IL156261A0 - Pyrroloquinoline and pyridoquinoline derivatives and pharmaceutical compositions containing the same - Google Patents

Pyrroloquinoline and pyridoquinoline derivatives and pharmaceutical compositions containing the same

Info

Publication number: IL156261A0
Authority: IL; Israel
Prior art keywords: disorders; novel compounds; pyridoquinoline; pyrroloquinoline; derivatives
Prior art date: 2000-12-20

Application number

IL15626101A

Other languages

English (en)

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-20

Filing date

2001-12-19

Publication date

2004-01-04

2001-12-19 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2004-01-04 Publication of IL156261A0 publication Critical patent/IL156261A0/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
OZKOMUDCMCEDTM-UHFFFAOYSA-N 1,7-phenanthroline Chemical class C1=CC=C2C3=NC=CC=C3C=CC2=N1 OZKOMUDCMCEDTM-UHFFFAOYSA-N 0.000 title 1
ZIUYHTQZEPDUCZ-UHFFFAOYSA-N 7h-pyrrolo[2,3-h]quinoline Chemical compound C1=CN=C2C(C=CN3)=C3C=CC2=C1 ZIUYHTQZEPDUCZ-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
206010041250 Social phobia Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003420 antiserotonin agent Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000004899 motility Effects 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
239000000952 serotonin receptor agonist Substances 0.000 abstract 1
208000012201 sexual and gender identity disease Diseases 0.000 abstract 1
208000015891 sexual disease Diseases 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Nutrition Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL15626101A 2000-12-20 2001-12-19 Pyrroloquinoline and pyridoquinoline derivatives and pharmaceutical compositions containing the same IL156261A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25674500P	2000-12-20	2000-12-20
PCT/US2001/049380 WO2002059124A2 (en)	2000-12-20	2001-12-19	Substituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists

Publications (1)

Publication Number	Publication Date
IL156261A0 true IL156261A0 (en)	2004-01-04

Family

ID=22973430

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15626101A IL156261A0 (en)	2000-12-20	2001-12-19	Pyrroloquinoline and pyridoquinoline derivatives and pharmaceutical compositions containing the same

Country Status (23)

Country	Link
US (1)	US6777406B2 (cs)
EP (1)	EP1399445B9 (cs)
JP (1)	JP4386639B2 (cs)
KR (1)	KR20030070590A (cs)
AT (1)	ATE438646T1 (cs)
AU (1)	AU2002246726B2 (cs)
BG (1)	BG107863A (cs)
BR (1)	BR0116348A (cs)
CA (1)	CA2432181C (cs)
CZ (1)	CZ20031707A3 (cs)
DE (1)	DE60139511D1 (cs)
EE (1)	EE200300303A (cs)
ES (1)	ES2329553T4 (cs)
HU (1)	HUP0303530A3 (cs)
IL (1)	IL156261A0 (cs)
IS (1)	IS6851A (cs)
MX (1)	MXPA03005355A (cs)
NO (1)	NO20032798L (cs)
PL (1)	PL366627A1 (cs)
RU (1)	RU2003121306A (cs)
SK (1)	SK7032003A3 (cs)
WO (1)	WO2002059124A2 (cs)
ZA (1)	ZA200304304B (cs)

