IL127797A - A one-step method of contraception and a kit containing a combination of progestin and estrogen - Google Patents

A one-step method of contraception and a kit containing a combination of progestin and estrogen

Info

Publication number: IL127797A
Authority: IL; Israel
Prior art keywords: estrogen; progestin; dosage; days; combination
Prior art date: 1996-07-26

Application number

IL12779797A

Other languages

English (en)

Hebrew (he)

Other versions

IL127797A0 (en

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-26

Filing date

1997-07-23

Publication date

2004-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24757773&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL127797(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-07-23 Application filed by Wyeth Corp filed Critical Wyeth Corp

1999-10-28 Publication of IL127797A0 publication Critical patent/IL127797A0/xx

2004-08-31 Publication of IL127797A publication Critical patent/IL127797A/en

Links

229940011871 estrogen Drugs 0.000 title claims abstract description 84
239000000262 estrogen Substances 0.000 title claims abstract description 84
239000000583 progesterone congener Substances 0.000 title claims abstract description 71
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title claims abstract description 68
238000000034 method Methods 0.000 title claims abstract description 25
239000003433 contraceptive agent Substances 0.000 title claims description 49
230000002254 contraceptive effect Effects 0.000 title claims description 35
BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims abstract description 83
BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims abstract description 82
229960002568 ethinylestradiol Drugs 0.000 claims abstract description 82
AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 claims abstract description 19
229960003309 dienogest Drugs 0.000 claims abstract description 19
JUNDJWOLDSCTFK-MTZCLOFQSA-N trimegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)[C@@H](O)C)(C)[C@@]1(C)CC2 JUNDJWOLDSCTFK-MTZCLOFQSA-N 0.000 claims abstract description 17
229950008546 trimegestone Drugs 0.000 claims abstract description 17
230000027758 ovulation cycle Effects 0.000 claims abstract description 13
230000001076 estrogenic effect Effects 0.000 claims abstract description 12
239000000902 placebo Substances 0.000 claims description 23
229940068196 placebo Drugs 0.000 claims description 23
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 10
METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims description 10
229960004845 drospirenone Drugs 0.000 claims description 10
METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims description 10
229960005309 estradiol Drugs 0.000 claims description 7
229960001390 mestranol Drugs 0.000 claims description 6
IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 claims description 6
DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 5
DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 5
229940035811 conjugated estrogen Drugs 0.000 claims description 5
229960003399 estrone Drugs 0.000 claims description 5
229910052742 iron Inorganic materials 0.000 claims description 5
239000013589 supplement Substances 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 4
VOXZDWNPVJITMN-UHFFFAOYSA-N 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2C3CCC(C)(C(CC4)O)C4C3CCC2=C1 VOXZDWNPVJITMN-UHFFFAOYSA-N 0.000 claims 1
229940053934 norethindrone Drugs 0.000 description 20
VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 20
229960004976 desogestrel Drugs 0.000 description 16
RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 description 16
239000006187 pill Substances 0.000 description 11
229940127234 oral contraceptive Drugs 0.000 description 10
239000003539 oral contraceptive agent Substances 0.000 description 10
WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 9
230000000694 effects Effects 0.000 description 8
229960004400 levonorgestrel Drugs 0.000 description 8
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 6
239000000203 mixture Substances 0.000 description 5
IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 4
230000000035 biogenic effect Effects 0.000 description 4
UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 description 4
229960000978 cyproterone acetate Drugs 0.000 description 4
229930182833 estradiol Natural products 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
210000004914 menses Anatomy 0.000 description 4
229960001652 norethindrone acetate Drugs 0.000 description 4
230000009467 reduction Effects 0.000 description 4
QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 3
CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 3
-1 dehydrogestrone Chemical compound 0.000 description 3
VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical compound [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 3
230000016087 ovulation Effects 0.000 description 3
239000000047 product Substances 0.000 description 3
230000003637 steroidlike Effects 0.000 description 3
RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
230000002411 adverse Effects 0.000 description 2
230000002051 biphasic effect Effects 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
229960001616 chlormadinone acetate Drugs 0.000 description 2
229960004766 estradiol valerate Drugs 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000008101 lactose Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
239000011591 potassium Substances 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
229960003387 progesterone Drugs 0.000 description 2
239000000186 progesterone Substances 0.000 description 2
239000007921 spray Substances 0.000 description 2
230000009424 thromboembolic effect Effects 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 1
VNFVKWMKVDOSKT-LREBCSMRSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;piperazine Chemical class C1CNCCN1.OC(=O)[C@H](O)[C@@H](O)C(O)=O VNFVKWMKVDOSKT-LREBCSMRSA-N 0.000 description 1
102000006771 Gonadotropins Human genes 0.000 description 1
108010086677 Gonadotropins Proteins 0.000 description 1
206010060800 Hot flush Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
206010022998 Irritability Diseases 0.000 description 1
102000004895 Lipoproteins Human genes 0.000 description 1
108090001030 Lipoproteins Proteins 0.000 description 1
206010027514 Metrorrhagia Diseases 0.000 description 1
208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
206010047998 Withdrawal bleed Diseases 0.000 description 1
230000001833 anti-estrogenic effect Effects 0.000 description 1
230000002513 anti-ovulatory effect Effects 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000023852 carbohydrate metabolic process Effects 0.000 description 1
235000021256 carbohydrate metabolism Nutrition 0.000 description 1
210000003756 cervix mucus Anatomy 0.000 description 1
239000003086 colorant Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
229940007694 dienogest and ethinylestradiol Drugs 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
229940007690 drospirenone and ethinylestradiol Drugs 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
210000004696 endometrium Anatomy 0.000 description 1
229960001348 estriol Drugs 0.000 description 1
PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
239000000328 estrogen antagonist Substances 0.000 description 1
239000002622 gonadotropin Substances 0.000 description 1
229940094892 gonadotropins Drugs 0.000 description 1
230000036541 health Effects 0.000 description 1
230000002439 hemostatic effect Effects 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
238000002657 hormone replacement therapy Methods 0.000 description 1
238000002513 implantation Methods 0.000 description 1
231100000546 inhibition of ovulation Toxicity 0.000 description 1
206010022437 insomnia Diseases 0.000 description 1
230000001788 irregular Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
229960002985 medroxyprogesterone acetate Drugs 0.000 description 1
RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 1
229960004296 megestrol acetate Drugs 0.000 description 1
230000002175 menstrual effect Effects 0.000 description 1
230000004066 metabolic change Effects 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
208000031225 myocardial ischemia Diseases 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000008520 organization Effects 0.000 description 1
150000002923 oximes Chemical class 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000036515 potency Effects 0.000 description 1
230000001072 progestational effect Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
230000015887 sperm entry Effects 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
208000023516 stroke disease Diseases 0.000 description 1
230000001629 suppression Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
210000004291 uterus Anatomy 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)

