IL126998A - Potassium, sodium or tris oxaprozin salt pharmaceutical formulations - Google Patents

Potassium, sodium or tris oxaprozin salt pharmaceutical formulations

Info

Publication number: IL126998A
Authority: IL; Israel
Prior art keywords: sodium; potassium; pharmaceutical formulations; salt pharmaceutical; tris
Prior art date: 1996-05-20

Application number

IL12699897A

Other languages

English (en)

Other versions

IL126998A0 (en

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-20

Filing date

1997-05-14

Publication date

2003-12-10

1997-05-14 Application filed by Searle & Co filed Critical Searle & Co

1999-09-22 Publication of IL126998A0 publication Critical patent/IL126998A0/xx

2003-12-10 Publication of IL126998A publication Critical patent/IL126998A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title abstract 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 title abstract 2
OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical class O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 title abstract 2
229910052700 potassium Inorganic materials 0.000 title abstract 2
239000011591 potassium Substances 0.000 title abstract 2
229910052708 sodium Inorganic materials 0.000 title abstract 2
239000011734 sodium Substances 0.000 title abstract 2
239000007983 Tris buffer Substances 0.000 title 1
206010061218 Inflammation Diseases 0.000 abstract 2
230000004054 inflammatory process Effects 0.000 abstract 2
239000013543 active substance Substances 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
201000008482 osteoarthritis Diseases 0.000 abstract 1
229960002739 oxaprozin Drugs 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

IL12699897A 1996-05-20 1997-05-14 Potassium, sodium or tris oxaprozin salt pharmaceutical formulations IL126998A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1903396P	1996-05-20	1996-05-20
PCT/US1997/007637 WO1997044022A1 (en)	1996-05-20	1997-05-14	Potassium, sodium and tris oxaprozin salt pharmaceutical formulations

Publications (2)

Publication Number	Publication Date
IL126998A0 IL126998A0 (en)	1999-09-22
IL126998A true IL126998A (en)	2003-12-10

Family

ID=21791076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12699897A IL126998A (en)	1996-05-20	1997-05-14	Potassium, sodium or tris oxaprozin salt pharmaceutical formulations

Country Status (20)

Country	Link
US (1)	US6030643A (de)
EP (1)	EP0901372B1 (de)
JP (1)	JP4185974B2 (de)
KR (1)	KR20000015865A (de)
CN (1)	CN1129429C (de)
AT (1)	ATE299699T1 (de)
AU (1)	AU718030B2 (de)
BR (1)	BR9710448A (de)
CA (1)	CA2255064C (de)
CZ (1)	CZ370298A3 (de)
DE (1)	DE69733752T2 (de)
ES (1)	ES2248850T3 (de)
IL (1)	IL126998A (de)
NO (1)	NO985414L (de)
NZ (1)	NZ332861A (de)
PL (1)	PL330145A1 (de)
RU (1)	RU2197244C2 (de)
TW (1)	TW586929B (de)
WO (1)	WO1997044022A1 (de)
ZA (1)	ZA974366B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU777415B2 (en) *	1999-09-29	2004-10-14	R.P. Scherer Technologies, Inc.	Hydrolyzed cellulose granulations of salts of drugs
US6497157B1 (en) *	1999-11-29	2002-12-24	Distek, Inc.	Intrinsic dissolution apparatus with stationary sample holder
FR2828810B1 (fr) *	2001-08-27	2005-10-07	Lvmh Rech	Composition cosmetique a effet tenseur contenant un polymere d'origine naturelle et un agent hydratant polyhydroxyle
KR100574554B1 (ko) *	2004-05-28	2006-04-27	한미약품 주식회사	니아신의 경구투여용 서방성 조성물
AU2006228869A1 (en) *	2005-03-30	2006-10-05	Astion Pharma A/S	Oxaprozin or a closely related compound for the treatment of eczema
UY29449A1 (es) *	2005-03-30	2006-10-02	Astion Dev As	Tratamiento de enfermedades dermatólogicas y del prurito.
EP1888056A4 (de) *	2005-06-01	2008-09-03	Teva Pharma	Verwendung von ladostigil zur behandlung von multipler sklerose
CL2008000280A1 (es)	2007-02-01	2008-08-18	Takeda Pharmaceutical	Composicion farmaceutica en forma de comprimido que contiene un granulo que comprende un principio activo que induce facilmente a un problema en la compresion y celulosa microcristalina y un auxiliar de compresion que contiene estearato de magnesio y
EA038195B1 (ru)	2009-01-16	2021-07-22	Экселиксис, Инк.	Малатная соль n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида и ее применение для лечения рака почек и печени
TWI640509B (zh)	2011-02-10	2018-11-11	艾克塞里克斯公司	製造喹啉化合物之方法及包含該化合物之醫藥組合物
JP2015510947A (ja) *	2012-03-22	2015-04-13	トランステック・ファーマ，エルエルシー	小分子ｇｌｐ１ｒアゴニストのトリス（ヒドロキシメチル）アミノメタン塩ならびにその医薬組成物および使用
EP3275433A1 (de)	2016-07-29	2018-01-31	Som Innovation Biotech S.L.	Zusammensetzung mit verzögerter freisetzung mit mikronisiertem tolcapon