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US6777407B2 (en)	2000-11-03	2004-08-17	Wyeth	Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
AR031199A1 (es)	2000-11-03	2003-09-10	Wyeth Corp	Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados
TWI312781B (en)	2002-04-25	2009-08-01		[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en)	2002-04-25	2003-12-16	Wyeth Corp	[1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
TW200307682A (en)	2002-04-25	2003-12-16	Wyeth Corp	1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
CL2004000826A1 (es)	2003-04-25	2005-03-04	Pfizer	Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
JP5173190B2 (ja)	2004-08-25	2013-03-27	武田薬品工業株式会社	腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
US20070021612A1 (en) *	2004-11-04	2007-01-25	University Of Notre Dame Du Lac	Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof
US7235688B1 (en)	2004-11-04	2007-06-26	University Of Notre Dame Du Lac	Process for preparing histone deacetylase inhibitors and intermediates thereof
GT200500317A (es)	2004-11-05	2006-10-27		Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
AR054849A1 (es) *	2005-07-26	2007-07-18	Wyeth Corp	Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
TW200734334A (en) *	2006-01-13	2007-09-16	Wyeth Corp	Treatment of substance abuse
EP1998781A2 (en) *	2006-03-24	2008-12-10	Wyeth a Corporation of the State of Delaware	Treatment of pain
JP2009531435A (ja) *	2006-03-24	2009-09-03	ワイス	うつ病の治療用の新規な治療組み合わせ
JP5528699B2 (ja)	2006-05-16	2014-06-25	武田薬品工業株式会社	縮合複素環化合物およびその用途
CL2008002777A1 (es) *	2007-09-21	2010-01-22	Wyeth Corp	Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
JP5520051B2 (ja)	2007-11-15	2014-06-11	武田薬品工業株式会社	縮合ピリジン誘導体およびその用途
WO2011044506A2 (en)	2009-10-09	2011-04-14	Zafgen Corporation	Sulphone compounds and methods of making and using same
WO2011071136A1 (ja)	2009-12-11	2011-06-16	アステラス製薬株式会社	線維筋痛症治療剤
BR112013001613A2 (pt) *	2010-07-22	2016-05-24	Zafgen Inc	compostos tricíclicos e métodos para fazer e usar os mesmos.
US9321740B2 (en)	2011-01-26	2016-04-26	Zafgen, Inc.	Tetrazole compounds and methods of making and using same
WO2012154679A1 (en)	2011-05-06	2012-11-15	Zafgen Corporation	Tricyclic pyrazole sulfonamide compounds and methods of making and using same
US9290472B2 (en)	2011-05-06	2016-03-22	Zafgen, Inc.	Partially saturated tricyclic compounds and methods of making and using same
AU2012253759B2 (en)	2011-05-06	2016-01-21	Zafgen Inc.	Tricyclic sulfonamide compounds and methods of making and using same
BR112014017673A8 (pt)	2012-01-18	2017-07-11	Zafgen Inc	Compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos
AU2013209719A1 (en)	2012-01-18	2014-08-07	Zafgen, Inc.	Tricyclic sulfone compounds and methods of making and using same
BR112015010225A2 (pt)	2012-11-05	2017-07-11	Zafgen Inc	compostos tricíclicos e seus métodos de produção e utilização
CN104918928A (zh)	2012-11-05	2015-09-16	扎夫根股份有限公司	三环化合物及其制备方法和用途
NZ707773A (en)	2012-11-05	2019-05-31	Zafgen Inc	Methods of treating liver diseases
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
EP2981266B1 (en) *	2013-03-04	2018-01-03	Daya CNS LLC	Pentacyclic pyridoindolobenz[b,d]azepine derivatives and uses thereof
WO2015066344A1 (en)	2013-11-01	2015-05-07	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists and compositions and methods of use
EP3519816A4 (en)	2016-09-29	2020-05-06	The Regents of the University of California	CONNECTIONS FOR INCREASING NEURONAL PLASTICITY
WO2019131902A1 (ja)	2017-12-27	2019-07-04	武田薬品工業株式会社	腹圧性尿失禁および便失禁の治療薬
KR102946120B1 (ko)	2019-02-27	2026-03-30	더 리젠츠 오브 더 유니버시티 오브 캘리포니아	뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클
CN109897039B (zh) *	2019-03-13	2021-03-30	中国科学院化学研究所	一种制备吡咯并[3,2,1-ij]喹啉酮化合物的方法
WO2022221415A2 (en) *	2021-04-13	2022-10-20	The Regents Of The University Of California	Tetracyclic compounds for treating brain disorders
JP2025502615A (ja)	2021-12-15	2025-01-28	デリックスセラピューティクス，インク．	フェノキシおよびベンジルオキシ置換サイコプラストゲンならびにその使用

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US3914421A (en)	1972-06-19	1975-10-21	Endo Lab	Pyridopyrrolobenzheterocycles for combatting depression
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HUT61548A (en)	1990-08-27	1993-01-28	Sandoz Ag	Process for producing indolonaphthyridine derivatives and pharmaceutical compositions comprising such compounds

2001
- 2001-12-19 MX MXPA03005355A patent/MXPA03005355A/es unknown
- 2001-12-19 CA CA002432181A patent/CA2432181C/en not_active Expired - Fee Related
- 2001-12-19 AT AT01994318T patent/ATE438646T1/de not_active IP Right Cessation
- 2001-12-19 IL IL15626101A patent/IL156261A0/xx unknown
- 2001-12-19 EE EEP200300303A patent/EE200300303A/xx unknown
- 2001-12-19 EP EP01994318A patent/EP1399445B9/en not_active Expired - Lifetime
- 2001-12-19 JP JP2002559426A patent/JP4386639B2/ja not_active Expired - Fee Related
- 2001-12-19 PL PL01366627A patent/PL366627A1/xx unknown
- 2001-12-19 CZ CZ20031707A patent/CZ20031707A3/cs unknown
- 2001-12-19 WO PCT/US2001/049380 patent/WO2002059124A2/en not_active Ceased
- 2001-12-19 SK SK703-2003A patent/SK7032003A3/sk unknown
- 2001-12-19 RU RU2003121306/04A patent/RU2003121306A/ru not_active Application Discontinuation
- 2001-12-19 KR KR10-2003-7008267A patent/KR20030070590A/ko not_active Withdrawn
- 2001-12-19 AU AU2002246726A patent/AU2002246726B2/en not_active Ceased
- 2001-12-19 ES ES01994318T patent/ES2329553T4/es not_active Expired - Lifetime
- 2001-12-19 US US10/026,993 patent/US6777406B2/en not_active Expired - Lifetime
- 2001-12-19 DE DE60139511T patent/DE60139511D1/de not_active Expired - Lifetime
- 2001-12-19 BR BR0116348-5A patent/BR0116348A/pt not_active Application Discontinuation
- 2001-12-19 HU HU0303530A patent/HUP0303530A3/hu unknown
2003
- 2003-05-30 BG BG107863A patent/BG107863A/xx unknown
- 2003-06-02 ZA ZA200304304A patent/ZA200304304B/en unknown
- 2003-06-18 IS IS6851A patent/IS6851A/is unknown
- 2003-06-19 NO NO20032798A patent/NO20032798L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2002059124A2 (en)	2002-08-01
ATE438646T1 (de)	2009-08-15
BG107863A (en)	2004-06-30
IS6851A (is)	2003-06-18
NO20032798L (no)	2003-08-19
PL366627A1 (en)	2005-02-07
WO2002059124A3 (en)	2004-01-08
EE200300303A (et)	2003-12-15
BR0116348A (pt)	2004-11-23
RU2003121306A (ru)	2005-03-10
ES2329553T4 (es)	2010-12-07
JP2004528290A (ja)	2004-09-16
ZA200304304B (en)	2004-09-02
ES2329553T3 (es)	2009-11-27
US20040092502A1 (en)	2004-05-13
JP4386639B2 (ja)	2009-12-16
EP1399445A2 (en)	2004-03-24
US6777406B2 (en)	2004-08-17
NO20032798D0 (no)	2003-06-19
EP1399445B1 (en)	2009-08-05
CZ20031707A3 (cs)	2003-11-12
EP1399445B9 (en)	2010-07-21
MXPA03005355A (es)	2004-05-27
CA2432181C (en)	2009-11-17
KR20030070590A (ko)	2003-08-30
HUP0303530A3 (en)	2012-10-29
HUP0303530A2 (hu)	2004-01-28
CA2432181A1 (en)	2002-08-01
DE60139511D1 (de)	2009-09-17
AU2002246726B2 (en)	2007-03-01
SK7032003A3 (en)	2004-04-06

Publication	Publication Date	Title
PL366627A1 (en)	2005-02-07	Substituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists
HK1043112A1 (zh)	2002-09-06	取代的稠杂环γ-咔啉
WO2002059129A3 (en)	2003-01-30	Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists
AU2003303210A8 (en)	2004-07-14	Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists
MX2007007220A (es)	2007-08-20	Compuestos de pirazolona como agonistas de receptor de glutamato metabotropico para el tratamiento de trastornos neurologicos y psiquiatricos.
IL177291A0 (en)	2006-12-10	Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
IL156201A0 (en)	2003-12-23	Pyrazinoquioxaline derivatives and pharmaceutical compositions containing the same
GB0311349D0 (en)	2003-06-25	Therapeutic agents, compositions, preparations and uses