IL149493A0 - 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity - Google Patents

5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity

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Publication number
IL149493A0
IL149493A0 IL14949300A IL14949300A IL149493A0 IL 149493 A0 IL149493 A0 IL 149493A0 IL 14949300 A IL14949300 A IL 14949300A IL 14949300 A IL14949300 A IL 14949300A IL 149493 A0 IL149493 A0 IL 149493A0
Authority
IL
Israel
Prior art keywords
hypoglycemic
membered
heterocyclic compounds
hypolipidemic activity
hypolipidemic
Prior art date
Application number
IL14949300A
Other languages
English (en)
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of IL149493A0 publication Critical patent/IL149493A0/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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IL14949300A 1999-11-10 2000-11-09 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity IL149493A0 (en)

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Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60139025D1 (de) * 2000-12-28 2009-07-30 Takeda Pharmaceutical Alkansäurederivate, verfahren zu deren herstellung und deren verwendung
EP1394154A4 (en) 2001-03-23 2005-05-18 Takeda Pharmaceutical FIVE-GLASS HETEROCYCLIC ALKANIC ACID DERIVATIVE
EP1392326B1 (en) * 2001-04-04 2009-09-09 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators
CA2442917C (en) * 2001-04-04 2011-02-01 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and ppar modulators
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
CA2445322C (en) * 2001-04-25 2011-06-14 Takeda Chemical Industries, Ltd. Use of the abc expression promoting agent pioglitazone for the treatment of arteriosclerosis obliterans
US6967212B2 (en) * 2001-05-30 2005-11-22 Bristol-Myers Squibb Company Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
US7105556B2 (en) * 2001-05-30 2006-09-12 Bristol-Myers Squibb Company Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
US20030092736A1 (en) * 2001-05-30 2003-05-15 Cheng Peter T. Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
WO2002098840A1 (en) * 2001-06-04 2002-12-12 Eisai Co., Ltd. Carboxylic acid derivative and medicine comprising salt or ester of the same
WO2003000685A1 (fr) * 2001-06-20 2003-01-03 Takeda Chemical Industries, Ltd. Derives heterocycliques a 5 chainons
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist
KR20050044460A (ko) * 2001-11-13 2005-05-12 다케다 야쿠힌 고교 가부시키가이샤 피라졸 화합물의 제조 방법
DE60329073D1 (de) 2002-01-18 2009-10-15 Merck & Co Inc Edg-rezeptoragonisten
US6716842B2 (en) 2002-04-05 2004-04-06 Warner-Lambert Company, Llc Antidiabetic agents
JP2004277397A (ja) * 2002-05-24 2004-10-07 Takeda Chem Ind Ltd １，２−アゾール誘導体
US20060148858A1 (en) * 2002-05-24 2006-07-06 Tsuyoshi Maekawa 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity
ATE543497T1 (de) 2002-07-09 2012-02-15 Bristol Myers Squibb Co Substituierte heterozyklische derivate als mittel gegen diabetes und adipositas und verfahren
PL374860A1 (en) * 2002-07-09 2005-11-14 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
EP1541564A1 (en) * 2002-09-10 2005-06-15 Takeda Pharmaceutical Company Limited Five-membered heterocyclic compounds
JP2004123732A (ja) * 2002-09-10 2004-04-22 Takeda Chem Ind Ltd ５員複素環化合物
AU2003277576A1 (en) 2002-11-08 2004-06-07 Takeda Pharmaceutical Company Limited Receptor function controlling agent
AU2003284479A1 (en) * 2002-11-28 2004-06-18 Sumitomo Pharmaceuticals Co., Ltd. Novel heteroaryl derivative
ES2571779T3 (es) * 2002-12-13 2016-05-26 Ym Biosciences Australia Pty Inhibidores de cinasa a base de nicotinamida
US7572922B2 (en) * 2003-01-27 2009-08-11 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
