IL146148A0 - Use of phthalazine derivatives - Google Patents
Use of phthalazine derivativesInfo
- Publication number
- IL146148A0 IL146148A0 IL14614800A IL14614800A IL146148A0 IL 146148 A0 IL146148 A0 IL 146148A0 IL 14614800 A IL14614800 A IL 14614800A IL 14614800 A IL14614800 A IL 14614800A IL 146148 A0 IL146148 A0 IL 146148A0
- Authority
- IL
- Israel
- Prior art keywords
- phthalazine derivatives
- parp
- inhibitors
- homologous enzymes
- phthalazine
- Prior art date
Links
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical class C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 abstract 1
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 abstract 1
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19921567A DE19921567A1 (de) | 1999-05-11 | 1999-05-11 | Verwendung von Phthalazine-Derivaten |
| PCT/EP2000/003967 WO2000067734A2 (fr) | 1999-05-11 | 2000-05-03 | Utilisation de derives de phtalazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL146148A0 true IL146148A0 (en) | 2002-07-25 |
Family
ID=7907632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14614800A IL146148A0 (en) | 1999-05-11 | 2000-05-03 | Use of phthalazine derivatives |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6903098B1 (fr) |
| EP (1) | EP1231982B1 (fr) |
| JP (1) | JP2003502286A (fr) |
| KR (1) | KR20020000642A (fr) |
| CN (1) | CN1399573A (fr) |
| AT (1) | ATE357272T1 (fr) |
| AU (1) | AU5064000A (fr) |
| BG (1) | BG106056A (fr) |
| BR (1) | BR0010428A (fr) |
| CA (1) | CA2372704A1 (fr) |
| CZ (1) | CZ20014038A3 (fr) |
| DE (2) | DE19921567A1 (fr) |
| ES (1) | ES2284499T3 (fr) |
| HU (1) | HUP0202477A3 (fr) |
| IL (1) | IL146148A0 (fr) |
| NO (1) | NO20015462D0 (fr) |
| PL (1) | PL352150A1 (fr) |
| SK (1) | SK286676B6 (fr) |
| TR (1) | TR200103236T2 (fr) |
| WO (1) | WO2000067734A2 (fr) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291425B1 (en) | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
| EP1223932A4 (fr) * | 1999-10-01 | 2003-01-15 | Smithkline Beecham Corp | Composes et methodes |
| NZ521792A (en) * | 2000-03-20 | 2004-06-25 | N Gene Res Lab Inc | Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and use in treating conditions connected with oxygen deficiency |
| US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| KR100955015B1 (ko) * | 2001-08-15 | 2010-04-28 | 이코스 코포레이션 | 2h-프탈라진-1-온 및 이것의 사용 방법 |
| DE60335359D1 (de) | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
| ATE405658T1 (de) | 2002-07-26 | 2008-09-15 | Basf Plant Science Gmbh | Neue selektionsverfahren |
| JP4520406B2 (ja) | 2002-10-01 | 2010-08-04 | 田辺三菱製薬株式会社 | イソキノリン化合物及びその医薬用途 |
| US7501412B2 (en) | 2002-11-22 | 2009-03-10 | Mitsubishi Tanabe Pharma Corporation | Isoquinoline compounds and medicinal use thereof |
| GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| CN101137752B (zh) | 2005-03-08 | 2013-04-03 | 巴斯福植物科学有限公司 | 增强表达的内含子序列 |
| CA2615374A1 (fr) * | 2005-07-18 | 2007-01-25 | Ernest Kun Kun | Traitement du cancer |
| GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
| US20100279327A1 (en) * | 2006-06-12 | 2010-11-04 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
| WO2008147418A1 (fr) * | 2006-06-12 | 2008-12-04 | Bipar Sciences, Inc. | Procédé permettant de traiter des maladies avec des inhibiteurs de parp |
| US20080262062A1 (en) * | 2006-11-20 | 2008-10-23 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
| JP2010502730A (ja) * | 2006-09-05 | 2010-01-28 | バイパー サイエンシズ,インコーポレイティド | 癌の治療法 |
| CA2662337A1 (fr) * | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition de la synthese d'acides gras au moyen d'inhibiteurs parp et methodes de traitement associees |
| UY30639A1 (es) | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
| DK2120579T3 (da) * | 2006-12-28 | 2014-02-03 | Abbvie Inc | Inhibitorer af poly(ADP-ripose)polymerase |
| US8466150B2 (en) * | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
| MX2010002749A (es) | 2007-09-14 | 2010-06-25 | Astrazeneca Ab | Derivados de ftalazinona. |
| KR20100102607A (ko) * | 2007-11-12 | 2010-09-24 | 바이파 사이언스 인코포레이티드 | Parp 억제제를 단독으로 사용하거나 항종양제와 병용하여 자궁암 및 난소암을 치료하는 방법 |
| CN103169973A (zh) * | 2007-11-12 | 2013-06-26 | 彼帕科学公司 | 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌 |
| CA2708157A1 (fr) * | 2007-12-07 | 2009-06-11 | Bipar Sciences, Inc. | Traitement du cancer avec des combinaisons d'inhibiteurs de topoisomerase et d'inhibiteurs de parp |
| AR070221A1 (es) | 2008-01-23 | 2010-03-25 | Astrazeneca Ab | Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas. |
| CA2713156A1 (fr) * | 2008-02-04 | 2009-08-13 | Bipar Sciences, Inc. | Procedes de diagnostic et de traitement de maladies mediees par parp |
| ES2625817T3 (es) | 2008-08-06 | 2017-07-20 | Medivation Technologies, Inc. | Inhibidores de tipo Dihidropiridoftalazinona de poli(ADP-ribosa)polimerasa (PARP) |
| ES2598178T5 (es) | 2008-10-07 | 2023-12-26 | Kudos Pharm Ltd | Formulación farmacéutica 514 |
| US10316304B2 (en) | 2009-11-27 | 2019-06-11 | Basf Plant Science Company Gmbh | Chimeric endonucleases and uses thereof |
| WO2011064751A1 (fr) | 2009-11-27 | 2011-06-03 | Basf Plant Science Company Gmbh | Endonucléases chimériques et utilisations de celles-ci |
| EP2504439B1 (fr) | 2009-11-27 | 2016-03-02 | BASF Plant Science Company GmbH | Endonucléases optimisées et leurs utilisations |
| CA2787844C (fr) | 2010-02-03 | 2019-08-27 | Biomarin Pharmaceutical Inc. | Inhibiteurs a base de dihydropyridophtalazinone de la poly(adp-ribose) polymerase (parp) utilisables dans le cadre du traitement de maladies associees a un deficit en pten |
| PT2533640T (pt) * | 2010-02-08 | 2017-01-03 | Medivation Technologies Inc | Processos de síntese de derivados de di-hidropiridoftalazinona |
| JP2013526514A (ja) | 2010-05-10 | 2013-06-24 | ラディカル・セラピューティックス・インコーポレイテッド | リポ酸およびニトロキシド誘導体およびその使用 |
| NZ609490A (en) | 2010-10-21 | 2015-06-26 | Biomarin Pharm Inc | Crystalline (8s,9r)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1h-1,2,4-triazol-5-yl)-8,9-dihydro-2h-pyrido[4,3,2-de]phthalazin-3(7h)-one tosylate salt |
| WO2012074840A2 (fr) | 2010-11-22 | 2012-06-07 | The General Hospital Corporation | Compositions et procédés d'imagerie in vivo |
| CN103130723B (zh) | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
| CN103325380B (zh) | 2012-03-23 | 2017-09-12 | 杜比实验室特许公司 | 用于信号增强的增益后处理 |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| US10874641B2 (en) | 2016-07-28 | 2020-12-29 | Mitobridge, Inc. | Methods of treating acute kidney injury |
| AU2017355402A1 (en) | 2016-11-02 | 2019-05-30 | Health Research, Inc. | Combination treatment with antibody-drug conjugates and PARP inhibitors |
| US20240343727A1 (en) * | 2021-08-17 | 2024-10-17 | InventisBio Co., Ltd. | Pyridazinone or pyridinone compounds, preparation methods and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58116471A (ja) * | 1981-12-29 | 1983-07-11 | Nippon Kayaku Co Ltd | 4−ヒドロキシメチル−1−フタラゾンエステル誘導体およびその塩 |
| US4939140A (en) * | 1985-11-07 | 1990-07-03 | Pfizer Inc. | Heterocyclic oxophthalazinyl acetic acids |
| WO1996005176A1 (fr) | 1994-08-09 | 1996-02-22 | Eisai Co., Ltd. | Compose de pyridazine condense |
| US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
| AU6966498A (en) | 1997-12-02 | 1998-10-30 | Dr. Reddy's Research Foundation | Thiazolidinedione and oxazolidinedione derivatives having antidiabetic, hypol ipidaemic and antihypertensive properties |
| CO5070700A1 (es) | 1998-06-05 | 2001-08-28 | Basf Ag | Genes novedosos de (adp-ribosa) polimerasa |
| ITMI981671A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
| ITMI981670A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
-
1999
- 1999-05-11 DE DE19921567A patent/DE19921567A1/de not_active Withdrawn
-
2000
- 2000-05-03 ES ES00934980T patent/ES2284499T3/es not_active Expired - Lifetime
- 2000-05-03 TR TR2001/03236T patent/TR200103236T2/xx unknown
- 2000-05-03 EP EP00934980A patent/EP1231982B1/fr not_active Expired - Lifetime
- 2000-05-03 CA CA002372704A patent/CA2372704A1/fr not_active Abandoned
- 2000-05-03 BR BR0010428-0A patent/BR0010428A/pt not_active IP Right Cessation
- 2000-05-03 SK SK1595-2001A patent/SK286676B6/sk not_active IP Right Cessation
- 2000-05-03 JP JP2000616761A patent/JP2003502286A/ja active Pending
- 2000-05-03 PL PL00352150A patent/PL352150A1/xx not_active Application Discontinuation
- 2000-05-03 CZ CZ20014038A patent/CZ20014038A3/cs unknown
- 2000-05-03 AU AU50640/00A patent/AU5064000A/en not_active Abandoned
- 2000-05-03 IL IL14614800A patent/IL146148A0/xx unknown
- 2000-05-03 KR KR1020017014342A patent/KR20020000642A/ko not_active Ceased
- 2000-05-03 CN CN00808074A patent/CN1399573A/zh active Pending
- 2000-05-03 HU HU0202477A patent/HUP0202477A3/hu unknown
- 2000-05-03 US US09/959,404 patent/US6903098B1/en not_active Expired - Fee Related
- 2000-05-03 DE DE50014190T patent/DE50014190D1/de not_active Expired - Lifetime
- 2000-05-03 AT AT00934980T patent/ATE357272T1/de not_active IP Right Cessation
- 2000-05-03 WO PCT/EP2000/003967 patent/WO2000067734A2/fr not_active Ceased
-
2001
- 2001-10-26 BG BG106056A patent/BG106056A/xx unknown
- 2001-11-08 NO NO20015462A patent/NO20015462D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20014038A3 (cs) | 2002-06-12 |
| EP1231982A2 (fr) | 2002-08-21 |
| NO20015462L (no) | 2001-11-08 |
| BR0010428A (pt) | 2002-04-30 |
| DE50014190D1 (de) | 2007-05-03 |
| ES2284499T3 (es) | 2007-11-16 |
| SK15952001A3 (sk) | 2002-08-06 |
| ATE357272T1 (de) | 2007-04-15 |
| PL352150A1 (en) | 2003-07-28 |
| EP1231982B1 (fr) | 2007-03-21 |
| KR20020000642A (ko) | 2002-01-05 |
| WO2000067734A3 (fr) | 2002-06-20 |
| AU5064000A (en) | 2000-11-21 |
| NO20015462D0 (no) | 2001-11-08 |
| CA2372704A1 (fr) | 2000-11-16 |
| DE19921567A1 (de) | 2000-11-16 |
| HUP0202477A3 (en) | 2003-02-28 |
| TR200103236T2 (tr) | 2004-08-23 |
| BG106056A (en) | 2002-06-28 |
| SK286676B6 (sk) | 2009-03-05 |
| HUP0202477A2 (hu) | 2002-12-28 |
| WO2000067734A2 (fr) | 2000-11-16 |
| CN1399573A (zh) | 2003-02-26 |
| JP2003502286A (ja) | 2003-01-21 |
| US6903098B1 (en) | 2005-06-07 |
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