IL160367A0 - Pyrrolo pyrimidines as agents for the inhibition of cystein proteases - Google Patents

Pyrrolo pyrimidines as agents for the inhibition of cystein proteases

Info

Publication number: IL160367A0
Authority: IL; Israel
Prior art keywords: inhibition; agents; cystein proteases; pyrimidines; pyrrolo
Prior art date: 2001-08-30

Application number

IL16036702A

Other languages

English (en)

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-30

Filing date

2002-08-29

Publication date

2004-07-25

2002-08-29 Application filed by Novartis Ag filed Critical Novartis Ag

2004-07-25 Publication of IL160367A0 publication Critical patent/IL160367A0/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL16036702A 2001-08-30 2002-08-29 Pyrrolo pyrimidines as agents for the inhibition of cystein proteases IL160367A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0121033.5A GB0121033D0 (en)	2001-08-30	2001-08-30	Organic compounds
PCT/EP2002/009663 WO2003020721A1 (en)	2001-08-30	2002-08-29	Pyrrolo pyrimidines as agents for the inhibition of cystein proteases

Publications (1)

Publication Number	Publication Date
IL160367A0 true IL160367A0 (en)	2004-07-25

Family

ID=9921234

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL16036702A IL160367A0 (en)	2001-08-30	2002-08-29	Pyrrolo pyrimidines as agents for the inhibition of cystein proteases
IL160367A IL160367A (en)	2001-08-30	2004-02-12	Pyrrolo pyrimidines as agents for the inhibition of cysteine proteases
IL198643A IL198643A (en)	2001-08-30	2009-05-07	Pyrrolo pyrimidines as agents for the inhibition of cystein proteases

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL160367A IL160367A (en)	2001-08-30	2004-02-12	Pyrrolo pyrimidines as agents for the inhibition of cysteine proteases
IL198643A IL198643A (en)	2001-08-30	2009-05-07	Pyrrolo pyrimidines as agents for the inhibition of cystein proteases

Country Status (29)

Country	Link
US (2)	US7452886B2 (pl)
EP (1)	EP1423391B8 (pl)
JP (1)	JP4629334B2 (pl)
KR (1)	KR100695845B1 (pl)
CN (1)	CN100372849C (pl)
AR (1)	AR036374A1 (pl)
AT (1)	ATE326469T1 (pl)
AU (1)	AU2002333760B2 (pl)
BR (1)	BR0212226A (pl)
CA (1)	CA2458684C (pl)
CY (1)	CY1105573T1 (pl)
DE (1)	DE60211530T2 (pl)
DK (1)	DK1423391T3 (pl)
EC (1)	ECSP044998A (pl)
ES (1)	ES2262888T3 (pl)
GB (1)	GB0121033D0 (pl)
HU (1)	HUP0401301A3 (pl)
IL (3)	IL160367A0 (pl)
MX (1)	MXPA04001935A (pl)
MY (1)	MY157368A (pl)
NO (1)	NO328890B1 (pl)
NZ (1)	NZ531343A (pl)
PE (1)	PE20030418A1 (pl)
PL (1)	PL368280A1 (pl)
PT (1)	PT1423391E (pl)
RU (1)	RU2331644C2 (pl)
TW (1)	TWI297690B (pl)
WO (1)	WO2003020721A1 (pl)
ZA (1)	ZA200401042B (pl)

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GB0220187D0 (en) *	2002-08-30	2002-10-09	Novartis Ag	Organic compounds
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AR043692A1 (es) *	2003-02-06	2005-08-10	Novartis Ag	2-cianopirrolopirimidinas y sus usos farmaceuticos
GB0304640D0 (en) *	2003-02-28	2003-04-02	Novartis Ag	Organic compounds
JP4710606B2 (ja) *	2003-04-18	2011-06-29	小野薬品工業株式会社	スピロピペリジン化合物およびその医薬用途
BRPI0409868A (pt) *	2003-04-28	2006-05-16	Novartis Ag	composição farmacêutica que compreende um inibidor da catepsina s e um opióide
EP1797883A3 (en) *	2003-04-28	2007-08-01	Novartis AG	Pharmaceutical composition comprising a cathepsin S inhibitor and an opioid
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CN101845023A (zh)	2004-02-18	2010-09-29	阿斯利康(瑞典)有限公司	四唑化合物及其作为代谢型谷氨酸受体拮抗剂的应用
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US7326715B2 (en)	2005-09-23	2008-02-05	N.V. Organon	4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
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US7687515B2 (en)	2006-01-17	2010-03-30	N.V. Organon	6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
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US8759359B2 (en)	2009-12-18	2014-06-24	Incyte Corporation	Substituted heteroaryl fused derivatives as PI3K inhibitors
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US9115126B2 (en)	2010-01-15	2015-08-25	Merck Sharp & Dohme B.V.	1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derivatives
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WO2012027495A1 (en)	2010-08-27	2012-03-01	University Of The Pacific	Piperazinylpyrimidine analogues as protein kinase inhibitors
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US9126948B2 (en)	2011-03-25	2015-09-08	Incyte Holdings Corporation	Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
UA121539C2 (uk)	2011-09-02	2020-06-25	Інсайт Холдинґс Корпорейшн	Гетероцикліламіни як інгібітори рі3к
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2001
- 2001-08-30 GB GBGB0121033.5A patent/GB0121033D0/en not_active Ceased
2002
- 2002-08-27 MY MYPI20023181A patent/MY157368A/en unknown
- 2002-08-28 TW TW091119570A patent/TWI297690B/zh not_active IP Right Cessation
- 2002-08-28 AR ARP020103229A patent/AR036374A1/es unknown
- 2002-08-29 CA CA002458684A patent/CA2458684C/en not_active Expired - Fee Related
- 2002-08-29 PL PL02368280A patent/PL368280A1/pl not_active Application Discontinuation
- 2002-08-29 DE DE60211530T patent/DE60211530T2/de not_active Expired - Lifetime
- 2002-08-29 HU HU0401301A patent/HUP0401301A3/hu unknown
- 2002-08-29 DK DK02797553T patent/DK1423391T3/da active
- 2002-08-29 US US10/487,760 patent/US7452886B2/en not_active Expired - Fee Related
- 2002-08-29 BR BR0212226-0A patent/BR0212226A/pt not_active Application Discontinuation
- 2002-08-29 WO PCT/EP2002/009663 patent/WO2003020721A1/en not_active Ceased
- 2002-08-29 PT PT02797553T patent/PT1423391E/pt unknown
- 2002-08-29 EP EP02797553A patent/EP1423391B8/en not_active Expired - Lifetime
- 2002-08-29 RU RU2004109815/04A patent/RU2331644C2/ru not_active IP Right Cessation
- 2002-08-29 MX MXPA04001935A patent/MXPA04001935A/es active IP Right Grant
- 2002-08-29 IL IL16036702A patent/IL160367A0/xx unknown
- 2002-08-29 PE PE2002000833A patent/PE20030418A1/es not_active Application Discontinuation
- 2002-08-29 AU AU2002333760A patent/AU2002333760B2/en not_active Ceased
- 2002-08-29 NZ NZ531343A patent/NZ531343A/en not_active IP Right Cessation
- 2002-08-29 ES ES02797553T patent/ES2262888T3/es not_active Expired - Lifetime
- 2002-08-29 AT AT02797553T patent/ATE326469T1/de active
- 2002-08-29 CN CNB028168402A patent/CN100372849C/zh not_active Expired - Fee Related
- 2002-08-29 JP JP2003524991A patent/JP4629334B2/ja not_active Expired - Fee Related
- 2002-08-29 KR KR1020047003048A patent/KR100695845B1/ko not_active Expired - Fee Related
2004
- 2004-02-09 ZA ZA200401042A patent/ZA200401042B/en unknown
- 2004-02-12 IL IL160367A patent/IL160367A/en not_active IP Right Cessation
- 2004-03-01 EC EC2004004998A patent/ECSP044998A/es unknown
- 2004-03-19 NO NO20041180A patent/NO328890B1/no not_active IP Right Cessation
2006
- 2006-08-03 CY CY20061101095T patent/CY1105573T1/el unknown
2008
- 2008-09-25 US US12/237,896 patent/US20090054467A1/en not_active Abandoned
2009
- 2009-05-07 IL IL198643A patent/IL198643A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1423391E (pt)	2006-09-29
NZ531343A (en)	2006-01-27
ZA200401042B (en)	2004-10-25
JP2005502683A (ja)	2005-01-27
ES2262888T3 (es)	2006-12-01
CN1549817A (zh)	2004-11-24
PL368280A1 (pl)	2005-03-21
GB0121033D0 (en)	2001-10-24
NO328890B1 (no)	2010-06-07
CA2458684C (en)	2009-04-07
US20050054851A1 (en)	2005-03-10
AR036374A1 (es)	2004-09-01
CY1105573T1 (el)	2010-07-28
CA2458684A1 (en)	2003-03-13
MXPA04001935A (es)	2004-06-15
EP1423391A1 (en)	2004-06-02
DE60211530D1 (de)	2006-06-22
IL198643A (en)	2010-12-30
AU2002333760B2 (en)	2007-01-04
MY157368A (en)	2016-06-15
TWI297690B (en)	2008-06-11
KR20040029123A (ko)	2004-04-03
EP1423391B1 (en)	2006-05-17
PE20030418A1 (es)	2003-06-12
US7452886B2 (en)	2008-11-18
IL160367A (en)	2009-12-24
NO20041180L (no)	2004-03-19
CN100372849C (zh)	2008-03-05
DK1423391T3 (da)	2006-09-25
HUP0401301A3 (en)	2008-03-28
EP1423391B8 (en)	2007-12-12
BR0212226A (pt)	2004-08-17
ATE326469T1 (de)	2006-06-15
RU2331644C2 (ru)	2008-08-20
WO2003020721A1 (en)	2003-03-13
HK1072254A1 (zh)	2005-08-19
KR100695845B1 (ko)	2007-03-20
HUP0401301A2 (hu)	2004-10-28
RU2004109815A (ru)	2005-10-20
ECSP044998A (es)	2004-04-28
DE60211530T2 (de)	2006-12-21
JP4629334B2 (ja)	2011-02-09
US20090054467A1 (en)	2009-02-26

Publication	Publication Date	Title
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GB0112802D0 (en)	2001-07-18	Pyrimidine derivatives
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SI1423391T1 (sl)	2006-10-31	Pirolo pirimidini kot sredstva, ki inhibirajo cisteinske proteaze
GB0119477D0 (en)	2001-10-03	Pyrimidine derivatives
GB0119460D0 (en)	2001-10-03	The use of inhibitors of the renin-angiotensin system
IL160626A0 (en)	2004-07-25	Antiviral protease inhibitors
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AU2002245330A1 (en)	2002-08-12	Inhibition of proteasomes to prevent restenosis
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