IL157061A0 - Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof - Google Patents

Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof

Info

Publication number: IL157061A0
Authority: IL; Israel
Prior art keywords: fluorophenethyl; methanone; piperazin; indol; cyano
Prior art date: 2001-01-23

Application number

IL15706101A

Other languages

English (en)

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-23

Filing date

2001-12-21

Publication date

2004-02-08

2001-12-21 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2004-02-08 Publication of IL157061A0 publication Critical patent/IL157061A0/xx

Links

AQRLDDAFYYAIJP-UHFFFAOYSA-N Pruvanserin Chemical compound C1=CC(F)=CC=C1CCN1CCN(C(=O)C=2C=3NC=C(C=3C=CC=2)C#N)CC1 AQRLDDAFYYAIJP-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D201/00—Preparation, separation, purification or stabilisation of unsubstituted lactams
- C07D201/02—Preparation of lactams
- C07D201/04—Preparation of lactams from or via oximes by Beckmann rearrangement
- C07D201/06—Preparation of lactams from or via oximes by Beckmann rearrangement from ketones by simultaneous oxime formation and rearrangement
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Toxicology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Nutrition Science (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL15706101A 2001-01-23 2001-12-21 Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof IL157061A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10102944A DE10102944A1 (de)	2001-01-23	2001-01-23	Verfahren zur Herstellung von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon und dessen Salzen
PCT/EP2001/015240 WO2002059092A1 (en)	2001-01-23	2001-12-21	Process for the preparation of (3-cyano-1h-indol-7-yl)(4-(4-fluorophenethyl)piperazin-1-yl)-methanone and salts thereof

Publications (1)

Publication Number	Publication Date
IL157061A0 true IL157061A0 (en)	2004-02-08

Family

ID=7671481

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL15706101A IL157061A0 (en)	2001-01-23	2001-12-21	Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof
IL157061A IL157061A (en)	2001-01-23	2003-07-22	Process and intermediates for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl)piperazin -1-yl)-methanone and salts thereof

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL157061A IL157061A (en)	2001-01-23	2003-07-22	Process and intermediates for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl)piperazin -1-yl)-methanone and salts thereof

Country Status (29)

Country	Link
US (1)	US7312342B2 (da)
EP (1)	EP1353906B1 (da)
JP (1)	JP4215195B2 (da)
KR (1)	KR100820763B1 (da)
CN (1)	CN1213029C (da)
AR (1)	AR032261A1 (da)
AT (1)	ATE269849T1 (da)
AU (1)	AU2002219220B2 (da)
BR (1)	BR0116816A (da)
CA (1)	CA2435426C (da)
CZ (1)	CZ20032202A3 (da)
DE (2)	DE10102944A1 (da)
DK (1)	DK1353906T3 (da)
EC (1)	ECSP034737A (da)
ES (1)	ES2223738T3 (da)
HU (1)	HUP0401039A3 (da)
IL (2)	IL157061A0 (da)
MX (1)	MXPA03006534A (da)
MY (1)	MY126252A (da)
NZ (1)	NZ527779A (da)
PL (1)	PL209416B1 (da)
PT (1)	PT1353906E (da)
RU (1)	RU2295519C2 (da)
SK (1)	SK286565B6 (da)
TR (1)	TR200402142T4 (da)
TW (1)	TW588044B (da)
UA (1)	UA74039C2 (da)
WO (1)	WO2002059092A1 (da)
ZA (1)	ZA200306540B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10246357A1 (de) *	2002-10-04	2004-04-15	Merck Patent Gmbh	Verwendung von 5-HT2Rezeptorantagonisten
DE102004047517A1 (de) *	2004-09-28	2006-03-30	Merck Patent Gmbh	Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
KR20090017569A (ko) *	2006-05-05	2009-02-18	메르크 파텐트 게엠베하	결정질 (３-시아노-１ｈ-인돌-７-일)-[４-(４-플루오로펜에틸)피페라진-１-일]메탄온 포스페이트
CN101437793B (zh) *	2006-05-05	2012-08-22	默克专利股份有限公司	结晶的（3-氰基-1h-吲哚-7-基）-[4-（4-氟苯乙基）哌嗪-1-基]甲酮磷酸盐
CN102816104B (zh) *	2012-08-30	2014-05-21	浙江大学	一种3-氰基吲哚类化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH421107A (de) *	1963-06-04	1966-09-30	Sandoz Ag	Verfahren zur Herstellung neuer heterocyclischer Verbindungen
CA2084531A1 (en) *	1991-12-19	1993-06-20	David W. Smith	Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines

2001
- 2001-01-23 DE DE10102944A patent/DE10102944A1/de not_active Withdrawn
- 2001-12-21 US US10/466,991 patent/US7312342B2/en not_active Expired - Fee Related
- 2001-12-21 RU RU2003124068/04A patent/RU2295519C2/ru not_active IP Right Cessation
- 2001-12-21 BR BR0116816-9A patent/BR0116816A/pt not_active Application Discontinuation
- 2001-12-21 EP EP01273449A patent/EP1353906B1/en not_active Expired - Lifetime
- 2001-12-21 NZ NZ527779A patent/NZ527779A/xx unknown
- 2001-12-21 CA CA002435426A patent/CA2435426C/en not_active Expired - Fee Related
- 2001-12-21 MX MXPA03006534A patent/MXPA03006534A/es active IP Right Grant
- 2001-12-21 ES ES01273449T patent/ES2223738T3/es not_active Expired - Lifetime
- 2001-12-21 TR TR2004/02142T patent/TR200402142T4/xx unknown
- 2001-12-21 KR KR1020037009645A patent/KR100820763B1/ko not_active Expired - Fee Related
- 2001-12-21 CZ CZ20032202A patent/CZ20032202A3/cs unknown
- 2001-12-21 JP JP2002559394A patent/JP4215195B2/ja not_active Expired - Fee Related
- 2001-12-21 UA UA2003076931A patent/UA74039C2/uk unknown
- 2001-12-21 CN CNB018221882A patent/CN1213029C/zh not_active Expired - Fee Related
- 2001-12-21 DE DE60104024T patent/DE60104024T2/de not_active Expired - Lifetime
- 2001-12-21 PT PT01273449T patent/PT1353906E/pt unknown
- 2001-12-21 AU AU2002219220A patent/AU2002219220B2/en not_active Ceased
- 2001-12-21 WO PCT/EP2001/015240 patent/WO2002059092A1/en not_active Ceased
- 2001-12-21 SK SK1046-2003A patent/SK286565B6/sk not_active IP Right Cessation
- 2001-12-21 HU HU0401039A patent/HUP0401039A3/hu unknown
- 2001-12-21 IL IL15706101A patent/IL157061A0/xx unknown
- 2001-12-21 DK DK01273449T patent/DK1353906T3/da active
- 2001-12-21 AT AT01273449T patent/ATE269849T1/de active
- 2001-12-21 PL PL364392A patent/PL209416B1/pl not_active IP Right Cessation
2002
- 2002-01-17 TW TW091100688A patent/TW588044B/zh not_active IP Right Cessation
- 2002-01-18 MY MYPI20020201A patent/MY126252A/en unknown
- 2002-01-23 AR ARP020100222A patent/AR032261A1/es unknown
2003
- 2003-07-22 IL IL157061A patent/IL157061A/en not_active IP Right Cessation
- 2003-08-19 EC EC2003004737A patent/ECSP034737A/es unknown
- 2003-08-21 ZA ZA200306540A patent/ZA200306540B/en unknown

Also Published As

Publication number	Publication date
MY126252A (en)	2006-09-29
PL209416B1 (pl)	2011-08-31
BR0116816A (pt)	2004-01-27
DE10102944A1 (de)	2002-07-25
EP1353906B1 (en)	2004-06-23
CA2435426A1 (en)	2002-08-01
HUP0401039A3 (en)	2008-05-28
SK286565B6 (sk)	2009-01-07
KR100820763B1 (ko)	2008-04-10
ATE269849T1 (de)	2004-07-15
DE60104024T2 (de)	2005-07-07
HUP0401039A2 (hu)	2004-08-30
EP1353906A1 (en)	2003-10-22
ECSP034737A (es)	2003-09-24
AU2002219220B2 (en)	2007-01-11
IL157061A (en)	2009-09-01
NZ527779A (en)	2004-12-24
ES2223738T3 (es)	2005-03-01
RU2003124068A (ru)	2005-01-10
TR200402142T4 (tr)	2004-10-21
DK1353906T3 (da)	2004-10-11
RU2295519C2 (ru)	2007-03-20
CZ20032202A3 (cs)	2004-01-14
PL364392A1 (en)	2004-12-13
ZA200306540B (en)	2004-09-02
PT1353906E (pt)	2004-11-30
HK1063182A1 (en)	2004-12-17
JP4215195B2 (ja)	2009-01-28
MXPA03006534A (es)	2003-09-22
US20040063723A1 (en)	2004-04-01
CN1487923A (zh)	2004-04-07
TW588044B (en)	2004-05-21
KR20030068590A (ko)	2003-08-21
DE60104024D1 (de)	2004-07-29
JP2004519466A (ja)	2004-07-02
UA74039C2 (en)	2005-10-17
CN1213029C (zh)	2005-08-03
CA2435426C (en)	2009-10-27
WO2002059092A1 (en)	2002-08-01
AR032261A1 (es)	2003-10-29
US7312342B2 (en)	2007-12-25
SK10462003A3 (sk)	2003-12-02

Publication	Publication Date	Title
HUP0400236A3 (en)	2010-06-28	Polymorphic forms of 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride, process for their preparation and pharmaceutical compositions containing them
AU2003233010A8 (en)	2003-12-19	Process for the preparation of 3,3,4,4-tetrafluoropyrrolidine and derivatives thereof
HUP0402264A3 (en)	2010-03-29	Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines process for preparing them, pharmaceutical compositions containing them and use thereof
AU2001262723A1 (en)	2002-03-14	1,2-dihydropyridine compounds, process for preparation of the same and use thereof
MXPA02008801A (es)	2003-07-07	Derivados de indol, proceso para la preparacion de los mismos y su uso.
AU2002224927A1 (en)	2002-06-24	Use of substituted imidazoazines, novel imidazoazines, methods for the production thereof, and agents containing these compounds
HUP0300567A3 (en)	2003-11-28	Process for preparation of novel piperazine derivatives
HUP0302656A3 (en)	2009-08-28	Fumaric acid amides, their use for preparation of pharmaceutical compositions and pharmaceutical compositions containing the compounds
HUP0402554A3 (en)	2009-01-28	Condensated heterocyclic succinimide compounds, their use, process for the preparation of some of them and pharmaceutical compositions containing the compounds
IL158693A0 (en)	2004-05-12	Azole compounds, process for preparation of the same and use thereof
HUP0303109A3 (en)	2010-04-28	Indolin-2-one derivatives, process for producing them and pharmaceutical compositions containing them
HUP0103063A3 (en)	2005-06-28	Novel 2h-pyridazin-3-one derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HUP0401747A3 (en)	2005-06-28	Piridazine derivatives of hydrazono-malonitriles, their use, process for preparation of the compounds and pharmaceutical compositions containing the compounds
HUP0202414A3 (en)	2003-05-28	Process for the preparation of perindopril, their analogous and their salts
NO20033433L (no)	2003-09-25	Fremgangsmåte for fremstilling av 2-(2-pyridylmetyl)sulfinyl- 1H-benzimidasol
IL159067A0 (en)	2004-05-12	METHODS FOR PREPARATION AND USE OF 1alpha,24 (S) -DIHYDROXYVITAMIN D2
IL160043A0 (en)	2004-06-20	Process for the preparation of indole derivatives
HUP0401600A3 (en)	2008-05-28	Process for the preparation of 14-hydroxymorphine derivatives
IL157709A0 (en)	2004-03-28	Process for the preparation of 1,2-benzisoxazole-3-acetic acid
IL157061A0 (en)	2004-02-08	Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof
HUP0103712A3 (en)	2002-09-30	Salts of paroxetine, process for their preparation and their pharmaceutical use
HUP0402475A3 (en)	2008-10-28	Process for the preparation of [1,4,5]-oxadiazepine derivatives
NO20004545L (no)	2000-11-13	FremgangsmÕte for fremstilling av (R)-<alfa>-(2,3- dimetoksyfenyl)-1-[2-(4-fluorofenyl)etyl]-4-piperidinmetanol
SI1353906T1 (en)	2005-02-28	Process for the preparation of (3-cyano-1h-indol-7-yl)(4-(4-fluorophenethyl)piperazin-1-yl)-methanone and salts thereof
PL363224A1 (en)	2004-11-15	Process for the preparation of quinoline derivatives