IL126593A - Process for preparing benzoic acid derivative intermediates - Google Patents

Process for preparing benzoic acid derivative intermediates

Info

Publication number: IL126593A
Authority: IL; Israel
Prior art keywords: compound; formula; product; chem; alkyl
Prior art date: 1994-08-31

Application number

IL12659395A

Other languages

English (en)

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-31

Filing date

1995-08-28

Publication date

2000-08-31

1995-08-28 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2000-08-31 Publication of IL126593A publication Critical patent/IL126593A/xx

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
IOHPVZBSOKLVMN-UHFFFAOYSA-N 2-(2-phenylethyl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1CCC1=CC=CC=C1 IOHPVZBSOKLVMN-UHFFFAOYSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 8
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 6
239000000047 product Substances 0.000 abstract 6
ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 4
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 4
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 4
PXHHIBMOFPCBJQ-UHFFFAOYSA-N 1,2-dimethylpyrrolidine Chemical compound CC1CCCN1C PXHHIBMOFPCBJQ-UHFFFAOYSA-N 0.000 abstract 2
AVFZOVWCLRSYKC-UHFFFAOYSA-N 1-methylpyrrolidine Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 abstract 2
FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 abstract 2
KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 abstract 2
AHVYPIQETPWLSZ-UHFFFAOYSA-N N-methyl-pyrrolidine Natural products CN1CC=CC1 AHVYPIQETPWLSZ-UHFFFAOYSA-N 0.000 abstract 2
238000009835 boiling Methods 0.000 abstract 2
239000003054 catalyst Substances 0.000 abstract 2
239000007795 chemical reaction product Substances 0.000 abstract 2
238000009833 condensation Methods 0.000 abstract 2
230000005494 condensation Effects 0.000 abstract 2
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
-1 methylpyrrolidino, dimethylpyrrolidino, morpholino, dimethylamino, diethylamino Chemical group 0.000 abstract 2
125000003386 piperidinyl group Chemical group 0.000 abstract 2
RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 abstract 2
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Physical Education & Sports Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Cephalosporin Compounds (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

IL12659395A 1994-08-31 1995-08-28 Process for preparing benzoic acid derivative intermediates IL126593A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/298,891 US5731436A (en)	1994-08-31	1994-08-31	Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
IL11509195A IL115091A (en)	1994-08-31	1995-08-28	Process for preparing benzothiophene pharmaceutical agents

Publications (1)

Publication Number	Publication Date
IL126593A true IL126593A (en)	2000-08-31

Family

ID=23152424

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL12659395A IL126593A (en)	1994-08-31	1995-08-28	Process for preparing benzoic acid derivative intermediates
IL11509195A IL115091A (en)	1994-08-31	1995-08-28	Process for preparing benzothiophene pharmaceutical agents
IL12659398A IL126593A0 (en)	1994-08-31	1995-08-28	Process for preparing benzoic acid derivative intermediates

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL11509195A IL115091A (en)	1994-08-31	1995-08-28	Process for preparing benzothiophene pharmaceutical agents
IL12659398A IL126593A0 (en)	1994-08-31	1995-08-28	Process for preparing benzoic acid derivative intermediates

Country Status (15)

Country	Link
US (2)	US5731436A (de)
EP (1)	EP0699673B1 (de)
JP (1)	JPH08119912A (de)
KR (1)	KR960007544A (de)
AT (1)	ATE165356T1 (de)
BR (1)	BR9503847A (de)
CA (1)	CA2157235A1 (de)
DE (1)	DE69502153T2 (de)
DK (1)	DK0699673T3 (de)
ES (1)	ES2114722T3 (de)
FI (1)	FI954068A7 (de)
GR (1)	GR3026743T3 (de)
HU (1)	HUT73136A (de)
IL (3)	IL126593A (de)
TW (1)	TW368497B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en)	1993-01-28	1998-09-22	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en)	1993-05-13	2001-06-26	Neorx Corporation	Prevention and treatment of cardiovascular pathologies
US6491938B2 (en)	1993-05-13	2002-12-10	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
US5731436A (en) *	1994-08-31	1998-03-24	Eli Lilly And Company	Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
CA2213810C (en) *	1996-08-29	2006-06-06	Lewis Dale Pennington	Benzo¬b\|thiophene compounds, intermediates, processes, compositions and methods
US5948796A (en) *	1996-10-10	1999-09-07	Eli Lilly And Company	Benzo B!thiophene compounds, intermediates, formulations, and methods
AU6959898A (en)	1997-04-11	1998-11-11	David J. Grainger	Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
US6017914A (en) *	1997-09-03	2000-01-25	Eli Lilly And Company	Benzo[b]thiophene compounds, intermediates, formulations, and methods
FR2817865B1 (fr) *	2000-12-11	2005-02-18	Sanofi Synthelabo	Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
AU2003266940B2 (en)	2002-09-30	2007-02-08	A/S Gea Farmaceutisk Fabrik	Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
JP5603019B2 (ja) *	2008-03-26	2014-10-08	帝人株式会社	植物由来成分を有するポリエステルおよびその製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3864501A (en) *	1973-10-10	1975-02-04	Us Agriculture	Method of enhancing coloration of fruits and vegetables with a dialhylamino-alkoxybenzene
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
IL65379A0 (en) *	1981-04-03	1982-05-31	Lilly Co Eli	Process for preparing acylated benzothiophenes
US4380635A (en) *	1981-04-03	1983-04-19	Eli Lilly And Company	Synthesis of acylated benzothiophenes
WO1989003819A1 (fr) *	1987-10-20	1989-05-05	Otsuka Pharmaceutical Co., Ltd.	Derives d'acide phenylcarboxylique
JPH02101048A (ja) *	1988-10-07	1990-04-12	Fuji Photo Film Co Ltd	サリチル酸誘導体の製造方法
US5731436A (en) *	1994-08-31	1998-03-24	Eli Lilly And Company	Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

