IL155657A0 - Acylaminoalkyl-substituted benzenesulfonamide derivatives - Google Patents
Acylaminoalkyl-substituted benzenesulfonamide derivativesInfo
- Publication number
- IL155657A0 IL155657A0 IL15565701A IL15565701A IL155657A0 IL 155657 A0 IL155657 A0 IL 155657A0 IL 15565701 A IL15565701 A IL 15565701A IL 15565701 A IL15565701 A IL 15565701A IL 155657 A0 IL155657 A0 IL 155657A0
- Authority
- IL
- Israel
- Prior art keywords
- cardiac
- acylaminoalkyl
- compounds
- heart
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Hybrid Cells (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10054481A DE10054481A1 (de) | 2000-11-03 | 2000-11-03 | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| PCT/EP2001/012143 WO2002036556A2 (fr) | 2000-11-03 | 2001-10-20 | Derives de benzenesulfonamide substitues par acylaminoalkyle, leur preparation, leur utilisation et preparations pharmaceutiques les contenant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL155657A0 true IL155657A0 (en) | 2003-11-23 |
Family
ID=7662009
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15565701A IL155657A0 (en) | 2000-11-03 | 2001-10-20 | Acylaminoalkyl-substituted benzenesulfonamide derivatives |
| IL155657A IL155657A (en) | 2000-11-03 | 2003-04-29 | Acylaminoalkyl-substituted benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions comprising them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL155657A IL155657A (en) | 2000-11-03 | 2003-04-29 | Acylaminoalkyl-substituted benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions comprising them |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6511989B2 (fr) |
| EP (1) | EP1345892B1 (fr) |
| JP (1) | JP4039625B2 (fr) |
| AT (1) | ATE290525T1 (fr) |
| AU (2) | AU1825302A (fr) |
| CA (1) | CA2427429C (fr) |
| DE (2) | DE10054481A1 (fr) |
| ES (1) | ES2237614T3 (fr) |
| IL (2) | IL155657A0 (fr) |
| MX (1) | MXPA03003608A (fr) |
| PT (1) | PT1345892E (fr) |
| WO (1) | WO2002036556A2 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6677364B2 (en) * | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| EP2438913B1 (fr) * | 2002-03-20 | 2020-05-06 | University of Maryland, Baltimore | Canal de cations non sélectif dans les cellules neuronales et procédés de traitement du gonflement cérébral |
| US8980952B2 (en) * | 2002-03-20 | 2015-03-17 | University Of Maryland, Baltimore | Methods for treating brain swelling with a compound that blocks a non-selective cation channel |
| AU2003291255A1 (en) * | 2002-11-06 | 2004-06-03 | Smithkline Beecham Corporation | Sulfonamides |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
| EP1802313B1 (fr) * | 2004-09-18 | 2010-11-03 | University of Maryland, Baltimore | Agents therapeutiques ciblant le canal ncca-atp et leurs methodes d'utilisation |
| JP5085326B2 (ja) * | 2004-09-18 | 2012-11-28 | ユニバーシティ オブ メリーランド,ボルチモア | NCCa−ATPチャネルを標的とする処置剤およびその使用方法 |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| US9511075B2 (en) * | 2007-01-12 | 2016-12-06 | The University Of Maryland, Baltimore | Targeting NCCA-ATP channel for organ protection following ischemic episode |
| EP2114160B1 (fr) * | 2007-02-09 | 2016-11-16 | University of Maryland, Baltimore | Antagonistes d'un canal cationique non sélectif dans des cellules neurales |
| CA2691199C (fr) | 2007-06-22 | 2017-09-12 | Marc J. Simard | Inhibiteurs de canaux nc<sb>ca-atp</sb> pour therapie |
| BR112013018374A2 (pt) * | 2011-01-25 | 2016-10-11 | Monell Chemical Senses Centre | composições e métodos para fornecer ou modular o sabor doce e métodos para rastrear os mesmos |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| CN108383759B (zh) * | 2018-03-19 | 2021-01-26 | 江西师范大学 | 炔酰胺的胺氢化和膦氢化反应 |
| CN113831259B (zh) * | 2021-11-05 | 2023-07-25 | 内蒙古工业大学 | 一种芳香族偶氮化合物的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1185180B (de) | 1963-10-19 | 1965-01-14 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1493672C3 (de) | 1964-08-01 | 1974-05-02 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1518874C3 (de) | 1964-10-07 | 1975-03-13 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
| DE1518816C3 (de) | 1965-03-24 | 1975-05-22 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| US4066639A (en) | 1965-05-06 | 1978-01-03 | Hoechst Aktiengesellschaft | Benzene-sulfonyl semicarbazides and process for preparing them |
| DE59401361D1 (de) | 1993-02-23 | 1997-02-06 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| DE4341655A1 (de) | 1993-12-07 | 1995-06-08 | Hoechst Ag | Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| DE19505397A1 (de) | 1995-02-17 | 1996-08-22 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832009A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
| TR200100692T2 (tr) * | 1998-09-10 | 2001-07-23 | Aventis Pharma Deutschland Gmbh | Otonom sinir sisteminin disfonksiyonlarının önlenmesinde Benzensulfonil (Tiyo) ürelerin kullanımı |
| DE19923086A1 (de) | 1999-05-20 | 2000-11-23 | Aventis Pharma Gmbh | Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
-
2000
- 2000-11-03 DE DE10054481A patent/DE10054481A1/de not_active Withdrawn
-
2001
- 2001-10-20 PT PT01992696T patent/PT1345892E/pt unknown
- 2001-10-20 WO PCT/EP2001/012143 patent/WO2002036556A2/fr not_active Ceased
- 2001-10-20 CA CA2427429A patent/CA2427429C/fr not_active Expired - Fee Related
- 2001-10-20 AT AT01992696T patent/ATE290525T1/de active
- 2001-10-20 EP EP01992696A patent/EP1345892B1/fr not_active Expired - Lifetime
- 2001-10-20 AU AU1825302A patent/AU1825302A/xx active Pending
- 2001-10-20 ES ES01992696T patent/ES2237614T3/es not_active Expired - Lifetime
- 2001-10-20 MX MXPA03003608A patent/MXPA03003608A/es active IP Right Grant
- 2001-10-20 DE DE60109324T patent/DE60109324T2/de not_active Expired - Lifetime
- 2001-10-20 IL IL15565701A patent/IL155657A0/xx unknown
- 2001-10-20 JP JP2002539316A patent/JP4039625B2/ja not_active Expired - Fee Related
- 2001-10-20 AU AU2002218253A patent/AU2002218253B2/en not_active Ceased
- 2001-11-02 US US09/985,366 patent/US6511989B2/en not_active Expired - Lifetime
-
2003
- 2003-04-29 IL IL155657A patent/IL155657A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1345892B1 (fr) | 2005-03-09 |
| DE60109324T2 (de) | 2006-04-13 |
| CA2427429C (fr) | 2010-07-06 |
| IL155657A (en) | 2010-12-30 |
| ATE290525T1 (de) | 2005-03-15 |
| JP4039625B2 (ja) | 2008-01-30 |
| US6511989B2 (en) | 2003-01-28 |
| AU1825302A (en) | 2002-05-15 |
| WO2002036556A3 (fr) | 2002-07-04 |
| MXPA03003608A (es) | 2003-06-19 |
| JP2004513109A (ja) | 2004-04-30 |
| DE60109324D1 (de) | 2005-04-14 |
| US20020123494A1 (en) | 2002-09-05 |
| AU2002218253B2 (en) | 2006-07-06 |
| PT1345892E (pt) | 2005-06-30 |
| WO2002036556A2 (fr) | 2002-05-10 |
| CA2427429A1 (fr) | 2002-05-10 |
| ES2237614T3 (es) | 2005-08-01 |
| EP1345892A2 (fr) | 2003-09-24 |
| DE10054481A1 (de) | 2002-05-08 |
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