IL127487A - Use of thiazolidinone derivatives for the preparation of drugs for the treatment of neurodegenerative diseases - Google Patents
Use of thiazolidinone derivatives for the preparation of drugs for the treatment of neurodegenerative diseasesInfo
- Publication number
- IL127487A IL127487A IL12748797A IL12748797A IL127487A IL 127487 A IL127487 A IL 127487A IL 12748797 A IL12748797 A IL 12748797A IL 12748797 A IL12748797 A IL 12748797A IL 127487 A IL127487 A IL 127487A
- Authority
- IL
- Israel
- Prior art keywords
- thiazolidinone
- eae
- neurodegenerative disorders
- cells
- disease
- Prior art date
Links
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- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000155 toxicity by organ Toxicity 0.000 description 1
- 230000007675 toxicity by organ Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2157196P | 1996-07-11 | 1996-07-11 | |
| PCT/US1997/011586 WO1998002160A1 (en) | 1996-07-11 | 1997-07-01 | Method for treating and preventing neurodegenerative disorders by administering a thiazolidinone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL127487A0 IL127487A0 (en) | 1999-10-28 |
| IL127487A true IL127487A (en) | 2002-04-21 |
Family
ID=21804973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12748797A IL127487A (en) | 1996-07-11 | 1997-07-01 | Use of thiazolidinone derivatives for the preparation of drugs for the treatment of neurodegenerative diseases |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5912259A (de) |
| EP (1) | EP0914122B1 (de) |
| JP (1) | JP2001508028A (de) |
| KR (1) | KR20000023683A (de) |
| CN (1) | CN1145481C (de) |
| AT (1) | ATE250416T1 (de) |
| AU (1) | AU726664B2 (de) |
| BR (1) | BR9710467A (de) |
| CA (1) | CA2255073A1 (de) |
| CO (1) | CO4940509A1 (de) |
| DE (1) | DE69725147T2 (de) |
| DK (1) | DK0914122T3 (de) |
| ES (1) | ES2205247T3 (de) |
| HR (1) | HRP970362A2 (de) |
| IL (1) | IL127487A (de) |
| NO (1) | NO990076L (de) |
| NZ (1) | NZ332763A (de) |
| PL (1) | PL331049A1 (de) |
| PT (1) | PT914122E (de) |
| TR (1) | TR199900040T2 (de) |
| WO (1) | WO1998002160A1 (de) |
| ZA (1) | ZA976142B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003104423A2 (en) * | 2002-06-11 | 2003-12-18 | Roy Ogle | Meningeal-derived stem cells |
| US20110104296A1 (en) * | 2008-05-08 | 2011-05-05 | Dipak Kumar Sarkar | Endorphin Therapy Compositions and Methods |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT83152B (pt) * | 1985-08-09 | 1989-03-30 | Lilly Co Eli | Processo para a preparacao de compostos di-t-butilfenoicos |
| ZA902520B (en) * | 1989-04-07 | 1991-12-24 | Lilly Co Eli | Aryl-substituted rhodanine derivatives |
| US5143928A (en) * | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
| US5192753A (en) * | 1991-04-23 | 1993-03-09 | Mcgeer Patrick L | Anti-rheumatoid arthritic drugs in the treatment of dementia |
| CZ181493A3 (en) * | 1992-09-10 | 1994-03-16 | Lilly Co Eli | The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease |
| EP0722729A3 (de) * | 1995-01-23 | 1997-11-26 | Eli Lilly And Company | Aryl-substituierte Rhodaninen zur Behandlung multipler Sklerose |
| EP0833622B8 (de) * | 1995-06-12 | 2005-10-12 | G.D. Searle & Co. | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
-
1997
- 1997-07-01 DE DE69725147T patent/DE69725147T2/de not_active Expired - Fee Related
- 1997-07-01 NZ NZ332763A patent/NZ332763A/xx unknown
- 1997-07-01 IL IL12748797A patent/IL127487A/en not_active IP Right Cessation
- 1997-07-01 BR BR9710467A patent/BR9710467A/pt not_active Application Discontinuation
- 1997-07-01 AT AT97933264T patent/ATE250416T1/de not_active IP Right Cessation
- 1997-07-01 WO PCT/US1997/011586 patent/WO1998002160A1/en not_active Ceased
- 1997-07-01 TR TR1999/00040T patent/TR199900040T2/xx unknown
- 1997-07-01 ES ES97933264T patent/ES2205247T3/es not_active Expired - Lifetime
- 1997-07-01 DK DK97933264T patent/DK0914122T3/da active
- 1997-07-01 JP JP50606698A patent/JP2001508028A/ja not_active Ceased
- 1997-07-01 PL PL97331049A patent/PL331049A1/xx unknown
- 1997-07-01 CA CA002255073A patent/CA2255073A1/en not_active Abandoned
- 1997-07-01 CN CNB971960429A patent/CN1145481C/zh not_active Expired - Fee Related
- 1997-07-01 AU AU36491/97A patent/AU726664B2/en not_active Ceased
- 1997-07-01 EP EP97933264A patent/EP0914122B1/de not_active Expired - Lifetime
- 1997-07-01 US US09/171,891 patent/US5912259A/en not_active Expired - Fee Related
- 1997-07-01 PT PT97933264T patent/PT914122E/pt unknown
- 1997-07-03 HR HR60/021,571A patent/HRP970362A2/xx not_active Application Discontinuation
- 1997-07-10 CO CO97038493A patent/CO4940509A1/es unknown
- 1997-07-10 ZA ZA9706142A patent/ZA976142B/xx unknown
-
1999
- 1999-01-08 NO NO990076A patent/NO990076L/no not_active Application Discontinuation
- 1999-01-09 KR KR1019997000140A patent/KR20000023683A/ko not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1145481C (zh) | 2004-04-14 |
| CN1223582A (zh) | 1999-07-21 |
| EP0914122A1 (de) | 1999-05-12 |
| TR199900040T2 (xx) | 1999-04-21 |
| NO990076D0 (no) | 1999-01-08 |
| DE69725147T2 (de) | 2004-07-22 |
| PT914122E (pt) | 2003-12-31 |
| CA2255073A1 (en) | 1998-01-22 |
| AU726664B2 (en) | 2000-11-16 |
| WO1998002160A1 (en) | 1998-01-22 |
| CO4940509A1 (es) | 2000-07-24 |
| DK0914122T3 (da) | 2003-12-22 |
| JP2001508028A (ja) | 2001-06-19 |
| ATE250416T1 (de) | 2003-10-15 |
| HRP970362A2 (en) | 1998-04-30 |
| HK1020533A1 (en) | 2000-05-12 |
| IL127487A0 (en) | 1999-10-28 |
| PL331049A1 (en) | 1999-06-21 |
| EP0914122B1 (de) | 2003-09-24 |
| BR9710467A (pt) | 1999-08-17 |
| US5912259A (en) | 1999-06-15 |
| AU3649197A (en) | 1998-02-09 |
| NO990076L (no) | 1999-01-08 |
| ZA976142B (en) | 1998-02-02 |
| NZ332763A (en) | 2000-07-28 |
| DE69725147D1 (de) | 2003-10-30 |
| KR20000023683A (ko) | 2000-04-25 |
| ES2205247T3 (es) | 2004-05-01 |
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Legal Events
| Date | Code | Title | Description |
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| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |