IL127923A - Pharmaceutical preparation swallowed to prevent pregnancy - Google Patents

Pharmaceutical preparation swallowed to prevent pregnancy

Info

Publication number: IL127923A
Authority: IL; Israel
Prior art keywords: administered; phase; daily dosage; combination; dosage
Prior art date: 1996-07-26

Application number

IL12792397A

Other languages

English (en)

Hebrew (he)

Other versions

IL127923A0 (en

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-26

Filing date

1997-07-23

Publication date

2004-07-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24757747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL127923(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-07-23 Application filed by Wyeth Corp filed Critical Wyeth Corp

1999-11-30 Publication of IL127923A0 publication Critical patent/IL127923A0/xx

2004-07-25 Publication of IL127923A publication Critical patent/IL127923A/en

Links

229940127234 oral contraceptive Drugs 0.000 title description 14
239000003539 oral contraceptive agent Substances 0.000 title description 14
BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims abstract description 136
BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims abstract description 136
229960002568 ethinylestradiol Drugs 0.000 claims abstract description 136
239000000583 progesterone congener Substances 0.000 claims abstract description 107
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims abstract description 104
229940011871 estrogen Drugs 0.000 claims abstract description 103
239000000262 estrogen Substances 0.000 claims abstract description 103
AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 claims abstract description 44
229960003309 dienogest Drugs 0.000 claims abstract description 44
METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims abstract description 42
229960004845 drospirenone Drugs 0.000 claims abstract description 42
METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims abstract description 42
229950008546 trimegestone Drugs 0.000 claims abstract description 35
JUNDJWOLDSCTFK-MTZCLOFQSA-N trimegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)[C@@H](O)C)(C)[C@@]1(C)CC2 JUNDJWOLDSCTFK-MTZCLOFQSA-N 0.000 claims abstract description 35
230000001076 estrogenic effect Effects 0.000 claims abstract description 24
238000000034 method Methods 0.000 claims abstract description 22
230000027758 ovulation cycle Effects 0.000 claims abstract description 10
239000003433 contraceptive agent Substances 0.000 claims description 42
230000002254 contraceptive effect Effects 0.000 claims description 28
239000000902 placebo Substances 0.000 claims description 21
229940068196 placebo Drugs 0.000 claims description 21
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
229960005309 estradiol Drugs 0.000 claims description 8
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 7
IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 claims description 7
229960001390 mestranol Drugs 0.000 claims description 7
DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 5
DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 5
229940035811 conjugated estrogen Drugs 0.000 claims description 5
229960003399 estrone Drugs 0.000 claims description 5
229910052742 iron Inorganic materials 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
239000013589 supplement Substances 0.000 claims description 4
WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 37
229960004400 levonorgestrel Drugs 0.000 description 36
229940053934 norethindrone Drugs 0.000 description 22
VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 22
229960004976 desogestrel Drugs 0.000 description 18
RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 description 16
SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 description 12
229960005352 gestodene Drugs 0.000 description 12
239000006187 pill Substances 0.000 description 10
230000000694 effects Effects 0.000 description 8
210000004914 menses Anatomy 0.000 description 7
239000000203 mixture Substances 0.000 description 5
230000000630 rising effect Effects 0.000 description 5
-1 3-KDSG Chemical compound 0.000 description 4
IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 4
230000000035 biogenic effect Effects 0.000 description 4
229960000978 cyproterone acetate Drugs 0.000 description 4
UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 description 4
229960001652 norethindrone acetate Drugs 0.000 description 4
230000009467 reduction Effects 0.000 description 4
QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 3
229930182833 estradiol Natural products 0.000 description 3
229960000417 norgestimate Drugs 0.000 description 3
KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 description 3
230000016087 ovulation Effects 0.000 description 3
