IL148482A0 - Methods of preparing substituted tetracyclines with transition metal-based chemistries - Google Patents

Methods of preparing substituted tetracyclines with transition metal-based chemistries

Info

Publication number: IL148482A0
Authority: IL; Israel
Prior art keywords: tetracycline; substituted; compounds; transition metal; reactive
Prior art date: 1999-09-14

Application number

IL14848200A

Other languages

English (en)

Original Assignee

Tufts College

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-14

Filing date

2000-09-13

Publication date

2002-09-12

2000-09-13 Application filed by Tufts College filed Critical Tufts College

2002-09-12 Publication of IL148482A0 publication Critical patent/IL148482A0/xx

Links

239000004098 Tetracycline Substances 0.000 title abstract 8
235000019364 tetracycline Nutrition 0.000 title abstract 8
150000003522 tetracyclines Chemical class 0.000 title abstract 3
229910052723 transition metal Inorganic materials 0.000 title abstract 3
150000003624 transition metals Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
229940040944 tetracyclines Drugs 0.000 title 1
229960002180 tetracycline Drugs 0.000 abstract 7
229930101283 tetracycline Natural products 0.000 abstract 7
125000001424 substituent group Chemical group 0.000 abstract 5
-1 tetracycline compounds Chemical class 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
239000002243 precursor Substances 0.000 abstract 4
150000001336 alkenes Chemical class 0.000 abstract 2
239000003054 catalyst Substances 0.000 abstract 2
230000000844 anti-bacterial effect Effects 0.000 abstract 1
239000012954 diazonium Substances 0.000 abstract 1
150000002390 heteroarenes Chemical class 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000178 monomer Substances 0.000 abstract 1
PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 abstract 1
125000000391 vinyl group Chemical class [H]C([*])=C([H])[H] 0.000 abstract 1
229920002554 vinyl polymer Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IL14848200A 1999-09-14 2000-09-13 Methods of preparing substituted tetracyclines with transition metal-based chemistries IL148482A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US15470199P	1999-09-14	1999-09-14
US23209100P	2000-09-12	2000-09-12
PCT/US2000/025040 WO2001019784A1 (en)	1999-09-14	2000-09-13	Methods of preparing substituted tetracyclines with transition metal-based chemistries

Publications (1)

Publication Number	Publication Date
IL148482A0 true IL148482A0 (en)	2002-09-12

Family

ID=26851695

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
IL14848200A IL148482A0 (en)	1999-09-14	2000-09-13	Methods of preparing substituted tetracyclines with transition metal-based chemistries
IL148482A IL148482A (en)	1999-09-14	2002-03-04	Methods of preparing substituted tetracyclines with transition metal-based chemistries, some such novel compounds and use thereof in the preparation of medicaments
IL183125A IL183125A0 (en)	1999-09-14	2007-05-10	Methods of preparing substituted tetracyclines with transition metal-based chemistries, some such novel compounds and use thereof in the preparation of medicaments
IL183124A IL183124A (en)	1999-09-14	2007-05-10	9-Metamorphic Tetric Compound and Use of Metamorphic 9-Metric Compound in Preparation

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
IL148482A IL148482A (en)	1999-09-14	2002-03-04	Methods of preparing substituted tetracyclines with transition metal-based chemistries, some such novel compounds and use thereof in the preparation of medicaments
IL183125A IL183125A0 (en)	1999-09-14	2007-05-10	Methods of preparing substituted tetracyclines with transition metal-based chemistries, some such novel compounds and use thereof in the preparation of medicaments
IL183124A IL183124A (en)	1999-09-14	2007-05-10	9-Metamorphic Tetric Compound and Use of Metamorphic 9-Metric Compound in Preparation

Country Status (21)

Country	Link
US (3)	US6617318B1 (de)
EP (5)	EP1666454B1 (de)
JP (2)	JP5093953B2 (de)
KR (1)	KR100764992B1 (de)
CN (2)	CN102336680A (de)
AT (2)	ATE323671T1 (de)
AU (3)	AU781439C (de)
BR (1)	BR0013993A (de)
CA (2)	CA2672722C (de)
CY (1)	CY1105094T1 (de)
CZ (1)	CZ301835B6 (de)
DE (1)	DE60027465T2 (de)
DK (1)	DK1240133T3 (de)
EA (3)	EA005118B1 (de)
ES (1)	ES2260051T3 (de)
HR (1)	HRP20020322B1 (de)
HU (1)	HUP0202798A3 (de)
IL (4)	IL148482A0 (de)
MX (1)	MXPA02002595A (de)
PT (1)	PT1240133E (de)
WO (1)	WO2001019784A1 (de)

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2000
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Also Published As

Publication number	Publication date
ATE523485T1 (de)	2011-09-15
AU781439B2 (en)	2005-05-26
HRP20020322A2 (en)	2004-02-29
AU781439C (en)	2006-05-25
EP2327686A2 (de)	2011-06-01
IL183124A (en)	2012-05-31
US7067681B2 (en)	2006-06-27
PT1240133E (pt)	2006-07-31
WO2001019784A1 (en)	2001-03-22
EA012203B1 (ru)	2009-08-28
BR0013993A (pt)	2002-07-02
IL183125A0 (en)	2007-09-20
CZ2002872A3 (cs)	2002-08-14
EP2327687A3 (de)	2012-08-15
US20040033996A1 (en)	2004-02-19
EP2327686A3 (de)	2012-08-22
JP2003509404A (ja)	2003-03-11
ES2260051T3 (es)	2006-11-01
US7696187B2 (en)	2010-04-13
EP1666454A1 (de)	2006-06-07
KR20020044141A (ko)	2002-06-14
AU2005204259B2 (en)	2009-07-16
EP1666454B1 (de)	2011-09-07
KR100764992B1 (ko)	2007-10-09
CN102336680A (zh)	2012-02-01
CZ301835B6 (cs)	2010-07-07
HUP0202798A3 (en)	2003-11-28
JP2012031185A (ja)	2012-02-16
EA200400944A1 (ru)	2005-04-28
MXPA02002595A (es)	2003-07-21
IL183124A0 (en)	2007-09-20
US6617318B1 (en)	2003-09-09
AU7375600A (en)	2001-04-17
DE60027465D1 (de)	2006-05-24
HRP20020322B1 (en)	2009-04-30
IL148482A (en)	2010-12-30
CA2383364A1 (en)	2001-03-22
CN1399627A (zh)	2003-02-26
DE60027465T2 (de)	2007-02-01
EA200200366A1 (ru)	2002-10-31
EA005118B1 (ru)	2004-10-28
EA200900632A1 (ru)	2009-10-30
EP1240133B1 (de)	2006-04-19
CY1105094T1 (el)	2009-11-04
AU2005204259A1 (en)	2005-09-22
EA016099B1 (ru)	2012-02-28
US20060166946A1 (en)	2006-07-27
EP1666453A1 (de)	2006-06-07
AU2009225351A1 (en)	2009-11-05
AU2009225351B2 (en)	2012-04-12
DK1240133T3 (da)	2006-08-21
CA2383364C (en)	2009-11-17
ATE323671T1 (de)	2006-05-15
CA2672722A1 (en)	2001-03-22
EP1240133A1 (de)	2002-09-18
CA2672722C (en)	2013-11-05
JP5093953B2 (ja)	2012-12-12
HUP0202798A2 (hu)	2002-12-28
EP2327687A2 (de)	2011-06-01

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