IL143983A0 - Use of cellular transport systems for the transfer of nucleic acids through the nuclear envelope - Google Patents

Use of cellular transport systems for the transfer of nucleic acids through the nuclear envelope

Info

Publication number
IL143983A0
IL143983A0 IL14398300A IL14398300A IL143983A0 IL 143983 A0 IL143983 A0 IL 143983A0 IL 14398300 A IL14398300 A IL 14398300A IL 14398300 A IL14398300 A IL 14398300A IL 143983 A0 IL143983 A0 IL 143983A0
Authority
IL
Israel
Prior art keywords
transfer
nucleic acids
transport systems
nuclear envelope
cellular transport
Prior art date
Application number
IL14398300A
Other languages
English (en)
Original Assignee
Amaxa Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19933939A external-priority patent/DE19933939A1/de
Application filed by Amaxa Gmbh filed Critical Amaxa Gmbh
Publication of IL143983A0 publication Critical patent/IL143983A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
IL14398300A 1999-01-08 2000-01-03 Use of cellular transport systems for the transfer of nucleic acids through the nuclear envelope IL143983A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19900513 1999-01-08
DE19933939A DE19933939A1 (de) 1999-01-08 1999-07-20 Ausnutzung zelleigener Transportsysteme zum Transfer von Nukleinsäuren durch die Kernhülle
PCT/DE2000/000061 WO2000040742A1 (fr) 1999-01-08 2000-01-03 Utilisation de systemes de transport propres aux cellules pour transferer des acides nucleiques a travers l'enveloppe nucleaire

Publications (1)

Publication Number Publication Date
IL143983A0 true IL143983A0 (en) 2002-04-21

Family

ID=26051245

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14398300A IL143983A0 (en) 1999-01-08 2000-01-03 Use of cellular transport systems for the transfer of nucleic acids through the nuclear envelope

Country Status (8)

Country Link
US (1) US6521456B1 (fr)
EP (1) EP1141364A1 (fr)
JP (2) JP3997056B2 (fr)
CN (1) CN1262668C (fr)
AU (1) AU764660B2 (fr)
CA (1) CA2358040C (fr)
IL (1) IL143983A0 (fr)
WO (1) WO2000040742A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069173A1 (en) * 1998-03-16 2003-04-10 Life Technologies, Inc. Peptide-enhanced transfections
EP1141364A1 (fr) * 1999-01-08 2001-10-10 Amaxa GmbH Utilisation de systemes de transport propres aux cellules pour transferer des acides nucleiques a travers l'enveloppe nucleaire
EP1235914A2 (fr) * 1999-11-24 2002-09-04 Joseph Rosenecker Polypeptides comprenant des multimeres de signaux de localisation nucleaire ou de domaines de transduction de proteine et utilisations de ces derniers pour transferer des molecules dans des cellules
US20040063906A1 (en) * 2000-11-24 2004-04-01 Nielsen Peter E. Pna analogues
WO2002053574A2 (fr) * 2001-01-05 2002-07-11 Pantheco A/S Molecules pna modifiees
KR100912741B1 (ko) 2001-01-10 2009-08-18 아막사 아게 모듈식 트랜스펙션 시스템
WO2003092735A2 (fr) * 2002-05-01 2003-11-13 Pantheco A/S Conjugues d'acide nucleique peptidique
US8324365B2 (en) * 2003-04-03 2012-12-04 Korea Advanced Institute Of Science And Technology Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
US8969543B2 (en) * 2003-04-03 2015-03-03 Bioneer Corporation SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
US20070149496A1 (en) * 2003-10-31 2007-06-28 Jack Tuszynski Water-soluble compound
CA2619533C (fr) * 2005-08-17 2014-02-04 Bioneer Corporation Conjugues siarn-polymeres hydrophiles pour l'administration intracellulaire de petits arn interferents et methode associee
EP1900820A1 (fr) * 2006-09-13 2008-03-19 Amaxa AG Agent de transport au nucleus et méthode pour sa fabrication
AU2019269066B2 (en) 2018-05-18 2022-10-06 F. Hoffmann-La Roche Ag Targeted intracellular delivery of large nucleic acids

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
WO1993019768A1 (fr) * 1992-04-03 1993-10-14 The Regents Of The University Of California Systeme de livraison d'un polynucleotide a assemblage autonome
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
US5631237A (en) 1992-12-22 1997-05-20 Dzau; Victor J. Method for producing in vivo delivery of therapeutic agents via liposomes
EP0745134A1 (fr) * 1994-02-22 1996-12-04 Danafarber Cancer Institute Systeme de liberation d'acide nucleique, son procede de synthese et ses utilisations
EP0753069A1 (fr) * 1994-04-15 1997-01-15 Targeted Genetics Corporation Proteine de fusion d'apport de gene
US5670347A (en) * 1994-05-11 1997-09-23 Amba Biosciences Llc Peptide-mediated gene transfer
EP0874910A4 (fr) 1995-06-07 1999-04-21 Life Technologies Inc Transfection par lipides cationiques amelioree par des peptides
DE19541679A1 (de) 1995-11-08 1997-05-15 Gerhard Dr Friedrich Nicht virale Gentransfersysteme mit NLS (nuclear localization sequences) und/oder magnetisierbaren Mikropartikeln und das damit verbundene Herstellungsverfahren
AUPN741696A0 (en) * 1996-01-05 1996-01-25 Commonwealth Scientific And Industrial Research Organisation Delivery of nucleic acids ii
EP0946718A1 (fr) * 1996-12-23 1999-10-06 Gene-Cell Constructions d'acide nucleique et leur utilisation en vue d'une incorporation directe dans les cellules
JP2002514078A (ja) * 1997-04-18 2002-05-14 ミレニアム ファーマシューティカルズ インク． Ｆｔｈｍａ−０７０関連蛋白質ファミリーおよびｔ８５関連蛋白質ファミリーの新規分子ならびにそれらの使用
EP1141364A1 (fr) * 1999-01-08 2001-10-10 Amaxa GmbH Utilisation de systemes de transport propres aux cellules pour transferer des acides nucleiques a travers l'enveloppe nucleaire
US6312956B1 (en) * 1999-10-01 2001-11-06 Vanderbilt University Nuclear targeted peptide nucleic acid oligomer

Also Published As

Publication number Publication date
AU764660B2 (en) 2003-08-28
EP1141364A1 (fr) 2001-10-10
CN1339068A (zh) 2002-03-06
AU2533700A (en) 2000-07-24
JP2006345867A (ja) 2006-12-28
US6521456B1 (en) 2003-02-18
JP3997056B2 (ja) 2007-10-24
CA2358040A1 (fr) 2000-07-13
CN1262668C (zh) 2006-07-05
JP2002534437A (ja) 2002-10-15
WO2000040742A1 (fr) 2000-07-13
CA2358040C (fr) 2008-06-10

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