IL142983A0 - Nucleosides with anti-hepatisis b virus activity - Google Patents

Nucleosides with anti-hepatisis b virus activity

Info

Publication number: IL142983A0
Authority: IL; Israel
Prior art keywords: hepatisis; nucleosides; acyl; virus activity; virus
Prior art date: 1998-11-05

Application number

IL14298399A

Other languages

English (en)

Original Assignee

Centre Nat Rech Scient

Univ Emory

Uab Research Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-05

Filing date

1999-11-05

Publication date

2002-04-21

1999-11-05 Application filed by Centre Nat Rech Scient, Univ Emory, Uab Research Foundation filed Critical Centre Nat Rech Scient

2002-04-21 Publication of IL142983A0 publication Critical patent/IL142983A0/xx

Links

241000700605 Viruses Species 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
125000003835 nucleoside group Chemical group 0.000 title 1
125000002252 acyl group Chemical group 0.000 abstract 2
241000700721 Hepatitis B virus Species 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000001177 diphosphate Substances 0.000 abstract 1
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
235000011180 diphosphates Nutrition 0.000 abstract 1
229960004413 flucytosine Drugs 0.000 abstract 1
208000002672 hepatitis B Diseases 0.000 abstract 1
150000004712 monophosphates Chemical class 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000001226 triphosphate Substances 0.000 abstract 1
235000011178 triphosphate Nutrition 0.000 abstract 1
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

IL14298399A 1998-11-05 1999-11-05 Nucleosides with anti-hepatisis b virus activity IL142983A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US10711698P	1998-11-05	1998-11-05
US11565399P	1999-01-13	1999-01-13
PCT/US1999/026157 WO2000026225A2 (en)	1998-11-05	1999-11-05	Nucleosides with anti-hepatitis b virus activity

Publications (1)

Publication Number	Publication Date
IL142983A0 true IL142983A0 (en)	2002-04-21

Family

ID=26804401

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL14298399A IL142983A0 (en)	1998-11-05	1999-11-05	Nucleosides with anti-hepatisis b virus activity
IL142983A IL142983A (en)	1998-11-05	2001-05-04	History of ß - L - (2 'or 3') - Azido - 2 ', 3' - Dioxy - 5 - Fluorocytocine with antiviral activity and hepatitis preparations containing them

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL142983A IL142983A (en)	1998-11-05	2001-05-04	History of ß - L - (2 'or 3') - Azido - 2 ', 3' - Dioxy - 5 - Fluorocytocine with antiviral activity and hepatitis preparations containing them

Country Status (13)

Country	Link
US (1)	US6458773B1 (de)
EP (1)	EP1124839B1 (de)
JP (2)	JP2002528554A (de)
KR (1)	KR100618028B1 (de)
CN (1)	CN1216893C (de)
AT (1)	ATE315574T1 (de)
AU (1)	AU774720B2 (de)
BR (1)	BR9915555A (de)
CA (1)	CA2348470C (de)
DE (1)	DE69929460D1 (de)
IL (2)	IL142983A0 (de)
MX (1)	MXPA01004504A (de)
WO (1)	WO2000026225A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100719606B1 (ko) *	1998-02-25	2007-05-17	에모리 유니버시티	2'-플루오로뉴클레오사이드
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
KR20080021797A (ko)	2000-05-26	2008-03-07	이데닉스(케이만)리미티드	플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
EP1387850A2 (de)	2001-05-18	2004-02-11	Rakesh Kumar	Antivirale nukleoside
NZ537662A (en)	2002-06-28	2007-10-26	Idenix Cayman Ltd	2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) *	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
PL374781A1 (en)	2002-06-28	2005-10-31	Idenix (Cayman) Limited	2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US20040067877A1 (en)	2002-08-01	2004-04-08	Schinazi Raymond F.	2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections
JP5046219B2 (ja) *	2002-10-31	2012-10-10	リガンド・ファーマシューティカルズ・インコーポレイテッド	１，３−プロパン−１−アリールジオールの新規環状リン酸ジエステルおよびそのプロドラッグへの使用
HUE033832T2 (en)	2002-11-15	2018-01-29	Idenix Pharmaceuticals Llc	2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
RU2005121904A (ru)	2002-12-12	2006-01-20	Айденикс (Кайман) Лимитед (Ky)	Способ получения 2`-разветвленных нуклеозидов
EP1976382B1 (de)	2005-12-23	2013-04-24	IDENIX Pharmaceuticals, Inc.	Verfahren zur herstellung eines synthetischen zwischenprodukts für die herstellung von verzweigten nukleosiden
JP2017512183A (ja)	2014-02-13	2017-05-18	リガンド・ファーマシューティカルズ・インコーポレイテッド	プロドラッグ化合物およびそれらの使用
CN106687118A (zh)	2014-07-02	2017-05-17	配体药物公司	前药化合物及其用途
RU2020126177A (ru)	2018-01-09	2022-02-10	Лиганд Фармасьютикалз, Инк.	Ацетальные соединения и их терапевтическое применение

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4841039A (en)	1986-05-01	1989-06-20	Emory University	2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US4916122A (en)	1987-01-28	1990-04-10	University Of Georgia Research Foundation, Inc.	3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US4681933A (en)	1986-05-01	1987-07-21	University Of Georgia Research Foundation, Inc.	2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US5084445A (en)	1986-05-01	1992-01-28	University Of Georgia Research Foundation, Inc.	3'-azido-2',3'-dideoxy-5-methylcytidine
US5077279A (en)	1986-05-01	1991-12-31	University Of Georgia Research Foundation, Inc.	3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US5190926A (en)	1987-01-28	1993-03-02	University Of Georgia Research Foundation, Inc.	3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
NZ228645A (en)	1988-04-11	1991-09-25	Iaf Biochem Int	1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US5047407A (en)	1989-02-08	1991-09-10	Iaf Biochem International, Inc.	2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5041449A (en)	1988-04-11	1991-08-20	Iaf Biochem International, Inc.	4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
DD293498A5 (de) *	1989-07-20	1991-09-05	Zi Fuer Molekularbiologie Der Adw,De	Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
US5204466A (en)	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
DE4224737A1 (de)	1992-07-27	1994-02-03	Herbert Prof Dr Schott	Neue Cytosinnucleosidanaloga, Verfahren zu ihrer Herstellung und ihre Verwendung
CA2637774C (en)	1993-09-10	2011-07-19	Emory University	Nucleosides with anti-hepatitis b virus activity
FR2709754B1 (fr)	1993-09-10	1995-12-01	Centre Nat Rech Scient	Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.
DE4418690A1 (de)	1994-05-28	1996-01-11	Boehringer Mannheim Gmbh	Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
US5559101A (en)	1994-10-24	1996-09-24	Genencor International, Inc.	L-ribofuranosyl nucleosides
US5703058A (en)	1995-01-27	1997-12-30	Emory University	Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
EP0831852B1 (de)	1995-06-07	2006-11-29	Emory University	Nucleoside mit anti-hepatitis b virus wirksamkeit
JPH11512397A (ja)	1995-09-07	1999-10-26	ユニバーシティーオブジョージアリサーチファウンデーション，インコーポレイテッド	治療用アジド化合物
IL129126A0 (en)	1996-10-16	2000-02-17	Icn Pharmaceuticals	Monocyclic l-nucleosides analogs and uses thereof

1999
- 1999-11-05 US US09/435,261 patent/US6458773B1/en not_active Expired - Lifetime
- 1999-11-05 IL IL14298399A patent/IL142983A0/xx active IP Right Grant
- 1999-11-05 EP EP99958793A patent/EP1124839B1/de not_active Expired - Lifetime
- 1999-11-05 MX MXPA01004504A patent/MXPA01004504A/es not_active IP Right Cessation
- 1999-11-05 AT AT99958793T patent/ATE315574T1/de not_active IP Right Cessation
- 1999-11-05 WO PCT/US1999/026157 patent/WO2000026225A2/en not_active Ceased
- 1999-11-05 DE DE69929460T patent/DE69929460D1/de not_active Expired - Lifetime
- 1999-11-05 CA CA002348470A patent/CA2348470C/en not_active Expired - Fee Related
- 1999-11-05 KR KR1020017005679A patent/KR100618028B1/ko not_active Expired - Fee Related
- 1999-11-05 CN CN998141895A patent/CN1216893C/zh not_active Expired - Fee Related
- 1999-11-05 AU AU16085/00A patent/AU774720B2/en not_active Ceased
- 1999-11-05 JP JP2000579613A patent/JP2002528554A/ja not_active Withdrawn
- 1999-11-05 BR BR9915555-9A patent/BR9915555A/pt not_active IP Right Cessation
2001
- 2001-05-04 IL IL142983A patent/IL142983A/en not_active IP Right Cessation
2011
- 2011-06-22 JP JP2011138647A patent/JP2011246469A/ja active Pending

Also Published As

Publication number	Publication date
JP2002528554A (ja)	2002-09-03
BR9915555A (pt)	2002-01-15
DE69929460D1 (de)	2006-04-06
WO2000026225A3 (en)	2000-10-05
HK1036069A1 (en)	2001-12-21
EP1124839A2 (de)	2001-08-22
EP1124839B1 (de)	2006-01-11
US6458773B1 (en)	2002-10-01
CN1216893C (zh)	2005-08-31
CA2348470C (en)	2007-06-05
WO2000026225A2 (en)	2000-05-11
CA2348470A1 (en)	2000-05-11
CN1329618A (zh)	2002-01-02
KR100618028B1 (ko)	2006-08-30
AU1608500A (en)	2000-05-22
KR20020013474A (ko)	2002-02-20
AU774720B2 (en)	2004-07-08
ATE315574T1 (de)	2006-02-15
IL142983A (en)	2006-07-05
JP2011246469A (ja)	2011-12-08
MXPA01004504A (es)	2005-04-19

Legal Events

Date	Code	Title
2006-12-27	FF	Patent granted
2006-12-27	KB	Patent renewed
2010-05-17	KB	Patent renewed

Publication	Publication Date	Title
IL142983A0 (en)	2002-04-21	Nucleosides with anti-hepatisis b virus activity
DK1104436T3 (da)	2006-04-03	Beta-L-2'-deoxy-nukleosider til behandling af hepatitis B-virus
CA2268703A1 (en)	1994-05-11	Enantiomerically pure .beta.-d-dioxolane nucleosides with selective anti-hepatitis b virus activity
NZ330137A (en)	2000-08-25	L-nucleoside and L-nucleotide derivatives and their use in treating a human infected with HBV or EBV
IL173586A0 (en)	2006-07-05	Use of nucleoside analogues and doxorubicin in medicaments for treating leukemia
CA2215190A1 (en)	1996-09-26	Aryl-ester phosphoramidate derivatives of nucleosides
KR970701198A (ko)	1997-03-17	3'-치환 뉴클레오시드 유도체(3'-substituted nucleoside derivative)
ATE157252T1 (de)	1997-09-15	3'-azido-2',3'-dideoxy-5-methylcytidin enthaltende antivirale zusammensetzungen
CA2287370A1 (en)	1998-09-24	Synthesis, anti-human immunodeficiency virus and anti-hepatitis b virus activities of 1,3-oxaselenolane nucleosides
BR9915037A (pt)	2001-11-20	Nucleosìdeos ß-l-2'-deoxi para o tratamento deinfecção de hiv
Long et al.	1972	Synthesis and antitumor antiviral activities of 1-. beta.-D-arabinofuranosylpyrimidine 3', 5'-cyclic phosphates
Lu et al.	1976	Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA
RU2001115094A (ru)	2003-03-10	Нуклеозиды, обладающие активностью против вируса гепатита в
CA2538205A1 (en)	1996-12-19	Nucleosides with anti-hepatitis b virus activity
RU96117323A (ru)	1998-12-10	L-нуклеозиды для лечения заболеваний, вызванных вирусом гепатита b и вирусом эпштейна - барра
JPS6426594A (en)	1989-01-27	Nucleotides and antitumor agent
MX9603029A (es)	1998-01-31	Nucleosidos-l para el tratamiento del virus-b de hepatitis y el virus de epstein-barr.
MX9709788A (es)	1998-10-31	Analogos de nucleotidos para tratamiento topico de enfermedades proliferativas de la piel.