IL154456A - S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting - Google Patents
S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomitingInfo
- Publication number
- IL154456A IL154456A IL154456A IL15445603A IL154456A IL 154456 A IL154456 A IL 154456A IL 154456 A IL154456 A IL 154456A IL 15445603 A IL15445603 A IL 15445603A IL 154456 A IL154456 A IL 154456A
- Authority
- IL
- Israel
- Prior art keywords
- migraine
- headache
- compound
- nausea
- ethylisothiouronium
- Prior art date
Links
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- 206010019233 Headaches Diseases 0.000 title claims abstract description 84
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- 206010028813 Nausea Diseases 0.000 title claims description 32
- 230000008693 nausea Effects 0.000 title claims description 32
- 238000011282 treatment Methods 0.000 claims abstract description 62
- CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 claims abstract description 49
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL154456A IL154456A (en) | 2000-09-05 | 2003-02-13 | S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22981200P | 2000-09-05 | 2000-09-05 | |
| IL14463201A IL144632A0 (en) | 2001-07-30 | 2001-07-30 | Method and pharmaceutical compositions for treating headache, nausea and migraine |
| PCT/IL2001/000817 WO2002019961A2 (en) | 2000-09-05 | 2001-08-30 | Pharmaceutical compositions for headache, migraine, nausea and emesis |
| IL154456A IL154456A (en) | 2000-09-05 | 2003-02-13 | S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL154456A true IL154456A (en) | 2013-05-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL154456A IL154456A (en) | 2000-09-05 | 2003-02-13 | S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7148208B2 (de) |
| EP (1) | EP1315505B1 (de) |
| JP (1) | JP2004508311A (de) |
| KR (1) | KR100849999B1 (de) |
| CN (1) | CN100448439C (de) |
| AT (1) | ATE375797T1 (de) |
| AU (2) | AU8617801A (de) |
| BR (1) | BR0113698A (de) |
| CA (1) | CA2420410C (de) |
| CY (1) | CY1107270T1 (de) |
| DE (1) | DE60131004T2 (de) |
| DK (1) | DK1315505T3 (de) |
| ES (1) | ES2296792T3 (de) |
| HU (1) | HUP0302362A3 (de) |
| IL (1) | IL154456A (de) |
| MD (1) | MD2447G2 (de) |
| MX (1) | MXPA03001737A (de) |
| NO (1) | NO20031902L (de) |
| NZ (1) | NZ524903A (de) |
| PT (1) | PT1315505E (de) |
| WO (1) | WO2002019961A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1315505B1 (de) * | 2000-09-05 | 2007-10-17 | Meditor Pharmaceuticals Ltd. | Pharmazeutische zubereitungen gegen kopfschmerz, migräne, nausea und erbrechen |
| US20090186854A1 (en) * | 2006-03-23 | 2009-07-23 | Meditor Pharmaceuticals Ltd. | S-alkylisothiouronium derivatives for the treatment of inflammatory diseases |
| WO2008152619A1 (en) * | 2007-06-13 | 2008-12-18 | Meditor Pharmaceuticals Ltd. | Taste masked pharmaceutical compositions of s-alkylisothiouronium derivatives |
| RU2342923C1 (ru) * | 2007-07-26 | 2009-01-10 | Общество с ограниченной ответственностью "Бентус лаборатории" | Дезинфицирующее антисептическое средство для обработки рук с увлажняющим эффектом (варианты) |
| MD3619G2 (ro) * | 2007-11-06 | 2009-01-31 | Рафаэль Баркан | Remediu medicamentos nazal cu acţiune anticongestivă |
| CN101917848B (zh) * | 2007-11-06 | 2014-02-12 | 巴坎-法尔玛有限责任公司 | 用于治疗子宫收缩过强病症的s-烷基异硫脲衍生物 |
| US12011423B2 (en) | 2007-11-06 | 2024-06-18 | Foraviset Ltd. | S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders |
| US7974787B2 (en) * | 2008-04-24 | 2011-07-05 | The Invention Science Fund I, Llc | Combination treatment alteration methods and systems |
