IL149280A0 - Methods, kits and compositions for using pyrrole derivatives - Google Patents

Methods, kits and compositions for using pyrrole derivatives

Info

Publication number: IL149280A0
Authority: IL; Israel
Prior art keywords: kits; compositions; methods; compound; pyrrole derivatives
Prior art date: 2001-04-30

Application number

IL14928002A

Other languages

English (en)

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-30

Filing date

2002-04-22

Publication date

2002-11-10

2002-04-22 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2002-11-10 Publication of IL149280A0 publication Critical patent/IL149280A0/xx

Links

239000000203 mixture Substances 0.000 title abstract 2
150000003233 pyrroles Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
230000003287 optical effect Effects 0.000 abstract 2
229940002612 prodrug Drugs 0.000 abstract 2
239000000651 prodrug Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
ADHYPRBHQVZOTP-UHFFFAOYSA-N 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-hydroxy-5-methyl-2-oxohexyl)-3h-isoindol-1-one Chemical compound C1=CC(Cl)=NC2=NC(N3C(C4=CC=CC=C4C3=O)CC(=O)CCC(C)(O)C)=CC=C21 ADHYPRBHQVZOTP-UHFFFAOYSA-N 0.000 abstract 1
206010041250 Social phobia Diseases 0.000 abstract 1
HIUPRQPBWVEQJJ-UHFFFAOYSA-N pagoclone Chemical compound C1=CC(Cl)=NC2=NC(N3C(C4=CC=CC=C4C3=O)CC(=O)CCC(C)C)=CC=C21 HIUPRQPBWVEQJJ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IL14928002A 2001-04-30 2002-04-22 Methods, kits and compositions for using pyrrole derivatives IL149280A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28754501P	2001-04-30	2001-04-30

Publications (1)

Publication Number	Publication Date
IL149280A0 true IL149280A0 (en)	2002-11-10

Family

ID=23103396

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL204665A IL204665A (en)	2001-04-30	2002-04-22	Use of 2-(7-chloro-1, 8 -naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone and 2-(7-chloro-1, 8 - naphthyridine-2-yl) -3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone or a pharmaceutically acceptabla salt or optical isomer thereof in the preparation of medicaments for the curative, palliative or prophylactic treatment of obsessive-compulsive disorder
IL14928002A IL149280A0 (en)	2001-04-30	2002-04-22	Methods, kits and compositions for using pyrrole derivatives

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IL204665A IL204665A (en)	2001-04-30	2002-04-22	Use of 2-(7-chloro-1, 8 -naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone and 2-(7-chloro-1, 8 - naphthyridine-2-yl) -3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone or a pharmaceutically acceptabla salt or optical isomer thereof in the preparation of medicaments for the curative, palliative or prophylactic treatment of obsessive-compulsive disorder

Country Status (20)

Country	Link
US (2)	US7026332B2 (pl)
EP (2)	EP1642576B1 (pl)
JP (1)	JP2002326934A (pl)
KR (1)	KR20020084413A (pl)
CN (1)	CN1384104A (pl)
AT (2)	ATE331513T1 (pl)
AU (1)	AU783516B2 (pl)
CA (1)	CA2383599C (pl)
CY (1)	CY1109129T1 (pl)
DE (2)	DE60212757T2 (pl)
DK (1)	DK1642576T3 (pl)
ES (2)	ES2323646T3 (pl)
HU (1)	HU228826B1 (pl)
IL (2)	IL204665A (pl)
MY (1)	MY129575A (pl)
NZ (1)	NZ518615A (pl)
PL (2)	PL207738B1 (pl)
PT (1)	PT1642576E (pl)
TW (1)	TWI302455B (pl)
ZA (1)	ZA200203347B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1633360A1 (en) *	2003-05-16	2006-03-15	Pfizer Products Incorporated	Treatment of psychotic and depressive disorders
CA2525868A1 (en) *	2003-05-16	2004-11-25	Pfizer Products Inc.	Anxiety treatments with ziprasidone
AU2004271800A1 (en) *	2003-09-12	2005-03-24	Pfizer Inc.	Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
JP2007505095A (ja) *	2003-09-12	2007-03-08	ワーナー−ランバートカンパニーリミティドライアビリティーカンパニー	うつ病及び不安障害の治療のためのアルファ−２−デルタリガンド及びｓｓｒｉ及び／又はｓｎｒｉを含む組み合わせ
WO2005105061A2 (en) *	2004-04-14	2005-11-10	Indevus Pharmaceuticals, Inc.	Transdermal patch
EP1744750A2 (en) *	2004-05-06	2007-01-24	Sandoz AG	Pharmaceutical composition comprising hydrophobic drug having improved solubility
SG157299A1 (en)	2008-05-09	2009-12-29	Agency Science Tech & Res	Diagnosis and treatment of kawasaki disease
WO2012116288A1 (en) *	2011-02-25	2012-08-30	Concert Pharmaceuticals Inc.	2-amino-naphthyridine derivatives
CA3132810A1 (en) *	2019-03-18	2020-09-24	Neurocycle Therapeutics, Inc.	Use of gabaa receptor modulators for treatment of fybromyalgia

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2607503B1 (fr)	1986-12-02	1989-02-24	Rhone Poulenc Sante	Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
DE3814022A1 (de)	1988-04-26	1989-11-09	Davy Mckee Ag	Verfahren zur herstellung linearer polyester, insbesondere fuer filme und folien
EP0521622B1 (en)	1991-07-03	1997-08-13	PHARMACIA & UPJOHN COMPANY	Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
FR2678934B1 (fr)	1991-07-12	1995-01-13	Rhone Poulenc Rorer Sa	Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone.
FR2678932B1 (fr)	1991-07-12	1993-09-24	Rhone Poulenc Rorer Sa	Procede de preparation des isomeres optiques d'un derive de l'amino-2 naphtyridine.
FR2681068B1 (fr)	1991-09-09	1993-11-19	Rhone Poulenc Rorer Sa	Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone.
FR2684673B1 (fr)	1991-12-04	1994-01-21	Rhone Poulenc Rorer Sa	Procede de preparation d'un derive de l'amino-2 naphtyridine racemique.
FR2687154B1 (fr) *	1992-02-07	1995-05-12	Rhone Poulenc Rorer Sa	Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
FR2695389B1 (fr)	1992-09-08	1994-11-04	Rhone Poulenc Rorer Sa	Nouveau dérivé de l'isoindolinone, sa préparation et les compositions pharmaceutiques qui le contiennent.
US5498716A (en) *	1994-01-12	1996-03-12	Rhone-Poulenc Rorer S.A.	2-amino naphthyridine derivative, its preparation and its use
GB2305859A (en) *	1996-03-29	1997-04-23	Lilly Co Eli	Treatment of obsessive-compulsive disorder
US6541669B1 (en) *	1998-06-08	2003-04-01	Theravance, Inc.	β2-adrenergic receptor agonists
AU6381000A (en) *	1999-07-29	2001-02-19	Interneuron Pharmaceuticals, Inc.	Methods and compositions for alleviating stuttering
DE19939980A1 (de)	1999-08-24	2001-03-01	Merck Patent Gmbh	Inhibitoren des Integrins alphavbeta¶3¶
AU2756602A (en) *	2001-04-25	2002-10-31	Pfizer Products Inc.	Methods and kits for treating depression or preventing deterioration of cognitive function

2002
- 2002-03-22 AU AU27609/02A patent/AU783516B2/en not_active Ceased
- 2002-03-28 MY MYPI20021125A patent/MY129575A/en unknown
- 2002-04-16 PT PT05028364T patent/PT1642576E/pt unknown
- 2002-04-16 ES ES05028364T patent/ES2323646T3/es not_active Expired - Lifetime
- 2002-04-16 DK DK05028364T patent/DK1642576T3/da active
- 2002-04-16 DE DE60212757T patent/DE60212757T2/de not_active Expired - Lifetime
- 2002-04-16 AT AT02252684T patent/ATE331513T1/de not_active IP Right Cessation
- 2002-04-16 EP EP05028364A patent/EP1642576B1/en not_active Expired - Lifetime
- 2002-04-16 ES ES02252684T patent/ES2267943T3/es not_active Expired - Lifetime
- 2002-04-16 DE DE60231568T patent/DE60231568D1/de not_active Expired - Lifetime
- 2002-04-16 EP EP02252684A patent/EP1254660B1/en not_active Expired - Lifetime
- 2002-04-16 AT AT05028364T patent/ATE424820T1/de active
- 2002-04-18 CN CN02116105A patent/CN1384104A/zh active Pending
- 2002-04-22 IL IL204665A patent/IL204665A/en not_active IP Right Cessation
- 2002-04-22 IL IL14928002A patent/IL149280A0/xx not_active IP Right Cessation
- 2002-04-25 US US10/133,471 patent/US7026332B2/en not_active Expired - Fee Related
- 2002-04-25 JP JP2002123928A patent/JP2002326934A/ja active Pending
- 2002-04-26 ZA ZA2002/03347A patent/ZA200203347B/en unknown
- 2002-04-26 CA CA002383599A patent/CA2383599C/en not_active Expired - Fee Related
- 2002-04-29 NZ NZ518615A patent/NZ518615A/en not_active IP Right Cessation
- 2002-04-29 PL PL353681A patent/PL207738B1/pl unknown
- 2002-04-29 KR KR1020020023430A patent/KR20020084413A/ko not_active Ceased
- 2002-04-29 TW TW091108876A patent/TWI302455B/zh not_active IP Right Cessation
- 2002-04-29 HU HU0201394A patent/HU228826B1/hu not_active IP Right Cessation
- 2002-04-29 PL PL390683A patent/PL207725B1/pl unknown
2006
- 2006-02-13 US US11/352,286 patent/US7553847B2/en not_active Expired - Fee Related
2009
- 2009-06-01 CY CY20091100582T patent/CY1109129T1/el unknown

Also Published As

Publication number	Publication date
IL204665A (en)	2011-05-31
KR20020084413A (ko)	2002-11-07
AU783516B2 (en)	2005-11-03
NZ518615A (en)	2004-03-26
CA2383599C (en)	2006-10-31
EP1642576A2 (en)	2006-04-05
EP1254660B1 (en)	2006-06-28
HUP0201394A2 (hu)	2002-12-28
ES2323646T3 (es)	2009-07-22
US20060128746A1 (en)	2006-06-15
US7026332B2 (en)	2006-04-11
DE60231568D1 (de)	2009-04-23
HU228826B1 (en)	2013-05-28
ATE424820T1 (de)	2009-03-15
CY1109129T1 (el)	2014-07-02
ES2267943T3 (es)	2007-03-16
ATE331513T1 (de)	2006-07-15
US7553847B2 (en)	2009-06-30
PL390683A1 (pl)	2010-05-24
EP1254660A2 (en)	2002-11-06
DE60212757T2 (de)	2007-06-28
EP1254660A3 (en)	2003-03-26
PL207738B1 (pl)	2011-01-31
PT1642576E (pt)	2009-05-21
JP2002326934A (ja)	2002-11-15
PL353681A1 (en)	2002-11-04
CN1384104A (zh)	2002-12-11
EP1642576A3 (en)	2007-01-10
DE60212757D1 (de)	2006-08-10
EP1642576B1 (en)	2009-03-11
HK1094307A1 (en)	2007-03-30
HUP0201394A3 (en)	2003-12-29
US20030022915A1 (en)	2003-01-30
ZA200203347B (en)	2003-11-26
AU2760902A (en)	2002-10-31
DK1642576T3 (da)	2009-04-14
MY129575A (en)	2007-04-30
TWI302455B (en)	2008-11-01
PL207725B1 (pl)	2011-01-31
CA2383599A1 (en)	2002-10-30
HU0201394D0 (pl)	2002-06-29

Legal Events

Date	Code	Title
2011-02-28	FF	Patent granted
2012-04-30	KB	Patent renewed
2016-04-21	KB	Patent renewed
2020-11-30	MM9K	Patent not in force due to non-payment of renewal fees

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WO2006110816A3 (en)	2007-01-04	1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
SE9900100D0 (sv)	1999-01-15	New compounds
DK1578740T3 (da)	2007-07-30	1,2,4-triaminobenzenderivater, der er egnede til behandling af lidelser i centralnervesystemet
ATE522509T1 (de)	2011-09-15	Pyrimidylcyclopentane als inhibitoren der akt- proteinkinase
MXPA04006184A (es)	2004-12-06	Compuestos derivados de 1h-pirazolilo, para el uso en enfermedades asociadas con el receptor 5-ht2c.
ATE277072T1 (de)	2004-10-15	Sapogenin derivate zur behandlung von kognitiven störungen
CY1109129T1 (el)	2014-07-02	Χρηση παραγωγων πυρρολιου για καταπολεμηση του αγχους
WO2003057213A3 (en)	2004-02-19	Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
ATE407923T1 (de)	2008-09-15	Tyrosinderivate als phosphatase inhibitoren
DE602005007765D1 (de)	2008-08-07	Neue indol- oder benzimidazol-derivate
AU2002364711A1 (en)	2003-06-30	Substituted 5-hydroxy-indole compounds for the treatment of glaucoma
AU2002214657A1 (en)	2002-04-29	Substituted heterocyclic compounds for treating multidrug resistance
ZA200400824B (en)	2004-07-20	Pyridin-2-yl-methlyamine derivatives for treating opioid dependence.
DE50307080D1 (de)	2007-05-31	Verfahren zur herstellung von norgalanthamin, ihren isomeren, salzen und hydraten