IL157188A - Apparatus and method for mixing materials sealed in a container under sterile conditions - Google Patents
Apparatus and method for mixing materials sealed in a container under sterile conditionsInfo
- Publication number
- IL157188A IL157188A IL15718802A IL15718802A IL157188A IL 157188 A IL157188 A IL 157188A IL 15718802 A IL15718802 A IL 15718802A IL 15718802 A IL15718802 A IL 15718802A IL 157188 A IL157188 A IL 157188A
- Authority
- IL
- Israel
- Prior art keywords
- container
- tube
- rod
- seal
- bag
- Prior art date
Links
- 238000002156 mixing Methods 0.000 title claims abstract description 36
- 239000000463 material Substances 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims abstract description 9
- 125000006850 spacer group Chemical group 0.000 claims abstract description 16
- 238000012545 processing Methods 0.000 claims abstract description 9
- 230000033001 locomotion Effects 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000007246 mechanism Effects 0.000 claims description 4
- 238000010364 biochemical engineering Methods 0.000 abstract description 10
- 238000012993 chemical processing Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 21
- 210000003739 neck Anatomy 0.000 description 7
- -1 serum Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 5
- 230000002572 peristaltic effect Effects 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 229960000074 biopharmaceutical Drugs 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 240000008100 Brassica rapa Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000004323 axial length Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000002783 friction material Substances 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
- B01F27/1126—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades the stirrer being a bent rod supported at one end only
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/051—Stirrers characterised by their elements, materials or mechanical properties
- B01F27/054—Deformable stirrers, e.g. deformed by a centrifugal force applied during operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/88—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with a separate receptacle-stirrer unit that is adapted to be coupled to a drive mechanism
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
- B01F35/146—Working under sterile conditions; Sterilizing the mixer or parts thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
- B01F35/7137—Piercing, perforating or melting membranes or closures which seal the compartments
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
- B01F2035/35—Use of other general mechanical engineering elements in mixing devices
- B01F2035/351—Sealings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Accessories For Mixers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26665101P | 2001-02-06 | 2001-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL157188A true IL157188A (en) | 2004-07-25 |
Family
ID=23015437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15718802A IL157188A (en) | 2001-02-06 | 2002-02-05 | Apparatus and method for mixing materials sealed in a container under sterile conditions |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6494613B2 (fr) |
| EP (2) | EP2272583B1 (fr) |
| JP (1) | JP4369121B2 (fr) |
| AT (1) | ATE510614T1 (fr) |
| CA (1) | CA2437391C (fr) |
| IL (1) | IL157188A (fr) |
| WO (1) | WO2002062458A1 (fr) |
Families Citing this family (82)
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|---|---|---|---|---|
| US7762716B2 (en) | 2000-10-09 | 2010-07-27 | Levtech, Inc. | Mixing vessel with a fluid-agitating element supported by a roller bearing |
| US6837613B2 (en) * | 2001-04-10 | 2005-01-04 | Levtech, Inc. | Sterile fluid pumping or mixing system and related method |
| US8182137B2 (en) | 2000-10-09 | 2012-05-22 | Atmi Packaging, Inc. | Mixing bag or vessel with a fluid-agitating element |
| WO2003028869A2 (fr) | 2001-10-03 | 2003-04-10 | Levtech, Inc. | Recipient ou sac de melange possedant un receptacle pour un element agitateur de fluide |
| US7086778B2 (en) * | 2000-10-09 | 2006-08-08 | Levtech, Inc. | System using a levitating, rotating pumping or mixing element and related methods |
| EP1352685A3 (fr) * | 2002-04-12 | 2005-04-27 | Hynetics, LLC | Récipient mélangeur |
| US6981794B2 (en) | 2002-04-12 | 2006-01-03 | Hynetics Llc | Methods for mixing solutions |
| US6908223B2 (en) * | 2002-04-12 | 2005-06-21 | Hynetics Llc | Systems for mixing liquid solutions and methods of manufacture |
| US6923567B2 (en) * | 2002-04-12 | 2005-08-02 | Hynetics Llc | Mixing tank assembly |
| US6837610B2 (en) * | 2002-09-27 | 2005-01-04 | Ilc Dover Lpp | Bioprocess container, bioprocess container mixing device and method of use thereof |
| US7153021B2 (en) * | 2003-03-28 | 2006-12-26 | Hyclone Laboratories, Inc. | Container systems for mixing fluids with a magnetic stir bar |
| US7249880B2 (en) * | 2003-10-14 | 2007-07-31 | Advanced Technology Materials, Inc. | Flexible mixing bag for mixing solids, liquids and gases |
| CA2552717C (fr) * | 2004-01-07 | 2011-11-29 | Levtech, Inc. | Sac melangeur a arroseur integre et receptacle pour detecteur |
| DE102004013078B4 (de) * | 2004-03-17 | 2010-12-09 | Sartorius Stedim Biotech Gmbh | Mischeinrichtung für Flüssigkeiten in flexiblen Einwegbehältern |
| US7326355B2 (en) * | 2004-03-31 | 2008-02-05 | Hyclone Laboratories, Inc. | Mobile filtration facility and methods of use |