IL12779797A 1996-07-26 1997-07-23 A one-step method of contraception and a kit containing a combination of progestin and estrogen IL127797A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68679096A	1996-07-26	1996-07-26
PCT/US1997/012795 WO1998004269A1 (en)	1996-07-26	1997-07-23	Monophasic contraceptive method and kit comprising a combination of a progestin and estrogen

Publications (2)

Publication Number	Publication Date
IL127797A0 IL127797A0 (en)	1999-10-28
IL127797A true IL127797A (en)	2004-08-31

Family

ID=24757773

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12779797A IL127797A (en)	1996-07-26	1997-07-23	A one-step method of contraception and a kit containing a combination of progestin and estrogen

Country Status (15)

Country	Link
EP (1)	EP0956024B1 (de)
JP (1)	JP2000515890A (de)
KR (1)	KR100518102B1 (de)
CN (1)	CN1186024C (de)
AT (1)	ATE271386T1 (de)
AU (1)	AU726091B2 (de)
BR (1)	BR9710566A (de)
CA (1)	CA2261689A1 (de)
DE (1)	DE69729956T2 (de)
ES (1)	ES2223081T3 (de)
HU (1)	HUP9904344A3 (de)
IL (1)	IL127797A (de)
NZ (1)	NZ333750A (de)
PT (1)	PT956024E (de)
WO (1)	WO1998004269A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4344462C2 (de)	1993-12-22	1996-02-01	Schering Ag	Zusammensetzung für die Empfängnisverhütung
SK287634B6 (sk) *	1999-08-31	2011-04-05	Bayer Schering Pharma Aktiengesellschaft	Farmaceutická kompozícia obsahujúca drospirenón a etinylestradiol a farmaceutický prípravok
EP2305267A3 (de) *	1999-08-31	2011-08-17	Bayer Schering Pharma Aktiengesellschaft	Pharmazeutische Kombination von Ethinylestradiol und Drospirenon zur Verwendung als Verhütungsmittel
US6787531B1 (en)	1999-08-31	2004-09-07	Schering Ag	Pharmaceutical composition for use as a contraceptive
BR0014159A (pt) *	1999-08-31	2002-05-07	Schering Ag	Combinação farmacêutica de etinilestradiol e drospirenona para uso como um anticoncepcional
FR2801218B1 (fr) *	1999-11-23	2001-12-28	Hoechst Marion Roussel Inc	Compositions pharmaceutiques comprenant de la trimegestone, leurs procedes de preparation ainsi que le conditionnement primaire les renfermant
IL150775A0 (en) *	2000-01-18	2003-02-12	Schering Ag	Drospirenone for hormone replacement therapy
DE10045380A1 (de)	2000-09-14	2002-04-04	Schering Ag	Verfahren zur Kontrazeption und dessen Darreichungsform
CA2431521E (en) *	2000-12-14	2013-04-16	Ortho-Mcneil Pharmaceutical, Inc.	Steroid hormone products and methods for preparing them
EP1216713A1 (de) *	2000-12-20	2002-06-26	Schering Aktiengesellschaft	Zusammensetzungen von Estrogen-Zyklodextrin Komplexe
WO2004112797A1 (en) *	2003-06-25	2004-12-29	Schering Ag	Hormone replacement- and depression therapy comprising dienogest
DE102004019743B4 (de)	2004-04-20	2008-11-27	Bayer Schering Pharma Aktiengesellschaft	Mehrphasenpräparat zur Kontrazeption auf der Basis eines natürlichen Estrogens
AU2011226911B2 (en) *	2004-04-30	2014-06-19	Bayer Intellectual Property Gmbh	Management of breakthrough bleeding in extended hormonal contraceptive regimens
MY151322A (en) *	2004-04-30	2014-05-15	Bayer Ip Gmbh	Management of breakthrough bleeding in extended hormonal contraceptive regimens
SV2006002165A (es) *	2004-07-07	2006-05-09	Wyeth Corp	Regimenes y kits de progestina ciclica ref. am101677
EP1690529A1 (de) *	2005-02-15	2006-08-16	Schering AG	Feste perorale Arzneiform zur Kontrazeption, die Dienogest und Ethinylestradiol enthält
EP1690543A1 (de) *	2005-02-15	2006-08-16	Schering AG	Pharmazeutisches Präparat zur Kontrazeption
RS50597B (sr) *	2005-02-15	2010-05-07	Jenapharm Gmbh. & Co.Kg.	Peroralna dozna forma u čvrstom stanju namenjena kontracepciji koja sadrži dienogest i etinilestradiol
DE102005034498A1 (de) *	2005-07-20	2007-01-25	Grünenthal GmbH	Orale Kontrazeption mit Trimegeston
US8153616B2 (en)	2005-10-17	2012-04-10	Bayer Pharma Aktiengesellschaft	Combination preparation for oral contraception and oral therapy of dysfunctional uterine bleeding containing estradiol valerate and dienogest and method of using same
EP1930010A1 (de)	2006-10-20	2008-06-11	Bayer Schering Pharma Aktiengesellschaft	Verwendung von Estradiolvalerat oder 17ß-Estradiol in Kombination mit Dienogest zur oralen Therapie für den Erhalt und/oder die Steigerung der weiblichen Libido
DE102008040908A1 (de)	2008-07-31	2010-02-11	Deere & Company, Moline	Kühleranordnung für ein Fahrzeugkühlsystem
EP2324832B2 (de) *	2009-11-09	2016-11-30	Biogena Naturprodukte GmbH & Co KG	Nahrungsergänzungsmittel bei Einnahme von hormonellen Kontrazeptiva

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE61236B1 (en) *	1986-07-15	1994-10-19	American Home Prod	Combination dosage form for pre-menopausal women
IE71203B1 (en) *	1990-12-13	1997-02-12	Akzo Nv	Low estrogen oral contraceptives
DE4344462C2 (de) *	1993-12-22	1996-02-01	Schering Ag	Zusammensetzung für die Empfängnisverhütung
DE4411585A1 (de) *	1994-03-30	1995-10-05	Schering Ag	Pharmazeutisches Kombinationspräparat zur hormonalen Kontrazeption
DE19525017A1 (de) *	1995-06-28	1997-01-02	Schering Ag	Pharmazeutisches Kombinatonspräparat, Kit und Methode zur hormonalen Kontrazeption