TW200526588A (en) * 2003-11-17 2005-08-16 Smithkline Beecham Corp Chemical compounds
EP1731505B1 (en) 2004-03-30 2015-01-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
AU2005228289B2 (en) * 2004-03-31 2008-01-10 Nippon Soda Co., Ltd. Cyclic amine compound and pest control agent
WO2005099759A1 (ja) * 2004-04-16 2005-10-27 Institute Of Medicinal Molecular Design. Inc. 動脈硬化症の予防及び／又は治療のための医薬
PT1756064E (pt) * 2004-06-04 2008-07-22 Merck & Co Inc Derivados de pirazole, composições contendo tais compostos e métodos de utilização
WO2006001463A1 (ja) 2004-06-23 2006-01-05 Ono Pharmaceutical Co., Ltd. Ｓ１ｐ受容体結合能を有する化合物およびその用途
AU2005272043B2 (en) * 2004-07-07 2010-07-29 Merck Sharp & Dohme Corp. Pyrazole amide derivatives, compositions containing such compounds and methods of use
WO2006036007A2 (en) * 2004-09-30 2006-04-06 Takeda Pharmaceutical Company Limited Modified-release preparation
WO2006057448A1 (ja) * 2004-11-26 2006-06-01 Takeda Pharmaceutical Company Limited アリールアルカン酸誘導体
EP1837329A4 (en) * 2005-01-14 2009-08-05 Dainippon Sumitomo Pharma Co NEW HETEROARYL DERIVATIVE
EP2308839B1 (en) 2005-04-20 2017-03-01 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
US7989445B2 (en) 2005-04-28 2011-08-02 Takeda Pharmaceutical Company Limited Thienopyrimidone compound
WO2006132440A1 (ja) 2005-06-09 2006-12-14 Takeda Pharmaceutical Company Limited 固形製剤
PT1904455E (pt) * 2005-07-05 2011-10-04 Hoffmann La Roche Derivados de piridazina
RU2290185C1 (ru) * 2005-07-26 2006-12-27 Дмитрий Николаевич Мясников Композиция для нормализации липидного обмена и снижения массы тела и способ её получения
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
US8338607B2 (en) 2005-10-06 2012-12-25 Nippon Soda Co., Ltd. Cyclic amine compounds and agents for pest control
NZ569661A (en) 2005-12-28 2011-06-30 Takeda Pharmaceutical Therapeutic agent for diabetes
BRPI0713378A8 (pt) 2006-06-27 2018-01-02 Takeda Pharmaceutical composto, pró-droga, modulador da função do receptor gpr40, agente farmacêutico uso do composto, e, método de produção de uma forma opticamente ativa de um composto
EP2058309A4 (en) 2006-08-04 2010-12-22 Takeda Pharmaceutical CONDENSED HETEROCYCLIC COMPOUND
US20080207654A1 (en) 2006-11-24 2008-08-28 Takeda Pharmaceutical Company Limited Heteromonocyclic compound and use thereof
HRP20120522T1 (hr) 2007-03-30 2012-08-31 Ambrx Modificirani fgf-21 polipeptidi i njihova uporaba
EP2149550A4 (en) 2007-04-27 2010-08-11 Takeda Pharmaceutical NITROGENIC FIVE-GLOSS HETEROCYCLIC COMPOUND
EP2253630A1 (en) 2007-05-21 2010-11-24 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
WO2008145616A1 (en) * 2007-05-25 2008-12-04 Abbott Gmbh & Co. Kg Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mglu2 receptor)
US8461348B2 (en) 2008-04-04 2013-06-11 Takeda Pharmaceutical Company Limited Heterocyclic derivative and use thereof
US8349886B2 (en) 2008-04-16 2013-01-08 Takeda Pharmaceutical Company Limited Nitrogenated 5-membered heterocyclic compound
EP2322222A4 (en) 2008-08-07 2011-12-21 Takeda Pharmaceutical THERAPEUTIC FOR IRRITATION SYNDROME
US8334236B2 (en) 2009-02-03 2012-12-18 Kumiai Chemical Industry Co., Ltd. Ring-fused 2-pyridone derivatives and herbicides
JP2010254623A (ja) 2009-04-24 2010-11-11 Takeda Chem Ind Ltd ベンゾオキサジノン化合物の結晶
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
BR112012018695A2 (pt) * 2010-01-27 2016-04-12 Boehringer Ingelheim Int compostos pirazol como antagonistas crth2
WO2012011591A1 (ja) 2010-07-23 2012-01-26 武田薬品工業株式会社 縮合複素環化合物およびその用途
US8759386B2 (en) 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
US9206164B2 (en) 2011-03-25 2015-12-08 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