239000000047 product Substances 0.000 description 3
230000003637 steroidlike Effects 0.000 description 3
VOXZDWNPVJITMN-UHFFFAOYSA-N 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2C3CCC(C)(C(CC4)O)C4C3CCC2=C1 VOXZDWNPVJITMN-UHFFFAOYSA-N 0.000 description 2
RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 description 2
PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 2
230000002411 adverse Effects 0.000 description 2
230000002051 biphasic effect Effects 0.000 description 2
229960001616 chlormadinone acetate Drugs 0.000 description 2
229940007694 dienogest and ethinylestradiol Drugs 0.000 description 2
229940007690 drospirenone and ethinylestradiol Drugs 0.000 description 2
229960004766 estradiol valerate Drugs 0.000 description 2
229960000225 ferrous fumarate Drugs 0.000 description 2
235000002332 ferrous fumarate Nutrition 0.000 description 2
239000011773 ferrous fumarate Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
229960003387 progesterone Drugs 0.000 description 2
239000000186 progesterone Substances 0.000 description 2
230000009424 thromboembolic effect Effects 0.000 description 2
PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 1
VNFVKWMKVDOSKT-LREBCSMRSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;piperazine Chemical class C1CNCCN1.OC(=O)[C@H](O)[C@@H](O)C(O)=O VNFVKWMKVDOSKT-LREBCSMRSA-N 0.000 description 1
DBPWSSGDRRHUNT-UHFFFAOYSA-N 17alpha-hydroxy progesterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C(=O)C)(O)C1(C)CC2 DBPWSSGDRRHUNT-UHFFFAOYSA-N 0.000 description 1
102000006771 Gonadotropins Human genes 0.000 description 1
108010086677 Gonadotropins Proteins 0.000 description 1
206010060800 Hot flush Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
206010022998 Irritability Diseases 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
102000004895 Lipoproteins Human genes 0.000 description 1
108090001030 Lipoproteins Proteins 0.000 description 1
206010027514 Metrorrhagia Diseases 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
206010047998 Withdrawal bleed Diseases 0.000 description 1
230000001833 anti-estrogenic effect Effects 0.000 description 1
230000002513 anti-ovulatory effect Effects 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000023852 carbohydrate metabolic process Effects 0.000 description 1
235000021256 carbohydrate metabolism Nutrition 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
210000003756 cervix mucus Anatomy 0.000 description 1
239000003086 colorant Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
210000004696 endometrium Anatomy 0.000 description 1
229960001348 estriol Drugs 0.000 description 1
PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
239000000328 estrogen antagonist Substances 0.000 description 1
GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 description 1
239000002622 gonadotropin Substances 0.000 description 1
229940094892 gonadotropins Drugs 0.000 description 1
230000036541 health Effects 0.000 description 1
230000002439 hemostatic effect Effects 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
238000002657 hormone replacement therapy Methods 0.000 description 1
238000002513 implantation Methods 0.000 description 1
231100000546 inhibition of ovulation Toxicity 0.000 description 1
206010022437 insomnia Diseases 0.000 description 1
230000001788 irregular Effects 0.000 description 1
239000008101 lactose Substances 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
229960002985 medroxyprogesterone acetate Drugs 0.000 description 1
RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 1
229960004296 megestrol acetate Drugs 0.000 description 1
230000002175 menstrual effect Effects 0.000 description 1
230000004066 metabolic change Effects 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
208000031225 myocardial ischemia Diseases 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000008520 organization Effects 0.000 description 1
150000002923 oximes Chemical class 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
230000036515 potency Effects 0.000 description 1
230000001072 progestational effect Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
230000015887 sperm entry Effects 0.000 description 1
239000007921 spray Substances 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
208000023516 stroke disease Diseases 0.000 description 1
230000001629 suppression Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
210000004291 uterus Anatomy 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL12792397A 1996-07-26 1997-07-23 Pharmaceutical preparation swallowed to prevent pregnancy IL127923A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68678696A	1996-07-26	1996-07-26
PCT/US1997/012786 WO1998004268A1 (en)	1996-07-26	1997-07-23	Oral contraceptive