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1206403A (en) *	1966-12-15	1970-09-23	Wyeth John & Brother Ltd	Oxazoles
US3578671A (en) *	1967-11-06	1971-05-11	Wyeth John & Brother Ltd	Oxazoles
US3998815A (en) *	1974-06-24	1976-12-21	Interx Research Corporation	1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts
US4190584A (en) *	1976-08-13	1980-02-26	John Wyeth & Brother Limited	Process for preparing oxazoles
GB2097389B (en) *	1981-04-28	1984-11-28	Wyeth John & Brother Ltd	Oxazole derivative
IE52909B1 (en) *	1981-04-28	1988-04-13	Wyeth John & Brother Ltd	Oxazole derivatives
US4385049A (en) *	1981-05-12	1983-05-24	K-V Pharmaceutical Company	Stable high internal phase ratio topical emulsions
US4599359A (en) *	1982-12-09	1986-07-08	Stephen A. Cooper	Hydroxyzine-containing analgesic combinations
GB8329326D0 (en) *	1983-11-03	1983-12-07	Wyeth John & Brother Ltd	Oxazole derivatives
IT1204751B (it) *	1986-01-03	1989-03-10	Therapicon Srl	Derivati idrosolubili dell'acido 4,5 -difenil- 2 -ossazolpropionico,loro preparazione ed utilizzo in composizioni farmaceutiche
GB8630273D0 (en) *	1986-12-18	1987-01-28	Til Medical Ltd	Pharmaceutical delivery systems
US5059626A (en) *	1988-07-25	1991-10-22	Applied Analytical Industries, Inc.	Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs
US5350769A (en) *	1990-10-30	1994-09-27	Ss Pharmaceutical Co., Ltd.	Antiinflammatory gel preparation
CN1130354A (zh) *	1993-09-07	1996-09-04	普罗克特和廿保尔公司	含有丙酸类非甾体消炎药氨基酸盐和减充血药、祛痰药、抗组胺药和镇咳药中至少一种的组合物
BR9407415A (pt) *	1993-09-07	1996-11-12	Procter & Gamble	Composições contendo um sal de aminoácido de agente antiinflamatório não-esteróide de ácido propiônico e caféina

1997
- 1997-05-14 DE DE69733752T patent/DE69733752T2/de not_active Expired - Lifetime
- 1997-05-14 CA CA002255064A patent/CA2255064C/en not_active Expired - Fee Related
- 1997-05-14 BR BR9710448A patent/BR9710448A/pt not_active Application Discontinuation
- 1997-05-14 JP JP54242197A patent/JP4185974B2/ja not_active Expired - Fee Related
- 1997-05-14 WO PCT/US1997/007637 patent/WO1997044022A1/en not_active Ceased
- 1997-05-14 PL PL97330145A patent/PL330145A1/xx unknown
- 1997-05-14 AU AU30597/97A patent/AU718030B2/en not_active Ceased
- 1997-05-14 ES ES97925466T patent/ES2248850T3/es not_active Expired - Lifetime
- 1997-05-14 CN CN97196583A patent/CN1129429C/zh not_active Expired - Fee Related
- 1997-05-14 CZ CZ983702A patent/CZ370298A3/cs unknown
- 1997-05-14 EP EP97925466A patent/EP0901372B1/de not_active Expired - Lifetime
- 1997-05-14 NZ NZ332861A patent/NZ332861A/xx unknown
- 1997-05-14 AT AT97925466T patent/ATE299699T1/de not_active IP Right Cessation
- 1997-05-14 RU RU98123101/14A patent/RU2197244C2/ru not_active IP Right Cessation
- 1997-05-14 IL IL12699897A patent/IL126998A/xx not_active IP Right Cessation
- 1997-05-14 KR KR1019980709415A patent/KR20000015865A/ko not_active Ceased
- 1997-05-16 US US08/857,999 patent/US6030643A/en not_active Expired - Fee Related
- 1997-05-20 ZA ZA9704366A patent/ZA974366B/xx unknown
- 1997-05-20 TW TW086106729A patent/TW586929B/zh not_active IP Right Cessation
1998
- 1998-11-20 NO NO985414A patent/NO985414L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TW586929B (en)	2004-05-11
ES2248850T3 (es)	2006-03-16
IL126998A0 (en)	1999-09-22
CN1129429C (zh)	2003-12-03
CN1225580A (zh)	1999-08-11
JP4185974B2 (ja)	2008-11-26
US6030643A (en)	2000-02-29
CZ370298A3 (cs)	1999-05-12
DE69733752T2 (de)	2006-06-01
BR9710448A (pt)	1999-08-17
CA2255064C (en)	2006-10-10
ATE299699T1 (de)	2005-08-15
EP0901372B1 (de)	2005-07-20
CA2255064A1 (en)	1997-11-27
PL330145A1 (en)	1999-04-26
DE69733752D1 (de)	2005-08-25
KR20000015865A (ko)	2000-03-15
AU718030B2 (en)	2000-04-06
NO985414L (no)	1999-01-19
AU3059797A (en)	1997-12-09
NO985414D0 (no)	1998-11-20
EP0901372A1 (de)	1999-03-17
NZ332861A (en)	2000-08-25
ZA974366B (en)	1998-05-20
WO1997044022A1 (en)	1997-11-27
RU2197244C2 (ru)	2003-01-27
JP2001503734A (ja)	2001-03-21

Legal Events

Date	Code	Title
2004-05-12	FF	Patent granted
2004-06-01	KB	Patent renewed
2008-01-22	MM9K	Patent not in force due to non-payment of renewal fees

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