1997
- 1997-07-23 EP EP97936149A patent/EP0956024B1/de not_active Revoked
- 1997-07-23 KR KR10-1999-7000553A patent/KR100518102B1/ko not_active Expired - Fee Related
- 1997-07-23 IL IL12779797A patent/IL127797A/en not_active IP Right Cessation
- 1997-07-23 BR BR9710566A patent/BR9710566A/pt not_active Application Discontinuation
- 1997-07-23 CN CNB971967636A patent/CN1186024C/zh not_active Expired - Fee Related
- 1997-07-23 HU HU9904344A patent/HUP9904344A3/hu unknown
- 1997-07-23 AU AU38887/97A patent/AU726091B2/en not_active Ceased
- 1997-07-23 NZ NZ333750A patent/NZ333750A/xx unknown
- 1997-07-23 JP JP10508924A patent/JP2000515890A/ja not_active Ceased
- 1997-07-23 WO PCT/US1997/012795 patent/WO1998004269A1/en not_active Ceased
- 1997-07-23 DE DE69729956T patent/DE69729956T2/de not_active Expired - Fee Related
- 1997-07-23 AT AT97936149T patent/ATE271386T1/de not_active IP Right Cessation
- 1997-07-23 CA CA002261689A patent/CA2261689A1/en not_active Abandoned
- 1997-07-23 ES ES97936149T patent/ES2223081T3/es not_active Expired - Lifetime
- 1997-07-23 PT PT97936149T patent/PT956024E/pt unknown

Also Published As

Publication number	Publication date
HUP9904344A3 (en)	2001-03-28
BR9710566A (pt)	1999-08-17
PT956024E (pt)	2004-10-29
EP0956024B1 (de)	2004-07-21
HUP9904344A2 (hu)	2000-05-28
AU726091B2 (en)	2000-11-02
KR20000029515A (ko)	2000-05-25
WO1998004269A1 (en)	1998-02-05
AU3888797A (en)	1998-02-20
ATE271386T1 (de)	2004-08-15
DE69729956T2 (de)	2004-12-16
IL127797A0 (en)	1999-10-28
ES2223081T3 (es)	2005-02-16
NZ333750A (en)	2000-09-29
KR100518102B1 (ko)	2005-10-04
HK1022843A1 (en)	2000-08-25
JP2000515890A (ja)	2000-11-28
CN1226168A (zh)	1999-08-18
DE69729956D1 (de)	2004-08-26
EP0956024A1 (de)	1999-11-17
CN1186024C (zh)	2005-01-26
CA2261689A1 (en)	1998-02-05

Legal Events

Date	Code	Title
2005-01-24	FF	Patent granted
2005-02-20	KB	Patent renewed
2008-04-13	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5888543A (en)	1999-03-30	Oral contraceptives
US5858405A (en)	1999-01-12	Oral contraceptive
US5747480A (en)	1998-05-05	Oral contraceptive
EP0956024B1 (de)	2004-07-21	Orale einstufige empfängnisverhütungsmethode und kombinationspräparat das gestagen und estrogen enthält
US6479475B1 (en)	2002-11-12	Oral contraceptive
EP0917466B1 (de)	2004-10-06	Orales contrazeptivum
WO1998004246A2 (en)	1998-02-05	Triphasic contraceptive method and kit comprising a combination of a progestin and estrogen
US6451778B1 (en)	2002-09-17	Oral contraceptive
EP0921804B1 (de)	2003-09-10	Biphasische orale verhuetungsmethode und kit die eine kombination von progestin und eines oestrogens enthalten
AU759925B2 (en)	2003-05-01	Oral contraceptive preparation having a first phase comprising progestin/estrogen and a second phase comprising progestin
WO1998004267A1 (en)	1998-02-05	Progestin/estrogen oral contraceptive
WO1998004266A1 (en)	1998-02-05	Oral contraceptive
WO1997041868A1 (en)	1997-11-13	Oral contraceptive
WO1997041870A1 (en)	1997-11-13	Oral contraceptive
WO1997041869A1 (en)	1997-11-13	Oral contraceptive
WO1997041871A1 (en)	1997-11-13	Oral contraceptive
WO1997041872A1 (en)	1997-11-13	Oral contraceptive
HK1022843B (en)	2005-01-07	Monophasic oral contraceptive method and kit comprising a combination of progestin and estrogen
MXPA99000801A (en)	1999-09-20	Monophasic contraceptive method and kit comprising a combination of a progestin and estrogen
MXPA99000883A (en)	1999-10-14	Oral contraceptive