| AU2005240969A1 (en) * | 2004-04-27 | 2005-11-17 | Baxter Healthcare S.A. | Stirred-tank reactor system |
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| US8603805B2 (en) | 2005-04-22 | 2013-12-10 | Hyclone Laboratories, Inc. | Gas spargers and related container systems |
| US7682067B2 (en) * | 2005-04-22 | 2010-03-23 | Hyclone Laboratories, Inc. | Mixing systems and related mixers |
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| US20060246008A1 (en) * | 2005-04-29 | 2006-11-02 | Jenkins Lauri L | Process for the formulation of therapeutic protein |
| US20060246546A1 (en) * | 2005-04-29 | 2006-11-02 | Jenkins Lauri L | Manufacture of biologic cellular products |
| US20060243666A1 (en) * | 2005-04-29 | 2006-11-02 | Jenkins Lauri L | Process for the preparation of protein separation solution |
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| DE102006020813B3 (de) * | 2006-05-03 | 2007-10-04 | Sartorius Biotech Gmbh | Behälteranordnung mit einem Behälter mit flexibler Wandung |
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| US8840299B2 (en) * | 2007-06-04 | 2014-09-23 | Ge Healthcare Bio-Sciences Corp. | Apparatus for mixing the contents of a container |
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| FR2929253B1 (fr) | 2008-03-28 | 2013-09-13 | Sartorius Stedim Biotech Sa | Cadre rigide pour conteneur 3d a contenant au moins partiellement deformable |
| DE102008058338B4 (de) | 2008-11-20 | 2010-11-11 | Sartorius Stedim Biotech Gmbh | Rührer für Bioreaktor |
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| DK3065691T3 (da) | 2013-12-10 | 2021-02-01 | Abec Inc | Steril engangsbeholder med en aftagelig fastgørelsesindretning |
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| EP3623039B1 (fr) * | 2018-09-13 | 2022-01-26 | BPC Instruments AB | Unité d'agitateur, système et procédé |
| USD943365S1 (en) * | 2019-03-21 | 2022-02-15 | Ezpb Llc | Stirring implement |
| US20220250013A1 (en) * | 2019-06-19 | 2022-08-11 | Merck Sharp & Dohme Corp. | Containment System for Mixing Dry Powders with Solvents During Drug Production or Processing |
| EP4054749A4 (fr) * | 2019-11-04 | 2024-01-10 | Parker-Hannifin Corporation | Dispositif mélangeur en ligne, procédés de mélange et procédés de fabrication d'un dispositif mélangeur en ligne |
| BR112022013998A2 (pt) | 2020-02-03 | 2022-10-11 | Life Technologies Corp | Sistemas de mistura de fluidos com rotores modulares e métodos relacionados |
| DE102020123520A1 (de) | 2020-09-09 | 2022-03-10 | EKATO Rühr- und Mischtechnik GmbH | Rührorganvorrichtung und Verfahren zur Herstellung einer Rührorganvorrichtung |
| FR3113909B1 (fr) * | 2020-09-10 | 2022-08-26 | Commissariat Energie Atomique | Kit d’analyse et de suivi d’un parametre, au moyen d’un capteur mobile, d’une reaction chimique ou biochimique ou biologique dans une enceinte reactionnelle |
| US20250214045A1 (en) * | 2022-03-01 | 2025-07-03 | Sartorius Stedim Biotech Gmbh | Containers including internal mixers and methods of use |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US370549A (en) * | 1887-09-27 | Device for aging and purifying liquors | ||
| US1501870A (en) * | 1922-09-26 | 1924-07-15 | Walter Wood Trading As R D Woo | Gas producer |
| US1579382A (en) * | 1924-05-12 | 1926-04-06 | Mitchell James Garth | Hand device for beating fabrics and the like |
| GB691048A (en) * | 1949-06-07 | 1953-05-06 | Fond Emanuele Paterno | Foamless stirring and/or homogenising process, and apparatus therefor |
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| US2877994A (en) * | 1954-05-03 | 1959-03-17 | Harold D Jones | Sealing devices for use with rotary or oscillatory shafts |
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| US3647397A (en) * | 1969-11-19 | 1972-03-07 | Charles M Coleman | Reagent solution preparation |
| JPS4810530Y1 (fr) * | 1970-09-19 | 1973-03-20 | ||
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| JPS5157064A (en) * | 1974-11-14 | 1976-05-19 | Masao Moryama | Gaikinifurezuni kongosuru hoho |
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-
2002
- 2002-02-05 IL IL15718802A patent/IL157188A/en not_active IP Right Cessation
- 2002-02-05 EP EP10180958.0A patent/EP2272583B1/fr not_active Expired - Lifetime
- 2002-02-05 AT AT02718914T patent/ATE510614T1/de not_active IP Right Cessation
- 2002-02-05 US US10/068,373 patent/US6494613B2/en not_active Expired - Lifetime
- 2002-02-05 WO PCT/US2002/003434 patent/WO2002062458A1/fr not_active Ceased
- 2002-02-05 EP EP02718914A patent/EP1365854B1/fr not_active Expired - Lifetime
- 2002-02-05 JP JP2002562460A patent/JP4369121B2/ja not_active Expired - Lifetime
- 2002-02-05 CA CA2437391A patent/CA2437391C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2437391C (fr) | 2010-04-20 |
| CA2437391A1 (fr) | 2002-08-15 |
| EP2272583B1 (fr) | 2013-10-30 |
| JP4369121B2 (ja) | 2009-11-18 |
| EP1365854A4 (fr) | 2006-05-31 |
| ATE510614T1 (de) | 2011-06-15 |
| WO2002062458A1 (fr) | 2002-08-15 |
| US20020105856A1 (en) | 2002-08-08 |
| JP2004532719A (ja) | 2004-10-28 |
| EP1365854B1 (fr) | 2011-05-25 |
| EP1365854A1 (fr) | 2003-12-03 |
| EP2272583A1 (fr) | 2011-01-12 |
| US6494613B2 (en) | 2002-12-17 |
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Legal Events
| Date | Code | Title | Description |
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| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |