IL128106A - Continuous monitoring of blood glucose in an impermeable manner - Google Patents

Continuous monitoring of blood glucose in an impermeable manner

Info

Publication number: IL128106A
Authority: IL; Israel
Prior art keywords: infrared; spectral lines; human body; emission spectral; emission
Prior art date: 1997-05-20

Application number

IL12810698A

Other languages

English (en)

Hebrew (he)

Other versions

IL128106A0 (en

Original Assignee

Buchert Janusz M

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-20

Filing date

1998-05-18

Publication date

2004-08-31

1998-05-18 Application filed by Buchert Janusz M filed Critical Buchert Janusz M

1999-11-30 Publication of IL128106A0 publication Critical patent/IL128106A0/xx

2004-08-31 Publication of IL128106A publication Critical patent/IL128106A/en

Links

239000008280 blood Substances 0.000 title claims description 70
210000004369 blood Anatomy 0.000 title claims description 70
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims description 63
239000008103 glucose Substances 0.000 title claims description 61
238000012544 monitoring process Methods 0.000 title description 8
230000003595 spectral effect Effects 0.000 claims abstract description 104
239000012491 analyte Substances 0.000 claims abstract description 58
238000005259 measurement Methods 0.000 claims abstract description 36
238000000034 method Methods 0.000 claims abstract description 27
239000000470 constituent Substances 0.000 claims abstract description 11
230000005855 radiation Effects 0.000 claims description 67
210000003454 tympanic membrane Anatomy 0.000 claims description 29
238000001228 spectrum Methods 0.000 claims description 13
210000000613 ear canal Anatomy 0.000 claims description 11
230000003287 optical effect Effects 0.000 claims description 6
238000003780 insertion Methods 0.000 claims description 4
230000037431 insertion Effects 0.000 claims description 4
238000001914 filtration Methods 0.000 claims 3
238000010521 absorption reaction Methods 0.000 description 12
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 12
238000001514 detection method Methods 0.000 description 8
230000005670 electromagnetic radiation Effects 0.000 description 7
102000004877 Insulin Human genes 0.000 description 6
108090001061 Insulin Proteins 0.000 description 6
229940125396 insulin Drugs 0.000 description 6
230000036760 body temperature Effects 0.000 description 5
239000000126 substance Substances 0.000 description 4
230000005457 Black-body radiation Effects 0.000 description 3
238000000862 absorption spectrum Methods 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
238000013459 approach Methods 0.000 description 3
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
230000000712 assembly Effects 0.000 description 2
238000000429 assembly Methods 0.000 description 2
230000033228 biological regulation Effects 0.000 description 2
230000036770 blood supply Effects 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
238000005100 correlation spectroscopy Methods 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
206010012601 diabetes mellitus Diseases 0.000 description 2
235000019441 ethanol Nutrition 0.000 description 2
210000003016 hypothalamus Anatomy 0.000 description 2
238000002329 infrared spectrum Methods 0.000 description 2
238000002796 luminescence method Methods 0.000 description 2
238000012986 modification Methods 0.000 description 2
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239000010703 silicon Substances 0.000 description 2
238000004497 NIR spectroscopy Methods 0.000 description 1
208000012641 Pigmentation disease Diseases 0.000 description 1
102220469584 Voltage-dependent L-type calcium channel subunit beta-2_P62K_mutation Human genes 0.000 description 1
102100038968 WAP four-disulfide core domain protein 1 Human genes 0.000 description 1
125000003158 alcohol group Chemical group 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
230000008859 change Effects 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
230000036757 core body temperature Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000007943 implant Substances 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000004020 luminiscence type Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
238000000691 measurement method Methods 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
239000000203 mixture Substances 0.000 description 1
230000008520 organization Effects 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
238000000790 scattering method Methods 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000010183 spectrum analysis Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
210000004243 sweat Anatomy 0.000 description 1
230000001360 synchronised effect Effects 0.000 description 1
210000001138 tear Anatomy 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000004861 thermometry Methods 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6815—Ear
- A61B5/6817—Ear canal
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J5/00—Radiation pyrometry, e.g. infrared or optical thermometry
- G01J5/02—Constructional details
- G01J5/08—Optical arrangements
- G01J5/0801—Means for wavelength selection or discrimination
- G01J5/0802—Optical filters
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J5/00—Radiation pyrometry, e.g. infrared or optical thermometry
- G01J5/10—Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors
- G01J5/12—Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors using thermoelectric elements, e.g. thermocouples
- G01J5/14—Electrical features thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Physics & Mathematics (AREA)
Medical Informatics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Pathology (AREA)
Molecular Biology (AREA)
Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Optics & Photonics (AREA)
Otolaryngology (AREA)
Spectroscopy & Molecular Physics (AREA)
Emergency Medicine (AREA)
High Energy & Nuclear Physics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Radiology & Medical Imaging (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

IL12810698A 1997-05-20 1998-05-18 Continuous monitoring of blood glucose in an impermeable manner IL128106A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/859,579 US5823966A (en)	1997-05-20	1997-05-20	Non-invasive continuous blood glucose monitoring
PCT/US1998/010012 WO1998052469A1 (fr)	1997-05-20	1998-05-18	Glycometrie continue non invasive

Publications (2)

Publication Number	Publication Date
IL128106A0 IL128106A0 (en)	1999-11-30
IL128106A true IL128106A (en)	2004-08-31

Family

ID=25331255

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12810698A IL128106A (en)	1997-05-20	1998-05-18	Continuous monitoring of blood glucose in an impermeable manner

Country Status (10)

Country	Link
US (1)	US5823966A (fr)
EP (1)	EP0939603A4 (fr)
JP (1)	JP2001506164A (fr)
KR (1)	KR100695761B1 (fr)
AU (1)	AU7491798A (fr)
CA (1)	CA2290957C (fr)
EA (1)	EA002288B1 (fr)
IL (1)	IL128106A (fr)
PL (1)	PL331145A1 (fr)
WO (1)	WO1998052469A1 (fr)

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- 1997-05-20 US US08/859,579 patent/US5823966A/en not_active Expired - Fee Related
1998
- 1998-05-18 PL PL98331145A patent/PL331145A1/xx not_active Application Discontinuation
- 1998-05-18 EP EP98922347A patent/EP0939603A4/fr not_active Withdrawn
- 1998-05-18 IL IL12810698A patent/IL128106A/en not_active IP Right Cessation
- 1998-05-18 CA CA002290957A patent/CA2290957C/fr not_active Expired - Fee Related
- 1998-05-18 JP JP55046898A patent/JP2001506164A/ja active Pending
- 1998-05-18 WO PCT/US1998/010012 patent/WO1998052469A1/fr not_active Ceased
- 1998-05-18 EA EA199900145A patent/EA002288B1/ru not_active IP Right Cessation
- 1998-05-18 KR KR1019997000425A patent/KR100695761B1/ko not_active Expired - Fee Related
- 1998-05-18 AU AU74917/98A patent/AU7491798A/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0939603A4 (fr)	2005-12-14
EA002288B1 (ru)	2002-02-28
KR100695761B1 (ko)	2007-03-16
AU7491798A (en)	1998-12-11
JP2001506164A (ja)	2001-05-15
CA2290957A1 (fr)	1998-11-26
PL331145A1 (en)	1999-06-21
US5823966A (en)	1998-10-20
EA199900145A1 (ru)	1999-08-26
WO1998052469A1 (fr)	1998-11-26
KR20000029457A (ko)	2000-05-25
EP0939603A1 (fr)	1999-09-08
CA2290957C (fr)	2004-12-14
IL128106A0 (en)	1999-11-30

Legal Events

Date	Code	Title
2005-01-24	FF	Patent granted
2005-03-20	KB	Patent renewed
2008-07-09	KB	Patent renewed
2013-02-03	MM9K	Patent not in force due to non-payment of renewal fees

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