Publications (2)

Publication Number	Publication Date
IL127923A0 IL127923A0 (en)	1999-11-30
IL127923A true IL127923A (en)	2004-07-25

Family

ID=24757747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12792397A IL127923A (en)	1996-07-26	1997-07-23	Pharmaceutical preparation swallowed to prevent pregnancy

Country Status (17)

Country	Link
EP (1)	EP0917466B1 (de)
JP (1)	JP2000515888A (de)
KR (1)	KR100501021B1 (de)
CN (1)	CN1119999C (de)
AT (1)	ATE278406T1 (de)
AU (1)	AU713016B2 (de)
BR (1)	BR9710565A (de)
CA (1)	CA2261687A1 (de)
DE (1)	DE69731092T2 (de)
DK (1)	DK0917466T3 (de)
ES (1)	ES2229378T3 (de)
HU (1)	HUP9904345A3 (de)
IL (1)	IL127923A (de)
NZ (1)	NZ333862A (de)
PT (1)	PT917466E (de)
SI (1)	SI0917466T1 (de)
WO (1)	WO1998004268A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4344462C2 (de)	1993-12-22	1996-02-01	Schering Ag	Zusammensetzung für die Empfängnisverhütung
FR2754179B1 (fr)	1996-10-08	1998-12-24	Theramex	Nouvelle composition hormononale et son utilisation
DK1380301T3 (da) *	1999-08-31	2009-04-20	Bayer Schering Pharma Ag	Farmaceutisk sammensætning af ethinylestradiol og drospirenon til anvendelse som svangerskabsforebyggende middel
FR2801218B1 (fr) *	1999-11-23	2001-12-28	Hoechst Marion Roussel Inc	Compositions pharmaceutiques comprenant de la trimegestone, leurs procedes de preparation ainsi que le conditionnement primaire les renfermant
US7297688B2 (en)	2000-06-08	2007-11-20	Wyeth	Starter kit for low dose oral contraceptives
NZ591627A (en) *	2001-12-05	2012-09-28	Teva Womens Health Inc	Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
EP1735056B1 (de)	2004-03-19	2012-10-24	Warner Chilcott Company, LLC	Mehrphasige orale kontrazeptionsmethode mit verlängertem zyklus
DE102004019743B4 (de)	2004-04-20	2008-11-27	Bayer Schering Pharma Aktiengesellschaft	Mehrphasenpräparat zur Kontrazeption auf der Basis eines natürlichen Estrogens
US8022053B2 (en) *	2004-11-02	2011-09-20	Bayer Schering Pharma Aktiengesellschaft	Oral solid dosage forms containing a low dose of estradiol
US7704984B2 (en) *	2005-04-22	2010-04-27	Warner Chilcott Company, Llc	Extended estrogen dosing contraceptive regimen
DE102005034498A1 (de) *	2005-07-20	2007-01-25	Grünenthal GmbH	Orale Kontrazeption mit Trimegeston
US8153616B2 (en)	2005-10-17	2012-04-10	Bayer Pharma Aktiengesellschaft	Combination preparation for oral contraception and oral therapy of dysfunctional uterine bleeding containing estradiol valerate and dienogest and method of using same
MX2008011074A (es)	2006-03-02	2008-09-10	Warner Chilcott Co Inc	Metodo anticonceptivo oral multifasico de ciclo prolongado.
EP1930010A1 (de)	2006-10-20	2008-06-11	Bayer Schering Pharma Aktiengesellschaft	Verwendung von Estradiolvalerat oder 17ß-Estradiol in Kombination mit Dienogest zur oralen Therapie für den Erhalt und/oder die Steigerung der weiblichen Libido

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2365103C3 (de) *	1973-12-21	1980-08-28	Schering Ag, 1000 Berlin Und 4619 Bergkamen	V erwendung von Hormonen zur Kontrazeption
US4616006A (en) *	1983-09-26	1986-10-07	Ortho Pharmaceutical Corporation	Triphasic oral contraceptive
US4628051A (en) *	1983-09-26	1986-12-09	Ortho Pharmaceutical Corporation	Triphasic oral contraceptive
FI101601B (fi) *	1987-09-24	1998-07-31	Jencap Res Ltd	Ehkäisyvalmiste sekä estrogeenin ja progestiinin käyttö ehkäisyvalmist een valmistusmenetelmässä
IE71203B1 (en) *	1990-12-13	1997-02-12	Akzo Nv	Low estrogen oral contraceptives
IE62665B1 (en) *	1990-12-17	1995-02-22	Akzo Nv	Contraceptive regimen
DE4313926A1 (de) *	1993-04-28	1994-11-03	Jenapharm Gmbh	Pharmazeutisches Mehrphasenpräparat zur hormonalen Kontrazeption
NL9301562A (nl) *	1993-09-09	1995-04-03	Saturnus Ag	Preparaat voor substitutietherapie.
DE4344462C2 (de) *	1993-12-22	1996-02-01	Schering Ag	Zusammensetzung für die Empfängnisverhütung
DE4411585A1 (de) *	1994-03-30	1995-10-05	Schering Ag	Pharmazeutisches Kombinationspräparat zur hormonalen Kontrazeption
DE4429374C1 (de) *	1994-08-12	1996-02-01	Jenapharm Gmbh	Pharmazeutische Präparate zur Kontrazeption/Hormonsubstitution mit biogener Estrogenkomponente

