IL143660A0 - Troxerutin with high trihydroxy-ethyl-rutin content and method for preparing same - Google Patents

Troxerutin with high trihydroxy-ethyl-rutin content and method for preparing same

Info

Publication number: IL143660A0
Authority: IL; Israel
Prior art keywords: troxerutin; wettability; water; trihydroxy; ethyl
Prior art date: 1998-12-11

Application number

IL14366099A

Other languages

English (en)

Original Assignee

Negma Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-11

Filing date

1999-12-10

Publication date

2002-04-21

1999-12-10 Application filed by Negma Lab filed Critical Negma Lab

2002-04-21 Publication of IL143660A0 publication Critical patent/IL143660A0/xx

Links

IYVFNTXFRYQLRP-VVSTWUKXSA-N 2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-3-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-({[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-4h-chromen-4-one Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(OCCO)C=C3OC=2C=2C=C(OCCO)C(OCCO)=CC=2)=O)O1 IYVFNTXFRYQLRP-VVSTWUKXSA-N 0.000 title abstract 10
229960003232 troxerutin Drugs 0.000 title abstract 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
239000000843 powder Substances 0.000 abstract 2
238000005303 weighing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

IL14366099A 1998-12-11 1999-12-10 Troxerutin with high trihydroxy-ethyl-rutin content and method for preparing same IL143660A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9815710A FR2787111B1 (fr)	1998-12-11	1998-12-11	Troxerutine a forte teneur en trihydroxy-ethyl-rutoside, a mouillabilite elevee, et procede de preparation
PCT/FR1999/003100 WO2000035933A1 (fr)	1998-12-11	1999-12-10	Troxerutine a forte teneur en trihydroxy-ethyl-rutoside et procede de preparation

Publications (1)

Publication Number	Publication Date
IL143660A0 true IL143660A0 (en)	2002-04-21

Family

ID=9533903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14366099A IL143660A0 (en)	1998-12-11	1999-12-10	Troxerutin with high trihydroxy-ethyl-rutin content and method for preparing same

Country Status (21)

Country	Link
US (1)	US6855697B1 (cs)
EP (1)	EP1137653B1 (cs)
JP (1)	JP2003505338A (cs)
KR (1)	KR100644478B1 (cs)
CN (1)	CN1196709C (cs)
AT (1)	ATE276265T1 (cs)
AU (1)	AU1569300A (cs)
BR (1)	BR9916130A (cs)
CA (1)	CA2354574C (cs)
CZ (1)	CZ20011998A3 (cs)
DE (1)	DE69920263T2 (cs)
ES (1)	ES2229795T3 (cs)
FR (1)	FR2787111B1 (cs)
HU (1)	HUP0104689A3 (cs)
IL (1)	IL143660A0 (cs)
PL (1)	PL195116B1 (cs)
RU (1)	RU2242478C2 (cs)
SK (1)	SK7822001A3 (cs)
TR (1)	TR200101695T2 (cs)
WO (1)	WO2000035933A1 (cs)
ZA (1)	ZA200105072B (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1302774C (zh) *	2003-11-07	2007-03-07	邱学良	一种含有曲克芦丁的泡腾片及制法
RU2299070C2 (ru) *	2005-02-08	2007-05-20	Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН")	Фармацевтическая композиция для лечения заболевания вен и способ ее получения
RU2295970C1 (ru) *	2006-05-23	2007-03-27	Общество С Ограниченной Ответственностью "Сиа Пептайдс"	Пептид, повышающий резистентность капилляров, фармацевтическая композиция на его основе и способ ее применения
CN103113437A (zh) *	2013-01-05	2013-05-22	河北联合大学	曲克芦丁的制备方法
CN104177461B (zh) *	2013-05-21	2016-11-09	济南新力特科技有限公司	三羟乙基芦丁的制备方法
KR101809943B1 (ko) *	2014-05-23	2017-12-18	지난 신라이트 테크놀로지 컴퍼니 리미티드	트리하이드록시에틸 루토사이드의 제조방법
CN104628799B (zh) *	2014-12-24	2017-10-03	苏州亚宝药物研发有限公司	一种曲克芦丁中杂质a及其分离方法
CN111333602B (zh) *	2020-04-16	2022-12-16	四川协力制药股份有限公司	一种曲克芦丁生产废弃母液的回收转化工艺
CN112057424B (zh) *	2020-09-18	2022-09-16	开封康诺药业有限公司	一种曲克芦丁冻干粉针剂及其制备方法
JP2024518639A (ja)	2021-05-20	2024-05-01	ロックオプコリミテッドライアビリティカンパニー	ビタミンｃ化合物を含有する化粧品組成物及びその使用
CN116903574B (zh) *	2023-07-18	2025-10-10	陕西琦羿健康产业有限公司	一种利用曲克芦丁废液粉制备槲皮素的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH423808A (fr) *	1964-03-26	1966-11-15	Zyma Sa	Procédé pour la préparation d'éthers O-B-hydroxyéthylés de la rutine
FR5072M (cs) *	1965-10-25	1967-05-16
US4153788A (en) *	1974-04-09	1979-05-08	Zyma S.A.	Process of preparing mono-O-β-hydroxyethyl-7 rutoside
CH581127A5 (cs) *	1974-04-09	1976-10-29	Zyma Sa
CS225440B1 (cs) *	1982-04-06	1984-02-13	Frantisek Ing Kvis	Způsob přípravy směsi 0-hydroxyethylovaných derivátů rutinu
CN1032658A (zh) *	1987-10-19	1989-05-03	烟台人民制药厂	芦丁羟乙基衍生物的精制方法

1998
- 1998-12-11 FR FR9815710A patent/FR2787111B1/fr not_active Expired - Fee Related
1999
- 1999-12-10 TR TR2001/01695T patent/TR200101695T2/xx unknown
- 1999-12-10 ES ES99958302T patent/ES2229795T3/es not_active Expired - Lifetime
- 1999-12-10 CA CA002354574A patent/CA2354574C/fr not_active Expired - Fee Related
- 1999-12-10 JP JP2000588191A patent/JP2003505338A/ja active Pending
- 1999-12-10 RU RU2001119173/04A patent/RU2242478C2/ru active
- 1999-12-10 SK SK782-2001A patent/SK7822001A3/sk unknown
- 1999-12-10 PL PL99348200A patent/PL195116B1/pl not_active IP Right Cessation
- 1999-12-10 AU AU15693/00A patent/AU1569300A/en not_active Abandoned
- 1999-12-10 CN CNB998143650A patent/CN1196709C/zh not_active Expired - Fee Related
- 1999-12-10 BR BR9916130-3A patent/BR9916130A/pt not_active Application Discontinuation
- 1999-12-10 US US09/857,846 patent/US6855697B1/en not_active Expired - Fee Related
- 1999-12-10 KR KR1020017007287A patent/KR100644478B1/ko not_active Expired - Fee Related
- 1999-12-10 DE DE69920263T patent/DE69920263T2/de not_active Expired - Fee Related
- 1999-12-10 EP EP99958302A patent/EP1137653B1/fr not_active Expired - Lifetime
- 1999-12-10 CZ CZ20011998A patent/CZ20011998A3/cs unknown
- 1999-12-10 IL IL14366099A patent/IL143660A0/xx not_active IP Right Cessation
- 1999-12-10 HU HU0104689A patent/HUP0104689A3/hu unknown
- 1999-12-10 AT AT99958302T patent/ATE276265T1/de not_active IP Right Cessation
- 1999-12-10 WO PCT/FR1999/003100 patent/WO2000035933A1/fr not_active Ceased
2001
- 2001-06-20 ZA ZA200105072A patent/ZA200105072B/en unknown

Also Published As

Publication number	Publication date
WO2000035933A1 (fr)	2000-06-22
CZ20011998A3 (cs)	2001-10-17
HUP0104689A3 (en)	2003-12-29
JP2003505338A (ja)	2003-02-12
PL195116B1 (pl)	2007-08-31
FR2787111A1 (fr)	2000-06-16
ATE276265T1 (de)	2004-10-15
ZA200105072B (en)	2002-12-20
CN1331697A (zh)	2002-01-16
HUP0104689A2 (hu)	2002-04-29
EP1137653B1 (fr)	2004-09-15
CN1196709C (zh)	2005-04-13
EP1137653A1 (fr)	2001-10-04
US6855697B1 (en)	2005-02-15
AU1569300A (en)	2000-07-03
DE69920263T2 (de)	2005-09-29
PL348200A1 (en)	2002-05-06
TR200101695T2 (tr)	2002-04-22
KR20010101173A (ko)	2001-11-14
CA2354574C (fr)	2009-07-28
DE69920263D1 (de)	2004-10-21
ES2229795T3 (es)	2005-04-16
FR2787111B1 (fr)	2001-02-23
RU2242478C2 (ru)	2004-12-20
BR9916130A (pt)	2001-09-04
CA2354574A1 (fr)	2000-06-22
SK7822001A3 (en)	2002-01-07
KR100644478B1 (ko)	2006-11-10

Legal Events

Date	Code	Title	Description
2006-08-01	FF	Patent granted
2010-11-30	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
PL348200A1 (en)	2002-05-06	Troxerutin with high trihydroxy-ethyl-rutin content and method for preparing same
JPS5731466A (en)	1982-02-19	Manufacture of composite material
EP0151344A3 (en)	1987-04-15	A chewing gum composition, a process for preparing a chewing gum tablet therefrom, and a chewing gum tablet
JPS56169598A (en)	1981-12-26	Measuring composition
GB2161800B (en)	1988-08-10	Water soluble compositions for preparing analytical solutions
IE791107L (en)	1979-09-29	Anaerobic compositions
EP0309360A3 (en)	1989-10-18	Electrochemical captor, with integrated structure, for measuring relative concentrations of reactive components
IE800313L (en)	1980-09-23	Detergent composition containing soluble citric acid salts.
JPS56100892A (en)	1981-08-13	Bulk density enhancing agent of stock coal for preparing coke
JPS5724634A (en)	1982-02-09	Deoxydizer composition
AU645205B2 (en)	1994-01-06	Stabilized solid dosage forms of choline metal carboxymethylcellulose salicylate compositions
PT74969B (en)	1983-12-29	Process for the preparation of flowable water based compositions containing n-<(trichloromethyl)thio>-4-ciclohexene-1,2-dicarboximide for use as seed dressings
AU3350599A (en)	1999-10-18	A method to produce compacted graphite iron (cgi)
DE3162067D1 (en)	1984-03-08	Plant-growth regulating compositions containing as active agent 2-methylene-succinamic acid derivatives, and derivatives of this acid useful in these compositions
JPS5595885A (en)	1980-07-21	Crystal for scintillator
Prochazka	1983	Sintering and properties of dense aluminium germanate
JPS5594641A (en)	1980-07-18	Deoxidizing agent
Chung et al.	1987	A longitudinal study of change in mandibular lateral surface and its relationship to the body height
Menk et al.	1989	Process for manufacturing cast iron containing vermicular graphite
PIEVSKII	1986	METHOD FOR DETERMINING THE RATIONAL COMPOSITION OF CERAMIC BODIES
JPS52108013A (en)	1977-09-10	Artificial saliva
PT75251B (en)	1985-10-04	Process for the preparation of 6-<3,6-dihydro-1(2h)-pyridyl>-pyrimidine-3-oxides
Jangg	1986	Process for Manufacturing a Porous Filter Body From Metal Powder
NZ504391A (en)	2002-09-27	Use of a benzoic acid derivative as a precipitation temperature lowering agent for a chloroacetamide herbicide
Havranek et al.	1989	CORROSION RESISTANCE OF CORUNDUM-BADDELEYITE REFRACTORIES TO MELTS