WO2012175513A1 (en) 2011-06-20 2012-12-27 Bayer Intellectual Property Gmbh Thienylpyri(mi)dinylpyrazole
WO2012177896A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
CN103906733A (zh) 2011-06-24 2014-07-02 安姆根有限公司 Trpm8拮抗剂及其在治疗中的用途
JP6299591B2 (ja) 2012-07-03 2018-03-28 小野薬品工業株式会社 ソマトスタチン受容体作動活性を有する化合物およびその医薬用途
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
CA2882879A1 (en) 2012-08-24 2014-02-27 Takeda Pharmaceutical Company Limited Heterocyclic compound
KR20150074007A (ko) * 2012-10-26 2015-07-01 에프. 호프만-라 로슈 아게 3,4-이치환된 1h-피라졸 및 4,5-이치환된 티아졸 syk 억제제
RU2666352C2 (ru) 2013-09-30 2018-09-07 Оно Фармасьютикал Ко., Лтд. Соединение с агонистической активностью в отношении рецепторов соматостатина и его фармацевтическое применение
KR20160106627A (ko) * 2013-12-30 2016-09-12 라이프에스씨아이 파마슈티컬스, 인크. 치료적 억제 화합물
PE20170669A1 (es) 2014-10-24 2017-06-06 Takeda Pharmaceuticals Co Compuesto heterociclico
SMT202100388T1 (it) 2014-10-24 2021-09-14 Bristol Myers Squibb Co Polipeptidi fgf-21 modificati e loro usi
EP3581569A4 (en) 2017-02-08 2020-02-19 ONO Pharmaceutical Co., Ltd. CONNECTION WITH AGONISTIC SOMATOSTATIN RECEPTOR ACTIVITY AND PHARMACEUTICAL USE THEREOF
KR102236356B1 (ko) 2017-11-24 2021-04-05 주식회사 종근당 루푸스의 예방 또는 치료를 위한 조성물
KR20190099952A (ko) * 2018-02-20 2019-08-28 주식회사 종근당 포도막염의 예방 또는 치료를 위한 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06779B2 (ja) 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
DE3600390A1 (de) 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
TW222626B (cs) * 1991-07-22 1994-04-21 Pfizer
DE4206041A1 (de) * 1992-02-27 1993-09-02 Bayer Ag Sulfonylbenzyl-substituierte imidazolylpropensaeurederivate
US5591862A (en) * 1993-06-11 1997-01-07 Takeda Chemical Industries, Ltd. Tetrazole derivatives, their production and use
FR2707641B1 (fr) * 1993-07-16 1995-08-25 Fournier Ind & Sante Composés de l'imidazol-5-carboxamide, leur procédé de préparation leurs intermédiaires et leur utilisation en thérapeutique.
DE19602505A1 (de) 1996-01-25 1997-07-31 Merck Patent Gmbh 1-(Pyrazol-4-Indol-3-yl)-Piperidine
JPH1072434A (ja) 1996-04-08 1998-03-17 Nissan Chem Ind Ltd ２，４−置換アニリン誘導体
TR200002225T2 (tr) 1998-01-28 2000-12-21 Shionogi & Co., Ltd Yeni trisiklik bileşimler
US6251926B1 (en) 1998-05-11 2001-06-26 Takeda Chemical Industries, Ltd. Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity
US6548529B1 (en) 1999-04-05 2003-04-15 Bristol-Myers Squibb Company Heterocyclic containing biphenyl aP2 inhibitors and method

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RU2252939C2 (ru) 2005-05-27
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HK1045991B (en) 2004-12-10
NZ519238A (en) 2003-11-28
ATE271049T1 (de) 2004-07-15
AU1303101A (en) 2001-06-04
PE20011021A1 (es) 2001-09-19
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HUP0203165A3 (en) 2004-03-29
AU780948C (en) 2006-09-14
HUP0203165A2 (hu) 2003-01-28
JP2001226350A (ja) 2001-08-21
EP1457490A1 (en) 2004-09-15
EP1228067B1 (en) 2004-07-14
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JP4416994B2 (ja) 2010-02-17
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SI1228067T1 (en) 2005-02-28
SK6432002A3 (en) 2003-02-04
CZ20021604A3 (cs) 2002-09-11
CO5261501A1 (es) 2003-03-31
DE60012213D1 (de) 2004-08-19
MY141468A (en) 2010-04-30
JP2003137865A (ja) 2003-05-14
JP3723071B2 (ja) 2005-12-07
NO20022108L (no) 2002-07-08
US7179823B1 (en) 2007-02-20
PT1228067E (pt) 2004-11-30
CN1413207A (zh) 2003-04-23
BR0015466A (pt) 2002-08-06
TR200402512T4 (tr) 2004-12-21
NO20022108D0 (no) 2002-05-02
CN1260227C (zh) 2006-06-21
HK1045991A1 (en) 2002-12-20
WO2001038325A1 (en) 2001-05-31
KR100518142B1 (ko) 2005-10-04
AU780948B2 (en) 2005-04-28
AR026414A1 (es) 2003-02-12
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