IL126581A - Biosensor for detecting a binding event between a ligand and ligand-binding receptor - Google Patents

Biosensor for detecting a binding event between a ligand and ligand-binding receptor

Info

Publication number: IL126581A
Authority: IL; Israel
Prior art keywords: ligand; monolayer; receptor; binding; chains
Prior art date: 1996-04-25

Application number

IL12658197A

Other languages

English (en)

Other versions

IL126581A0 (en

Original Assignee

Pence Inc

Univ Mcgill

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-25

Filing date

1997-04-25

Publication date

2004-03-28

1997-04-25 Application filed by Pence Inc, Univ Mcgill filed Critical Pence Inc

1999-08-17 Publication of IL126581A0 publication Critical patent/IL126581A0/xx

2004-03-28 Publication of IL126581A publication Critical patent/IL126581A/en

Links

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GJBXIPOYHVMPQJ-UHFFFAOYSA-N hexadecane-1,16-diol Chemical compound OCCCCCCCCCCCCCCCCO GJBXIPOYHVMPQJ-UHFFFAOYSA-N 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
239000000710 homodimer Substances 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
125000002883 imidazolyl group Chemical group 0.000 description 1
238000003119 immunoblot Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
125000003010 ionic group Chemical group 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
238000002955 isolation Methods 0.000 description 1
125000003473 lipid group Chemical group 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
230000004001 molecular interaction Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
239000012811 non-conductive material Substances 0.000 description 1
238000003199 nucleic acid amplification method Methods 0.000 description 1
238000010915 one-step procedure Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000000863 peptide conjugate Substances 0.000 description 1
239000000813 peptide hormone Substances 0.000 description 1
108010011903 peptide receptors Proteins 0.000 description 1
102000014187 peptide receptors Human genes 0.000 description 1
VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
229920006254 polymer film Polymers 0.000 description 1
229960003548 polymyxin b sulfate Drugs 0.000 description 1
ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
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UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000010188 recombinant method Methods 0.000 description 1
238000006479 redox reaction Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000027756 respiratory electron transport chain Effects 0.000 description 1
229910052707 ruthenium Inorganic materials 0.000 description 1
108010038196 saccharide-binding proteins Proteins 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
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150000007970 thio esters Chemical class 0.000 description 1
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238000000108 ultra-filtration Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
- C12Q1/003—Functionalisation
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Organic Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Zoology (AREA)
Food Science & Technology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Peptides Or Proteins (AREA)

IL12658197A 1996-04-25 1997-04-25 Biosensor for detecting a binding event between a ligand and ligand-binding receptor IL126581A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US1638596P	1996-04-25	1996-04-25
US1638496P	1996-04-25	1996-04-25
US1619696P	1996-04-25	1996-04-25
PCT/CA1997/000276 WO1997041425A1 (en)	1996-04-25	1997-04-25	Biosensor device and method

Publications (2)

Publication Number	Publication Date
IL126581A0 IL126581A0 (en)	1999-08-17
IL126581A true IL126581A (en)	2004-03-28

Family

ID=27360510

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12658197A IL126581A (en)	1996-04-25	1997-04-25	Biosensor for detecting a binding event between a ligand and ligand-binding receptor

Country Status (9)

Country	Link
EP (1)	EP1005644B1 (de)
JP (1)	JP2000510233A (de)
AT (1)	ATE234462T1 (de)
AU (1)	AU711861B2 (de)
CA (1)	CA2251674C (de)
DE (1)	DE69719817T2 (de)
DK (1)	DK1005644T3 (de)
IL (1)	IL126581A (de)
WO (1)	WO1997041425A1 (de)

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1997
- 1997-04-25 WO PCT/CA1997/000276 patent/WO1997041425A1/en not_active Ceased
- 1997-04-25 CA CA002251674A patent/CA2251674C/en not_active Expired - Fee Related
- 1997-04-25 AU AU25639/97A patent/AU711861B2/en not_active Ceased
- 1997-04-25 AT AT97917195T patent/ATE234462T1/de not_active IP Right Cessation
- 1997-04-25 IL IL12658197A patent/IL126581A/en not_active IP Right Cessation
- 1997-04-25 JP JP09538422A patent/JP2000510233A/ja active Pending
- 1997-04-25 EP EP97917195A patent/EP1005644B1/de not_active Expired - Lifetime
- 1997-04-25 DE DE69719817T patent/DE69719817T2/de not_active Expired - Fee Related
- 1997-04-25 DK DK97917195T patent/DK1005644T3/da active

Also Published As

Publication number	Publication date
EP1005644B1 (de)	2003-03-12
WO1997041425A1 (en)	1997-11-06
AU711861B2 (en)	1999-10-21
DK1005644T3 (da)	2003-06-23
EP1005644A1 (de)	2000-06-07
IL126581A0 (en)	1999-08-17
AU2563997A (en)	1997-11-19
CA2251674C (en)	2004-12-14
DE69719817D1 (de)	2003-04-17
JP2000510233A (ja)	2000-08-08
CA2251674A1 (en)	1997-11-06
ATE234462T1 (de)	2003-03-15
DE69719817T2 (de)	2003-12-24

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