IL153230A0 - Liposomal benzoquinazoline thymidylate synthase inhibitor formulations - Google Patents
Liposomal benzoquinazoline thymidylate synthase inhibitor formulationsInfo
- Publication number
- IL153230A0 IL153230A0 IL15323001A IL15323001A IL153230A0 IL 153230 A0 IL153230 A0 IL 153230A0 IL 15323001 A IL15323001 A IL 15323001A IL 15323001 A IL15323001 A IL 15323001A IL 153230 A0 IL153230 A0 IL 153230A0
- Authority
- IL
- Israel
- Prior art keywords
- liposomal
- synthase inhibitor
- thymidylate synthase
- inhibitor formulations
- benzoquinazoline thymidylate
- Prior art date
Links
- 229940122149 Thymidylate synthase inhibitor Drugs 0.000 title 1
- PQIUGRLKNKSKTC-UHFFFAOYSA-N benzo[h]quinazoline Chemical compound N1=CN=C2C3=CC=CC=C3C=CC2=C1 PQIUGRLKNKSKTC-UHFFFAOYSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000003734 thymidylate synthase inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21059200P | 2000-06-09 | 2000-06-09 | |
| PCT/US2001/018224 WO2001095884A2 (fr) | 2000-06-09 | 2001-06-06 | Preparations d'inhibiteurs de benzoquinazoline thymidylate synthase en liposomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL153230A0 true IL153230A0 (en) | 2003-07-06 |
Family
ID=22783495
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15323001A IL153230A0 (en) | 2000-06-09 | 2001-06-06 | Liposomal benzoquinazoline thymidylate synthase inhibitor formulations |
| IL153230A IL153230A (en) | 2000-06-09 | 2002-12-02 | Liposomal preparations of benzoxoinazoline thymidylate synthesis inhibitor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL153230A IL153230A (en) | 2000-06-09 | 2002-12-02 | Liposomal preparations of benzoxoinazoline thymidylate synthesis inhibitor |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6689381B2 (fr) |
| EP (1) | EP1286661A2 (fr) |
| JP (1) | JP2004503491A (fr) |
| KR (1) | KR100851957B1 (fr) |
| CN (1) | CN1446080A (fr) |
| AU (2) | AU7526901A (fr) |
| BR (1) | BR0111541A (fr) |
| CA (1) | CA2412165A1 (fr) |
| IL (2) | IL153230A0 (fr) |
| MX (1) | MXPA02012068A (fr) |
| NZ (1) | NZ522842A (fr) |
| PL (1) | PL360470A1 (fr) |
| TW (1) | TWI282741B (fr) |
| WO (1) | WO2001095884A2 (fr) |
| ZA (1) | ZA200209524B (fr) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| AU2003213092A1 (en) | 2002-02-15 | 2003-09-09 | Smithkline Beecham Corporation | Syntheses of quinazolinones |
| EP1503993A4 (fr) | 2002-05-09 | 2006-05-03 | Cytokinetics Inc | Composes, compositions et procedes |
| JP2005530785A (ja) | 2002-05-09 | 2005-10-13 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、及び方法 |
| EP1513820A4 (fr) | 2002-05-23 | 2006-09-13 | Cytokinetics Inc | Composes, compositions et procedes |
| EP1556357A4 (fr) | 2002-06-14 | 2006-09-13 | Cytokinetics Inc | Composes, compositions et procedes |
| US7211580B2 (en) | 2002-07-23 | 2007-05-01 | Cytokinetics, Incorporated | Compounds, compositions, and methods |
| JP2006501306A (ja) | 2002-09-30 | 2006-01-12 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| WO2004047800A2 (fr) * | 2002-11-26 | 2004-06-10 | Gilead Sciences, Inc. | Procede de chargement de medicament dans des liposomes par gradient |
| JP2007513154A (ja) | 2003-12-08 | 2007-05-24 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
| JP5032849B2 (ja) * | 2004-01-14 | 2012-09-26 | ギリアード サイエンシーズ， インコーポレイテッド | 薬物送達に有用な脂質ベースの分散物 |
| US20060051406A1 (en) * | 2004-07-23 | 2006-03-09 | Manjeet Parmar | Formulation of insoluble small molecule therapeutics in lipid-based carriers |
| US20070082042A1 (en) * | 2004-08-06 | 2007-04-12 | Deok-Hoon Park | Multiple-layered liposome and preparation method thereof |
| US20080213345A1 (en) * | 2004-09-13 | 2008-09-04 | Gilead Sciences, Inc. | Delivering Iron to an Animal |
| US20060159735A1 (en) * | 2005-01-20 | 2006-07-20 | Nicholas Bonham | Method of reclaiming drug compound from liposomal drug manufacturing stream |
| WO2006078253A1 (fr) * | 2005-01-20 | 2006-07-27 | Osi Pharmaceuticals, Inc. | Procede de recuperation d’un compose medicamenteux osi-7904 a partir d’un flux de fabrication de medicaments liposomaux |
| EP1745788A1 (fr) * | 2005-07-22 | 2007-01-24 | KTB Tumorforschungsgesellschaft mbH | Acylglycerophospholipides pour le traitement du cancer et de la cachexie |
| CN100348194C (zh) * | 2005-07-26 | 2007-11-14 | 康辰医药发展有限公司 | 盐酸洛拉曲克的脂质体制剂及其制备方法 |
| JP2009518443A (ja) * | 2005-12-06 | 2009-05-07 | リゲル ファーマシューティカルズ インコーポレーティッド | 脂質を主材料とする担体に内封された、不溶性小分子治療剤の製剤 |
| US9493810B2 (en) * | 2012-06-07 | 2016-11-15 | Pioma, Inc. | 5-ALA for detection of brain tumors |
| JP2015524411A (ja) * | 2012-07-18 | 2015-08-24 | オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | エポキシケトン系プロテアソーム阻害剤のリポソーム組成物 |
| WO2018031967A1 (fr) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Antifolates de polyglutamates et leurs utilisations. |
| EA201990473A1 (ru) | 2016-08-12 | 2019-07-31 | Эл.И.Эй.Эф. ХОЛДИНГС ГРУП ЭлЭлСи | Полиглутамированные антифолаты и их применение |
| EP3749318A4 (fr) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | Raltitrexed gamma-polyglutamaté et utilisations associées |
| CA3090389A1 (fr) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Raltitrexed alpha-polyglutamate et utilisations associees |
| CN111954529A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化氨甲蝶呤及其用途 |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| US12076402B2 (en) | 2018-02-07 | 2024-09-03 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| US11779584B2 (en) | 2018-02-07 | 2023-10-10 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pemetrexed and uses thereof |
| WO2019157123A1 (fr) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Aminoptérine alpha-polyglutamatée et utilisations associées |
| CA3090506A1 (fr) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Tetrahydrofolates alpha polyglutames et leurs utilisations |
| EP3749312A4 (fr) | 2018-02-07 | 2022-02-23 | L.E.A.F Holdings Group LLC | Lométrexol alpha-polyglutamaté et utilisations associées |
| EP3749316A4 (fr) | 2018-02-07 | 2021-10-27 | L.E.A.F Holdings Group LLC | Pralatrexate alpha-polyglutamaté et utilisations associées |
| EP3749311A4 (fr) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | Compositions de pémétrexed polyglutamaté gamma et leurs utilisations |
| US12048766B2 (en) | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated tetrahydrofolates and uses thereof |
| US11771700B2 (en) | 2018-02-14 | 2023-10-03 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| EP3752156A4 (fr) | 2018-02-14 | 2021-10-27 | L.E.A.F Holdings Group LLC | Pralatrexate gamma-polyglutamaté et utilisations associées |
| CA3090943A1 (fr) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Aminopterine gamma polyglutamique et ses utilisations |
| CN111936145A (zh) | 2018-02-14 | 2020-11-13 | L.E.A.F.控股集团公司 | γ聚谷氨酸化氨甲蝶呤及其用途 |
| WO2025095862A1 (fr) * | 2023-10-30 | 2025-05-08 | National University Of Singapore | Composition, procédé de fabrication et utilisations de ladite composition |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4460577A (en) * | 1977-09-30 | 1984-07-17 | Farmitalia Carlo Erba S.P.A. | Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same |
| US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
| US4755388A (en) * | 1984-11-09 | 1988-07-05 | The Regents Of The University Of California | Liposome-encapsulated 5-fluoropyrimidines and methods for their use |
| US4753788A (en) * | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
| GB9013615D0 (en) * | 1990-06-19 | 1990-08-08 | Wellcome Found | Pharmaceutical compounds |
| EP0671953A4 (fr) | 1992-11-13 | 1996-01-10 | Univ Ohio State Res Found | Analogues arylamide de n-(4-hydroxyphenyl)retinamide-o-glucuronide. |
| JPH11199488A (ja) * | 1998-01-09 | 1999-07-27 | Sankyo Co Ltd | 抗腫瘍薬のリポソーム化製剤 |
-
2001
- 2001-06-06 US US09/875,713 patent/US6689381B2/en not_active Expired - Fee Related
- 2001-06-06 KR KR1020027016698A patent/KR100851957B1/ko not_active Expired - Fee Related
- 2001-06-06 CN CN01813943A patent/CN1446080A/zh active Pending
- 2001-06-06 MX MXPA02012068A patent/MXPA02012068A/es unknown
- 2001-06-06 AU AU7526901A patent/AU7526901A/xx active Pending
- 2001-06-06 EP EP01941961A patent/EP1286661A2/fr not_active Withdrawn
- 2001-06-06 PL PL36047001A patent/PL360470A1/xx not_active Application Discontinuation
- 2001-06-06 CA CA002412165A patent/CA2412165A1/fr not_active Abandoned
- 2001-06-06 AU AU2001275269A patent/AU2001275269B2/en not_active Ceased
- 2001-06-06 JP JP2002510063A patent/JP2004503491A/ja active Pending
- 2001-06-06 WO PCT/US2001/018224 patent/WO2001095884A2/fr not_active Ceased
- 2001-06-06 NZ NZ522842A patent/NZ522842A/en unknown
- 2001-06-06 IL IL15323001A patent/IL153230A0/xx active IP Right Grant
- 2001-06-06 BR BR0111541-3A patent/BR0111541A/pt not_active Application Discontinuation
- 2001-06-08 TW TW090113942A patent/TWI282741B/zh active
-
2002
- 2002-11-22 ZA ZA200209524A patent/ZA200209524B/en unknown
- 2002-12-02 IL IL153230A patent/IL153230A/en not_active IP Right Cessation
-
2003
- 2003-07-01 US US10/612,768 patent/US20040057990A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200209524B (en) | 2003-11-22 |
| BR0111541A (pt) | 2003-07-01 |
| CN1446080A (zh) | 2003-10-01 |
| TWI282741B (en) | 2007-06-21 |
| IL153230A (en) | 2009-02-11 |
| WO2001095884A3 (fr) | 2002-06-13 |
| AU2001275269B2 (en) | 2006-07-13 |
| KR100851957B1 (ko) | 2008-08-12 |
| CA2412165A1 (fr) | 2001-12-20 |
| US6689381B2 (en) | 2004-02-10 |
| KR20030038552A (ko) | 2003-05-16 |
| US20040057990A1 (en) | 2004-03-25 |
| PL360470A1 (en) | 2004-09-06 |
| NZ522842A (en) | 2004-11-26 |
| MXPA02012068A (es) | 2004-08-19 |
| JP2004503491A (ja) | 2004-02-05 |
| EP1286661A2 (fr) | 2003-03-05 |
| US20020034538A1 (en) | 2002-03-21 |
| WO2001095884A2 (fr) | 2001-12-20 |
| AU7526901A (en) | 2001-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |