IL158385A0 - Modified cyclosporin which can be used as a pro-drug and use thereof - Google Patents

Modified cyclosporin which can be used as a pro-drug and use thereof

Info

Publication number: IL158385A0
Authority: IL; Israel
Prior art keywords: pro; drug; modified cyclosporin; cyclosporin; modified
Prior art date: 2001-04-20

Application number

IL15838502A

Other languages

English (en)

Original Assignee

Debiopharm Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-20

Filing date

2002-04-22

Publication date

2004-05-12

2002-04-22 Application filed by Debiopharm Sa filed Critical Debiopharm Sa

2004-05-12 Publication of IL158385A0 publication Critical patent/IL158385A0/xx

Links

229940002612 prodrug Drugs 0.000 title abstract 2
239000000651 prodrug Substances 0.000 title abstract 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Virology (AREA)
Transplantation (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL15838502A 2001-04-20 2002-04-22 Modified cyclosporin which can be used as a pro-drug and use thereof IL158385A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH7202001		2001-04-20
PCT/CH2002/000222 WO2002085928A2 (fr)	2001-04-20	2002-04-22	Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation

Publications (1)

Publication Number	Publication Date
IL158385A0 true IL158385A0 (en)	2004-05-12

Family

ID=4531478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15838502A IL158385A0 (en)	2001-04-20	2002-04-22	Modified cyclosporin which can be used as a pro-drug and use thereof

Country Status (17)

Country	Link
US (1)	US6995139B2 (de)
EP (1)	EP1379547B1 (de)
JP (1)	JP4588979B2 (de)
KR (1)	KR100932859B1 (de)
CN (1)	CN1507451A (de)
AT (1)	ATE313557T1 (de)
AU (1)	AU2002245996B8 (de)
BR (1)	BR0208923A (de)
CA (1)	CA2444278C (de)
DE (1)	DE60208180T2 (de)
ES (1)	ES2256450T3 (de)
IL (1)	IL158385A0 (de)
MX (1)	MXPA03009586A (de)
RU (1)	RU2290196C2 (de)
UA (1)	UA75136C2 (de)
WO (1)	WO2002085928A2 (de)
ZA (1)	ZA200307794B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7232924B2 (en)	2001-06-11	2007-06-19	Xenoport, Inc.	Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en)	2001-06-11	2004-11-16	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en)	2001-06-11	2007-03-06	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7354574B2 (en) *	2002-11-07	2008-04-08	Advanced Ocular Systems Limited	Treatment of ocular disease
US7538084B2 (en)	2003-03-17	2009-05-26	Amr Technology, Inc.	Cyclosporins
US7083803B2 (en)	2003-09-19	2006-08-01	Advanced Ocular Systems Limited	Ocular solutions
US7087237B2 (en)	2003-09-19	2006-08-08	Advanced Ocular Systems Limited	Ocular solutions
WO2006115509A2 (en)	2004-06-24	2006-11-02	Novartis Vaccines And Diagnostics Inc.	Small molecule immunopotentiators and assays for their detection
JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
JP2008514702A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
JP2008515886A (ja)	2004-10-06	2008-05-15	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
EP1904056B1 (de)	2005-07-18	2009-04-29	Minu, L.L.C.	Verwendung von Makroliden zur Wiederherstellung der Kornealempfindungen
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
WO2008013860A2 (en) *	2006-07-28	2008-01-31	Xenoport, Inc.	Acyloxyalkyl carbamate prodrugs of alpha-amino acids, methods of synthesis and use
US8394763B2 (en)	2007-09-26	2013-03-12	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009098533A1 (en) *	2008-02-08	2009-08-13	Debiopharm Sa	Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
GB0912584D0 (en) *	2009-07-20	2009-08-26	Ucl Business Plc	Cyclosporin conjugates
BR112013014890B1 (pt)	2010-12-15	2023-10-24	Contravir Pharmaceuticals, Inc	Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos
AR090964A1 (es) *	2012-05-09	2014-12-17	Novartis Ag	Proceso para la elaboracion de undecapeptidos ciclicos
CN113388002A (zh) *	2021-06-10	2021-09-14	梯尔希（南京）药物研发有限公司	一种环孢菌素相关化合物的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE54936B1 (en) *	1980-02-14	1990-03-28	Sandoz Ltd	A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4396542A (en) *	1980-02-14	1983-08-02	Sandoz Ltd.	Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US5169773A (en) *	1984-10-04	1992-12-08	Sandoz Ltd.	Monoclonal antibodies to cyclosporins
EP0177654B1 (de) *	1984-10-10	1989-05-31	Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France	Synergistische empfängnisverhütende Mischung
US4764503A (en) *	1986-11-19	1988-08-16	Sandoz Ltd.	Novel cyclosporins
GB8717300D0 (en) *	1987-07-22	1987-08-26	Nat Res Dev	Cyclosporins
HU201577B (en) *	1988-12-20	1990-11-28	Gyogyszerkutato Intezet	Process for producing cyclosporin antibiotics
GB9116836D0 (en) *	1991-08-05	1991-09-18	Sandoz Ltd	Organic compounds
FI111730B (fi) *	1990-11-02	2003-09-15	Novartis Ag	Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi
GB9204466D0 (en) *	1992-03-02	1992-04-15	Sandoz Ltd	Improvements in or relating to organic compounds
US6187547B1 (en) *	1993-09-08	2001-02-13	Novartis Ag	Assay kit
GB9624038D0 (en) *	1996-11-19	1997-01-08	Sandoz Ltd	Organic compounds
US6017879A (en) *	1998-04-03	2000-01-25	B.M.R.A. Corporation B.V.	Template associated NPY Y2-receptor agonists
AU759480B2 (en)	1998-07-01	2003-04-17	Debiopharm S.A.	Novel cyclosporin with improved activity profile
US6204257B1 (en) *	1998-08-07	2001-03-20	Universtiy Of Kansas	Water soluble prodrugs of hindered alcohols
WO2000046239A1 (fr) *	1999-02-05	2000-08-10	Debiopharm S.A.	Derives de cyclosporine et procede de preparation desdits derives
US6765019B1 (en) *	1999-05-06	2004-07-20	University Of Kentucky Research Foundation	Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
WO2001005819A1 (en) *	1999-07-15	2001-01-25	Kuhnil Pharm. Co., Ltd.	Novel water soluble-cyclosporine conjugated compounds
US6593292B1 (en) *	1999-08-24	2003-07-15	Cellgate, Inc.	Compositions and methods for enhancing drug delivery across and into epithelial tissues

2002
- 2002-04-22 US US10/474,396 patent/US6995139B2/en not_active Expired - Fee Related
- 2002-04-22 UA UA20031110436A patent/UA75136C2/uk unknown
- 2002-04-22 EP EP02713992A patent/EP1379547B1/de not_active Expired - Lifetime
- 2002-04-22 AT AT02713992T patent/ATE313557T1/de not_active IP Right Cessation
- 2002-04-22 AU AU2002245996A patent/AU2002245996B8/en not_active Ceased
- 2002-04-22 BR BR0208923-8A patent/BR0208923A/pt active Search and Examination
- 2002-04-22 JP JP2002583454A patent/JP4588979B2/ja not_active Expired - Fee Related
- 2002-04-22 ES ES02713992T patent/ES2256450T3/es not_active Expired - Lifetime
- 2002-04-22 IL IL15838502A patent/IL158385A0/xx not_active IP Right Cessation
- 2002-04-22 CN CNA028094050A patent/CN1507451A/zh active Pending
- 2002-04-22 CA CA2444278A patent/CA2444278C/en not_active Expired - Fee Related
- 2002-04-22 WO PCT/CH2002/000222 patent/WO2002085928A2/fr not_active Ceased
- 2002-04-22 RU RU2003133742/15A patent/RU2290196C2/ru not_active IP Right Cessation
- 2002-04-22 MX MXPA03009586A patent/MXPA03009586A/es active IP Right Grant
- 2002-04-22 DE DE60208180T patent/DE60208180T2/de not_active Expired - Lifetime
2003
- 2003-10-06 ZA ZA200307794A patent/ZA200307794B/en unknown
- 2003-10-17 KR KR1020037013666A patent/KR100932859B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1379547A2 (de)	2004-01-14
UA75136C2 (en)	2006-03-15
KR100932859B1 (ko)	2009-12-23
CN1507451A (zh)	2004-06-23
KR20030094357A (ko)	2003-12-11
ATE313557T1 (de)	2006-01-15
ES2256450T3 (es)	2006-07-16
RU2290196C2 (ru)	2006-12-27
AU2002245996B8 (en)	2005-07-14
DE60208180T2 (de)	2006-08-17
ZA200307794B (en)	2004-07-19
DE60208180D1 (de)	2006-01-26
RU2003133742A (ru)	2005-03-20
US6995139B2 (en)	2006-02-07
WO2002085928A2 (fr)	2002-10-31
CA2444278A1 (en)	2002-10-31
JP2004536051A (ja)	2004-12-02
AU2002245996B2 (en)	2005-06-30
JP4588979B2 (ja)	2010-12-01
CA2444278C (en)	2011-11-22
MXPA03009586A (es)	2004-05-24
BR0208923A (pt)	2004-04-27
EP1379547B1 (de)	2005-12-21
WO2002085928A3 (fr)	2003-04-17
US20040138108A1 (en)	2004-07-15

Legal Events

Date	Code	Title
2011-02-28	FF	Patent granted
2011-05-31	KB	Patent renewed
2012-05-31	KB	Patent renewed
2016-11-30	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL158385A0 (en)	2004-05-12	Modified cyclosporin which can be used as a pro-drug and use thereof
AP2000001856A0 (en)	2000-09-30	Prodrugs of aspartyl protease inhibitors.
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HK1043534A1 (zh)	2002-09-20	蛋白酶抑制剂
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