1997
- 1997-07-23 AU AU38076/97A patent/AU713016B2/en not_active Ceased
- 1997-07-23 AT AT97935047T patent/ATE278406T1/de not_active IP Right Cessation
- 1997-07-23 NZ NZ333862A patent/NZ333862A/xx unknown
- 1997-07-23 EP EP97935047A patent/EP0917466B1/de not_active Revoked
- 1997-07-23 DE DE69731092T patent/DE69731092T2/de not_active Expired - Fee Related
- 1997-07-23 DK DK97935047T patent/DK0917466T3/da active
- 1997-07-23 KR KR10-1999-7000594A patent/KR100501021B1/ko not_active Expired - Fee Related
- 1997-07-23 PT PT97935047T patent/PT917466E/pt unknown
- 1997-07-23 IL IL12792397A patent/IL127923A/en not_active IP Right Cessation
- 1997-07-23 JP JP10508919A patent/JP2000515888A/ja not_active Ceased
- 1997-07-23 BR BR9710565A patent/BR9710565A/pt not_active Application Discontinuation
- 1997-07-23 ES ES97935047T patent/ES2229378T3/es not_active Expired - Lifetime
- 1997-07-23 WO PCT/US1997/012786 patent/WO1998004268A1/en not_active Ceased
- 1997-07-23 CA CA002261687A patent/CA2261687A1/en not_active Abandoned
- 1997-07-23 SI SI9730679T patent/SI0917466T1/xx unknown
- 1997-07-23 HU HU9904345A patent/HUP9904345A3/hu unknown
- 1997-07-23 CN CN97198093A patent/CN1119999C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK0917466T3 (da)	2004-12-20
NZ333862A (en)	2000-08-25
AU3807697A (en)	1998-02-20
PT917466E (pt)	2004-12-31
BR9710565A (pt)	1999-08-17
CN1230888A (zh)	1999-10-06
SI0917466T1 (en)	2005-02-28
ES2229378T3 (es)	2005-04-16
CN1119999C (zh)	2003-09-03
JP2000515888A (ja)	2000-11-28
DE69731092D1 (de)	2004-11-11
CA2261687A1 (en)	1998-02-05
IL127923A0 (en)	1999-11-30
HUP9904345A3 (en)	2000-11-28
AU713016B2 (en)	1999-11-18
EP0917466B1 (de)	2004-10-06
ATE278406T1 (de)	2004-10-15
KR20000029537A (ko)	2000-05-25
EP0917466A1 (de)	1999-05-26
DE69731092T2 (de)	2005-02-10
HUP9904345A2 (hu)	2000-06-28
WO1998004268A1 (en)	1998-02-05
KR100501021B1 (ko)	2005-07-18

Legal Events

Date	Code	Title
2004-12-15	FF	Patent granted
2005-02-20	KB	Patent renewed
2008-04-13	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US5888543A (en)	1999-03-30	Oral contraceptives
US5858405A (en)	1999-01-12	Oral contraceptive
US5747480A (en)	1998-05-05	Oral contraceptive
EP0956024B1 (de)	2004-07-21	Orale einstufige empfängnisverhütungsmethode und kombinationspräparat das gestagen und estrogen enthält
US6479475B1 (en)	2002-11-12	Oral contraceptive
EP0917466B1 (de)	2004-10-06	Orales contrazeptivum
WO1998004246A2 (en)	1998-02-05	Triphasic contraceptive method and kit comprising a combination of a progestin and estrogen
US6451778B1 (en)	2002-09-17	Oral contraceptive
AU759925B2 (en)	2003-05-01	Oral contraceptive preparation having a first phase comprising progestin/estrogen and a second phase comprising progestin
EP0921804B1 (de)	2003-09-10	Biphasische orale verhuetungsmethode und kit die eine kombination von progestin und eines oestrogens enthalten
WO1998004267A1 (en)	1998-02-05	Progestin/estrogen oral contraceptive
WO1998004266A1 (en)	1998-02-05	Oral contraceptive
WO1997041868A1 (en)	1997-11-13	Oral contraceptive
WO1997041870A1 (en)	1997-11-13	Oral contraceptive
WO1997041871A1 (en)	1997-11-13	Oral contraceptive
WO1997041869A1 (en)	1997-11-13	Oral contraceptive
WO1997041872A1 (en)	1997-11-13	Oral contraceptive
HK1022843B (en)	2005-01-07	Monophasic oral contraceptive method and kit comprising a combination of progestin and estrogen
MXPA99000801A (en)	1999-09-20	Monophasic contraceptive method and kit comprising a combination of a progestin and estrogen
MXPA99000883A (en)	1999-10-14	Oral contraceptive