1994
- 1994-08-31 US US08/298,891 patent/US5731436A/en not_active Expired - Lifetime
1995
- 1995-08-28 IL IL12659395A patent/IL126593A/xx active IP Right Grant
- 1995-08-28 IL IL11509195A patent/IL115091A/xx active IP Right Grant
- 1995-08-28 IL IL12659398A patent/IL126593A0/xx unknown
- 1995-08-30 ES ES95306053T patent/ES2114722T3/es not_active Expired - Lifetime
- 1995-08-30 CA CA002157235A patent/CA2157235A1/en not_active Abandoned
- 1995-08-30 TW TW084109068A patent/TW368497B/zh active
- 1995-08-30 KR KR1019950027530A patent/KR960007544A/ko not_active Ceased
- 1995-08-30 DE DE69502153T patent/DE69502153T2/de not_active Expired - Fee Related
- 1995-08-30 AT AT95306053T patent/ATE165356T1/de not_active IP Right Cessation
- 1995-08-30 DK DK95306053T patent/DK0699673T3/da active
- 1995-08-30 FI FI954068A patent/FI954068A7/fi unknown
- 1995-08-30 HU HU9502539A patent/HUT73136A/hu unknown
- 1995-08-30 EP EP95306053A patent/EP0699673B1/de not_active Expired - Lifetime
- 1995-08-30 BR BR9503847A patent/BR9503847A/pt not_active Application Discontinuation
- 1995-08-31 JP JP7223184A patent/JPH08119912A/ja not_active Withdrawn
1998
- 1998-01-30 US US09/016,761 patent/US5955608A/en not_active Expired - Lifetime
- 1998-04-28 GR GR980400936T patent/GR3026743T3/el unknown

Also Published As

Publication number	Publication date
IL115091A0 (en)	1995-12-08
BR9503847A (pt)	1996-09-17
EP0699673B1 (de)	1998-04-22
KR960007544A (ko)	1996-03-22
EP0699673A1 (de)	1996-03-06
FI954068A7 (fi)	1996-03-01
DE69502153D1 (de)	1998-05-28
US5731436A (en)	1998-03-24
JPH08119912A (ja)	1996-05-14
IL126593A0 (en)	1999-08-17
HUT73136A (en)	1996-06-28
HU9502539D0 (en)	1995-10-30
DK0699673T3 (da)	1998-10-07
DE69502153T2 (de)	1998-09-17
IL115091A (en)	2000-08-31
CA2157235A1 (en)	1996-03-01
US5955608A (en)	1999-09-21
FI954068A0 (fi)	1995-08-30
TW368497B (en)	1999-09-01
ATE165356T1 (de)	1998-05-15
GR3026743T3 (en)	1998-07-31
ES2114722T3 (es)	1998-06-01

Legal Events

Date	Code	Title	Description
2001-01-11	FF	Patent granted

Publication	Publication Date	Title
IL126593A (en)	2000-08-31	Process for preparing benzoic acid derivative intermediates
HU0003473D0 (de)	1995-08-30
HU209788B (en)	1994-11-28	Process for preparing n-alkyl-carbamides
US4217366A (en)	1980-08-12	Pharmaceutically active 2-(4-aminobutoxy)stilbenes
HU209723B (en)	1994-10-28	Process for producing of piperazine derivatives
US4134889A (en)	1979-01-16	Manufacture of glycinonitriles
US4284637A (en)	1981-08-18	Pharmaceutically active 2-(4-aminobutoxy)stilbenes
IE48915B1 (en)	1985-06-12	Aminoalkoxyphenylpyrrolidones,process for their manufacture and their use
HU219493B (hu)	2001-04-28	Alkil-trazodon-származékok előállítására alkalmazható piperazinszármazékok és eljárás előállításukra
AU737994B2 (en)	2001-09-06	Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
Reddy et al.	1993	Unique zeolite-catalyzed synthesis of nitroketene S, N-acetals
CA1080219A (en)	1980-06-24	Piperazine derivatives and a process for the preparation thereof
US6794543B2 (en)	2004-09-21	Method for producing arylpoly(oxalkyl)-benzyldimethyl-ammonium derivatives
US5118682A (en)	1992-06-02	P-hydroxy phenone derivatives and the use thereof
GB2135994A (en)	1984-09-12	Process for the preparation of basic oxime ethers
US4873343A (en)	1989-10-10	Process for the preparation of N-(2-chlorobenzyl)-2-(2-thienyl) ethylamine
IL22567A (en)	1968-10-24	New thiepin and oxepin derivatives and a process for their production
HU189227B (en)	1986-06-30	Process for preparing basic oxime-ethers
US3095425A (en)	1963-06-25	Alkanoylthiaxanthenes and-xanthenes
US4709026A (en)	1987-11-24	Ketosultams
US2980672A (en)	1961-04-18	Phenothiazine tfflocarboxyiates
EP0170583B1 (de)	1988-06-15	Ammoniumsalze von Hexahydrodibenzodioxan-Derivaten, deren Zwischenprodukte, deren Herstellung und deren Verwendung in Arzneimitteln
US5922874A (en)	1999-07-13	Process for preparing N-aryl-N'-alkyl-piperazines
WO2001032641A1 (en)	2001-05-10	Process for preparing piperazine-substituted aliphatic carboxylates
NO167974B (no)	1991-09-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive aminopropanolderivater av 3-(2-hydroksyfenyl)-1-propanonforbindelser.