO CO96063581A patent/CO4940459A1/es unknown
- 1996-12-07 MY MYPI96005154A patent/MY113635A/en unknown
- 1996-12-26 TW TW085116051A patent/TW445143B/zh active
1998
- 1998-06-08 NO NO19982635A patent/NO319386B1/no unknown
- 1998-06-08 MX MX9804577A patent/MX9804577A/es unknown

Also Published As

Publication number	Publication date
NO982635L (no)	1998-08-04
US5744168A (en)	1998-04-28
CO4940459A1 (es)	2000-07-24
MY113635A (en)	2002-04-30
CA2239423C (en)	2003-04-01
TR199801024T2 (xx)	1998-09-21
CA2239423A1 (en)	1997-06-12
NO982635D0 (no)	1998-06-08
ES2191776T3 (es)	2003-09-16
BR9612123A (pt)	1999-02-17
NO319386B1 (no)	2005-08-08
TW445143B (en)	2001-07-11
EP0865284A1 (de)	1998-09-23
WO1997020565A1 (en)	1997-06-12
IL124792A0 (en)	1999-01-26
PT865284E (pt)	2003-06-30
DE69626036D1 (de)	2003-03-06
ATE231726T1 (de)	2003-02-15
DK0865284T3 (da)	2003-05-19
DE69626036T2 (de)	2004-01-22
EP0865284B1 (de)	2003-01-29
MX9804577A (es)	1998-10-31

Legal Events

Date	Code	Title
2004-06-01	FF	Patent granted
2004-06-20	KB	Patent renewed
2007-07-24	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
DE3650787T2 (de)	2006-11-16	Pharmazeutische Zusammensetzung zur Behandlung gastrointestinaler Beschwerden, die Wismut und ein antimikrobielles Mittel enthält
CA2108455C (en)	1999-01-19	Pharmaceutical compositions against gastric disorders
AU590578B2 (en)	1989-11-09	Treatment of non-ulcer dyspepsia with bismuth salts
JP2001526179A (ja)	2001-12-18	金属／チオール殺生剤
JPH09241173A (ja)	1997-09-16	乳酸菌を有効成分とする抗胃炎剤、抗潰瘍剤および醗酵食品
CA2127987C (en)	2002-08-13	Pharmaceutical bacteriocin compositions
KR0145553B1 (ko)	1998-08-17	클로스트리듐 디피실레 하리증 및 위막성 대장염의 예방 및 치료용 의약조성물
US5866150A (en)	1999-02-02	Antibacterially active extracts from the marine algae chaetoceros and methods of use
US5744168A (en)	1998-04-28	Methods and compositions for the prevention and treatment of gastrointestinal disorders
CA2136936A1 (en)	1995-05-31	Moenomycin and its derivatives for the production of pharmaceuticals, and pharmaceuticals containing moenomycin or its derivatives
EP0865287B1 (de)	2002-02-27	Bismut enthaltende zusammensetzungen zur verhütung und behandlung gastrointestinaler beschwerden
Nusbaum et al.	1981	Action of selected antibiotics on four common bacteria associated with diseases of fish
FR2472389A1 (fr)	1981-07-03	Compositions antibiotiques contenant un macrolide et un aminoheteroside
FR2550707A1 (fr)	1985-02-22	Medicament immunomodulateur d'origine biologique et son procede de preparation
WO1996035436A1 (en)	1996-11-14	Compositions comprising bismuth and one or more antimicrobials, for the treatment and prevention of gastrointestinal disorders
Andersen et al.	1980	Pivmecillinam in the treatment of therapy resistant urinary tract infections: A comparison with pivmecillinam, pivampicillin and their combination
CA2239420C (en)	2003-03-18	Compositions, comprising bismuth and one or more antimicrobials, for the prevention and treatment of gastrointestinal disorders
AU6415698A (en)	1999-10-18	The process for the preparation of a stable fixed dose pharmaceutical composition of anti infective agent/agents and micro organisms as active ingredients
Goodwin et al.	1988	Differences between in vitro and in vivo sensitivity of Campylobacter pylori to antibacterials
KR20010077797A (ko)	2001-08-20	위장 질환 개선을 위한 천연 항균물질 조성물
Craven	1995	Salmonella typhimurium, hydrophobic antibiotics, and the intestinal colonization of broiler chicks
Gordon et al.	1980	Ampicillin-gentamicin synergism against Listeria monocytogenes in vitro
JPH0840924A (ja)	1996-02-13	抗菌性薬剤の増強剤
Hughes	1979	Antibiotic treatment of chronic bronchitis
Kırmusaoğlu et al.	2007	Effects of fermented sumach on the formation of slime layer of staphylococcus aureus