| US9449150B2 (en) | 2008-04-24 | 2016-09-20 | The Invention Science Fund I, Llc | Combination treatment selection methods and systems |
| US8876688B2 (en) | 2008-04-24 | 2014-11-04 | The Invention Science Fund I, Llc | Combination treatment modification methods and systems |
| US9662391B2 (en) | 2008-04-24 | 2017-05-30 | The Invention Science Fund I Llc | Side effect ameliorating combination therapeutic products and systems |
| US9064036B2 (en) | 2008-04-24 | 2015-06-23 | The Invention Science Fund I, Llc | Methods and systems for monitoring bioactive agent use |
| US8682687B2 (en) | 2008-04-24 | 2014-03-25 | The Invention Science Fund I, Llc | Methods and systems for presenting a combination treatment |
| US9560967B2 (en) | 2008-04-24 | 2017-02-07 | The Invention Science Fund I Llc | Systems and apparatus for measuring a bioactive agent effect |
| US9026369B2 (en) | 2008-04-24 | 2015-05-05 | The Invention Science Fund I, Llc | Methods and systems for presenting a combination treatment |
| US8930208B2 (en) | 2008-04-24 | 2015-01-06 | The Invention Science Fund I, Llc | Methods and systems for detecting a bioactive agent effect |
| US20090270687A1 (en) * | 2008-04-24 | 2009-10-29 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems for modifying bioactive agent use |
| US9282927B2 (en) | 2008-04-24 | 2016-03-15 | Invention Science Fund I, Llc | Methods and systems for modifying bioactive agent use |
| US20100069724A1 (en) * | 2008-04-24 | 2010-03-18 | Searete Llc | Computational system and method for memory modification |
| US8606592B2 (en) | 2008-04-24 | 2013-12-10 | The Invention Science Fund I, Llc | Methods and systems for monitoring bioactive agent use |
| US20100130811A1 (en) * | 2008-04-24 | 2010-05-27 | Searete Llc | Computational system and method for memory modification |
| US9649469B2 (en) | 2008-04-24 | 2017-05-16 | The Invention Science Fund I Llc | Methods and systems for presenting a combination treatment |
| US9239906B2 (en) | 2008-04-24 | 2016-01-19 | The Invention Science Fund I, Llc | Combination treatment selection methods and systems |
| US20100063368A1 (en) * | 2008-04-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation | Computational system and method for memory modification |
| US8615407B2 (en) | 2008-04-24 | 2013-12-24 | The Invention Science Fund I, Llc | Methods and systems for detecting a bioactive agent effect |
| US8357117B2 (en) * | 2008-08-06 | 2013-01-22 | Family Health International | Device and method for delivering an agent into breast milk while breastfeeding |
| WO2012018341A1 (en) * | 2010-08-05 | 2012-02-09 | Family Health International | Device and method for delivering an agent into breast milk while breastfeeding |
| CN109523244B (zh) * | 2018-11-02 | 2023-06-27 | 创新先进技术有限公司 | 一种基于母子账户的用于转移款项数据的方法和系统 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2419675A1 (fr) * | 1978-03-16 | 1979-10-12 | Philagro Sa | Compositions fongicides a base de phosphites d'isothiouronium |
| GB9418912D0 (en) * | 1994-09-20 | 1994-11-09 | Fisons Corp | Pharmaceutically active compounds |
| MD263C2 (ro) * | 1995-03-01 | 1995-12-31 | Виктор ГИКАВЫЙ | Remediu cu acţiune antihipotensivă "IZOTURON" |
| MD586C2 (ro) * | 1995-05-25 | 1997-03-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Substanţă medicamentoasă cu acţiune antihipotensivă "Difetur" |
| FR2753098B1 (fr) * | 1996-09-06 | 1998-11-27 | Sod Conseils Rech Applic | Composition pharmaceutique comprenant au moins un inhibiteur de no synthase et au moins un piegeur des formes reactives de l'oxygene |
| PT928191E (pt) * | 1996-09-26 | 2003-01-31 | Meditor Pharmaceuticals Ltd | Formulacoes farmaceuticas compreendendo derivados de s-alquilisotiouronio |
| WO1998019674A2 (en) * | 1996-11-05 | 1998-05-14 | Head Explorer Aps | A method for treating tension-type headache |
| MD1138C2 (ro) * | 1997-02-17 | 1999-07-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Izopropilfosfit-S-izopropilizotiuroniu- substanţă cu acţiune hipertensivă |
| MD1223C2 (ro) * | 1997-07-15 | 2000-01-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Aplicarea dimetilfosfatului de S-metil-izo-tiouroniu în calitate de substanţă vasoconstrictoare şi preparat farmaceutic pe baza lui |
| US6127420A (en) * | 1997-08-22 | 2000-10-03 | The Medical College Of Wisconsin Research Foundation, Inc. | L-N5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof |
| MD1431G2 (ro) * | 1998-01-16 | 2001-02-28 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Remedii antihipotensive |
| US6093743A (en) * | 1998-06-23 | 2000-07-25 | Medinox Inc. | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor |
| FR2788771B1 (fr) * | 1999-01-22 | 2001-04-13 | Pf Medicament | Nouvelles 1,2-alcoyl-1-[1-[aryl (alcoyl) oxyalcoyl] piperidin-4-yl]-3-aryl isothiourees substituees, leur preparation et leur application en therapeutique |
| US6489308B1 (en) * | 1999-03-05 | 2002-12-03 | Trustees Of University Of Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions |
| EP1200127B1 (de) * | 1999-07-21 | 2008-06-25 | Omeros Corporation | Spüllösungen und verfahren zur schmerzhemmung, entzündungshemmung und hemmung des knorpelabbaus |
| EP1315505B1 (de) * | 2000-09-05 | 2007-10-17 | Meditor Pharmaceuticals Ltd. | Pharmazeutische zubereitungen gegen kopfschmerz, migräne, nausea und erbrechen |
-
2001
- 2001-08-30 EP EP01965546A patent/EP1315505B1/de not_active Expired - Lifetime
- 2001-08-30 AT AT01965546T patent/ATE375797T1/de active
- 2001-08-30 MD MDA20020139A patent/MD2447G2/ro not_active IP Right Cessation
- 2001-08-30 MX MXPA03001737A patent/MXPA03001737A/es active IP Right Grant
- 2001-08-30 JP JP2002524446A patent/JP2004508311A/ja active Pending
- 2001-08-30 BR BR0113698-4A patent/BR0113698A/pt not_active Application Discontinuation
- 2001-08-30 DK DK01965546T patent/DK1315505T3/da active
- 2001-08-30 DE DE60131004T patent/DE60131004T2/de not_active Expired - Lifetime
- 2001-08-30 PT PT01965546T patent/PT1315505E/pt unknown
- 2001-08-30 AU AU8617801A patent/AU8617801A/xx active Pending
- 2001-08-30 CN CNB018151795A patent/CN100448439C/zh not_active Expired - Fee Related
- 2001-08-30 AU AU2001286178A patent/AU2001286178B2/en not_active Ceased
- 2001-08-30 ES ES01965546T patent/ES2296792T3/es not_active Expired - Lifetime
- 2001-08-30 NZ NZ524903A patent/NZ524903A/en not_active IP Right Cessation
- 2001-08-30 KR KR1020037003277A patent/KR100849999B1/ko not_active Expired - Fee Related
- 2001-08-30 CA CA2420410A patent/CA2420410C/en not_active Expired - Fee Related
- 2001-08-30 HU HU0302362A patent/HUP0302362A3/hu unknown
- 2001-08-30 WO PCT/IL2001/000817 patent/WO2002019961A2/en not_active Ceased
-
2003
- 2003-02-13 IL IL154456A patent/IL154456A/en not_active IP Right Cessation
- 2003-03-05 US US10/382,217 patent/US7148208B2/en not_active Expired - Lifetime
- 2003-04-28 NO NO20031902A patent/NO20031902L/no not_active Application Discontinuation
-
2006
- 2006-10-18 US US11/550,548 patent/US8673979B2/en not_active Expired - Fee Related
-
2008
- 2008-01-17 CY CY20081100071T patent/CY1107270T1/el unknown
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| FF | Patent granted | ||
| KB | Patent renewed | ||
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| MM9K | Patent not in force due to non-payment of renewal fees |